Håkan Axelson


Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology


  • Kidney cancer, diagnosis, Cell signalling


Solid tumors are consistently less well-oxygenated than the normal tissues from which they arise. Associations between tumor hypoxia and aggressively malignant phenotypes are observed across a range of cancers, focusing attention on molecular dissection of these pathways and how they contribute to tumorigenesis.  Clear cell renal cell carcinoma (ccRCC) is characterized by a loss of the tumor suppressor gene VHL, and hence this tumor type is characterized by constitutive activation of the hypoxic response. As such, it represents a model system for tumor hypoxia in general. Our research is aimed at identifying and characterizing the different cell types from which kidney cancer is thought to develop, and to characterize how they respond to hypoxia and loss of VHL. We have also defined as a novel ccRCC specific biomarker, SLC6A3, and explore the diagnostic and therapeutic potential of this protein. We have previously shown that hyperactivated Notch signaling may complement loss of VHL in the formation of ccRCC. Based on these findings we are establishing a model system for ccRCC based on conditional deletion of VHL in conjunction with constitutive activation of the Notch signaling pathway.

Highlighted research outputs

David Lindgren, Jonas Sjölund & Håkan Axelson, 2018 Jul, In: Trends in Cancer . 4, 7, p. 472-484

Research output: Contribution to journalArticle

Jennifer Hansson, David Lindgren, Helén Nilsson, Elinn Johansson, Martin Johansson, Lena Gustavsson & Håkan Axelson, 2017, In: Clinical Cancer Research. 23, 8, p. 2105-2115

Research output: Contribution to journalArticle

Kristoffer von Stedingk, Katleen De Preter, Jo Vandesompele, Rosa Noguera, Ingrid Øra, Jan Koster, Rogier Versteeg, Sven Påhlman, David Lindgren & Håkan Axelson, 2015, In: International Journal of Cancer. 137, 4, p. 868-877

Research output: Contribution to journalArticle

Erinn B Rankin, Katherine C Fuh, Laura Castellini, Kartik Viswanathan, Elizabeth C Finger, Anh N Diep, Edward L LaGory, Mihalis S Kariolis, Andy Chan, David Lindgren, Håkan Axelson, Yu R Miao, Adam J Krieg & Amato J Giaccia, 2014, In: Proceedings of the National Academy of Sciences. 111, 37, p. 13373-13378

Research output: Contribution to journalArticle

Jennifer Hansson, Kjell Hultenby, Catharina Cramnert, Fredrik Pontén, Hannes Jansson, David Lindgren, Håkan Axelson & Martin Johansson, 2014, In: Human Pathology. 45, 2, p. 382-393

Research output: Contribution to journalArticle

Jonas Sjölund, Martin Johansson, Sugata Manna, Carl Norin, Alexander Pietras, Siv Beckman, Elise Nilsson, Börje Ljungberg & Håkan Axelson, 2008, In: Journal of Clinical Investigation. 118, 1, p. 217-228

Research output: Contribution to journalArticle

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