Darcy Wagner

Associate Senior Lecturer, Doctor of Philosophy (PhD) in Biomedical Engineering, Bachelor of Science in Mechanical Engineering (BSME)
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  1. 2019
  2. Translating Basic Research into Safe and Effective Cell-based Treatments for Respiratory Diseases

    Ikonomou, L., Darcy E Wagner, Turner, L. & Weiss, D. J., 2019 Mar 27, In : Annals of the American Thoracic Society.

    Research output: Contribution to journalArticle

  3. Generation of Human 3D Lung Tissue Cultures (3D-LTCs) for Disease Modeling

    Gerckens, M., Hani N Alsafadi, Darcy E Wagner, Lindner, M., Burgstaller, G. & Königshoff, M., 2019 Feb 12, In : Journal of visualized experiments : JoVE. 144, e58437 .

    Research output: Contribution to journalArticle

  4. 2018
  5. Dynamic expression of HOPX in alveolar epithelial cells reflects injury and repair during the progression of pulmonary fibrosis

    Ota, C., Ng-Blichfeldt, J-P., Korfei, M., Hani N. Alsafadi, Lehmann, M., Skronska-Wasek, W., Martina M. De Santis, Guenther, A., Darcy Wagner & Königshoff, M., 2018 Aug 28, In : Scientific Reports. 8, 12983.

    Research output: Contribution to journalArticle

  6. Co-opting of ClinicalTrials.gov by patient-funded studies

    Darcy E. Wagner, Turner, L., Panoskaltsis-Mortari, A., Weiss, D. J. & Ikonomou, L., 2018 Aug, In : The Lancet Respiratory Medicine. 6, 8, p. 579-581

    Research output: Contribution to journalArticle

  7. Increased Extracellular Vesicles Mediate WNT-5A Signaling in Idiopathic Pulmonary Fibrosis

    Martin-Medina, A., Lehmann, M., Burgy, O., Hermann, S., Baarsma, H. A., Darcy E Wagner, Martina M De Santis, Ciolek, F., Hofer, T. P., Frankenberger, M., Aichler, M., Lindner, M., Gesierich, W., Guenther, A., Walch, A., Coughlan, C., Wolters, P., Lee, J. S., Behr, J. & Königshoff, M., 2018 Jul 25, In : American Journal of Respiratory and Critical Care Medicine.

    Research output: Contribution to journalArticle

  8. Acellular human lung scaffolds to model lung disease and tissue regeneration

    Gilpin, S. E. & Darcy E. Wagner, 2018 Jun 30, In : European Respiratory Review. 27, 148, 180021.

    Research output: Contribution to journalArticle

  9. TGF-β1-induced deposition of provisional extracellular matrix by tracheal basal cells promotes epithelial-to-mesenchymal transition in a c-Jun NH2-terminal kinase-1-dependent manner

    van der Velden, J. L., Darcy E. Wagner, Lahue, K. G., Abdalla, S. T., Lam, Y. W., Weiss, D. J. & Janssen-Heininger, Y. M. W., 2018 Jun 1, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 314, 6, p. L984-L997

    Research output: Contribution to journalArticle

  10. Two succeeding fibroblastic lineages drive dermal development and the transition from regeneration to scarring

    Jiang, D., Correa-Gallegos, D., Christ, S., Stefanska, A., Liu, J., Ramesh, P., Rajendran, V., Martina M. De Santis, Darcy E. Wagner & Rinkevich, Y., 2018 Apr 1, In : Nature Cell Biology. 20, 4, p. 422-431 10 p.

