Håkan Olsson

Senior Professor, senior consultant, head physician, senior consultant´, PhD

Research areas and keywords

UKÄ subject classification

  • Medical and Health Sciences
  • Cancer and Oncology

Keywords

  • Cancer epidemiology, Cancer genetics, Tumour biology

Research

New predisposing genes in common malignancies and their interaction with non genetic risk factor.

Our research overall aim is to identify new modes of inheritance and predisposing genes in common malignant disease such as breast-, ovarian cancer and melanoma and also to study gene environment interactions and modifying genes affecting the penetrance and tumour panorama for strong genes as BRCA1/2 and CDKN2A.  We have a diversified approach to identify new modes of inheritance.

Firstly cancer  genetic information is collected by clinical materials and on going epidemiologic studies. Interesting families are expanded by help of tax authorities and DNA is collected from probands and/or other family members for targeted mutational analysis, exome or whole genome sequencing. Secondly we take part in large international GWAS studies to identify genes of low penetrance or modifying genes. Thirdly by using tumour biology information genetic subgroups of tumour types can more readily be identified.

Highlighted research outputs

E E Calle, C Rodriguez, R Talamini, S E Hankinson, S S Tworoger, A Chetrit, G Hirsh-Yechezkel, F Lubin, S Sadetzki, P Appleby, E Banks, V Beral, A Berrington de Gonzalez, D Bull, B Crossley, A Goodill, I Green, J Green, C Hermon, T Key & 31 others, G Reeves, R Collins, R Doll, R Peto, C A Gonzalez, N Lee, P Marchbanks, H W Ory, H B Peterson, P A Wingo, N Martin, T Pardthaisong, S Silpisornkosol, C Theetranont, B Boosiri, S Chutivongse, P Jimakorn, P Virutamasen, C Wongsrichanalai, L Titus-Ernstoff, B J Mosgaard, M Vessey, D Yeates, J Chang-Claude, M A Rossing, D Thomas, N Weiss, S Franceschi, Anna Bladström, Håkan Olsson & Collaborative Group on Epidemiological Studies of Ovarian Cancer Collaborative Group on Epidemiological Studies of Ovarian Cancer, 2008, In: The Lancet. 371, 9609, p. 303-314

Research output: Contribution to journalArticle

Corine Bertolotto, Fabienne Lesueur, Sandy Giuliano, Thomas Strub, Mahaut de Lichy, Karine Bille, Philippe Dessen, Benoit d'Hayer, Hamida Mohamdi, Audrey Remenieras, Eve Maubec, Arnaud de la Fouchardiere, Vincent Molinie, Pierre Vabres, Stephane Dalle, Nicolas Poulalhon, Tanguy Martin-Denavit, Luc Thomas, Pascale Andry-Benzaquen, Nicolas Dupin & 36 others, Francoise Boitier, Annick Rossi, Jean-Luc Perrot, Bruno Labeille, Caroline Robert, Bernard Escudier, Olivier Caron, Laurence Brugieres, Simon Saule, Betty Gardie, Sophie Gad, Stephane Richard, Jerome Couturier, Bin Tean Teh, Paola Ghiorzo, Lorenza Pastorino, Susana Puig, Celia Badenas, Håkan Olsson, Christian Ingvar, Etienne Rouleau, Rosette Lidereau, Philippe Bahadoran, Philippe Vielh, Eve Corda, Helene Blanche, Diana Zelenika, Pilar Galan, Valerie Chaudru, Gilbert M. Lenoir, Mark Lathrop, Irwin Davidson, Marie-Francoise Avril, Florence Demenais, Robert Ballotti & Brigitte Bressac-de Paillerets, 2011, In: Nature. 480, 7375, p. 94-98

