John W Semple

Professor, PhD, BSc
More filtering options
  1. 2019
  2. The Ultimate Murine Model of Immune Thrombocytopaenia

    John W. Semple & Kapur, R., 2019, In : Thrombosis and Haemostasis. 119, 3, p. 353-354 2 p.

    Research output: Contribution to journalDebate/Note/Editorial

  3. Transfusion-associated circulatory overload and transfusion-related acute lung injury.

    John W Semple, Johan Rebetz & Kapur, R., 2019, In : Blood. 133, 17, p. 1840-1853

    Research output: Contribution to journalReview article

  4. 2018
  5. Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury

    Kapur, R., Kim, M., Johan Rebetz, Hallström, B., Björkman, J. T., Takabe-French, A., Kim, N., Liu, J., Shanmugabhavananthan, S., Milosevic, S., McVey, M. J., Speck, E. R. & John W Semple, 2018 Jul 10, In : Blood Advances. 2, 13, p. 1651-1663

    Research output: Contribution to journalArticle

  6. Antiplatelet antibody-induced thrombocytopenia does not correlate with megakaryocyte abnormalities in murine immune thrombocytopenia

    Guo, L., Kapur, R., Aslam, R., Hunt, K., Hou, Y., Zufferey, A., Speck, E. R., Rondina, M. T., Lazarus, A. H., Ni, H. & J. W. Semple, 2018 Jul 1, In : Scandinavian Journal of Immunology. 88, 1, e12678.

    Research output: Contribution to journalArticle

  7. A highly purified form of staphylococcal protein A alleviates murine immune thrombocytopenia (ITP)

    Kapur, R., Catalina, M. D., Aslam, R., Speck, E. R., Francovitch, R. F. & John W. Semple, 2018, In : British Journal of Haematology. 183, 3, p. 501-503

    Research output: Contribution to journalLetter

  8. Intravenous immunoglobulin treatment of spleen cells from patients with immune thrombocytopenia significantly increases the percentage of myeloid-derived suppressor cells

    Aslam, R., Burack, W. R., Segel, G. B., McVey, M. J., Spence, S. A. & John W. Semple, 2018, In : British Journal of Haematology. 181, p. 262-264

    Research output: Contribution to journalLetter

  9. Moving target PF4 directs HIT responses

    John W. Semple & Kapur, R., 2018, In : Blood. 132, 7, p. 678-679 2 p.

    Research output: Contribution to journalReview article

  10. Targeting Transfusion-Related Acute Lung Injury: The Journey From Basic Science to Novel Therapies

    John W Semple, McVey, M. J., Kim, M., Johan Rebetz, Kuebler, W. M. & Kapur, R., 2018, In : Critical Care Medicine. 46, 5, p. e452-e458

    Research output: Contribution to journalReview article

  11. 2017
  12. Thymic-derived tolerizing dendritic cells are upregulated in the spleen upon treatment with intravenous immunoglobulin in a murine model of immune thrombocytopenia AU - Kapur, Rick

    Aslam, R., Kim, M., Guo, L., Ni, H., Segel, G. B. & John W. Semple, 2017 Jul 4, In : Platelets. 28, 5, p. 521-524

    Research output: Contribution to journalLetter

  13. Acid sphingomyelinase mediates murine acute lung injury following transfusion of aged platelets.

    McVey, M. J., Kim, M., Tabuchi, A., John W Semple & Kuebler, W. M., 2017, In : American Journal of Physiology: Lung Cellular and Molecular Physiology. 312, 5, p. L625-L637

    Research output: Contribution to journalArticle

  14. Low levels of interleukin-10 in patients with transfusion-related acute lung injury

    Kapur, R., Kim, M., Johan Rebetz, Rondina, M. T., Porcelijn, L. & John W. Semple, 2017, In : Annals of Translational Medicine. 5, 16, 339.

    Research output: Contribution to journalLetter

  15. Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets

    Zufferey, A., Speck, E. R., Machlus, K. R., Aslam, R., Guo, L., McVey, M. J., Kim, M., Kapur, R., Boilard, E., Italiano Jr., J. E. & John W Semple, 2017, In : Blood Advances. 1, 20, p. 1773-1785

    Research output: Contribution to journalArticle

  16. T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10

    Kapur, R., Kim, M., Aslam, R., McVey, M. J., Tabuchi, A., Luo, A., Liu, J., Li, Y., Shanmugabhavananthan, S., Speck, E. R., Zufferey, A., Yousef, G., Zhang, H., Rondina, M. T., Weyrich, A. S., Porcelijn, L., Kuebler, W. M., Slutsky, A. S. & John W Semple, 2017, In : Blood. 129, 18, p. 2557-2569 13 p.