    Research output: Contribution to journalArticle

  11. Avian lungs: A novel scaffold for lung bioengineering

    Wrenn, S. M., Griswold, E. D., Franziska E Uhl, Uriarte, J. J., Park, H. E., Coffey, A. L., Dearborn, J. S., Ahlers, B. A., Deng, B., Lam, Y-W., Huston, D. R., Lee, P. C., Darcy E Wagner & Weiss, D. J., 2018, In : PLoS ONE. 13, 6, p. e0198956

    Research output: Contribution to journalArticle

  12. Human pulmonary 3D models for translational research

    Zscheppang, K., Berg, J., Hedtrich, S., Verheyen, L., Darcy E Wagner, Suttorp, N., Hippenstiel, S. & Hocke, A. C., 2018, In : Biotechnology Journal. 13, 1

    Research output: Contribution to journalReview article

  13. S100a4 Is Secreted by Alternatively Activated Alveolar Macrophages and Promotes Activation of Lung Fibroblasts in Pulmonary Fibrosis

    Zhang, W., Ohno, S., Steer, B., Klee, S., Staab-Weijnitz, C. A., Darcy Wagner, Lehmann, M., Stoeger, T., Königshoff, M. & Adler, H., 2018, In : Frontiers in Immunology. 9, p. 1-14 1216.

    Research output: Contribution to journalArticle

  14. 2017
  15. Early Career Members at the ERS LSC 2017: mechanistic overlap between chronic lung injury and cancer

    Almendros, I., Bartel, S., Bostantzoglou, C., Jubrail, J., Lehmann, M. & Darcy Wagner, 2017 Dec, In : Breathe. 13, 4, p. 323-326

    Research output: Contribution to journalDebate/Note/Editorial

  16. LSC - 2017 - Hippo-YAP/TAZ signaling is deranged in IPF

    Darcy Wagner, Hani Alsafadi, Mutze, K., Costa, R., Stein, M., Schiller, H., Kaminski, N. & Koenigshoff, M., 2017 Sep 6, In : European Respiratory Journal. 50, Suppl. 61, OA475.

    Research output: Contribution to journalPublished meeting abstract

  17. Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo

    Lehmann, M., Korfei, M., Mutze, K., Klee, S., Skronska-Wasek, W., Hani N. Alsafadi, Ota, C., Costa, A. R., Schiller, H. B., Lindner, M., Darcy E Wagner, Günther, A. & Königshoff, M., 2017 Aug, In : European Respiratory Journal. 50, p. 1-15 1602367.

    Research output: Contribution to journalArticle

  18. Reduced frizzled receptor 4 expression prevents WNT/b-catenin-driven alveolar lung repair in chronic obstructive pulmonary disease

    Skronska-Wasek, W., Mutze, K., Baarsma, H. A., Bracke, K. R., Hani N. Alsafadi, Lehmann, M., Costa, A. R., Stornaiuolo, M., Novellino, E., Brusselle, G., Darcy E. Wagner, Yildirim, A. O. & Königshoff, M., 2017 Jul 15, In : American Journal of Respiratory and Critical Care Medicine. 196, 2, p. 172-185 14 p.

    Research output: Contribution to journalArticle

  19. Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair

    Poobalasingam, T., Yates, L. L., Walker, S. A., Pereira, M., Gross, N. Y., Ali, A., Kolatsi-Joannou, M., Jarvelin, M. R., Pekkanen, J., Papakrivopoulou, E., Long, D. A., Griffiths, M., Darcy Wagner, Konigshoff, M., Hind, M., Minelli, C., Lloyd, C. M. & Dean, C. H., 2017 Apr 1, In : DMM Disease Models and Mechanisms. 10, 4, p. 409-423

    Research output: Contribution to journalArticle

  20. Unproven Stem Cell Treatments for Lung Disease-An Emerging Public Health Problem

    American Thoracic Society Respiratory Cell and Molecular Biology Assembly Stem Cell Working Group, 2017 Apr 1, In : American Journal of Respiratory and Critical Care Medicine. 195, 7, p. P13-P14

    Research output: Contribution to journalDebate/Note/Editorial

  21. An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices

    Hani N. Alsafadi, Staab-Weijnitz, C. A., Lehmann, M., Lindner, M., Peschel, B., Königshoff, M. & Darcy E. Wagner, 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 6, p. L896-L902

    Research output: Contribution to journalArticle

  22. Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD

    Baarsma, H. A., Skronska-Wasek, W., Mutze, K., Ciolek, F., Darcy E. Wagner, John-Schuster, G., Heinzelmann, K., Günther, A., Bracke, K. R., Dagouassat, M., Boczkowski, J., Brusselle, G., Smits, R., Eickelberg, O., Yildirim, A. O. & Königshoff, M., 2017, In : Journal of Experimental Medicine. 214, 1, p. 143-163 21 p.

