David Gisselsson Nord

Professor, specialist Physician, Senior Consultant PathologistFormer name: David Gisselsson

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Keywords

  • Pathology, Paediatrics, Cancer, Childhood cancer

Research

David Gisselsson Nord is a clinician-researcher focused on understanding how cancer cells develop resilience against current ontological treatments. He has identified one of the most common mechanisms by which cancer cells alter their genome through repeated breakage of chromosomes with eroded telomeres. Dr. Gisselsson Nord has also established a series of methods for measuring genetic instability of cancer cells that allow better prediction of prognosis and treatment response. Today he divides his time between clinical work as a pediatric pathologist and research on childhood cancer. His combines high-resolution genomics on clinical samples with mathematical modeling and methods from species evolution. By this approach, his team produces detailed maps of how clones replace each other over space and time, with the main purpose to trace the ancestry of metastatic relapse. Dr. Gisselsson Nord and his team recently identified four fundamental evolutionary trajectories by which cancer cells compete with each other and evolve towards a higher degree of malignancy. He has received the Fernström Prize to Promising Young Investigators and a recent SIOP Award for Translational and Basic research from the International Society of Pediatric Oncology.

Professional work

David Gisselsson Nord is professor of molecular pathology at Lund University and process director for pediatric and fetal pathology in the southern healthcare region of Sweden. He is chair of the national committee for clinical genetic sequencing of childhood tumors, a joint effort between the Swedish Childhood Cancer Fund and Genomic Medicine Sweden. 

 

Highlighted research outputs

Jenny Karlsson, Anders Valind, Linda Holmquist Mengelbier, Bredin, S., Louise Cornmark, Jansson, C., Wali, A., Johan Staaf, Viklund, B., Ingrid Øra, Anna Börjesson, Backman, T., Noémie Braekeveldt, Sandstedt, B., Pal, N., Isaksson, A., Lackner, B. G., Tord Jonson, Daniel Bexell & David Gisselsson, 2018 Jul, In : Nature Genetics. 50, 7, p. 944-950

Research output: Contribution to journalArticle

David Gisselsson & Egnell, R., 2017, In : Trends in Cancer. 3, 2, p. 73-75

Research output: Contribution to journalArticle

Forsberg, L. A., David Gisselsson & Dumanski, J. P., 2017, In : Nature Reviews. Genetics. 18, p. 128-142

Research output: Contribution to journalArticle

Holmquist Mengelbier, L., Karlsson, J., Lindgren, D., Valind, A., Lilljebjörn, H., Jansson, C., Bexell, D., Braekeveldt, N., Ameur, A., Jonson, T., Kultima, H. G., Isaksson, A., Asmundsson, J., Versteeg, R., Rissler, M., Fioretos, T., Sandstedt, B., Börjesson, A., Backman, T., Pal, N. & 3 othersIngrid Øra, Mayrhofer, M. & David Gisselsson Nord, 2015, In : Nature Communications. 6, 6125.

Research output: Contribution to journalArticle

David Gisselsson Nord, Jin, Y., David Lindgren, Persson, J., Gisselsson, L., Hanks, S., Sehic, D., Linda Holmquist Mengelbier, Ingrid Øra, Rahman, N., Fredrik Mertens, Felix Mitelman & Nils Mandahl, 2010, In : Proceedings of the National Academy of Sciences. 107, 47, p. 20489-20493

Research output: Contribution to journalArticle

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