Ingrid Hedenfalk

Senior Lecturer, Associate professor, PhD

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology
  • Biomedical Laboratory Science/Technology
  • Cell and Molecular Biology

Keywords

  • HRD, cancer stem cells, PARP, breast cancer, ovarian cancer, gene expression, sequencing, BRCA1/2

Research

Breast and ovarian cancers share many features, including genetic predisposition caused by mutations in BRCA1/2. Epithelial ovarian cancer is heterogeneous and associated with poor survival relative to breast cancer. Utilizing comprehensive biobanks, genomics methods and in vitro model systems we aim to improve our understanding of tumour evolution, heterogeneity and therapy response. Events underlying malignant transformation are poorly characterised in ovarian cancer, but accumulating evidence suggests that a majority of ovarian cancers arise in the Fallopian tube epithelium.

We aim to increase our understanding of the origin and early genomic events leading to the development of epithelial ovarian cancer. The heterogeneity of the disease requires improved knowledge of key processes involved in tumour initiation, development and maintenance for translation into truly personalised treatment. Identification of novel therapeutic targets, stratified by histological as well as mutational and transcriptional phenotypes, should transform survival prospects. Our goal is to elucidate the molecular context and mechanisms by which aberrantly regulated genes contribute to breast and ovarian tumorigenesis.

Improved knowledge ofthe molecular landscapes of these heterogeneous malignancies in the primary as well as metastatic setting may lead to the development of next generation biomarkers and biologically informed treatment strategies.

Highlighted research outputs

Humphries, M. P., Rajan, S. S., Droop, A., Suleman, C. A. B., Carbone, C., Nilsson, C., Honarpisheh, H., Cserni, G., Dent, J., Fulford, L., Jordan, L. B., Jones, J. L., Kanthan, R., Litwiniuk, M., Di Benedetto, A., Mottolese, M., Provenzano, E., Shousha, S., Stephens, M., Walker, R. A. & 12 othersKulka, J., Ellis, I. O., Jeffery, M., Thygesen, H. H., Cappelletti, V., Daidone, M. G., Ingrid A. Hedenfalk, Fjällskog, M-L., Melisi, D., Stead, L. F., Shaaban, A. M. & Speirs, V., 2017 May 15, In : Clinical Cancer Research. 23, 10, p. 2575-2583 9 p.

Research output: Contribution to journalArticle

Nicolai Skovbjerg Arildsen, Jenny Maria Jönsson, Bartuma, K., Anna Ebbesson, Westbom-Fremer, S., Måsbäck, A., Malander, S., Mef Nilbert & Ingrid A. Hedenfalk, 2017 May 29, In : Frontiers in Oncology. 7, MAY, p. 1-11 109.

Research output: Contribution to journalArticle

Lawler, K., Papouli, E., Naceur-Lombardelli, C., Mera, A., Ougham, K., Tutt, A., Siker Kimbung, Ingrid Hedenfalk, Zhan, J., Zhang, H., Buus, R., Dowsett, M., Ng, T., Pinder, S. E., Parker, P., Holmberg, L., Gillett, C. E., Grigoriadis, A. & Purushotham, A., 2017 Oct 13, In : Breast Cancer Research. 19, 1, 113.

Research output: Contribution to journalArticle

Palazon, A., Tyrakis, P. A., Macias, D., Veliça, P., Rundqvist, H., Fitzpatrick, S., Vojnovic, N., Phan, A. T., Niklas Loman, Ingrid Hedenfalk, Hatschek, T., Lövrot, J., Foukakis, T., Goldrath, A. W., Bergh, J. & Johnson, R. S., 2017 Nov 13, In : Cancer Cell. 32, 5, p. 669-683.e5

Research output: Contribution to journalArticle

Grönberg, M., Nilsson, C., Markholm, I., Ingrid Hedenfalk, Blomqvist, C., Holmberg, L., Tiensuu Janson, E. & Fjällskog, M. L., 2018, In : Scientific Reports. 8, 1, 13586.

Research output: Contribution to journalArticle

Matikas, A., Lövrot, J., Ramberg, A., Eriksson, M., Lindsten, T., Lekberg, T., Ingrid Hedenfalk, Niklas Loman, Bergh, J., Hatschek, T., Erlandsson, A. & Foukakis, T., 2018, In : OncoImmunology. 7, 9, e1466017.

Research output: Contribution to journalArticle

Siker Kimbung, Markholm, I., Bjöhle, J., Lekberg, T., Wachenfeldt, V. A., Azavedo, E., Saracco, A., Hellström, M., Srinivas Veerla, Paquet, E., Pär Ola Bendahl, Mårten Fernö, Bergh, J., Niklas Loman, Hatschek, T. & Ingrid Hedenfalk, 2018, In : International Journal of Cancer. 142, 3, p. 618-628

Research output: Contribution to journalArticle

Severson, T. M., Kim, Y., Joosten, S. E. P., Schuurman, K., Van Der Groep, P., Moelans, C. B., Ter Hoeve, N. D., Manson, Q. F., Martens, J. W., Van Deurzen, C. H. M., Barbe, E., Ingrid Hedenfalk, Bult, P., Smit, V. T. H. B. M., Linn, S. C., Van Diest, P. J., Wessels, L. & Zwart, W., 2018 Dec 1, In : Nature Communications. 9, 1, 482.

Research output: Contribution to journalArticle

Tabariès, S., McNulty, A., Ouellet, V., Annis, M. G., Dessureault, M., Vinette, M., Hachem, Y., Lavoie, B., Omeroglu, A., Simon, H. G., Walsh, L. A., Siker Kimbung, Ingrid Hedenfalk & Siegel, P. M., 2019, In : Genes & Development. 33, 3-4, p. 180-193 14 p.

Research output: Contribution to journalArticle

Siker Kimbung, Johansson, I., Danielsson, A., Srinivas Veerla, Brage, S. E., Frostvik Stolt, M., Skoog, L., Carlsson, L., Einbeigi, Z., Lidbrink, E., Linderholm, B. K., Niklas Loman, Per Malmström, Söderberg, M., Walz, T. M., Fernö, M., Hatschek, T. & Ingrid Hedenfalk, 2016, In : Clinical Cancer Research. 22, 1, p. 146-157

Research output: Contribution to journalArticle

Jenny-Maria Jönsson, Nicolai Arildsen, Malander, S., Måsbäck, A., Linda Werner Hartman, Mef Nilbert & Ingrid Hedenfalk, 2015, In : Translational Oncology. 8, 5, p. 424-433

Research output: Contribution to journalArticle

Jenny-Maria Jönsson, Johansson, I., Dominguez, M., Siker Kimbung, Mats Jönsson, Bonde, J. H., Päivi Kannisto, Måsbäck, A., Malander, S., Mef Nilbert & Ingrid Hedenfalk, 2014, In : PLoS ONE. 9, 9, e107643.

Research output: Contribution to journalArticle

Johansson, I., Nilsson, C., Berglund, P., Martin Lauss, Markus Ringnér, Håkan Olsson, Luts, L., Sim, E., Thorstensson, S., Fjallskog, M-L. & Ingrid Hedenfalk, 2012, In : Breast Cancer Research. 14, 1, R31.

Research output: Contribution to journalArticle

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