Fredrik Mertens

Professor, specialist Physician, MD, PhD, MD, PhD

Research areas and keywords

UKÄ subject classification

  • Medical and Health Sciences
  • Cancer and Oncology
  • Medical Genetics

Keywords

  • Sarcoma , diagnosis, Gene fusions

Research

Soft tissue tumors (STT) constitute a heterogeneous group of neoplasms that clinically run the gamut from totally benign to highly malignant neoplasms. This clinical variability is reflected in the recognition of more than 100 histopathologic entities. Genetic analyses have provided a wealth of information on the genectic constitution of STT, and clearly nonrandom patterns of genetic changes, ranging from point mutations and gene fusions to massive genomic imbalalnces, have been identified in each histological entity studied in sufficient detail. The finding of a strong genotype-phenotype correlation has not only provided valuable clues to the cellular mechanisms behind STT development, but has also been of clinical significance by increasing the diagnostic accuracy.


Our research activites concerning STT are focused on the characterization of the spectrum of acquired genetic changes occuring in vivo, using state of the art  techniques. The aims of these studies are to identify genetic changes that are instrumental for tumor development and progression, to clarify the causes and consequences of increased genetic instability, which is a characteristic feature of several types of STT, and to establish objective and robust genetic assays that could improve the clinical management of patients with STT by adding diagnostic and prognostic precision.

Highlighted research outputs

Christine G. Joseph, Heejung Hwang, Yuchen Jiao, Laura D. Wood, Isaac Kinde, Jian Wu, Nils Mandahl, Jinyong Luo, Ralph H. Hruban, Luis A. Diaz Jr, Tong-Chuan He, Bert Vogelstein, Kenneth W. Kinzler, Fredrik Mertens & Nickolas Papadopoulos, 2014, In: Genes, Chromosomes and Cancer. 53, 1, p. 15-24

Research output: Contribution to journalArticle

Elsa Arbajian, Florian Puls, Linda Magnusson, Khin Thway, Cyril Fisher, Vaiyapuri P Sumathi, Johnbosco Tayebwa, Karolin Hansén Nord, Lars-Gunnar Kindblom & Fredrik Mertens, 2014, In: American Journal of Surgical Pathology. 38, 6, p. 801-808

Research output: Contribution to journalArticle

Charles Walther, Johnbosco Tayebwa, Henrik Lilljebjörn, Linda Magnusson, Jenny Nilsson, Fredrik Vult von Steyern, Ingrid Øra, Henryk Domanski, Thoas Fioretos, Karolin Hansén Nord, Christopher Dm Fletcher & Fredrik Mertens, 2014, In: Journal of Pathology. 232, 5, p. 534-540

Research output: Contribution to journalArticle

Jakob Hofvander, Johnbosco Tayebwa, Jenny Nilsson, Linda Magnusson, Otte Brosjö, Olle L Larsson, Fredrik Vult von Steyern, Nils Mandahl, Christopher Fletcher & Fredrik Mertens, 2015, In: Clinical Cancer Research. 21, 4, p. 864-869

Research output: Contribution to journalArticle

Florian Puls, Jakob Hofvander, Linda Magnusson, Jenny Nilsson, Elaine Haywood, Vaiyapuri P Sumathi, D Chas Mangham, Lars-Gunnar Kindblom & Fredrik Mertens, 2016, In: Journal of Pathology. 238, 4, p. 502-507

Research output: Contribution to journalArticle

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