Gunnar Gouras

Professor, Directly Appointed, Professor of Experimental Neurology
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  1. 2021
  2. APOE4 affects basal and NMDAR mediated protein synthesis in neurons by perturbing calcium homeostasis

    Sarayu Ramakrishna, Vishwaja Jhaveri, Sabine C Konings, Bharti Nawalpuri, Sumita Chakraborty, Bjørn Holst, Benjamin Schmid, Gunnar K Gouras, Kristine K Freude & Ravi S Muddashetty, 2021 Sep 2, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. JN-RM-0435-21.

    Research output: Contribution to journalArticle

  3. In memoriam for M. Flint Beal

    Gunnar K Gouras, 2021 Aug 13, In: Journal of Alzheimer's disease : JAD. p. 1-2

    Research output: Contribution to journalDebate/Note/Editorial

  4. DNAJB6b is Downregulated in Synucleinopathies

    Jonas Folke, Sertan Arkan, Isak Martinsson, Susana Aznar, Gunnar Gouras, Tomasz Brudek & Christian Hansen, 2021 Jul 26, In: Journal of Parkinson's Disease.

    Research output: Contribution to journalArticle

  5. Neuronal α-amylase is important for neuronal activity and glycogenolysis and reduces in presence of amyloid beta pathology

    Elin Byman, Isak Martinsson, Henriette Haukedal, Netherlands Brain Bank Netherlands Brain Bank, Gunnar Gouras, Kristine K Freude & Malin Wennström, 2021 Jul 14, In: Aging Cell. e13433.

    Research output: Contribution to journalArticle

  6. Up-regulation of APP endocytosis by neuronal aging drives amyloid dependent-synapse loss

    Tatiana Burrinha, Isak Martinsson, Ricardo Gomes, Ana Paula Terrasso, Gunnar K Gouras & Cláudia Guimas Almeida, 2021 May 1, In: Journal of Cell Science. 134, 9, jcs255752.

    Research output: Contribution to journalArticle

  7. Accumulation of cellular prion protein within β-amyloid oligomer plaques in aged human brains

    Reisuke H Takahashi, Mayumi Yokotsuka, Minoru Tobiume, Yuko Sato, Hideki Hasegawa, Toshitaka Nagao & Gunnar K Gouras, 2021 Feb 23, In: Brain Pathology. p. e12941

    Research output: Contribution to journalArticle

  8. 2020
  9. Super‐Resolution Infrared Imaging of Polymorphic Amyloid Aggregates Directly in Neurons

    Oxana Klementieva, Christophe Sandt, Isak Martinsson, Mustafa Kansiz, Gunnar Keppler Gouras & Ferenc Borondics, 2020 Feb 7, In: Advanced Science. 9 p., 1903004.

    Research output: Contribution to journalArticle

  10. Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies

    Yuriy Pomeshchik, Oxana Klementieva, Jeovanis Gil, Isak Martinsson, Marita Grønning Hansen, Tessa de Vries, Anna Sancho-Balsells, Kaspar Russ, Ekaterina Savchenko, Anna Collin, Ana Rita Vaz, Silvia Bagnoli, Benedetta Nacmias, Claire Rampon, Sandro Sorbi, Dora Brites, György Marko-Varga, Zaal Kokaia, Melinda Rezeli, Gunnar K. Gouras & 1 others, Laurent Roybon, 2020, In: Stem Cell Reports. 15, 1, p. 256-273 18 p.

    Research output: Contribution to journalArticle

  11. 2019
  12. Aging, metabolism, synaptic activity, and Aβ in Alzheimer's disease

    Gunnar K. Gouras, 2019 Jan 1, In: Frontiers in Aging Neuroscience. 10, JUL, 185.