Research output: Contribution to journalArticle

Jennifer H. Barrett, Mark M. Iles, Mark Harland, John C. Taylor, Joanne F. Aitken, Per Arne Andresen, Lars A. Akslen, Bruce K. Armstrong, Marie-Francoise Avril, Esther Azizi, Bert Bakker, Wilma Bergman, Giovanna Bianchi-Scarra, Brigitte Bressac-de Paillerets, Donato Calista, Lisa A. Cannon-Albright, Eve Corda, Anne E. Cust, Tadeusz Debniak, David Duffy & 55 others, Alison M. Dunning, Douglas F. Easton, Eitan Friedman, Pilar Galan, Paola Ghiorzo, Graham G. Giles, Johan Hansson, Marko Hocevar, Veronica Hoeiom, John L. Hopper, Christian Ingvar, Bart Janssen, Mark A. Jenkins, Göran B Jönsson, Richard F. Kefford, Giorgio Landi, Maria Teresa Landi, Julie Lang, Jan Lubinski, Rona Mackie, Josep Malvehy, Nicholas G. Martin, Anders Molven, Grant W. Montgomery, Frans A. van Nieuwpoort, Srdjan Novakovic, Håkan Olsson, Lorenza Pastorino, Susana Puig, Joan Anton Puig-Butille, Juliette Randerson-Moor, Helen Snowden, Rainer Tuominen, Patricia VanBelle, Nienke van der Stoep, David C. Whiteman, Diana Zelenika, Jiali Han, Shenying Fang, Jeffrey E. Lee, Qingyi Wei, G. Mark Lathrop, Elizabeth M. Gillanders, Kevin M. Brown, Alisa M. Goldstein, Peter A. Kanetsky, Graham J. Mann, Stuart MacGregor, David E. Elder, Christopher I. Amos, Nicholas K. Hayward, Nelleke A. Gruis, Florence Demenais, Julia A. Newton Bishop & D. Timothy Bishop, 2011, In: Nature Genetics. 43, 11, p. 1108-1113

Research output: Contribution to journalArticle

Stuart MacGregor, Grant W. Montgomery, Jimmy Z. Liu, Zhen Zhen Zhao, Anjali K. Henders, Mitchell Stark, Helen Schmid, Elizabeth A. Holland, David L. Duffy, Mingfeng Zhang, Jodie N. Painter, Dale R. Nyholt, Judith A. Maskiell, Jodie Jetann, Megan Ferguson, Anne E. Cust, Mark A. Jenkins, David C. Whiteman, Håkan Olsson, Susana Puig & 32 others, Giovanna Bianchi-Scarra, Johan Hansson, Florence Demenais, Maria Teresa Landi, Tadeusz Debniak, Rona Mackie, Esther Azizi, Brigitte Bressac-de Paillerets, Alisa M. Goldstein, Peter A. Kanetsky, Nelleke A. Gruis, David E. Elder, Julia A. Newton-Bishop, D. Timothy Bishop, Mark M. Iles, Per Helsing, Christopher I. Amos, Qingyi Wei, Li-E Wang, Jeffrey E. Lee, Abrar A. Qureshi, Richard F. Kefford, Graham G. Giles, Bruce K. Armstrong, Joanne F. Aitken, Jiali Han, John L. Hopper, Jeffrey M. Trent, Kevin M. Brown, Nicholas G. Martin, Graham J. Mann & Nicholas K. Hayward, 2011, In: Nature Genetics. 43, 11, p. 1114-1118

Research output: Contribution to journalArticle

Matthew H Law, D Timothy Bishop, Jeffrey E Lee, Myriam Brossard, Nicholas G Martin, Eric K Moses, Fengju Song, Jennifer H Barrett, Rajiv Kumar, Douglas F Easton, Paul D P Pharoah, Anthony J Swerdlow, Katerina P Kypreou, John C Taylor, Mark Harland, Juliette Randerson-Moor, Lars A Akslen, Per A Andresen, Marie-Françoise Avril, Esther Azizi & 55 others, Giovanna Bianchi Scarrà, Kevin M Brown, Tadeusz Dȩbniak, David L Duffy, David E Elder, Shenying Fang, Eitan Friedman, Pilar Galan, Paola Ghiorzo, Elizabeth M Gillanders, Alisa M Goldstein, Nelleke A Gruis, Johan Hansson, Per Helsing, Marko Hočevar, Veronica Höiom, Christian Ingvar, Peter A Kanetsky, Wei V Chen, Maria Teresa Landi, Julie Lang, G Mark Lathrop, Jan Lubiński, Rona M Mackie, Graham J Mann, Anders Molven, Grant W Montgomery, Srdjan Novaković, Håkan Olsson, Susana Puig, Joan Anton Puig-Butille, Abrar A Qureshi, Graham L Radford-Smith, Nienke van der Stoep, Remco van Doorn, David C Whiteman, Jamie E Craig, Dirk Schadendorf, Lisa A Simms, Kathryn P Burdon, Dale R Nyholt, Karen A Pooley, Nick Orr, Alexander J Stratigos, Anne E Cust, Sarah V Ward, Nicholas K Hayward, Jiali Han, Hans-Joachim Schulze, Alison M Dunning, Julia A Newton Bishop, Florence Demenais, Christopher I Amos, Stuart MacGregor & Mark M Iles, 2015, In: Nature Genetics. 47, 9, p. 987-995

Research output: Contribution to journalArticle

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