Johan Flygare

Senior Lecturer
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  1. 2020
  2. Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase

    Wilkes, M. C., Siva, K., Chen, J., Varetti, G., Youn, M. Y., Chae, H., Ek, F., Olsson, R., Lundbäck, T., Dever, D. P., Nishimura, T., Narla, A., Glader, B., Nakauchi, H., Porteus, M. H., Repellin, C. E., Gazda, H. T., Lin, S., Serrano, M., Flygare, J. & 1 others, Sakamoto, K. M., 2020, In : Nature Communications. 11, 1, 3344.

    Research output: Contribution to journalArticle

  3. 2019
  4. A Phenotypic Screening Assay Identifies Modulators of Diamond Blackfan Anemia

    Siva, K., Fredrik Ek, Jun Chen, Abdul Ghani Alattar, Sigmundsson, K., Roger Olsson, Wlodarski, M., Lundbäck, T. & Johan Flygare, 2019, In : SLAS discovery : advancing life sciences R & D. 24, 3, p. 304-313 10 p.

    Research output: Contribution to journalArticle

  5. Cyclin-dependent kinase 8/19 inhibition suppresses osteoclastogenesis by downregulating RANK and promotes osteoblast mineralization and cancellous bone healing

    Amirhosseini, M., Bernhardsson, M., Lång, P., Andersson, G., Johan Flygare & Fahlgren, A., 2019, In : Journal of Cellular Physiology. 234, 9, p. 16503-16516 14 p.

    Research output: Contribution to journalArticle

  6. 2018
  7. Direct Lineage Reprogramming of Adult Mouse Fibroblast to Erythroid Progenitors

    Melissa Ilsley, Sandra Capellera-Garcia, Dhulipala, K., Johansson, A. & Johan Flygare, 2018 Dec 14, In : Journal of visualized experiments : JoVE. 142, e58464.

    Research output: Contribution to journalArticle

  8. 2017
  9. Direct lineage reprogramming: a useful addition to the blood cell research toolbox

    Sandra Capellera-Garcia & Johan Flygare, 2017 Feb 1, In : Expert Review of Hematology. 10, 2, p. 107-109

    Research output: Contribution to journalDebate/Note/Editorial

  10. Lentiviral Vectors with Cellular Promoters Correct Anemia and Lethal Bone Marrow Failure in a Mouse Model for Diamond-Blackfan Anemia

    Debnath, S., Jaako, P., Siva, K., Rothe, M., Jun Chen, Maria Dahl, Gaspar, H. B., Johan Flygare, Schambach, A. & Stefan Karlsson, 2017, In : Molecular Therapy. 25, 8, p. 1805-1814

    Research output: Contribution to journalArticle

  11. 2016
  12. Direct Conversion of Fibroblasts to Megakaryocyte Progenitors

    Pulecio, J., Alejo-Valle, O., Sandra Capellera-Garcia, Vitaloni, M., Rio, P., Mejía-Ramírez, E., Caserta, I., Bueren, J. A., Johan Flygare & Raya, A., 2016 Oct 11, In : Cell Reports. 17, 3, p. 671-683 13 p.

    Research output: Contribution to journalArticle

  13. Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion

    Sandra Capellera-Garcia, Pulecio, J., Dhulipala, K., Siva, K., Rayon-Estrada, V., Sofie Singbrant, Mikael N E Sommarin, Walkley, C. R., Shamit Soneji, Göran Karlsson, Raya, Á., Sankaran, V. G. & Johan Flygare, 2016 Jun 14, In : Cell Reports. 15, 11, p. 2550-2562 13 p.