    Research output: Contribution to journalDebate/Note/Editorial

  13. APP depletion alters selective pre- and post-synaptic proteins

    Isak Martinsson, Estibaliz Capetillo-Zarate, Mathilde Faideau, Katarina Willén, Noemi Esteras, Susanne Frykman, Lars O. Tjernberg & Gunnar K. Gouras, 2019, In: Molecular and Cellular Neuroscience. 95, p. 86-95 10 p.

    Research output: Contribution to journalArticle

  14. Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection.

    Ester Aso, Isak Martinsson, Dietmar Appelhans, C Effenberg, Núria Benseny-Cases, Gunnar Gouras, Isidre Ferrer & Oxana Klementieva, 2019, In: Nanomedicine: Nanotechnology, Biology, and Medicine. p. 198-209

    Research output: Contribution to journalArticle

  15. 2018
  16. Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice

    O. Klementieva, J. Mathurin, A. Engdahl, R. Freitas, K. Willen, P. Uvdal, L. M. Miller & G. Gouras, 2018 Oct 29, 2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018. IEEE Computer Society, Vol. 2018-September. 8510376

    Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceeding

  17. Prion-like seeding and nucleation of intracellular amyloid-β

    Tomas T. Olsson, Oxana Klementieva & Gunnar K. Gouras, 2018 May 1, In: Neurobiology of Disease. 113, p. 1-10 10 p.

    Research output: Contribution to journalArticle

  18. S100A9-Driven Amyloid-Neuroinflammatory Cascade in Traumatic Brain Injury as a Precursor State for Alzheimer’s Disease

    Chao Wang, Igor A. Iashchishyn, Jonathan Pansieri, Sofie Nyström, Oxana Klementieva, John Kara, Istvan Horvath, Roman Moskalenko, Reza Rofougaran, Gunnar Gouras, Gabor G. Kovacs, S. K. Shankar & Ludmilla A. Morozova-Roche, 2018, In: Scientific Reports. 8, 1, 12836.

    Research output: Contribution to journalArticle

  19. 2017
  20. Plaque formation and the intraneuronal accumulation of β-amyloid in Alzheimer's disease

    Reisuke H. Takahashi, Toshitaka Nagao & Gunnar K. Gouras, 2017 Apr 1, In: Pathology International. 67, 4, p. 185-193 9 p.

    Research output: Contribution to journalReview article

  21. Pre-plaque conformational changes in Alzheimer's disease-linked Aβ and APP

    O. Klementieva, K. Willén, I. Martinsson, B. Israelsson, A. Engdahl, J. Cladera, P. Uvdal & G. K. Gouras, 2017 Mar 13, In: Nature Communications. 8, 14726.

    Research output: Contribution to journalArticle

  22. Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A

    Katarina Willén, James R Edgar, Takafumi Hasegawa, Nobuyuki Tanaka, Clare E Futter & Gunnar K Gouras, 2017, In: Molecular Neurodegeneration. 12, 61.

    Research output: Contribution to journalArticle

  23. Heterogeneous Association of Alzheimer's Disease-Linked Amyloid-β and Amyloid-β Protein Precursor with Synapses

    Katarina Willén, Agnieszka Sroka, Reisuke H. Takahashi & Gunnar K. Gouras, 2017, In: Journal of Alzheimer's Disease. 60, 2, p. 511-524 14 p.

    Research output: Contribution to journalArticle

  24. 2016
  25. Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease

    Brenna C. Beckelman, Stephen Day, Xueyan Zhou, Maggie Donohue, Gunnar K. Gouras, Eric Klann, C. Dirk Keene & Tao Ma, 2016 Sep 6, In: Journal of Alzheimer's Disease. 54, 2, p. 669-678 10 p.

    Research output: Contribution to journalArticle

  26. Brain activity and Alzheimer's disease: A complex relationship

    Oskar Hansson & Gunnar Gouras, 2016 Aug 1, In: Brain. 139, 8, p. 2109-2110 2 p.

    Research output: Contribution to journalDebate/Note/Editorial

  27. Direct High Affinity Interaction between Aβ42 and GSK3α Stimulates Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer's Disease?