    Research output: Contribution to journalArticle

  17. 2016
  18. The spleen dictates platelet destruction, anti-platelet antibody production, and lymphocyte distribution patterns in a murine model of immune thrombocytopenia

    Aslam, R., Kapur, R., Segel, G. B., Guo, L., Zufferey, A., Ni, H. & John W Semple, 2016 Jul 12, In : Experimental Hematology. 44, 10

    Research output: Contribution to journalArticle

  19. Microparticles as biomarkers of lung disease: enumeration in biological fluids using lipid bilayer microspheres

    McVey, M. J., Spring, C. M., John W Semple, Maishan, M. & Kuebler, W. M., 2016 May 1, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 310, 9, p. L802-14

    Research output: Contribution to journalArticle

  20. Splenic lymphocyte subtypes in immune thrombocytopenia: increased presence of a subtype of B-regulatory cells

    Aslam, R., Segel, G. B., Burack, R., Spence, S. A., Speck, E. R., Guo, L. & John W Semple, 2016 Apr, In : British Journal of Haematology. 173, 1, p. 159-60 2 p.

    Research output: Contribution to journalArticle

  21. The nonhemostatic immune functions of platelets

    Kapur, R. & John W Semple, 2016 Apr, In : Seminars in Hematology. 53, Suppl 1, p. S2-6 50858.

    Research output: Contribution to journalArticle

  22. Move over Tregs, MDSCs are here

    John W Semple, 2016 Mar 24, In : Blood. 127, 12, p. 1526-8 3 p.

    Research output: Contribution to journalDebate/Note/Editorial

  23. Acute Lung Injury Causes Asynchronous Alveolar Ventilation That Can Be Corrected by Individual Sighs

    Tabuchi, A., Nickles, H. T., Kim, M., John W Semple, Koch, E., Brochard, L., Slutsky, A. S., Pries, A. R. & Kuebler, W. M., 2016 Feb 15, In : American Journal of Respiratory and Critical Care Medicine. 193, 4, p. 396-406 11 p.

    Research output: Contribution to journalArticle

  24. CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia

    Guo, L., Kapur, R., Aslam, R., Speck, E. R., Zufferey, A., Zhao, Y., Kim, M., Lazarus, A. H., Ni, H. & John W Semple, 2016 Feb 11, In : Blood. 127, 6, p. 735-8 4 p.

