John W Semple

Professor, PhD, BSc

Research areas and keywords

UKÄ subject classification

  • Medical and Health Sciences
  • Immunology in the medical area

Keywords

  • Transfusion medicine, Platelets, Immune thrombocytopenia, Transfusion Adverse Effects, Transfusion related Acute Lung Injury

Research

Professor Semple obtained his PhD in Immunology from Queen’s University at Kingston and was a Diabetes Canada Fellow in the Banting and Best Dept. of Medical research at the C.H. Best Institute, University of Toronto. He joined St. Michael’s Hospital in 1990 and was a Senior Staff Scientist and Head of the Toronto Platelet Immunobiology Group at the Keenan Research Centre for Biomedical Sciences. He was also a Professor in the Departments of Pharmacology, Medicine and Laboratory Medicine and Pathobiology at the University of Toronto and an Adjunct Scientist with Canadian Blood Services.  He joined Lund University in 2016 as a Professor of Transfusion Medcine.  His research is aimed at understanding the cellular immune mechanisms responsible for the generation of IgG antibodies that recognize platelet antigens. These antibodies can lead to clinically significant adverse effects such as autoimmunity causing immune thrombocytopenia (ITP) and alloimmunity causing platelet transfusion refractoriness. In ITP, for example, his laboratory is interested in how platelet antigens are processed and presented by antigen-presenting cells to activate T lymphocytes. In platelet refractoriness, his group studies the pro-inflammatory nature of platelets responsible for adverse reactions during platelet transfusions, particularly how platelet Toll-like receptor expression modulates innate immune mechanisms. His laboratory also studies the recipient immune mechanisms that cause Transfusion Related Acute Lung Injury (TRALI), a serious complication of transfusion. Professor Semple is the recipient of many awards and a member of several organisations, including the American and European Societies of Hematology and has delivered over 140 presentations at international meetings. He is on the editiorial board of the journals Blood and Transfusion and has served as a reviewer for numerous journals and granting agencies.  He has authored more than 150 papers in the area of platelet immunology.

Recent research outputs

Kapur, R., Kasetty, G., Johan Rebetz, Arne Egesten & John W Semple, 2019 Jul 4, In : Blood. 134, 1, p. 74-84

Research output: Contribution to journalArticle

John W. Semple & Kapur, R., 2019, In : Thrombosis and Haemostasis. 119, 3, p. 353-354 2 p.

Research output: Contribution to journalDebate/Note/Editorial

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