    Christopher Dunning, Gavin McGauran, Katarina Willén, Gunnar Gouras, David J O'Connell & Sara Linse, 2016, In: ACS Chemical Neuroscience. 7, 2, p. 161-170

    Research output: Contribution to journalArticle

  28. 2015
  29. ADAM10 and BACE1 are localized to synaptic vesicles.

    Jolanta L Lundgren, Saheeb Ahmed, Sophia Schedin-Weiss, Gunnar Gouras, Bengt Winblad, Lars O Tjernberg & Susanne Frykman, 2015, In: Journal of Neurochemistry. 135, 3, p. 606-615

    Research output: Contribution to journalArticle

  30. β-amyloid Peptides and Amyloid Plaques in Alzheimer's Disease.

    Gunnar Gouras, Tomas Olsson & Oskar Hansson, 2015, In: Neurotherapeutics. 12, 1, p. 3-11

    Research output: Contribution to journalReview article

  31. 2014
  32. Detection of pre-plaque amyloid aggregation using FTIR

    Oxana Klementieva, Anders Engdahl, Mathilde Faideau, Katarina Willén, Per Uvdal & Gunnar Keppler Gouras, 2014 Jul 1, In: Alzheimer's and Dementia. 10, 4

    Research output: Contribution to journalArticle

  33. Activity-independent release of the amyloid β-peptide from rat brain nerve terminals.

    Jolanta L Lundgren, Saheeb Ahmed, Bengt Winblad, Gunnar Gouras, Lars O Tjernberg & Susanne Frykman, 2014, In: Neuroscience Letters. 566, Mar 3, p. 125-130

    Research output: Contribution to journalArticle

  34. Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease.

    Sonia George, Annica Rönnbäck, Gunnar Gouras, Géraldine Petit, Fiona Grueninger, Bengt Winblad, Caroline Graff & Patrik Brundin, 2014, In: Acta Neuropathologica Communications. 2, 1, 17.

    Research output: Contribution to journalArticle

  35. The Inside-Out Amyloid Hypothesis and Synapse Pathology in Alzheimer's Disease.

    Gunnar Gouras, Katarina Willén & Mathilde Faideau, 2014, In: Neurodegenerative Diseases. 13, 2-3, p. 142-146

    Research output: Contribution to journalArticle

  36. 2013
  37. Accumulation of Intraneuronal beta-Amyloid 42 Peptides Is Associated with Early Changes in Microtubule-Associated Protein 2 in Neurites and Synapses

    Reisuke H. Takahashi, Estibaliz Capetillo-Zarate, Michael T. Lin, Teresa A. Milner & Gunnar Gouras, 2013, In: PLoS ONE. 8, 1

    Research output: Contribution to journalArticle

  38. mTOR: at the crossroads of aging, chaperones, and Alzheimer's disease.

    Gunnar Gouras, 2013, In: Journal of Neurochemistry. 124, 6, p. 747-748

    Research output: Contribution to journalDebate/Note/Editorial

  39. 2012
  40. Critical role of intraneuronal A beta in Alzheimer's disease: Technical challenges in studying intracellular A beta

    Gunnar Gouras, Katarina Willén & Davide Tampellini, 2012, In: Life Sciences. 91, 23-24, p. 1153-1158

    Research output: Contribution to journalArticle

  41. Intraneuronal A beta Accumulation, Amyloid Plaques, and Synapse Pathology in Alzheimer's Disease

    Estibaliz Capetillo-Zarate, Luis Gracia, Davide Tampellini & Gunnar Gouras, 2012, In: Neurodegenerative Diseases. 10, 1-4, p. 56-59

    Research output: Contribution to journalArticle

  42. Pathology of Synapses and Dendritic Spines

    Shira Knafo, Gunnar Gouras, Xiao-Xin Yan & Tara Spires-Jones, 2012, In: Journal of Neural Transplantation & Plasticity. 972432.