    Research output: Contribution to journalArticle

  25. The european hematology association roadmap for european hematology research: A consensus document

    Engert, A., Balduini, C., Brand, A., Coiffier, B., Cordonnier, C., Döhner, H., De Wit, T. D., Eichinger, S., Fibbe, W., Green, T., De Haas, F., Iolascon, A., Jaffredo, T., Rodeghiero, F., Sall Es, G., Schuringa, J. J., André, M., Andre-Schmutz, I., Bacigalupo, A., Bochud, P. Y. & 261 othersDen Boer, M., Bonini, C., Camaschella, C., Cant, A., Cappellini, M. D., Cazzola, M., Celso, C. L., Dimopoulos, M., Douay, L., Dzierzak, E., Einsele, H., Ferreri, A., De Franceschi, L., Gaulard, P., Gottgens, B., Greinacher, A., Gresele, P., Gribben, J., De Haan, G., Hansen, J. B., Hochhaus, A., Kadir, R., Kaveri, S., Kouskoff, V., Kühne, T., Kyrle, P., Ljungman, P., Maschmeyer, G., Méndez-Ferrer, S., Milsom, M., Mummery, C., Ossenkoppele, G., Pecci, A., Peyvandi, F., Philipsen, S., Reitsma, P., Ribera, J. M., Risitano, A., Rivella, S., Ruf, W., Schroeder, T., Scully, M., Socie, G., Staal, F., Stanworth, S., Stauder, R., Stilgenbauer, S., Tamary, H., Theilgaard-Mönch, K., Thein, S. L., Tilly, H., Trneny, M., Vainchenker, W., Vannucchi, A. M., Viscoli, C., Vrielink, H., Zaaijer, H., Zanella, A., Zolla, L., Zwaginga, J. J., Martinez, P. A., Van Den Akker, E., Allard, S., Anagnou, N., Andolfo, I., Andrau, J. C., Angelucci, E., Anstee, D., Aurer, I., Avet-Loiseau, H., Aydinok, Y., Bakchoul, T., Balduini, A., Barcellini, W., Baruch, D., Baruchel, A., Bayry, J., Bento, C., Van Den Berg, A., Bernardi, R., Bianchi, P., Bigas, A., Biondi, A., Bohonek, M., Bonnet, D., Borchmann, P., Borregaard, N., Brækkan, S., Van Den Brink, M., Brodin, E., Bullinger, L., Buske, C., Butzeck, B., Cammenga, J., Campo, E., Carbone, A., Cervantes, F., Cesaro, S., Charbord, P., Claas, F., Cohen, H., Conard, J., Coppo, P., Vives Corron, J. L., Da Costa, L., Davi, F., Delwel, R., Dianzani, I., Domanović, D., Donnelly, P., Drnovšek, T. D., Dreyling, M., Du, M. Q., Dufour, C., Durand, C., Efremov, D., Eleftheriou, A., Elion, J., Emonts, M., Engelhardt, M., Ezine, S., Falkenburg, F., Favier, R., Federico, M., Fenaux, P., Fitzgibbon, J., Johan Flygare, Foà, R., Forrester, L., Galacteros, F., Garagiola, I., Gardiner, C., Garraud, O., Van Geet, C., Geiger, H., Geissler, J., Germing, U., Ghevaert, C., Girelli, D., Godeau, B., Gökbuget, N., Goldschmidt, H., Goodeve, A., Graf, T., Graziadei, G., Griesshammer, M., Gruel, Y., Guilhot, F., Von Gunten, S., Gyssens, I., Halter, J., Harrison, C., Harteveld, C., Hellström-Lindberg, E., Hermine, O., Higgs, D., Hillmen, P., Hirsch, H., Hoskin, P., Huls, G., Inati, A., Johnson, P., Kattamis, A., Kiefel, V., Kleanthous, M., Klump, H., Krause, D., Hovinga, J. K., Lacaud, G., Lacroix-Desmazes, S., Landman-Parker, J., Legouill, S., Lenz, G., Von Lilienfeld-Toal, M., Von Lindern, M., Lopez-Guillermo, A., Lopriore, E., Lozano, M., Macintyre, E., Makris, M., Mannhalter, C., Martens, J., Mathas, S., Matzdorff, A., Medvinsky, A., Menendez, P., Migliaccio, A. R., Kenichi Miharada, Mikulska, M., Minard, V., Montalbán, C., De Montalembert, M., Montserrat, E., Morange, P. E., Mountford, J., Muckenthaler, M., Müller-Tidow, C., Mumford, A., Nadel, B., Navarro, J. T., El Nemer, W., Noizat-Pirenne, F., O’Mahony, B., Oldenburg, J., Olsson, M., Oostendorp, R., Palumbo, A., Passamonti, F., Patient, R., De Latour, R. P., Pflumio, F., Pierelli, L., Piga, A., Pollard, D., Raaijmakers, M., Radford, J., Rambach, R., Koneti Rao, A., Raslova, H., Rebulla, P., Rees, D., Ribrag, V., Rijneveld, A., Rinalducci, S., Robak, T., Roberts, I., Rodrigues, C., Rosendaal, F., Rosenwald, A., Rule, S., Russo, R., Saglio, G., Sanchez, M., Scharf, R. E., Schlenke, P., John Semple, Sierra, J., So-Osman, C., Soria, J. M., Stamatopoulos, K., Stegmayr, B., Stunnenberg, H., Swinkels, D., Barata, J. P. T., Taghon, T., Taher, A., Terpos, E., Thachil, J., Tissot, J. D., Touw, I., Toye, A., Trappe, R., Traverse-Glehen, A., Unal, S., Vaulont, S., Viprakasit, V., Vitolo, U., Van Wijk, R., Wójtowicz, A., Zeerleder, S. & Zieger, B., 2016 Feb 1, In : Haematologica. 101, 2, p. 115-208 94 p.

    Research output: Contribution to journalArticle

  26. Alleviation of gram-negative bacterial lung inflammation by targeting HECTD2

    Kapur, R. & John W. Semple, 2016, In : Annals of Translational Medicine. 4, 24, 488.

