Helena Persson

Associate Researcher, Research team manager, PhD, MSc

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology
  • Cell and Molecular Biology
  • Bioinformatics and Systems Biology

Keywords

  • microRNA, non-coding RNA, sequencing

Research

Future cancer care will use mutation analysis of tumour DNA as a tool to match each patient with the best possible treatment. To be able to do this we must improve our understanding of the importance of different mutations. Today, analyses completely focus on the mutations that are relatively easy to interpret, while the so-called "silent" or synonymous mutations, which do not directly alter a protein, are filtered out. Many studies show, however, that also synonymous mutations can be functional through effects on e.g. mRNA splicing and stability or the speed of translation. We study synonymous mutations in breast cancers from several thousand Swedish women to investigate their effects on tumour behaviour with a combination of bioinformatic analyses and functional studies. Through this research we wish to demonstrate that also "silent" mutations are important so that more patients can receive targeted treatment. Hopefully, our work will also lead to the identification of new therapeutical targets and a reevaluation of the standard analysis of sequencing data.

Highlighted research outputs

Gorbatenko, A., Rolf Søkilde, Sorensen, E. E., Newie, I., Helena Persson, Morancho, B., Arribas, J., Litman, T., Carlos Rovira & Pedersen, S. F., 2019 Dec 1, In : Scientific Reports. 9, 1, 3352.

Research output: Contribution to journalArticle

De Rie, D., Abugessaisa, I., Alam, T., Arner, E., Arner, P., Ashoor, H., Åström, G., Babina, M., Bertin, N., Burroughs, A. M., Carlisle, A. J., Daub, C. O., Detmar, M., Deviatiiarov, R., Fort, A., Gebhard, C., Goldowitz, D., Guhl, S., Ha, T. J., Harshbarger, J. & 50 othersHasegawa, A., Hashimoto, K., Herlyn, M., Heutink, P., Hitchens, K. J., Hon, C. C., Huang, E., Ishizu, Y., Kai, C., Kasukawa, T., Klinken, P., Lassmann, T., Lecellier, C. H., Lee, W., Lizio, M., Makeev, V., Mathelier, A., Medvedeva, Y. A., Mejhert, N., Mungall, C. J., Noma, S., Ohshima, M., Okada-Hatakeyama, M., Helena Persson, Rizzu, P., Roudnicky, F., Sætrom, P., Sato, H., Severin, J., Shin, J. W., Swoboda, R. K., Tarui, H., Toyoda, H., Vitting-Seerup, K., Winteringham, L., Yamaguchi, Y., Yasuzawa, K., Yoneda, M., Yumoto, N., Zabierowski, S., Zhang, P. G., Wells, C. A., Summers, K. M., Kawaji, H., Sandelin, A., Rehli, M., Hayashizaki, Y., Carninci, P., Forrest, A. R. R. & De Hoon, M. J. L., 2017 Sep 1, In : Nature Biotechnology. 35, 9, p. 872-878 7 p.

Research output: Contribution to journalArticle

Helena Persson, Rolf Søkilde, Pirona, A. C. & Carlos Rovira, 2017, In : BioTechniques. 63, 2, p. 57-64 8 p.

Research output: Contribution to journalArticle

Newie, I., Rolf Søkilde, Helena Persson, Jacomasso, T., Gorbatenko, A., Åke Borg, De Hoon, M., Pedersen, S. F. & Carlos Rovira, 2016 Oct 18, In : Scientific Reports. 6, 35664.

Research output: Contribution to journalArticle

Helena Persson, Kwon, A. T., Ramilowski, J. A., Silberberg, G., Söderhäll, C., Christina Orsmark-Pietras, Nordlund, B., Konradsen, J. R., de Hoon, M. J. L., Melén, E., Hayashizaki, Y., Hedlin, G., Kere, J. & Daub, C. O., 2015 Sep, In : Journal of Allergy and Clinical Immunology. 136, 3, p. 638-48 11 p.

