Heiko Herwald

Professor, Medical Microbial Pathogenesis

Research areas and keywords

UKÄ subject classification

  • Medical and Health Sciences
  • Microbiology in the medical area
  • Immunology in the medical area

Research

Modulation of inflammatory responses to bacterial infections

Severe infectious diseases, including sepsis, remain a serious medical challenge worldwide. Clinical symptoms of patients suffering from sepsis are a culmination of complex interactions between the infecting microorganism and host immune responses, such as the induction of overwhelming inflammatory reactions, systemic activation of the coagulation system, and impaired fibrinolysis. These alarming findings prompted many research groups, including my own, to search for novel strategies to treat severe infectious diseases. Many of these approaches are focused on so-called “host effector systems”, since evidence has accumulated that complications from an infection are caused by an over-stimulation of host defense systems that are modulated by bacteria or bacterial products. In severe infections, such as sepsis and septic shock, vascular leakage, increased cytokine levels, and coagulation/fibrinolysis dysfunction are often observed.

My research projects aim to identify and characterize molecular mechanisms that lead to these complications. To accomplish these tasks various in vitro, ex vivo, and in vivo models will be employed. The results obtained from our investigations have a chance to open new routes for development of diagnostic tools and the discovery of novel treatments in severe infectious diseases.

Recent research outputs

Heiko Herwald & Arne Egesten, 2019 Aug 30, In : Journal of Innate Immunity. 11, 6, p. 1-2

Research output: Contribution to journalDebate/Note/Editorial

Samuelsson, L., Tydén, J., Heiko Herwald, Hultin, M., Walldén, J., Steinvall, I., Sjöberg, F. & Johansson, J., 2019 Aug 29, In : PLoS ONE. 14, 8, e0221813.

Research output: Contribution to journalArticle

Heiko Herwald, 2019 Apr 1, In : Nachrichten aus der Chemie. 67, 4, p. 3

Research output: Contribution to journalDebate/Note/Editorial

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