Hindrik Mulder

Professor, M.D., Ph. D. , Medical doctor
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  1. 2019
  2. Att inte debattera är inte ett alternativ

    Karin Broberg, Ingrid Dunér, Kristofer Hansson, Mats Hansson, Johan Jakobsson, Marcus Järås, Ulf Kristoffersson, Hindrik Mulder, Ana Nordberg, Anna Tunlid, Niklas Vareman & Karin E Wahlberg, 2019 Dec 8, Svenska Dagbladet, Stockholm.

    Research output: Contribution to specialist publication or newspaperNewspaper article

  3. Vi måste ta ställning till den nya gentekniken

    Karin Broberg, Ingrid Dunér, Kristofer Hansson, Mats Hansson, Johan Jakobsson, Marcus Järås, Ulf Kristoffersson, Hindrik Mulder, Ana Nordberg, Anna Tunlid, Niklas Vareman & Karin E Wahlberg, 2019 Nov 24, Svenska Dagbladet, Stockholm 1 p.

    Research output: Contribution to specialist publication or newspaperNewspaper article

  4. Metabolomics Analysis of Nutrient Metabolism in β-Cells

    Peter Spégel & Hindrik Mulder, 2019 Jul 17, In : Journal of Molecular Biology.

    Research output: Contribution to journalReview article

  5. Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production

    Knudsen, J. G., Alexander Hamilton, Ramracheya, R., Tarasov, A. I., Brereton, M., Haythorne, E., Chibalina, M. V., Peter Spégel, Hindrik Mulder, Zhang, Q., Ashcroft, F. M., Adam, J. & Rorsman, P., 2019, In : Cell Metabolism. 29, 2, p. 430-442.e4

    Research output: Contribution to journalArticle

  6. 2018
  7. The GTPase domain of gamma-tubulin is required for normal mitochondrial function and spatial organization

    Lindström, L., Li, T., Malycheva, D., Kancharla, A., Helén Nilsson, Neelanjan Vishnu, Hindrik Mulder, Martin Johansson, Rosselló, C. A. & Maria Alvarado-Kristensson, 2018 May 3, In : Communications Biology. 1, https://doi.org/10.1038/s42003-018-0037-3, 37.

    Research output: Contribution to journalArticle

  8. Novel subgroups of adult-onset diabetes and their association with outcomes: A data-driven cluster analysis of six variables

    Ahlqvist, E., Storm, P., Käräjämäki, A., Martinell, M., Dorkhan, M., Carlsson, A., Vikman, P., Prasad, R. B., Aly, D. M., Almgren, P., Wessman, Y., Shaat, N., Spégel, P., Mulder, H., Lindholm, E., Melander, O., Hansson, O., Malmqvist, U., Lernmark, Å., Lahti, K. & 4 others, Forsén, T., Tuomi, T., Anders H. Rosengren & Leif Groop, 2018 May, In : The Lancet Diabetes and Endocrinology. 6, 5, p. 361-369

    Research output: Contribution to journalArticle

  9. Glutamine-elicited secretion of glucagon-like peptide 1 is governed by an activated glutamate dehydrogenase

    Andersson, L. E., Shcherbina, L., Al-Majdoub, M., Neelanjan Vishnu, Arroyo, C. B., Carrara, J. A., Claes B. Wollheim, Malin Fex, Hindrik Mulder, Nils Wierup & Peter Spégel, 2018 Mar 1, In : Diabetes. 67, 3, p. 372-384 13 p.

    Research output: Contribution to journalArticle

  10. The effects of high glucose exposure on global gene expression and DNA methylation in human pancreatic islets

    Hall, E., Dekker Nitert, M., Volkov, P., Malmgren, S., Hindrik Mulder, Karl Bacos & Charlotte Ling, 2018, In : Molecular and Cellular Endocrinology. 472, p. 57-67

    Research output: Contribution to journalArticle

  11. The pathogenetic role of β-cell mitochondria in type 2 diabetes

    Malin Fex, Nicholas, L. M., Neelanjan Vishnu, Medina, A., Sharoyko, V. V., David G. Nicholls, Peter Spégel & Hindrik Mulder, 2018, In : Journal of Endocrinology. 236, 3, p. R145-R149

