Jun Chen

Research Engineer
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  1. 2020
  2. Lysine-specific demethylase 1A (LSD1) restricts ex vivo propagation of human HSCs and is a target of UM171

    Agatheeswaran Subramaniam, Kristijonas Zemaitis, Mehrnaz Safaee Talkhoncheh, David Yudovich, Alexandra Bäckström, Shubhranshu Debnath, Jun Chen, Mayur Vilas Jain, Roman Galeev, Massimiliano Gaetani, Roman A Zubarev & Jonas Larsson, 2020 Nov 5, In: Blood. 136, 19, p. 2151-2161 11 p.

    Research output: Contribution to journalArticle

  3. Metformin-induced suppression of Nemo-like kinase improves erythropoiesis in preclinical models of Diamond–Blackfan anemia through induction of miR-26a

    Mark C. Wilkes, Kavitha Siva, Gianluca Varetti, Jacqueline Mercado, Ethan P. Wentworth, Cristina A. Perez, Mallika Saxena, Sharon Kam, Simryn Kapur, Jun Chen, Anu Narla, Bert Glader, Shou Lin, Manuel Serrano, Johan Flygare & Kathleen M. Sakamoto, 2020 Nov 1, In: Experimental Hematology. 91, p. 65-77 13 p.

    Research output: Contribution to journalArticle

  4. Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase

    M. C. Wilkes, K. Siva, J. Chen, G. Varetti, M. Y. Youn, H. Chae, F. Ek, R. Olsson, T. Lundbäck, D. P. Dever, T. Nishimura, A. Narla, B. Glader, H. Nakauchi, M. H. Porteus, C. E. Repellin, H. T. Gazda, S. Lin, M. Serrano, J. Flygare & 1 others, K. M. Sakamoto, 2020, In: Nature Communications. 11, 1, 3344.

    Research output: Contribution to journalArticle

  5. 2019
  6. A Phenotypic Screening Assay Identifies Modulators of Diamond Blackfan Anemia

    Kavitha Siva, Fredrik Ek, Jun Chen, Abdul Ghani Alattar, Kristmundur Sigmundsson, Roger Olsson, Marcin Wlodarski, Thomas Lundbäck & Johan Flygare, 2019, In: SLAS Discovery. 24, 3, p. 304-313 10 p.

    Research output: Contribution to journalArticle

  7. 2017
  8. Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration

    Karolina Komorowska, Alexander Doyle, Martin Wahlestedt, Agatheeswaran Subramaniam, Shubhranshu Debnath, Jun Chen, Shamit Soneji, Ben Van Handel, Hanna K.A. Mikkola, Kenichi Miharada, David Bryder, Jonas Larsson & Mattias Magnusson, 2017 Dec 19, In: Cell Reports. 21, 12, p. 3514-3523 10 p.

    Research output: Contribution to journalArticle

  9. Lentiviral Vectors with Cellular Promoters Correct Anemia and Lethal Bone Marrow Failure in a Mouse Model for Diamond-Blackfan Anemia

    Shubhranshu Debnath, Pekka Jaako, Kavitha Siva, Michael Rothe, Jun Chen, Maria Dahl, H. Bobby Gaspar, Johan Flygare, Axel Schambach & Stefan Karlsson, 2017, In: Molecular Therapy. 25, 8, p. 1805-1814

    Research output: Contribution to journalArticle

  10. 2016
  11. Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice

    Jun Chen, Taku Kaitsuka, Rika Fujino, Kimi Araki, Kazuhito Tomizawa & Tetsuro Yamamoto, 2016 Aug 26, In: Neuroscience Letters. 629, p. 221-226 6 p.

    Research output: Contribution to journalArticle