    Research output: Contribution to journalArticle

  23. Preparation of Decellularized Lung Matrices for Cell Culture and Protein Analysis

    Franziska E Uhl, Darcy E Wagner & Weiss, D. J., 2017, In : Methods in Molecular Biology. 1627, p. 253-283

    Research output: Contribution to journalArticle

  24. 2016
  25. Linking bronchopulmonary dysplasia to adult chronic lung diseases: role of WNT signaling

    Ota, C., Baarsma, H. A., Darcy E Wagner, Hilgendorff, A. & Königshoff, M., 2016 Dec, In : Molecular and cellular pediatrics. 3, p. 1-13 34.

    Research output: Contribution to journalReview article

  26. A Computational Model of Cellular Engraftment on Lung Scaffolds

    Pothen, J. J., Rajendran, V., Darcy Wagner, Weiss, D. J., Smith, B. J., Ma, B. & Bates, J. H. T., 2016 Oct 1, In : BioResearch Open Access. 5, 1, p. 308-319

    Research output: Contribution to journalArticle

  27. Comparative Decellularization and Recellularization of Wild-Type and Alpha 1,3 Galactosyltransferase Knockout Pig Lungs: A Model for Ex Vivo Xenogeneic Lung Bioengineering and Transplantation

    Platz, J., Bonenfant, N. R., Franziska E. Uhl, Coffey, A. L., McKnight, T., Parsons, C., Sokocevic, D., Borg, Z. D., Lam, Y. W., Deng, B., Fields, J. G., DeSarno, M. J., Loi, R., Hoffman, A. M., Bianchi, J., Dacken, B., Petersen, T. N., Darcy E. Wagner & Weiss, D. J., 2016 Aug 1, In : Tissue Engineering - Part C: Methods. 22, 8, p. 725-739

    Research output: Contribution to journalArticle

  28. An Official American Thoracic Society Workshop Report 2015. Stem Cells and Cell Therapies in Lung Biology and Diseases

    Darcy E Wagner, Cardoso, W. V., Gilpin, S. E., Majka, S., Ott, H., Randell, S. H., Thébaud, B., Waddell, T., Weiss, D. J. & ATS Subcommittee on Stem Cells and Cell Therapies, 2016 Aug, In : Annals of the American Thoracic Society. 13, 8, p. S259-78

    Research output: Contribution to journalArticle

  29. Impairment of immunoproteasome function by cigarette smoke and in chronic obstructive pulmonary disease

    Kammerl, I. E., Dann, A., Mossina, A., Brech, D., Lukas, C., Vosyka, O., Nathan, P., Conlon, T. M., Wagner, D. E., Overkleeft, H. S., Prasse, A., Rosas, I. O., Straub, T., Krauss-Etschmann, S., Konigshoff, M., Preissler, G., Winter, H., Lindner, M., Hatz, R., Behr, J. & 5 othersHeinzelmann, K., Yildirim, A. O., Noessner, E., Eickelberg, O. & Meiners, S., 2016 Jun 1, In : American Journal of Respiratory and Critical Care Medicine. 193, 11, p. 1230-1241

    Research output: Contribution to journalArticle

  30. Residual Detergent Detection Method for Nondestructive Cytocompatibility Evaluation of Decellularized Whole Lung Scaffolds

    Zvarova, B., Franziska E. Uhl, Uriarte, J. J., Borg, Z. D., Coffey, A. L., Bonenfant, N. R., Weiss, D. J. & Darcy E. Wagner, 2016 May 1, In : Tissue Engineering - Part C: Methods. 22, 5, p. 418-428

    Research output: Contribution to journalArticle

  31. Decreased laminin expression by human lung epithelial cells and fibroblasts cultured in acellular lung scaffolds from aged mice

    Godin, L. M., Sandri, B. J., Darcy E. Wagner, Meyer, C. M., Price, A. P., Akinnola, I., Weiss, D. J. & Panoskaltsis-Mortari, A. P. M., 2016 Mar 1, In : PLoS ONE. 11, 3, e0150966.

