Johan Flygare

Senior Lecturer
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  1. 2019
  2. A Phenotypic Screening Assay Identifies Modulators of Diamond Blackfan Anemia

    Siva, K., Fredrik Ek, Chen, J., Abdul Ghani Alattar, Sigmundsson, K., Roger Olsson, Wlodarski, M., Lundbäck, T. & Johan Flygare, 2019, In : SLAS discovery : advancing life sciences R & D. 24, 3, p. 304-313 10 p.

    Research output: Contribution to journalArticle

  3. Cyclin-dependent kinase 8/19 inhibition suppresses osteoclastogenesis by downregulating RANK and promotes osteoblast mineralization and cancellous bone healing

    Amirhosseini, M., Bernhardsson, M., Lång, P., Andersson, G., Johan Flygare & Fahlgren, A., 2019, In : Journal of Cellular Physiology. 234, 9, p. 16503-16516 14 p.

    Research output: Contribution to journalArticle

  4. 2018
  5. Direct Lineage Reprogramming of Adult Mouse Fibroblast to Erythroid Progenitors

    Melissa Ilsley, Sandra Capellera-Garcia, Dhulipala, K., Johansson, A. & Johan Flygare, 2018 Dec 14, In : Journal of visualized experiments : JoVE. 142, e58464.

    Research output: Contribution to journalArticle

  6. 2017
  7. Direct lineage reprogramming: a useful addition to the blood cell research toolbox

    Sandra Capellera-Garcia & Johan Flygare, 2017 Feb 1, In : Expert Review of Hematology. 10, 2, p. 107-109

    Research output: Contribution to journalDebate/Note/Editorial

  8. Lentiviral Vectors with Cellular Promoters Correct Anemia and Lethal Bone Marrow Failure in a Mouse Model for Diamond-Blackfan Anemia

    Debnath, S., Jaako, P., Siva, K., Rothe, M., Chen, J., Maria Dahl, Gaspar, H. B., Johan Flygare, Schambach, A. & Stefan Karlsson, 2017, In : Molecular Therapy. 25, 8, p. 1805-1814

    Research output: Contribution to journalArticle

  9. 2016
  10. Direct Conversion of Fibroblasts to Megakaryocyte Progenitors

    Pulecio, J., Alejo-Valle, O., Sandra Capellera-Garcia, Vitaloni, M., Rio, P., Mejía-Ramírez, E., Caserta, I., Bueren, J. A., Johan Flygare & Raya, A., 2016 Oct 11, In : Cell Reports. 17, 3, p. 671-683 13 p.

    Research output: Contribution to journalArticle

  11. Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion

    Sandra Capellera-Garcia, Pulecio, J., Dhulipala, K., Siva, K., Rayon-Estrada, V., Sofie Singbrant, Mikael N E Sommarin, Walkley, C. R., Shamit Soneji, Göran Karlsson, Raya, Á., Sankaran, V. G. & Johan Flygare, 2016 Jun 14, In : Cell Reports. 15, 11, p. 2550-2562 13 p.