    Research output: Contribution to journalReview article

  12. 2017
  13. Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

    Adam, J., Ramracheya, R., Chibalina, M. V., Ternette, N., Hamilton, A., Tarasov, A. I., Zhang, Q., Rebelato, E., Rorsman, N. J. G., Martín-del-Río, R., Lewis, A., Özkan, G., Do, H. W., Spégel, P., Saitoh, K., Kato, K., Igarashi, K., Kessler, B. M., Pugh, C. W., Tamarit-Rodriguez, J. & 8 others, Hindrik Mulder, Clark, A., Frizzell, N., Soga, T., Ashcroft, F. M., Silver, A., Pollard, P. J. & Rorsman, P., 2017 Sep 26, In : Cell Reports. 20, 13, p. 3135-3148 14 p.

    Research output: Contribution to journalArticle

  14. Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells

    Nicholas, L. M., Valtat, B., Benavente, A. M., Andersson, L., Abels, M., Mollet, I., Jain, D., Lena Eliasson, Nils Wierup, Malin Fex & Hindrik Mulder, 2017 Jul, In : Molecular Metabolism. 6, 7, p. 651-663 13 p.

    Research output: Contribution to journalArticle

  15. Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

    Axelsson, A. S., Tubbs, E., Mecham, B., Chacko, S., Nenonen, H. A., Tang, Y., Fahey, J. W., Derry, J. M. J., Claes B. Wollheim, Nils Wierup, Haymond, M. W., Friend, S. H., Hindrik Mulder & Anders H. Rosengren, 2017 Jun 14, In : Science Translational Medicine. 9, 394, 4477.

    Research output: Contribution to journalArticle

  16. Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes

    Axelsson, A., Mahdi, T., Nenonen, H. A., Singh, T., Hänzelmann, S., Wendt, A., Bagge, A., Reinbothe, T. M., Millstein, J., Yang, X., Zhang, B., Gusmao, E. G., Shu, L., Szabat, M., Tang, Y., Wang, J., Salö, S., Eliasson, L., Artner, I., Fex, M. & 9 others, J D Johnson, C B Wollheim, Derry, J. M. J., Mecham, B., P Spégel, H Mulder, Costa, I. G., E Zhang & Rosengren, A. H., 2017 Jun 6, In : Nature Communications. 8, p. 15652

    Research output: Contribution to journalArticle

  17. NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells

    Santos, L. R. B., Muller, C., de Souza, A. H., Takahashi, H. K., Peter Spégel, Sweet, I. R., Chae, H., Hindrik Mulder & Jonas, J. C., 2017 Jun, In : Molecular Metabolism. 6, 6, p. 535-547 13 p.

    Research output: Contribution to journalArticle

  18. Bioenergetic Impairment in Congenital Muscular Dystrophy Type 1A and Leigh Syndrome Muscle Cells

    Fontes-Oliveira, C. C., Steinz, M., Schneiderat, P., Hindrik Mulder & Madeleine Durbeej, 2017 Apr 3, In : Scientific Reports. 7, 45272.

    Research output: Contribution to journalArticle

  19. HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells

    Daneshpajooh, M., Karl Bacos, Bysani, M., Bagge, A., Ottosson Laakso, E., Petter Vikman, Lena Eliasson, Hindrik Mulder & Charlotte Ling, 2017 Jan, In : Diabetologia. 60, 1, p. 116–125

    Research output: Contribution to journalArticle

  20. Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss

    Geidenstam, N., Martin Magnusson, Danielsson, A. P. H., Gerszten, R. E., Wang, T. J., Reinius, L. E., Hindrik Mulder, Olle Melander & Martin Ridderstråle, 2017, In : International Journal of Endocrinology. 2017, 6490473.

    Research output: Contribution to journalArticle

  21. Cartilage oligomeric matrix protein promotes prostate cancer progression by enhancing invasion and disrupting intracellular calcium homeostasis

    Emelie Englund, Canesin, G., Konstantinos S. Papadakos, Neelanjan Vishnu, Persson, E., Reitsma, B., Aseem Anand, Jacobsson, L., Helczynski, L., Hindrik Mulder, Anders Bjartell & Anna M. Blom, 2017, In : Oncotarget. 8, 58, p. 98298-98311 14 p.

