Helena Persson

Associate Senior Lecturer, Research team manager, PhD, MSc

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology
  • Cell and Molecular Biology
  • Bioinformatics and Systems Biology

Keywords

  • microRNA, non-coding RNA, sequencing

Research

We always welcome applications from students looking for experimental and/or bioinformatics master or bachelor projects.

Future cancer care will use mutation analysis of tumour DNA as a tool to match each patient with the best possible treatment. To be able to do this we must improve our understanding of the importance of different mutations. Today, analyses completely focus on the mutations that are relatively easy to interpret, while the so-called "silent" or synonymous mutations, which do not directly alter a protein, are filtered out. Many studies show, however, that also synonymous mutations can be functional through effects on e.g. mRNA splicing and stability or the speed of translation. We study synonymous mutations in breast cancers from several thousand Swedish women to investigate their effects on tumour behaviour with a combination of bioinformatic analyses and functional studies. Through this research we wish to demonstrate that also "silent" mutations are important so that more patients can receive targeted treatment. Hopefully, our work will also lead to the identification of new therapeutic targets and a reevaluation of the standard analysis of sequencing data.

Highlighted research outputs

Tamara Fernández-Calero, Marcos Davyt, Karen Perelmuter, Cora Chalar, Giovana Bampi, Helena Persson, Juan Pablo Tosar, Völundur Hafstað, Hugo Naya, Carlos Rovira, Mariela Bollati-Fogolín, Ricardo Ehrlich, Gilles Flouriot, Zoya Ignatova & Mónica Marín, 2020, In: Cancer & metabolism. 8, p. 8

Research output: Contribution to journalArticle

Rolf Søkilde, Helena Persson, Anna Ehinger, Anna Chiara Pirona, Mårten Fernö, Cecilia Hegardt, Christer Larsson, Niklas Loman, Martin Malmberg, Lisa Rydén, Lao Saal, Åke Borg, Johan Vallon-Christerson & Carlos Rovira, 2019 Jun 17, In: BMC Genomics. 20, 1, 12 p., 503.

Research output: Contribution to journalArticle

Andrej Gorbatenko, Rolf Søkilde, Ester E. Sorensen, Inga Newie, Helena Persson, Beatriz Morancho, Joaquin Arribas, Thomas Litman, Carlos Rovira & Stine Falsig Pedersen, 2019 Dec 1, In: Scientific Reports. 9, 1, 3352.

Research output: Contribution to journalArticle

Derek De Rie, Imad Abugessaisa, Tanvir Alam, Erik Arner, Peter Arner, Haitham Ashoor, Gaby Åström, Magda Babina, Nicolas Bertin, A. Maxwell Burroughs, Ailsa J. Carlisle, Carsten O. Daub, Michael Detmar, Ruslan Deviatiiarov, Alexandre Fort, Claudia Gebhard, Daniel Goldowitz, Sven Guhl, Thomas J. Ha, Jayson Harshbarger & 50 others, Akira Hasegawa, Kosuke Hashimoto, Meenhard Herlyn, Peter Heutink, Kelly J. Hitchens, Chung Chau Hon, Edward Huang, Yuri Ishizu, Chieko Kai, Takeya Kasukawa, Peter Klinken, Timo Lassmann, Charles Henri Lecellier, Weonju Lee, Marina Lizio, Vsevolod Makeev, Anthony Mathelier, Yulia A. Medvedeva, Niklas Mejhert, Christopher J. Mungall, Shohei Noma, Mitsuhiro Ohshima, Mariko Okada-Hatakeyama, Helena Persson, Patrizia Rizzu, Filip Roudnicky, Pål Sætrom, Hiroki Sato, Jessica Severin, Jay W. Shin, Rolf K. Swoboda, Hiroshi Tarui, Hiroo Toyoda, Kristoffer Vitting-Seerup, Louise Winteringham, Yoko Yamaguchi, Kayoko Yasuzawa, Misako Yoneda, Noriko Yumoto, Susan Zabierowski, Peter G. Zhang, Christine A. Wells, Kim M. Summers, Hideya Kawaji, Albin Sandelin, Michael Rehli, Yoshihide Hayashizaki, Piero Carninci, Alistair R.R. Forrest & Michiel J.L. De Hoon, 2017 Sep 1, In: Nature Biotechnology. 35, 9, p. 872-878 7 p.

Research output: Contribution to journalArticle

Helena Persson, Rolf Søkilde, Anna Chiara Pirona & Carlos Rovira, 2017, In: BioTechniques. 63, 2, p. 57-64 8 p.

Research output: Contribution to journalArticle

Inga Newie, Rolf Søkilde, Helena Persson, Thiago Jacomasso, Andrej Gorbatenko, Åke Borg, Michiel De Hoon, Stine F. Pedersen & Carlos Rovira, 2016 Oct 18, In: Scientific Reports. 6, 35664.

Research output: Contribution to journalArticle

Helena Persson, Andrew T Kwon, Jordan A Ramilowski, Gilad Silberberg, Cilla Söderhäll, Christina Orsmark-Pietras, Björn Nordlund, Jon R Konradsen, Michiel J L de Hoon, Erik Melén, Yoshihide Hayashizaki, Gunilla Hedlin, Juha Kere & Carsten O Daub, 2015 Sep, In: Journal of Allergy and Clinical Immunology. 136, 3, p. 638-48 11 p.