    Research output: Contribution to journalArticle

  14. The european hematology association roadmap for european hematology research: A consensus document

    Engert, A., Balduini, C., Brand, A., Coiffier, B., Cordonnier, C., Döhner, H., De Wit, T. D., Eichinger, S., Fibbe, W., Green, T., De Haas, F., Iolascon, A., Jaffredo, T., Rodeghiero, F., Sall Es, G., Schuringa, J. J., André, M., Andre-Schmutz, I., Bacigalupo, A., Bochud, P. Y. & 261 others, Den Boer, M., Bonini, C., Camaschella, C., Cant, A., Cappellini, M. D., Cazzola, M., Celso, C. L., Dimopoulos, M., Douay, L., Dzierzak, E., Einsele, H., Ferreri, A., De Franceschi, L., Gaulard, P., Gottgens, B., Greinacher, A., Gresele, P., Gribben, J., De Haan, G., Hansen, J. B., Hochhaus, A., Kadir, R., Kaveri, S., Kouskoff, V., Kühne, T., Kyrle, P., Ljungman, P., Maschmeyer, G., Méndez-Ferrer, S., Milsom, M., Mummery, C., Ossenkoppele, G., Pecci, A., Peyvandi, F., Philipsen, S., Reitsma, P., Ribera, J. M., Risitano, A., Rivella, S., Ruf, W., Schroeder, T., Scully, M., Socie, G., Staal, F., Stanworth, S., Stauder, R., Stilgenbauer, S., Tamary, H., Theilgaard-Mönch, K., Thein, S. L., Tilly, H., Trneny, M., Vainchenker, W., Vannucchi, A. M., Viscoli, C., Vrielink, H., Zaaijer, H., Zanella, A., Zolla, L., Zwaginga, J. J., Martinez, P. A., Van Den Akker, E., Allard, S., Anagnou, N., Andolfo, I., Andrau, J. C., Angelucci, E., Anstee, D., Aurer, I., Avet-Loiseau, H., Aydinok, Y., Bakchoul, T., Balduini, A., Barcellini, W., Baruch, D., Baruchel, A., Bayry, J., Bento, C., Van Den Berg, A., Bernardi, R., Bianchi, P., Bigas, A., Biondi, A., Bohonek, M., Bonnet, D., Borchmann, P., Borregaard, N., Brækkan, S., Van Den Brink, M., Brodin, E., Bullinger, L., Buske, C., Butzeck, B., Cammenga, J., Campo, E., Carbone, A., Cervantes, F., Cesaro, S., Charbord, P., Claas, F., Cohen, H., Conard, J., Coppo, P., Vives Corron, J. L., Da Costa, L., Davi, F., Delwel, R., Dianzani, I., Domanović, D., Donnelly, P., Drnovšek, T. D., Dreyling, M., Du, M. Q., Dufour, C., Durand, C., Efremov, D., Eleftheriou, A., Elion, J., Emonts, M., Engelhardt, M., Ezine, S., Falkenburg, F., Favier, R., Federico, M., Fenaux, P., Fitzgibbon, J., Johan Flygare, Foà, R., Forrester, L., Galacteros, F., Garagiola, I., Gardiner, C., Garraud, O., Van Geet, C., Geiger, H., Geissler, J., Germing, U., Ghevaert, C., Girelli, D., Godeau, B., Gökbuget, N., Goldschmidt, H., Goodeve, A., Graf, T., Graziadei, G., Griesshammer, M., Gruel, Y., Guilhot, F., Von Gunten, S., Gyssens, I., Halter, J., Harrison, C., Harteveld, C., Hellström-Lindberg, E., Hermine, O., Higgs, D., Hillmen, P., Hirsch, H., Hoskin, P., Huls, G., Inati, A., Johnson, P., Kattamis, A., Kiefel, V., Kleanthous, M., Klump, H., Krause, D., Hovinga, J. K., Lacaud, G., Lacroix-Desmazes, S., Landman-Parker, J., Legouill, S., Lenz, G., Von Lilienfeld-Toal, M., Von Lindern, M., Lopez-Guillermo, A., Lopriore, E., Lozano, M., Macintyre, E., Makris, M., Mannhalter, C., Martens, J., Mathas, S., Matzdorff, A., Medvinsky, A., Menendez, P., Migliaccio, A. R., Kenichi Miharada, Mikulska, M., Minard, V., Montalbán, C., De Montalembert, M., Montserrat, E., Morange, P. E., Mountford, J., Muckenthaler, M., Müller-Tidow, C., Mumford, A., Nadel, B., Navarro, J. T., El Nemer, W., Noizat-Pirenne, F., O’Mahony, B., Oldenburg, J., Olsson, M., Oostendorp, R., Palumbo, A., Passamonti, F., Patient, R., De Latour, R. P., Pflumio, F., Pierelli, L., Piga, A., Pollard, D., Raaijmakers, M., Radford, J., Rambach, R., Koneti Rao, A., Raslova, H., Rebulla, P., Rees, D., Ribrag, V., Rijneveld, A., Rinalducci, S., Robak, T., Roberts, I., Rodrigues, C., Rosendaal, F., Rosenwald, A., Rule, S., Russo, R., Saglio, G., Sanchez, M., Scharf, R. E., Schlenke, P., John Semple, Sierra, J., So-Osman, C., Soria, J. M., Stamatopoulos, K., Stegmayr, B., Stunnenberg, H., Swinkels, D., Barata, J. P. T., Taghon, T., Taher, A., Terpos, E., Thachil, J., Tissot, J. D., Touw, I., Toye, A., Trappe, R., Traverse-Glehen, A., Unal, S., Vaulont, S., Viprakasit, V., Vitolo, U., Van Wijk, R., Wójtowicz, A., Zeerleder, S. & Zieger, B., 2016 Feb 1, In : Haematologica. 101, 2, p. 115-208 94 p.

