Gabriela Godaly

Senior Lecturer

Research areas and keywords

UKÄ subject classification

  • Infectious Medicine

Keywords

  • tuberculosis, peptide, immunomodulator

Research

Despite the availability of antibiotics and the extensive use of the live attenuated vaccine Bacille Calmette-Guérin (BCG), tuberculosis (TB) remains a major health concern with an astounding 10 million new cases per year.

BCG prevents several severe forms of TB in children, but has inadequate efficacy against pulmonary TB in adults. The duration of the current antibiotic treatment is long, and it varies from six months for drug susceptible Mycobacterium tuberculosis (Mtb) strains to more than two years for multi-drug resistant (MDR-Mtb) strains.

Current tuberculosis drugs are effective for susceptible Mtb strains, but are limited by hepatotoxicity and poor ability to reach dormant bacilli inside granulomas. Co-infection with HIV and the increase in MDR-Mtb strains increase mortality rates, making the development of new drugs an urgent priority. Antimicrobial peptides (AMPs), such as defensins, offer exciting opportunities in this context. In addition to their direct antimicrobial activity, AMPs can protect the host by a range of immunomodulatory mechanisms making them pleiotropic.

Our research is focused on finding anti-mycobacterial peptides and inhibitors of immune responses for future TB therapy.

Recent research outputs

Nader Alaridah, Hallbäck, E. T., Tångrot, J., Niclas Winqvist, Erik Sturegård, Florén-Johansson, K., Jönsson, B., Erik Tenland, Welinder-Olsson, C., Patrik Medstrand, Kaijser, B. & Gabriela Godaly, 2019 Mar 20, In : Scientific Reports. 9, 1, 4931.

Research output: Contribution to journalArticle

Erik Tenland, Pochert, A., Krishnan, N., Rao, K. U., Kalsum, S., Braun, K., Glegola-Madejska, I., Lerm, M., Robertson, B. D., Lindén, M. & Gabriela Godaly, 2019 Feb 26, In : PLoS ONE. 14, 2, e0212858.

Research output: Contribution to journalArticle

Erik Tenland, Krishnan, N., Anna Rönnholm, Kalsum, S., Manoj Puthia, Mörgelin, M., Davoudi, M., Otrocka, M., Nader Alaridah, Glegola-Madejska, I., Erik Sturegård, Artur Schmidtchen, Lerm, M., Robertson, B. D. & Gabriela Godaly, 2018, In : Tuberculosis. 113, p. 231-238 8 p.

Research output: Contribution to journalArticle

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