Katrin Mani

Professor

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Keywords

  • Proteoglycan, Glycosaminoglycan, Growth factors

Research

Signaling by growth factors is finely balanced to ensure normal tissue homeostasis while avoiding abnormal neoplastic growth. Cell surface proteoglycans are strategically positioned to bind growth factors and their receptors and regulate their intracellular signaling events by acting as mandatory co-receptors. Intense research in the area of glycobiology reveals important roles for proteoglycans in neoplastic growth and cancer as a result of their interaction with growth factors and growth factor receptors. Our research focuses on understanding the regulatory role of proteoglycans and glycosaminoglycans in growth factor signaling within the tumor microenvironment. Proteoglycans are proteins substituted with polyanionic carbohydrate chains called glycosaminoglycans. The variable length of glycosaminoglycan chains together with detailed structural modifications result in extensive diversity and thereby various effects on growth factor signaling. We investigate the role of proteoglycans and their glycosaminoglycan chains in neoplastic behavior by studying their structural biology, growth factor signaling pathways, effects on gene and protein expressions as well as their effects on tumor growth and tumor metastasis using different in vitro and in vivo tumor models.

Highlighted research outputs

Aili, U., Johnsson, R., Lars-Åke Fransson, Ellervik, U. & Katrin Mani, 2010, In : Cancer Research. 70, 9, p. 3771-3779

Research output: Contribution to journalArticle

Thorsheim, K., Persson, A., Johnsson, R., Löfgren, J., Katrin Mani & Ulf Ellervik, 2013, In : Bioorganic & Medicinal Chemistry. 21, 11, p. 3310-3317

Research output: Contribution to journalArticle

Awad, W., Svensson Birkedal, G., Thunnissen, M. M. G. M., Katrin Mani & Logan, D. T., 2013, In : Acta Crystallographica. Section D: Biological Crystallography. 69, Pt 12, p. 2524-2533

Research output: Contribution to journalArticle

Abdelhady, W. A., Derek Logan & Katrin Mani, 2013

Research output: Non-textual formWeb publication/site

Awad, W., Adamczyk, B., Örnros, J., Karlsson, N. G., Katrin Mani & Logan, D. T., 2015, In : Journal of Biological Chemistry. 290, 38, p. 22991-23008

Research output: Contribution to journalArticle

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