    Research output: Contribution to journalArticle

  12. The european hematology association roadmap for european hematology research: A consensus document

    Engert, A., Balduini, C., Brand, A., Coiffier, B., Cordonnier, C., Döhner, H., De Wit, T. D., Eichinger, S., Fibbe, W., Green, T., De Haas, F., Iolascon, A., Jaffredo, T., Rodeghiero, F., Sall Es, G., Schuringa, J. J., André, M., Andre-Schmutz, I., Bacigalupo, A., Bochud, P. Y. & 261 othersDen Boer, M., Bonini, C., Camaschella, C., Cant, A., Cappellini, M. D., Cazzola, M., Celso, C. L., Dimopoulos, M., Douay, L., Dzierzak, E., Einsele, H., Ferreri, A., De Franceschi, L., Gaulard, P., Gottgens, B., Greinacher, A., Gresele, P., Gribben, J., De Haan, G., Hansen, J. B., Hochhaus, A., Kadir, R., Kaveri, S., Kouskoff, V., Kühne, T., Kyrle, P., Ljungman, P., Maschmeyer, G., Méndez-Ferrer, S., Milsom, M., Mummery, C., Ossenkoppele, G., Pecci, A., Peyvandi, F., Philipsen, S., Reitsma, P., Ribera, J. M., Risitano, A., Rivella, S., Ruf, W., Schroeder, T., Scully, M., Socie, G., Staal, F., Stanworth, S., Stauder, R., Stilgenbauer, S., Tamary, H., Theilgaard-Mönch, K., Thein, S. L., Tilly, H., Trneny, M., Vainchenker, W., Vannucchi, A. M., Viscoli, C., Vrielink, H., Zaaijer, H., Zanella, A., Zolla, L., Zwaginga, J. J., Martinez, P. A., Van Den Akker, E., Allard, S., Anagnou, N., Andolfo, I., Andrau, J. C., Angelucci, E., Anstee, D., Aurer, I., Avet-Loiseau, H., Aydinok, Y., Bakchoul, T., Balduini, A., Barcellini, W., Baruch, D., Baruchel, A., Bayry, J., Bento, C., Van Den Berg, A., Bernardi, R., Bianchi, P., Bigas, A., Biondi, A., Bohonek, M., Bonnet, D., Borchmann, P., Borregaard, N., Brækkan, S., Van Den Brink, M., Brodin, E., Bullinger, L., Buske, C., Butzeck, B., Cammenga, J., Campo, E., Carbone, A., Cervantes, F., Cesaro, S., Charbord, P., Claas, F., Cohen, H., Conard, J., Coppo, P., Vives Corron, J. L., Da Costa, L., Davi, F., Delwel, R., Dianzani, I., Domanović, D., Donnelly, P., Drnovšek, T. D., Dreyling, M., Du, M. Q., Dufour, C., Durand, C., Efremov, D., Eleftheriou, A., Elion, J., Emonts, M., Engelhardt, M., Ezine, S., Falkenburg, F., Favier, R., Federico, M., Fenaux, P., Fitzgibbon, J., Johan Flygare, Foà, R., Forrester, L., Galacteros, F., Garagiola, I., Gardiner, C., Garraud, O., Van Geet, C., Geiger, H., Geissler, J., Germing, U., Ghevaert, C., Girelli, D., Godeau, B., Gökbuget, N., Goldschmidt, H., Goodeve, A., Graf, T., Graziadei, G., Griesshammer, M., Gruel, Y., Guilhot, F., Von Gunten, S., Gyssens, I., Halter, J., Harrison, C., Harteveld, C., Hellström-Lindberg, E., Hermine, O., Higgs, D., Hillmen, P., Hirsch, H., Hoskin, P., Huls, G., Inati, A., Johnson, P., Kattamis, A., Kiefel, V., Kleanthous, M., Klump, H., Krause, D., Hovinga, J. K., Lacaud, G., Lacroix-Desmazes, S., Landman-Parker, J., Legouill, S., Lenz, G., Von Lilienfeld-Toal, M., Von Lindern, M., Lopez-Guillermo, A., Lopriore, E., Lozano, M., Macintyre, E., Makris, M., Mannhalter, C., Martens, J., Mathas, S., Matzdorff, A., Medvinsky, A., Menendez, P., Migliaccio, A. R., Kenichi Miharada, Mikulska, M., Minard, V., Montalbán, C., De Montalembert, M., Montserrat, E., Morange, P. E., Mountford, J., Muckenthaler, M., Müller-Tidow, C., Mumford, A., Nadel, B., Navarro, J. T., El Nemer, W., Noizat-Pirenne, F., O’Mahony, B., Oldenburg, J., Olsson, M., Oostendorp, R., Palumbo, A., Passamonti, F., Patient, R., De Latour, R. P., Pflumio, F., Pierelli, L., Piga, A., Pollard, D., Raaijmakers, M., Radford, J., Rambach, R., Koneti Rao, A., Raslova, H., Rebulla, P., Rees, D., Ribrag, V., Rijneveld, A., Rinalducci, S., Robak, T., Roberts, I., Rodrigues, C., Rosendaal, F., Rosenwald, A., Rule, S., Russo, R., Saglio, G., Sanchez, M., Scharf, R. E., Schlenke, P., John Semple, Sierra, J., So-Osman, C., Soria, J. M., Stamatopoulos, K., Stegmayr, B., Stunnenberg, H., Swinkels, D., Barata, J. P. T., Taghon, T., Taher, A., Terpos, E., Thachil, J., Tissot, J. D., Touw, I., Toye, A., Trappe, R., Traverse-Glehen, A., Unal, S., Vaulont, S., Viprakasit, V., Vitolo, U., Van Wijk, R., Wójtowicz, A., Zeerleder, S. & Zieger, B., 2016 Feb 1, In : Haematologica. 101, 2, p. 115-208 94 p.