    Research output: Contribution to journalDebate/Note/Editorial

  43. 2011
  44. Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of alzheimer's disease

    Magali Dumont, Khatuna Kipiani, Fangmin Yu, Elizabeth Wille, Maya Katz, Noel Y. Calingasan, Gunnar K. Gouras, Michael T. Lin & M. Flint Beal, 2011 Oct 28, In: Journal of Alzheimer's Disease. 27, 1, p. 211-223

    Research output: Contribution to journalArticle

  45. Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain

    Reisuke H. Takahashi, Minoru Tobiume, Yuko Sato, Tetsutaro Sata, Gunnar K. Gouras & Hidehiro Takahashi, 2011 Jun, In: Neuropathology. 31, 3, p. 208-214

    Research output: Contribution to journalArticle

  46. Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of CIC-7 to lysosomes

    Amitabha Majumdar, Estibaliz Capetillo-Zarate, Dana Cruz, Gunnar K. Gouras & Frederick R. Maxfield, 2011 May 15, In: Molecular Biology of the Cell. 22, 10, p. 1664-1676

    Research output: Contribution to journalArticle

  47. Analysis of vesicular trafficking in primary neurons by live imaging.

    Davide Tampellini & Gunnar Gouras, 2011, In: Methods in Molecular Biology. 793, p. 343-350

    Research output: Contribution to journalArticle

  48. High-Resolution 3D Reconstruction Reveals Intra-Synaptic Amyloid Fibrils

    Estibaliz Capetillo-Zarate, Luis Gracia, Fangmin Yu, Jason R. Banfelder, Michael T. Lin, Davide Tampellini & Gunnar Gouras, 2011, In: American Journal of Pathology. 179, 5, p. 2551-2558

    Research output: Contribution to journalArticle

  49. Impaired β-Amyloid Secretion in Alzheimer's Disease Pathogenesis.

    Davide Tampellini, Nawreen Rahman, Michael Linell, Estibaliz Capetillo-Zarate & Gunnar Gouras, 2011, In: The Journal of neuroscience. 31, 43, p. 15384-15390

    Research output: Contribution to journalArticle

  50. 2010
  51. Effects of synaptic modulation on β-amyloid, synaptophysin, and memory performance in Alzheimer's disease transgenic mice

    Davide Tampellini, Estibaliz Capetillo-Zarate, Magali Dumont, Zhenyong Huang, Fangmin Yu, Michael T. Lin & Gunnar K. Gouras, 2010 Oct 27, In: Journal of Neuroscience. 30, 43, p. 14299-14304

    Research output: Contribution to journalArticle

  52. Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease

    Tao Ma, Charles A. Hoeffer, Estibaliz Capetillo-Zarate, Fangmin Yu, Helen Wong, Michael T. Lin, Davide Tampellini, Eric Klann, Robert D. Blitzer & Gunnar K. Gouras, 2010 Sep 20, In: PLoS ONE. 5, 9, p. 1-10 e12845.

    Research output: Contribution to journalArticle

  53. Co-occurrence of Alzheimer's disease β-amyloid and tau pathologies at synapses

    Reisuke H. Takahashi, Estibaliz Capetillo-Zarate, Michael T. Lin, Teresa A. Milner & Gunnar K. Gouras, 2010 Jul, In: Neurobiology of Aging. 31, 7, p. 1145-1152

    Research output: Contribution to journalArticle

  54. Synapses, synaptic activity and intraneuronal Aβ in Alzheimer's disease

    Davide Tampellini & Gunnar K. Gouras, 2010 May 21, In: Frontiers in Aging Neuroscience. 2, MAY, 13.

    Research output: Contribution to journalReview article

  55. Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer's disease

    Gunnar K. Gouras, Davide Tampellini, Reisuke H. Takahashi & Estibaliz Capetillo-Zarate, 2010 May 1, In: Acta Neuropathologica. 119, 5, p. 523-541

    Research output: Contribution to journalReview article

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