    Research output: Contribution to journalArticle

  32. WISP1 mediates IL-6-dependent proliferation in primary human lung fibroblasts

    Klee, S., Lehmann, M., D. E. Wagner, Baarsma, H. A. & Konigshoff, M., 2016 Feb 12, In : Scientific Reports. 6, p. 1-11 20547.

    Research output: Contribution to journalArticle

  33. CD11b+ and sca-1+ cells exert the main beneficial effects of systemically administered bone marrow-derivedmononuclear cells in a murinemodel of mixed Th2/Th17 allergic airway inflammation

    Cruz, F. F., Borg, Z. D., Goodwin, M., Coffey, A. L., Darcy E. Wagner, Rocco, P. R. M. & Weiss, D. J., 2016, In : Stem cells translational medicine. 5, 4, p. 488-499

    Research output: Contribution to journalArticle

  34. The global emergence of unregulated stem cell treatments for respiratory diseases: Professional societies need to act

    Ikonomou, L., Freishtat, R. J., Darcy E. Wagner, Panoskaltsis-Mortari, A. & Weiss, D. J., 2016, In : Annals of the American Thoracic Society. 13, 8, p. 1205-1207

    Research output: Contribution to journalDebate/Note/Editorial

  35. 2015
  36. Systemic administration of human bone marrow-derived mesenchymal stromal cell extracellular vesicles ameliorates Aspergillus hyphal extract-induced allergic airway inflammation in immunocompetent mice

    Cruz, F. F., Borg, Z. D., Goodwin, M., Sokocevic, D., Darcy E. Wagner, Coffey, A. L., Antunes, M., Robinson, K. L., Mitsialis, S. A., Kourembanas, S., Thane, K., Hoffman, A. M., McKenna, D. H., Rocco, P. R. M. & Weiss, D. J., 2015 Nov 1, In : Stem cells translational medicine. 4, 11, p. 1302-1316

    Research output: Contribution to journalArticle

  37. Preclinical validation and imaging of Wnt-induced repair in human 3D lung tissue cultures

    Franziska E. Uhl, Vierkotten, S., Darcy E. Wagner, Burgstaller, G., Costa, A. R., Koch, I., Lindner, M., Meiners, S., Eickelberg, O. & Königshoff, M., 2015 Oct 1, In : European Respiratory Journal. 46, 4, p. 1150-1166

    Research output: Contribution to journalArticle

  38. An official American Thoracic Society workshop report: Stem cells and cell therapies in lung biology and diseases

    Weiss, D. J., Chambers, D., Giangreco, A., Keating, A., Kotton, D., Lelkes, P. I., Darcy E. Wagner, Prockop, D. J. & ATS Subcommittee on Stem Cells and Cell Therapies, 2015 Apr 1, In : Annals of the American Thoracic Society. 12, 4, p. S79-S97

    Research output: Contribution to journalReview article

  39. Freshly thawed and continuously cultured human bone marrow-derived mesenchymal stromal cells comparably ameliorate allergic airways inflammation in immunocompetent mice

    Cruz, F. F., Borg, Z. D., Goodwin, M., Sokocevic, D., Darcy Wagner, McKenna, D. H., Rocco, P. R. M. & Weiss, D. J., 2015, In : Stem cells translational medicine. 4, 6, p. 615-624 10 p.

    Research output: Contribution to journalArticle

  40. 2014
  41. Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis

    Lau, A. N., Curtis, S. J., Fillmore, C. M., Rowbotham, S. P., Mohseni, M., Darcy E. Wagner, Beede, A. M., Montoro, D. T., Sinkevicius, K. W., Walton, Z. E., Barrios, J., Weiss, D. J., Camargo, F. D., Wong, K. K. & Kim, C. F., 2014 Mar 3, In : EMBO Journal. 33, 5, p. 468-481

    Research output: Contribution to journalArticle

  42. Comparative decellularization and recellularization of normal versus emphysematous human lungs

    Darcy E. Wagner, Bonenfant, N. R., Parsons, C. S., Sokocevic, D., Brooks, E. M., Borg, Z. D., Lathrop, M. J., Wallis, J. D., Daly, A. B., Lam, Y. W., Deng, B., DeSarno, M. J., Ashikaga, T., Loi, R. & Weiss, D. J., 2014 Mar, In : Biomaterials. 35, 10, p. 3281-3297