    Research output: Contribution to journalArticle

  13. 2015
  14. Disruption of the 5S RNP-Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia.

    Jaako, P., Debnath, S., Karin Olsson, Zhang, Y., Johan Flygare, Lindström, M. S., David Bryder & Stefan Karlsson, 2015, In : Leukemia. 29, 11, p. 2221-2229

    Research output: Contribution to journalArticle

  15. Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond-Blackfan anaemia.

    Sara Sjögren, Siva, K., Shamit Soneji, George, A. J., Winkler, M., Jaako, P., Wlodarski, M., Stefan Karlsson, Hannan, R. D. & Johan Flygare, 2015, In : British Journal of Haematology. 171, 4, p. 517-529

    Research output: Contribution to journalArticle

  16. 2014
  17. Gene therapy cures the anemia and lethal bone marrow failure in mouse model for RPS19-deficient Diamond-Blackfan anemia.

    Jaako, P., Debnath, S., Karin Olsson, Modlich, U., Rothe, M., Schambach, A., Johan Flygare & Stefan Karlsson, 2014, In : Haematologica. 99, 12, p. 1792-1798

    Research output: Contribution to journalArticle

  18. 2013
  19. Fetal hepatic progenitors support long-term expansion of hematopoietic stem cells

    Chou, S., Johan Flygare & Lodish, H. F., 2013, In : Experimental Hematology. 41, 5, p. 479-490

    Research output: Contribution to journalArticle

  20. 2012
  21. Dietary L-leucine improves the anemia in a mouse model for Diamond-Blackfan anemia.

    Jaako, P., Debnath, S., Karin Olsson, David Bryder, Johan Flygare & Stefan Karlsson, 2012, In : Blood. 120, 11, p. 2225-2228

    Research output: Contribution to journalArticle

  22. Progress towards Mechanism-Based Treatment for Diamond-Blackfan Anemia.

    Sara Sjögren & Johan Flygare, 2012, In : Scientific World Journal. 2012, 184362.

    Research output: Contribution to journalArticle

  23. 2011
  24. From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications

    Hattangadi, S. M., Wong, P., Zhang, L., Johan Flygare & Lodish, H. F., 2011, In : Blood. 118, 24, p. 6258-6268

    Research output: Contribution to journalReview article

  25. Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia.

    Jaako, P., Johan Flygare, Karin Olsson, Quere, R., Mats Ehinger, Henson, A., Ellis, S., Schambach, A., Baum, C., Johan Richter, Jonas Larsson, David Bryder & Stefan Karlsson, 2011, In : Blood. 118, p. 6087-6096

    Research output: Contribution to journalArticle

  26. 2010
  27. Chronic RPS19 Deficiency Leads to Bone Marrow Failure In a Mouse Model for Diamond Blackfan Anemia

    Jaako, P., Johan Flygare, Karin Olsson, Quere, R., Jonas Larsson, David Bryder & Stefan Karlsson, 2010, In : Blood. 116, 21, p. 89-89

    Research output: Contribution to journalPublished meeting abstract

  28. 2008
  29. 2007
  30. Diamond-Blackfan anemia: erythropoiesis lost in translation.