    Research output: Contribution to journalArticle

  22. Transcribing β-cell mitochondria in health and disease

    Hindrik Mulder, 2017, In : Molecular Metabolism. 6, 9, p. 1040-1051

    Research output: Contribution to journalReview article

  23. 2016
  24. Glycogen metabolism in the glucose-sensing and supply-driven β-cell

    Andersson, L. E., Nicholas, L. M., Karin Filipsson, Jiangming Sun, Benavente, A. M., Al-Majdoub, M., Malin Fex, Hindrik Mulder & Peter Spégel, 2016 Dec 1, In : FEBS Letters. 590, 23, p. 4242-4251 10 p.

    Research output: Contribution to journalLetter

  25. Metabolic coupling in pancreatic beta cells: lipolysis revisited

    Hindrik Mulder, 2016 Dec 1, In : Diabetologia. 59, 12, p. 2510–2513 4 p.

    Research output: Contribution to journalArticle

  26. Discriminative prediction of A-To-I RNA editing events from DNA sequence

    Jiangming Sun, Yang De Marinis, Osmark, P., Singh, P., Bagge, A., Valtat, B., Petter Vikman, Peter Spégel & Hindrik Mulder, 2016 Oct 1, In : PLoS ONE. 11, 10, e0164962.

    Research output: Contribution to journalArticle

  27. Precise expression of Fis1 is important for glucose responsiveness of beta cells

    Schultz, J., Waterstradt, R., Kantowski, T., Rickmann, A., Reinhardt, F., Sharoyko, V., Hindrik Mulder, Tiedge, M. & Baltrusch, S., 2016 Jul, In : Journal of Endocrinology. 230, 1, p. 81-91 11 p.

    Research output: Contribution to journalArticle

  28. Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes

    Tuomi, T., Nagorny, C. L. F., Singh, P., Bennet, H., Yu, Q., Alenkvist, I., Isomaa, B., Östman, B., Söderström, J., Pesonen, A. K., Martikainen, S., Räikkönen, K., Forsén, T., Hakaste, L., Almgren, P., Storm, P., Asplund, O., Shcherbina, L., Fex, M., Fadista, J. & 4 others, Tengholm, A., Nils Wierup, Leif Groop & Hindrik Mulder, 2016 Jun 14, In : Cell Metabolism. 23, 6, p. 1067-1077 11 p.

    Research output: Contribution to journalArticle

  29. Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer

    E Englund, Bartoschek, M., Reitsma, B., Jacobsson, L., Escudero-Esparza, A., Orimo, A., K Leandersson, C Hagerling, A Aspberg, Storm, P., Okroj, M., H Mulder, K Jirström, K Pietras & A M Blom, 2016, In : Oncogene. 35, 43, p. 5585-5596 12 p.

    Research output: Contribution to journalArticle

  30. 2015
  31. The Human Diabetes Proteome Project (HDPP): The 2014 update

    Schvartz, D., Bergsten, P., Baek, K. H., De La Rosa, A. B., Cantley, J., Dayon, L., Finamore, F., Fontana, P., Gaudet, P., Goo, Y. A., Moulder, R., Goodlett, D. R., Johnson, J. D., Konvalinka, A., Mulder, H., Priego-Capote, F., Sechi, S., Snyder, K. M., Tiss, A., Wiederkehr, A. & 3 others, Xenarios, I., Kussmann, M. & Sanchez, J. C., 2015 Dec 1, In : Translational Proteomics. 8-9, p. 1-7 7 p.

    Research output: Contribution to journalArticle

  32. Calcium Modulation of Exocytosis-Linked Plasma Membrane Potential Oscillations in INS-1 832/13 Cells.

    Gerencser, A. A., Hindrik Mulder & Nicholls, D. G., 2015, In : Biochemical Journal. 471, 1, p. 111-122

    Research output: Contribution to journalArticle

  33. Characterization of Stimulus-Secretion Coupling in the Human Pancreatic EndoC-βH1 Beta Cell Line.

    Andersson, L., Valtat, B., Bagge, A., Sharoyko, V., David Nicholls, Ravassard, P., Scharfmann, R., Peter Spégel & Hindrik Mulder, 2015, In : PLoS ONE. 10, 3, e0120879.

