David Gisselsson Nord

Professor, specialist Physician, Senior Consultant PathologistFormer name: David Gisselsson

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Keywords

  • Pathology, Paediatrics, Cancer, Childhood cancer

Research

David Gisselsson Nord is a clinician-researcher focused on understanding how cancer cells develop resilience against current ontological treatments. He has identified one of the most common mechanisms by which cancer cells alter their genome through repeated breakage of chromosomes with eroded telomeres. Dr. Gisselsson Nord has also established a series of methods for measuring genetic instability of cancer cells that allow better prediction of prognosis and treatment response. Today he divides his time between clinical work as a pediatric pathologist and research on childhood cancer. His combines high-resolution genomics on clinical samples with mathematical modeling and methods from species evolution. By this approach, his team produces detailed maps of how clones replace each other over space and time, with the main purpose to trace the ancestry of metastatic relapse. Dr. Gisselsson Nord and his team recently identified four fundamental evolutionary trajectories by which cancer cells compete with each other and evolve towards a higher degree of malignancy. He has received the Fernström Prize to Promising Young Investigators and a recent SIOP Award for Translational and Basic research from the International Society of Pediatric Oncology.

Professional work

David Gisselsson Nord is professor of molecular pathology at Lund University and process director for pediatric and fetal pathology in the southern healthcare region of Sweden. He is chair of the national committee for clinical genetic sequencing of childhood tumors, a joint effort between the Swedish Childhood Cancer Fund and Genomic Medicine Sweden. 

 

Highlighted research outputs

Jenny Karlsson, Anders Valind, Linda Holmquist Mengelbier, Sofia Bredin, Louise Cornmark, Caroline Jansson, Amina Wali, Johan Staaf, Björn Viklund, Ingrid Øra, Anna Börjesson, Torbjörn Backman, Noémie Braekeveldt, Bengt Sandstedt, Niklas Pal, Anders Isaksson, Barbara Gürtl Lackner, Tord Jonson, Daniel Bexell & David Gisselsson, 2018 Jul, In: Nature Genetics. 50, 7, p. 944-950

Research output: Contribution to journalArticle

Natalie Andersson, Bjorn Bakker, Jenny Karlsson, Anders Valind, Linda Holmquist Mengelbier, Diana C J Spierings, Floris Foijer & David Gisselsson, 2020 Apr, In: Cancer Research. 80, 7, p. 1512-1523 12 p.

Research output: Contribution to journalArticle

David Gisselsson & Robert Egnell, 2017, In: Trends in Cancer. 3, 2, p. 73-75

Research output: Contribution to journalArticle

Linda Holmquist Mengelbier, Jenny Karlsson, David Lindgren, Anders Valind, Henrik Lilljebjörn, Caroline Jansson, Daniel Bexell, Noémie Braekeveldt, Adam Ameur, Tord Jonson, Hanna Göransson Kultima, Anders Isaksson, Jurate Asmundsson, Rogier Versteeg, Marianne Rissler, Thoas Fioretos, Bengt Sandstedt, Anna Börjesson, Torbjörn Backman, Niklas Pal & 3 others, Ingrid Øra, Markus Mayrhofer & David Gisselsson Nord, 2015, In: Nature Communications. 6, 6125.

Research output: Contribution to journalArticle

Lars A. Forsberg, David Gisselsson & Jan P. Dumanski, 2017, In: Nature Reviews. Genetics. 18, p. 128-142

Research output: Contribution to journalArticle

Linda Holmquist Mengelbier, Simon Lindell-Munther, Hiroaki Yasui, Caroline Jansson, Javanshir Esfandyari, Jenny Karlsson, Kimberly Lau, Chi chung Hui, Daniel Bexell, Sevan Hopyan & David Gisselsson, 2019 Jan, In: Journal of Pathology. 247, 1

Research output: Contribution to journalArticle

David Gisselsson Nord, Yuesheng Jin, David Lindgren, Johan Persson, Lennart Gisselsson, Sandra Hanks, Daniel Sehic, Linda Holmquist Mengelbier, Ingrid Øra, Nazneen Rahman, Fredrik Mertens, Felix Mitelman & Nils Mandahl, 2010, In: Proceedings of the National Academy of Sciences. 107, 47, p. 20489-20493

Research output: Contribution to journalArticle

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