    Johan Flygare & Stefan Karlsson, 2007, In : Blood. 109, 8, p. 3152-3160

    Research output: Contribution to journalReview article

  31. Diamond-Blackfan Anemia: Erythropoiesis Lost in Translation

    Johan Flygare, 2007, Faculty of Medicine, Lund University.

    Research output: ThesisDoctoral Thesis (compilation)

  32. Endoglin is not critical for hematopoietic stem cell engraftment and reconstitution but regulates adult erythroid development

    Moody, J., Sofie Singbrant, Göran Karlsson, Blank Savukinas, U., Aspling, M., Johan Flygare, David Bryder & Stefan Karlsson, 2007, In : Stem Cells. 25, 11, p. 2809-2819

    Research output: Contribution to journalArticle

  33. Human RPS19, the gene mutated in Diamond Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits.

    Johan Flygare, Aspesi, A., Bailey, J. C., Miyake, K., Caffrey, J. M., Stefan Karlsson & Ellis, S., 2007, In : Blood. 109, 3, p. 980-986

    Research output: Contribution to journalArticle

  34. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

    Varfolomeev, E., Blankenship, J. W., Wayson, S. M., Fedorova, A. V., Kayagaki, N., Garg, P., Zobel, K., Dynek, J. N., Elliott, L. O., Wallweber, H. J. A., Johan Flygare, Fairbrother, W. J., Deshayes, K. & Dixit, V., 2007, In : Cell. 131, 4, p. 669

    Research output: Contribution to journalArticle

  35. 2006
  36. Erythropoiesis in the Rps19 disrupted mouse: Analysis of erythropoietin response and biochemical markers for Diamond-Blackfan anemia

    Matsson, H., Davey, EJ., Frojmark, AS., Miyake, K., Utsugisawa, T., Johan Flygare, Zahou, E., Byman, I., Landin, B., Ronquist, G., Stefan Karlsson & Dahl, N., 2006, In : Blood Cells, Molecules & Diseases. 36, 2, p. 259-264

    Research output: Contribution to journalArticle

  37. 2005
  38. Deficiency of ribosomal protein S19 in CD34+ cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia.

    Johan Flygare, Kiefer, T., Miyake, K., Utsugisawa, T., Hamaguchi, I., Da Costa, L., Johan Richter, Davey, E. J., Matsson, H., Dahl, N., Wiznerowicz, M., Trono, D. & Stefan Karlsson, 2005, In : Blood. 105, 12, p. 4627-4634

    Research output: Contribution to journalArticle

  39. Development of cellular models for ribosomal protein S19 (RPS19)-deficient diamond-blackfan anemia using inducible expression of siRNA against RPS19.

    Miyake, K., Johan Flygare, Kiefer, T., Utsugisawa, T., Johan Richter, Ma, Z., Wiznerowicz, M., Trono, D. & Stefan Karlsson, 2005, In : Molecular Therapy. 11, 4, p. 627-637

    Research output: Contribution to journalArticle

  40. 2003
  41. Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis.

    Niels-Bjarne Woods, Muessig, A., Schmidt, M., Johan Flygare, Karin Olsson, Salmon, P., Trono, D., von Kalle, C. & Stefan Karlsson, 2003, In : Blood. 101, 4, p. 1284-1289

    Research output: Contribution to journalArticle

  42. Proliferation deficiency of multipotent hematopoietic progenitors in ribosomal protein S19 (RPS19)-deficient Diamond-Blackfan anemia improves following RPS19 gene transfer

    Hamaguchi, I., Johan Flygare, Nishiura, H., Brun, A., Ooka, A., Kiefer, T., Ma, Z., Dahl, N., Johan Richter & Stefan Karlsson, 2003, In : Molecular Therapy. 7, 5, p. 613-622

    Research output: Contribution to journalArticle