    Research output: Contribution to journalArticle

  43. Three-dimensional scaffolds of acellular human and porcine lungs for high throughput studies of lung disease and regeneration

    Darcy E. Wagner, Bonenfant, N. R., Sokocevic, D., DeSarno, M. J., Borg, Z. D., Parsons, C. S., Brooks, E. M., Platz, J., Khalpey, Z. I., Hoganson, D. M., Deng, B., Lam, Y. W., Oldinski, R. A., Ashikaga, T. & Weiss, D. J., 2014 Mar, In : Biomaterials. 35, 9, p. 2664-2679

    Research output: Contribution to journalArticle

  44. Design and synthesis of an artificial pulmonary pleura for high throughput studies in acellular human lungs

    Darcy E. Wagner, Fenn, S. L., Bonenfant, N. R., Marks, E. R., Borg, Z. D., Saunders, P., Oldinski, R. A. & Weiss, D. J., 2014, In : Cellular and Molecular Bioengineering. 7, 2, p. 184-195

    Research output: Contribution to journalArticle

  45. 2013
  46. Microwave-assisted solution combustion synthesis of high aspect ratio calcium phosphate nanoparticles

    Darcy E. Wagner, Lawrence, J. & Bhaduri, S. B., 2013 Nov 28, In : Journal of Materials Research. 28, 22, p. 3119-3129

    Research output: Contribution to journalArticle

  47. A microwave-assisted solution combustion synthesis to produce europium-doped calcium phosphate nanowhiskers for bioimaging applications

    Darcy E. Wagner, Eisenmann, K. M., Nestor-Kalinoski, A. L. & Bhaduri, S. B., 2013 Sep, In : Acta Biomaterialia. 9, 9, p. 8422-8432

    Research output: Contribution to journalArticle

  48. Can stem cells be used to generate new lungs? Ex vivo lung bioengineering with decellularized whole lung scaffolds

    Darcy E. Wagner, Bonvillain, R. W., Jensen, T., Girard, E. D., Bunnell, B. A., Finck, C. M., Hoffman, A. M. & Weiss, D. J., 2013 Aug, In : Respirology (Carlton, Vic.). 18, 6, p. 895-911

    Research output: Contribution to journalReview article

  49. Cytocompatibility evaluation of microwave sintered biphasic calcium phosphate scaffolds synthesized using pH control

    Darcy E. Wagner, Jones, A. D., Zhou, H. & Bhaduri, S. B., 2013 Apr 1, In : Materials Science and Engineering C. 33, 3, p. 1710-1719

    Research output: Contribution to journalArticle

  50. The effect of age and emphysematous and fibrotic injury on the re-cellularization of de-cellularized lungs

    Sokocevic, D., Bonenfant, N. R., Darcy E. Wagner, Borg, Z. D., Lathrop, M. J., Lam, Y. W., Deng, B., DeSarno, M. J., Ashikaga, T., Loi, R., Hoffman, A. M. & Weiss, D. J., 2013 Apr, In : Biomaterials. 34, 13, p. 3256-3269

    Research output: Contribution to journalArticle

  51. The effects of storage and sterilization on de-cellularized and re-cellularized whole lung

    Bonenfant, N. R., Sokocevic, D., Darcy E. Wagner, Borg, Z. D., Lathrop, M. J., Lam, Y. W., Deng, B., DeSarno, M. J., Ashikaga, T., Loi, R. & Weiss, D. J., 2013 Apr, In : Biomaterials. 34, 13, p. 3231-3245

    Research output: Contribution to journalArticle

  52. 2012
  53. 2010
  54. Heat transfer in laminar flows of extended modified power law fluids in rectangular ducts

    Capobianchi, M. & Darcy Wagner, 2010 Jan 15, In : International Journal of Heat and Mass Transfer. 53, 1-3, p. 558-563

    Research output: Contribution to journalArticle