    Research output: Contribution to journalArticle

  34. Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion

    Stamenkovic, J., Andersson, L., Adriaenssens, A. E., Bagge, A., Sharoyko, V., Gribble, F., Reimann, F., Claes Wollheim, Hindrik Mulder & Peter Spégel, 2015, In : Biochemical Journal. 468, p. 49-63

    Research output: Contribution to journalArticle

  35. Unique and Shared Metabolic Regulation in Clonal β-cells and Primary Islets Derived from Rat Revealed by Metabolomics Analysis.

    Peter Spégel, Andersson, L., Storm, P., Sharoyko, V., Göhring, I., Anders Rosengren & Hindrik Mulder, 2015, In : Endocrinology. 156, 6, p. 1995-2005

    Research output: Contribution to journalArticle

  36. 2014
  37. Genotype-based treatment of type 2 diabetes with an α2A-adrenergic receptor antagonist.

    Tang, Y., Axelsson, A., Peter Spégel, Andersson, L., Hindrik Mulder, Leif Groop, Erik Renström & Anders Rosengren, 2014, In : Science Translational Medicine. 6, 257, p. 257ra139

    Research output: Contribution to journalArticle

  38. Glucagon-Like Peptide 1 Stimulates Insulin Secretion via Inhibiting RhoA/ROCK Signaling and Disassembling Glucotoxicity-Induced Stress Fibers

    Kong, X., Yan, D., Jiangming Sun, Wu, X., Hindrik Mulder, Hua, X. & Ma, X., 2014, In : Endocrinology. 155, 12, p. 4676-4685

    Research output: Contribution to journalArticle

  39. Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes.

    Sharoyko, V., Abels, M., Jiangming Sun, Nicholas, L., Mollet, I., Stamenkovic, J., Göhring, I., Malmgren, S., Storm, P., Fadista, J., Peter Spégel, Metodiev, M. D., Larsson, N-G., Lena Eliasson, Nils Wierup & Hindrik Mulder, 2014, In : Human Molecular Genetics. 23, 21, p. 5733-5749

    Research output: Contribution to journalArticle

  40. Metabolite profile deviations in an oral glucose tolerance test-A comparison between lean and obese individuals.

    Geidenstam, N., Peter Spégel, Hindrik Mulder, Karin Filipsson, Martin Ridderstråle & Danielsson, A., 2014, In : Obesity. 22, 11, p. 2388-2395

    Research output: Contribution to journalArticle

  41. 2013
  42. Coordinate changes in histone modifications, mRNA levels and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity.

    Malmgren, S., Peter Spégel, Danielsson, A., Nagorny, C., Andersson, L., Dekker Nitert, M., Martin Ridderstråle, Hindrik Mulder & Charlotte Ling, 2013, In : Journal of Biological Chemistry. 288, 17, p. 11973-11987

    Research output: Contribution to journalArticle

  43. Diabetes in Friedreich Ataxia

    Cnop, M., Hindrik Mulder & Igoillo-Esteve, M., 2013, In : Journal of Neurochemistry. 126, p. 94-102

    Research output: Contribution to journalReview article

  44. Fracture Mechanics of Collagen Fibrils: Influence of Natural Cross-Links

    Svensson, R. B., Hindrik Mulder, Kovanen, V. & Magnusson, S. P., 2013, In : Biophysical Journal. 104, 11, p. 2476-2484

    Research output: Contribution to journalArticle

  45. Time-resolved metabolomics analysis of beta-cells implicates the pentose phosphate pathway in the control of insulin release

    Peter Spégel, Sharoyko, V., Göhring, I., Danielsson, A., Malmgren, S., Nagorny, C., Andersson, L., Köck, T., Sharp, G. W. G., Straub, S. G., Claes Wollheim & Hindrik Mulder, 2013, In : Biochemical Journal. 450, p. 595-605

    Research output: Contribution to journalArticle

  46. 2012
  47. Development of a gas chromatography/mass spectrometry based metabolomics protocol by means of statistical experimental design

    Danielsson, A., Moritz, T., Hindrik Mulder & Peter Spégel, 2012, In : Metabolomics. 8, 1, p. 50-63

    Research output: Contribution to journalArticle

  48. Regulation of core clock genes in human islets.

    Stamenkovic, J., Olsson, A. H., Nagorny, C., Malmgren, S., Dekker Nitert, M., Charlotte Ling & Hindrik Mulder, 2012, In : Metabolism, Clinical and Experimental. 61, 7, p. 978-985

    Research output: Contribution to journalArticle

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