Hans Lilja

Senior Professor

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Keywords

  • Prostate-specific antigen, Kallikrein-related peptidases, Serine proteinase inhibitors

Research

The objective of our projects is to satisfy the need for novel disease biomarkers that reliably predict clinical benefit in tumor recurrence in prostate cancer (PCa). We will utilize multiple different approaches to discover and evaluate novel noninvasive diagnostic and prognostic biomarkers, including measurements of four kallikrein markers and microseminoprotein-beta (MSP) in blood adjusted with the interaction from GWAS-based genetic variation in certain biomarker-encoding gene loci to further improve the specificity in our previously reported detection of lethal PCa-forms at very early, curable stages. We will also use internally standardized qRT-PCR assays to measure circulating tumor cells (CTCs) associated transcripts in whole blood, and use novel ultrasonic wave based microfluidics (acoustophoresis) to enable unbiased, label-free isolation of CTCs and extracellular vesicles (EVs) for subsequent molecular interrogation of the isolated/enriched populations of CTCs and EVs. As our acoustic separation methods are label-free, we are likely to detect new populations of CTCs and EVs compared to currently available methods, particularly due to mesenchyme-epithelium transitioning of CTCs. We aim to characterize the isolated CTCs and EVs after acoustic isolation and identify markers that may enable personalized medicine and more efficient cancer treatment.

Highlighted research outputs

Bryant, R. J., Sjoberg, D. D., Vickers, A. J., Robinson, M. C., Kumar, R., Marsden, L., Davis, M., Scardino, P. T., Donovan, J., Neal, D. E., Hans Lilja & Hamdy, F. C., 2015, In : Journal of the National Cancer Institute. 107, 7, p. djv095

Research output: Contribution to journalArticle

Stattin, P., Vickers, A. J., Sjoberg, D. D., Johansson, R., Granfors, T., Johansson, M., Pettersson, K., Scardino, P. T., Hallmans, G. & Hans Lilja, 2015, In : European Urology. 68, 2, p. 207-213

Research output: Contribution to journalArticle

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