    Research output: Contribution to journalArticle

  15. 2015
  16. Disruption of the 5S RNP-Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia.

    Jaako, P., Debnath, S., Karin Olsson, Zhang, Y., Johan Flygare, Lindström, M. S., David Bryder & Stefan Karlsson, 2015, In : Leukemia. 29, 11, p. 2221-2229

    Research output: Contribution to journalArticle

  17. Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond-Blackfan anaemia.

    Sara Sjögren, Siva, K., Shamit Soneji, George, A. J., Winkler, M., Jaako, P., Wlodarski, M., Stefan Karlsson, Hannan, R. D. & Johan Flygare, 2015, In : British Journal of Haematology. 171, 4, p. 517-529

    Research output: Contribution to journalArticle

  18. 2014
  19. Gene therapy cures the anemia and lethal bone marrow failure in mouse model for RPS19-deficient Diamond-Blackfan anemia.

    Jaako, P., Debnath, S., Karin Olsson, Modlich, U., Rothe, M., Schambach, A., Johan Flygare & Stefan Karlsson, 2014, In : Haematologica. 99, 12, p. 1792-1798 7 p.

    Research output: Contribution to journalArticle

  20. 2013
  21. Fetal hepatic progenitors support long-term expansion of hematopoietic stem cells

    Chou, S., Johan Flygare & Lodish, H. F., 2013, In : Experimental Hematology. 41, 5, p. 479-490

    Research output: Contribution to journalArticle

  22. 2012
  23. Dietary L-leucine improves the anemia in a mouse model for Diamond-Blackfan anemia.

    Jaako, P., Debnath, S., Karin Olsson, David Bryder, Johan Flygare & Stefan Karlsson, 2012, In : Blood. 120, 11, p. 2225-2228

    Research output: Contribution to journalArticle

  24. Progress towards Mechanism-Based Treatment for Diamond-Blackfan Anemia.

    Sara Sjögren & Johan Flygare, 2012, In : Scientific World Journal. 2012, 184362.

    Research output: Contribution to journalArticle

  25. 2011
  26. From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications

    Hattangadi, S. M., Wong, P., Zhang, L., Johan Flygare & Lodish, H. F., 2011, In : Blood. 118, 24, p. 6258-6268

    Research output: Contribution to journalReview article

  27. Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia.

    Jaako, P., Johan Flygare, Karin Olsson, Quere, R., Mats Ehinger, Henson, A., Ellis, S., Schambach, A., Baum, C., Johan Richter, Jonas Larsson, David Bryder & Stefan Karlsson, 2011, In : Blood. 118, p. 6087-6096

    Research output: Contribution to journalArticle

  28. 2010
  29. Chronic RPS19 Deficiency Leads to Bone Marrow Failure In a Mouse Model for Diamond Blackfan Anemia

    Jaako, P., Johan Flygare, Karin Olsson, Quere, R., Jonas Larsson, David Bryder & Stefan Karlsson, 2010, In : Blood. 116, 21, p. 89-89

    Research output: Contribution to journalPublished meeting abstract

  30. 2008
  31. 2007
  32. Diamond-Blackfan anemia: erythropoiesis lost in translation.