    Research output: Contribution to journalDebate/Note/Editorial

  27. 2015
  28. C-reactive protein enhances murine antibody-mediated transfusion-related acute lung injury

    Kapur, R., Kim, M., Shanmugabhavananthan, S., Liu, J., Li, Y. & John W Semple, 2015 Dec 17, In : Blood. 126, 25, p. 2747-51 5 p.

    Research output: Contribution to journalArticle

  29. 2015 proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine symposium

    Spitalnik, S. L., Triulzi, D., Devine, D. V., Dzik, W. H., Eder, A. F., Gernsheimer, T., Josephson, C. D., Kor, D. J., Luban, N. L. C., Roubinian, N. H., Mondoro, T., Welniak, L. A., Zou, S., Glynn, S. & State of the Science in Transfusion Medicine Working Groups, 2015 Sep, In : Transfusion. 55, 9, p. 2282-90 9 p.

    Research output: Contribution to journalReview article

  30. Nouvelle cuisine: platelets served with inflammation

    Kapur, R., Zufferey, A., Boilard, E. & John W Semple, 2015 Jun 15, In : Journal of Immunology. 194, 12, p. 5579-87 9 p.

    Research output: Contribution to journalArticle

  31. C-reactive protein boosts antibody-mediated platelet destruction

    John W Semple, 2015 Mar 12, In : Blood. 125, 11, p. 1690-1 2 p.

    Research output: Contribution to journalReview article

  32. 2014
  33. Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation

    Boudreau, L. H., Duchez, A-C., Cloutier, N., Soulet, D., Martin, N., Bollinger, J., Paré, A., Rousseau, M., Naika, G. S., Lévesque, T., Laflamme, C., Marcoux, G., Lambeau, G., Farndale, R. W., Pouliot, M., Hamzeh-Cognasse, H., Cognasse, F., Garraud, O., Nigrovic, P. A., Guderley, H. & 5 othersLacroix, S., Thibault, L., John W Semple, Gelb, M. H. & Boilard, E., 2014 Oct 2, In : Blood. 124, 14, p. 2173-83 11 p.

    Research output: Contribution to journalArticle

  34. A comprehensive study of ovine haemostasis to assess suitability to model human coagulation

    Foley, S. R., Solano, C., Simonova, G., Spanevello, M. M., Bird, R. J., John W Semple, Jackson, D. E., Schibler, A., Fraser, J. F. & Fung, Y. L., 2014 Aug, In : Thrombosis Research. 134, 2, p. 468-73 6 p.

    Research output: Contribution to journalArticle

  35. Peripheral blood monocyte-derived chemokine blockade prevents murine transfusion-related acute lung injury (TRALI)

    McKenzie, C. G. J., Kim, M., Singh, T. K., Milev, Y., Freedman, J. & John W Semple, 2014 May 29, In : Blood. 123, 22, p. 3496-503 8 p.

    Research output: Contribution to journalArticle

  36. Platelet GPIb-IX has suppressive effects on septic inflammation

    John W Semple, 2014 May, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 34, 5, p. 962-3 2 p.

    Research output: Contribution to journalDebate/Note/Editorial

  37. Pathogenesis of immune thrombocytopenia

    Cines, D. B., Cuker, A. & John W Semple, 2014 Apr, In : Presse médicale (Paris, France : 1983). 43, 4 Pt 2, p. e49-59

    Research output: Contribution to journalDebate/Note/Editorial

  38. Allogeneic platelet transfusions prevent murine T-cell-mediated immune thrombocytopenia

    Guo, L., Yang, L., Speck, E. R., Aslam, R., Kim, M., McKenzie, C. G. J., Lazarus, A. H., Ni, H., Hou, M., Freedman, J. & John W Semple, 2014 Jan 16, In : Blood. 123, 3, p. 422-7 6 p.

    Research output: Contribution to journalArticle

  39. 2013
  40. Cellular immune dysfunction in immune thrombocytopenia (ITP)

    McKenzie, C. G. J., Guo, L., Freedman, J. & John W Semple, 2013 Oct, In : British Journal of Haematology. 163, 1, p. 10-23 14 p.

    Research output: Contribution to journalArticle

  41. Platelets deliver small packages of genetic function

    John W Semple, 2013 Jul 11, In : Blood. 122, 2, p. 155-6 2 p.

