Kristian Pietras

Professor, Directly Appointed

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Keywords

  • Tumor microenvironment , Targeted therapy, Mouse models of cancer

Research

We aim to molecularly map the support functions performed by the various cell types comprising the tumor microenvironment. We believe that decisive treatment benefit can only be achieved by targeting distinct cell types and pathways that collectively sustain tumor
growth.

Specifically, molecular interactions between cancer-associated fibroblasts, pericytes and endothelial cells are explored with a special focus on novel anti-cancer strategies. Importantly, the cellular networks within tumors cannot be studied in isolation. Thus, our work ranges over many different topics, with methodology, technology and purpose as the common denominators.

We currently pursue three main avenues of research:

1. Basic Biology
Identification of new cellular subsets of the tumor stroma and their influence on
cancer progression

2. Pre-clinical studies Investigation of the therapeutic utility of the tumor stroma

3. Translational studies
Exploration of the tumor stroma as biomarkers of prognosis or response to
therapy in human cancer


Taken together, the overall aim of our work is to generate basic knowledge about the interdependent way cells within a tumor relate to each other, as well as produce information that will be immediately useful for the design and modification of clinical practice.

Highlighted research outputs

Eliane Cortez, Hanna Gladh, Sebastian Braun, Matteo Bocci, Eugenia Cordero, Niklas K Björkström, Hideki Miyazaki, Iacovos P Michael, Ulf Eriksson, Erika Folestad & Kristian Pietras, 2016, In: Proceedings of the National Academy of Sciences. 113, 7, p. E864-E873

Research output: Contribution to journalArticle

Sara I Cunha, Matteo Bocci, John Lövrot, Nikolas Eleftheriou, Pernilla Roswall, Eugenia Cordero, Linda Lindström, Michael Bartoschek, B Kristian Haller, R Scott Pearsall, Aaron W Mulivor, Ravindra Kumar, Christer Larsson, Jonas Bergh & Kristian Pietras, 2015, In: Cancer Research. 75, 12, p. 2445-2456

Research output: Contribution to journalArticle

Charlotte Anderberg, Sara I. Cunha, Zhenhua Zhai, Eliane Cortez, Evangelia Pardali, Jill R. Johnson, Marcela Franco, Marta Paez-Ribes, Ross Cordiner, Jonas Fuxe, Bengt R. Johansson, Marie-Jose Goumans, Oriol Casanovas, Peter ten Dijke, Helen M. Arthur & Kristian Pietras, 2013, In: Journal of Experimental Medicine. 210, 3, p. 563-579

Research output: Contribution to journalArticle

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