    Johan Flygare & Stefan Karlsson, 2007, In : Blood. 109, 8, p. 3152-3160

    Research output: Contribution to journalReview article

  33. Diamond-Blackfan Anemia: Erythropoiesis Lost in Translation

    Johan Flygare, 2007, Faculty of Medicine, Lund University.

    Research output: ThesisDoctoral Thesis (compilation)

  34. Endoglin is not critical for hematopoietic stem cell engraftment and reconstitution but regulates adult erythroid development

    Moody, J., Sofie Singbrant, Göran Karlsson, Blank Savukinas, U., Aspling, M., Johan Flygare, David Bryder & Stefan Karlsson, 2007, In : Stem Cells. 25, 11, p. 2809-2819

    Research output: Contribution to journalArticle

  35. Human RPS19, the gene mutated in Diamond Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits.

    Johan Flygare, Aspesi, A., Bailey, J. C., Miyake, K., Caffrey, J. M., Stefan Karlsson & Ellis, S., 2007, In : Blood. 109, 3, p. 980-986

    Research output: Contribution to journalArticle

  36. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

    Varfolomeev, E., Blankenship, J. W., Wayson, S. M., Fedorova, A. V., Kayagaki, N., Garg, P., Zobel, K., Dynek, J. N., Elliott, L. O., Wallweber, H. J. A., Johan Flygare, Fairbrother, W. J., Deshayes, K. & Dixit, V., 2007, In : Cell. 131, 4, p. 669

    Research output: Contribution to journalArticle

  37. 2006
  38. Erythropoiesis in the Rps19 disrupted mouse: Analysis of erythropoietin response and biochemical markers for Diamond-Blackfan anemia

    Matsson, H., Davey, EJ., Frojmark, AS., Miyake, K., Utsugisawa, T., Johan Flygare, Zahou, E., Byman, I., Landin, B., Ronquist, G., Stefan Karlsson & Dahl, N., 2006, In : Blood Cells, Molecules & Diseases. 36, 2, p. 259-264

    Research output: Contribution to journalArticle

  39. 2005
  40. Deficiency of ribosomal protein S19 in CD34+ cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia.

    Johan Flygare, Kiefer, T., Miyake, K., Utsugisawa, T., Hamaguchi, I., Da Costa, L., Johan Richter, Davey, E. J., Matsson, H., Dahl, N., Wiznerowicz, M., Trono, D. & Stefan Karlsson, 2005, In : Blood. 105, 12, p. 4627-4634

    Research output: Contribution to journalArticle

  41. Development of cellular models for ribosomal protein S19 (RPS19)-deficient diamond-blackfan anemia using inducible expression of siRNA against RPS19.

    Miyake, K., Johan Flygare, Kiefer, T., Utsugisawa, T., Johan Richter, Ma, Z., Wiznerowicz, M., Trono, D. & Stefan Karlsson, 2005, In : Molecular Therapy. 11, 4, p. 627-637

    Research output: Contribution to journalArticle

  42. 2003
  43. Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis.

    Niels-Bjarne Woods, Muessig, A., Schmidt, M., Johan Flygare, Karin Olsson, Salmon, P., Trono, D., von Kalle, C. & Stefan Karlsson, 2003, In : Blood. 101, 4, p. 1284-1289

    Research output: Contribution to journalArticle

  44. Proliferation deficiency of multipotent hematopoietic progenitors in ribosomal protein S19 (RPS19)-deficient Diamond-Blackfan anemia improves following RPS19 gene transfer

    Hamaguchi, I., Johan Flygare, Nishiura, H., Brun, A., Ooka, A., Kiefer, T., Ma, Z., Dahl, N., Johan Richter & Stefan Karlsson, 2003, In : Molecular Therapy. 7, 5, p. 613-622

    Research output: Contribution to journalArticle