    Research output: Contribution to journalDebate/Note/Editorial

  42. Innate and adaptive immunity in immune thrombocytopenia

    Lazarus, A. H., John W Semple & Cines, D. B., 2013 Jan, In : Seminars in Hematology. 50 , Suppl 1, p. S68-70

    Research output: Contribution to journalArticle

  43. 2012
  44. Bregging rights in ITP

    John W Semple, 2012 Oct 18, In : Blood. 120, 16, p. 3169

    Research output: Contribution to journalReview article

  45. Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia

    Aslam, R., Hu, Y., Gebremeskel, S., Segel, G. B., Speck, E. R., Guo, L., Kim, M., Ni, H., Freedman, J. & John W Semple, 2012 Sep 6, In : Blood. 120, 10, p. 2127-32 6 p.

    Research output: Contribution to journalArticle

  46. The immunopathogenesis of immune thrombocytopenia: T cells still take center-stage

    John W Semple & Provan, D., 2012 Sep, In : Current Opinion in Hematology. 19, 5, p. 357-62 6 p.

    Research output: Contribution to journalReview article

  47. T granules in human platelets function in TLR9 organization and signaling

    Thon, J. N., Peters, C. G., Machlus, K. R., Aslam, R., Rowley, J., Macleod, H., Devine, M. T., Fuchs, T. A., Weyrich, A. S., John W Semple, Flaumenhaft, R. & Italiano, J. E., 2012 Aug 20, In : Journal of Cell Biology. 198, 4, p. 561-74 14 p.

    Research output: Contribution to journalArticle

  48. HLA alloimmunization against platelet transfusions: pathophysiology, significance, prevention and management

    Pavenski, K., Freedman, J. & J W Semple, 2012 Apr, In : Tissue Antigens. 79, 4, p. 237-45 9 p.

    Research output: Contribution to journalReview article

  49. Intravenous immunoglobulin prevents murine antibody-mediated acute lung injury at the level of neutrophil reactive oxygen species (ROS) production

    John W Semple, Kim, M., Hou, J., McVey, M., Lee, Y. J., Tabuchi, A., Kuebler, W. M., Chai, Z-W. & Lazarus, A. H., 2012, In : PLoS ONE. 7, 2, e31357.

    Research output: Contribution to journalArticle

  50. 2011
  51. Management of immune thrombocytopenic purpura in children: potential role of novel agents

    Bredlau, A. L., John W Semple & Segel, G. B., 2011 Aug 1, In : Paediatric Drugs. 13, 4, p. 213-23 11 p.

    Research output: Contribution to journalArticle

  52. Single nucleotide polymorphism (SNP) analysis demonstrates a significant association of tumour necrosis factor-alpha (TNFA) with primary immune thrombocytopenia among Caucasian adults

    Sarpatwari, A., Bussel, J. B., Ahmed, M., Erqou, S., John W Semple, Newland, A. C., Bennett, D., Pharoah, P. & Provan, D., 2011 Jul, In : Hematology. 16, 4, p. 243-8 6 p.

    Research output: Contribution to journalArticle

  53. Platelets and the immune continuum

    John W Semple, Italiano, J. E. & Freedman, J., 2011 Apr, In : Nature Reviews Immunology. 11, 4, p. 264-74 11 p.

    Research output: Contribution to journalArticle

  54. Current problems and future directions of transfusion-induced alloimmunization: summary of an NHLBI working group

    Zimring, J. C., Welniak, L., John W Semple, Ness, P. M., Slichter, S. J., Spitalnik, S. L. & NHLBI Alloimmunization Working Group, 2011 Feb, In : Transfusion. 51, 2, p. 435-41 7 p.

    Research output: Contribution to journalArticle

  55. 2010
  56. Recent progress in understanding the pathogenesis of immune thrombocytopenia

    John W Semple, Provan, D., Garvey, M. B. & Freedman, J., 2010 Nov, In : Current Opinion in Hematology. 17, 6, p. 590-5 6 p.

    Research output: Contribution to journalArticle

  57. Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injury

    Fung, Y. L., Kim, M., Tabuchi, A., Aslam, R., Speck, E. R., Chow, L., Kuebler, W. M., Freedman, J. & John W Semple, 2010 Oct 21, In : Blood. 116, 16, p. 3073-9 7 p.

    Research output: Contribution to journalArticle

Previous 1 2 Next