Research output: Contribution to journalArticle

Matsson, H., Huss, M., Helena Persson, Einarsdottir, E., Tiraboschi, E., Nopola-Hemmi, J., Schumacher, J., Neuhoff, N., Warnke, A., Lyytinen, H., Schulte-Körne, G., Nöthen, M. M., Leppänen, P. H. T., Peyrard-Janvid, M. & Kere, J., 2015 Jul, In : Journal of Human Genetics. 60, 7, p. 399-401 3 p.

Research output: Contribution to journalArticle

Acevedo, N., Reinius, L. E., Greco, D., Gref, A., Christina Orsmark-Pietras, Helena Persson, Pershagen, G., Hedlin, G., Melén, E., Scheynius, A., Kere, J. & Söderhäll, C., 2015 Feb 1, In : Human Molecular Genetics. 24, 3, p. 875-90 16 p.

Research output: Contribution to journalArticle

Rolf Sökilde, Newie, I., Helena Persson, Åke Borg & Carlos Rovira, 2015, In : RNA Biology. 12, 8, p. 787-791

Research output: Contribution to journalArticle

Fernandez-Calero, T., Garcia-Silva, R., Pena, A., Robello, C., Helena Persson, Carlos Rovira, Naya, H. & Cayota, A., 2015, In : Molecular and Biochemical Parasitology. 199, 1-2, p. 19-28

Research output: Contribution to journalArticle

Forrest, A. R. R., Kawaji, H., Rehli, M., Baillie, J. K., de Hoon, M. J. L., Haberle, V., Lassmann, T., Kulakovskiy, I. V., Lizio, M., Itoh, M., Andersson, R., Mungall, C. J., Meehan, T. F., Schmeier, S., Bertin, N., Jørgensen, M., Dimont, E., Arner, E., Schmidl, C., Schaefer, U. & 31 othersMedvedeva, Y. A., Plessy, C., Vitezic, M., Severin, J., Semple, C. A., Ishizu, Y., Young, R. S., Francescatto, M., Alam, I., Albanese, D., Altschuler, G. M., Arakawa, T., Archer, J. A. C., Arner, P., Babina, M., Rennie, S., Balwierz, P. J., Beckhouse, A. G., Pradhan-Bhatt, S., Blake, J. A., Blumenthal, A., Bodega, B., Bonetti, A., Briggs, J., Brombacher, F., Burroughs, A. M., Califano, A., Lennartsson, A., Helena Persson, Thompson, M. & FANTOM Consortium and the RIKEN PMI and CLST (DGT), 2014 Mar 27, In : Nature. 507, 7493, p. 462-70 9 p.

Research output: Contribution to journalArticle

Boele, J., Persson, H., Shin, J. W., Ishizu, Y., Newie, I., Sökilde, R., Hawkins, S. M., Coarfa, C., Ikeda, K., Takayama, K-I., Horie-Inoue, K., Ando, Y., Burroughs, A. M., Sasaki, C., Suzuki, C., Sakai, M., Aoki, S., Ogawa, A., Hasegawa, A., Lizio, M. & 9 othersKaida, K., Teusink, B., Carninci, P., Suzuki, H., Inoue, S., Gunaratne, P. H., Carlos Rovira, Hayashizaki, Y. & de Hoon, M. J. L., 2014, In : Proceedings of the National Academy of Sciences. 111, 31, p. 11467-11472

Research output: Contribution to journalArticle

Rego, N., Bianchi, S., Moreno, P., Helena Persson, Anders Kvist, Pena, A., Oppezzo, P., Naya, H., Carlos Rovira, Dighiero, G. & Pritsch, O., 2012, In : British Journal of Haematology. 157, 6, p. 709-717

Research output: Contribution to journalArticle

Helena Persson, 2009, Department of Oncology, Clinical Sciences, Lund University. 130 p.

Research output: ThesisDoctoral Thesis (compilation)

Marton, S., Garcia, MR., Robello, C., Helena Persson, Trajtenberg, F., Pritsch, O., Carlos Rovira, Naya, H., Dighiero, G. & Cayota, A., 2008, In : Leukemia. 22, 2, p. 330-338

Research output: Contribution to journalArticle

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