Joao Duarte

Senior Lecturer, Ph.D., B.Sc.

Research areas and keywords

UKÄ subject classification

  • Medical and Health Sciences
  • Biochemistry and Molecular Biology
  • Neurosciences
  • Physiology

Keywords

  • diabetes, brain, metabolism, magnetic resonance

Research

Diabetes and Brain Function lab at Lund University

The increasing prevalence of type 2 diabetes (T2D) in western societies is closely associated with obesity, sedentary life-styles and the excessive consumption of food products rich in fat and sugar. The whole-body metabolic imbalance in diabetes has a detrimental impact on brain function, leading to increased risk of dementia.

Our previous work in rodent models of T2D identified diabetes-induced alterations of brain energy metabolism and metabolic profiles, changes in neuromodulation systems, astrogliosis and synaptic dysfunction underlying memory dysfunction. We further found that pharmacological interventions that target the adenosinergic neuromodulation system partly restore T2D-induced brain dysfunction.

Our current lab work mainly focuses on understanding early metabolic dysfunction that might precede and be involved in the diabetes-induced neurodegenerative process. In particular, we aim at understanding T2D-induced alterations of brain insulin-dependent metabolic regulation in neurons and astrocytes. Counteracting insulin signalling defects in brain areas regulating memory processes might provide a means of correcting energy fuelling to synaptic activity and plasticity, and prevent diabetes-induced synaptic dysfunction, neurodegeneration and memory dysfunction. 

Recent research outputs

Andreza Fabro de Bem, Rachel Krolow, Hémelin Resende Farias, Victória Linden de Rezende, Daniel Pens Gelain, José Cláudio Fonseca Moreira, João Miguel das Neves Duarte & Jade de Oliveira, 2021, In: Frontiers in Neuroscience. 14, 604150.

Research output: Contribution to journalReview article

Manabu Kubota, Yasuyuki Kimura, Masafumi Shimojo, Yuhei Takado, Joao M.N. Duarte, Hiroyuki Takuwa, Chie Seki, Hitoshi Shimada, Hitoshi Shinotoh, Keisuke Takahata, Soichiro Kitamura, Sho Moriguchi, Kenji Tagai, Takayuki Obata, Jin Nakahara, Yutaka Tomita, Masaki Tokunaga, Jun Maeda, Kazunori Kawamura, Ming Rong Zhang & 3 others, Masanori Ichise, Tetsuya Suhara & Makoto Higuchi, 2021, In: Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticle

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