Research output: Contribution to journalArticle

Hans Matsson, Mikael Huss, Helena Persson, Elisabet Einarsdottir, Ettore Tiraboschi, Jaana Nopola-Hemmi, Johannes Schumacher, Nina Neuhoff, Andreas Warnke, Heikki Lyytinen, Gert Schulte-Körne, Markus M Nöthen, Paavo H T Leppänen, Myriam Peyrard-Janvid & Juha Kere, 2015 Jul, In: Journal of Human Genetics. 60, 7, p. 399-401 3 p.

Research output: Contribution to journalArticle

Nathalie Acevedo, Lovisa E Reinius, Dario Greco, Anna Gref, Christina Orsmark-Pietras, Helena Persson, Göran Pershagen, Gunilla Hedlin, Erik Melén, Annika Scheynius, Juha Kere & Cilla Söderhäll, 2015 Feb 1, In: Human Molecular Genetics. 24, 3, p. 875-90 16 p.

Research output: Contribution to journalArticle

Rolf Sökilde, Inga Newie, Helena Persson, Åke Borg & Carlos Rovira, 2015, In: RNA Biology. 12, 8, p. 787-791

Research output: Contribution to journalArticle

Tamara Fernandez-Calero, Rosa Garcia-Silva, Alvaro Pena, Carlos Robello, Helena Persson, Carlos Rovira, Hugo Naya & Alfonso Cayota, 2015, In: Molecular and Biochemical Parasitology. 199, 1-2, p. 19-28

Research output: Contribution to journalArticle

Alistair R R Forrest, Hideya Kawaji, Michael Rehli, J Kenneth Baillie, Michiel J L de Hoon, Vanja Haberle, Timo Lassmann, Ivan V Kulakovskiy, Marina Lizio, Masayoshi Itoh, Robin Andersson, Christopher J Mungall, Terrence F Meehan, Sebastian Schmeier, Nicolas Bertin, Mette Jørgensen, Emmanuel Dimont, Erik Arner, Christian Schmidl, Ulf Schaefer & 31 others, Yulia A Medvedeva, Charles Plessy, Morana Vitezic, Jessica Severin, Colin A Semple, Yuri Ishizu, Robert S Young, Margherita Francescatto, Intikhab Alam, Davide Albanese, Gabriel M Altschuler, Takahiro Arakawa, John A C Archer, Peter Arner, Magda Babina, Sarah Rennie, Piotr J Balwierz, Anthony G Beckhouse, Swati Pradhan-Bhatt, Judith A Blake, Antje Blumenthal, Beatrice Bodega, Alessandro Bonetti, James Briggs, Frank Brombacher, A Maxwell Burroughs, Andrea Califano, Andreas Lennartsson, Helena Persson, Mark Thompson & FANTOM Consortium and the RIKEN PMI and CLST (DGT) FANTOM Consortium and the RIKEN PMI and CLST (DGT), 2014 Mar 27, In: Nature. 507, 7493, p. 462-70 9 p.

Research output: Contribution to journalArticle

Joost Boele, Helena Persson, Jay W Shin, Yuri Ishizu, Inga Newie, Rolf Sökilde, Shannon M Hawkins, Cristian Coarfa, Kazuhiro Ikeda, Ken-Ichi Takayama, Kuniko Horie-Inoue, Yoshinari Ando, A Maxwell Burroughs, Chihiro Sasaki, Chizuru Suzuki, Mizuho Sakai, Shintaro Aoki, Ayumi Ogawa, Akira Hasegawa, Marina Lizio & 9 others, Kaoru Kaida, Bas Teusink, Piero Carninci, Harukazu Suzuki, Satoshi Inoue, Preethi H Gunaratne, Carlos Rovira, Yoshihide Hayashizaki & Michiel J L de Hoon, 2014, In: Proceedings of the National Academy of Sciences. 111, 31, p. 11467-11472

Research output: Contribution to journalArticle

Inga Newie, Rolf Sökilde, Helena Persson, Dorthe Grabau, Natalia Rego, Anders Kvist, Kristoffer von Stedingk, Håkan Axelson, Åke Borg, Johan Vallon-Christersson & Carlos Rovira, 2014, In: PLoS ONE. 9, 5, e97200.

Research output: Contribution to journalArticle

Natalia Rego, Sergio Bianchi, Pilar Moreno, Helena Persson, Anders Kvist, Alvaro Pena, Pablo Oppezzo, Hugo Naya, Carlos Rovira, Guillermo Dighiero & Otto Pritsch, 2012, In: British Journal of Haematology. 157, 6, p. 709-717

Research output: Contribution to journalArticle

Helena Persson, 2009, Department of Oncology, Clinical Sciences, Lund University. 130 p.

Research output: ThesisDoctoral Thesis (compilation)

S Marton, MR Garcia, C Robello, Helena Persson, F Trajtenberg, O Pritsch, Carlos Rovira, H Naya, G Dighiero & A. Cayota, 2008, In: Leukemia. 22, 2, p. 330-338

Research output: Contribution to journalArticle

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