Kristina E M Persson

Senior Lecturer, consultant

Research areas and keywords

UKÄ subject classification

  • Medical and Health Sciences

Keywords

  • Malaria, Babesia, Parasite, Immunity, Antibodies, Host-pathogen interactions

Research

Malaria is a major problem globally with many deaths every year. The disease is often caused by the parasite Plasmodium falciparum and it is spread by mosquitoes. Resistance against medications used is an increasing problem. If we can understand how immunity against malaria is formed, we can make a vaccine. You need to have malaria many times (and survive every time!) before immunity against the disease is reached. We have developed a new method to measure malaria-specific B-cells directly in peripheral blood, using flow cytometry, and we found that many of the B-cells are atypical which could help in explaining why it takes so long to become immune against malaria. To find out more about this, we also have ongoing studies of patients with malaria both in Sweden and in Uganda. We also have projects to investigate how the parasite can enter red blood cells, and which antibodies that are functional enough to stop this process. This is done in collaboration with Prof Martin L Olsson and Ass Prof Jill Storry at Transfusion Medicine.

In the group there are three PhD-students, two working with malaria and one studying Babesia. The latter looks almost like malaria in the microscope, but it is spread in Sweden by ticks. Babesia causes a disease with fever that can become life threatening in immunosuppressed patients, and it is probably underdiagnosed in Sweden. It can also spread easily via blood transfusions. We have an ongoing study where we will investigate how common Babesia is in humans who are often exposed to tick bites.

For those who want to watch a short movie about Babesia, and learn how to protect yourself against ticks: https://players.brightcove.net/3193745440001/default_default/index.html?videoId=6046923423001

Recent research outputs

Joel Svensson, Lazarevic, V., Bläckberg, J., Martin Olsson & Kristina Persson, 2019 Jun 28, Lakartidningen, 116.

Research output: Contribution to specialist publication or newspaperSpecialist publication article

Reiling, L., Boyle, M. J., White, M. T., Wilson, D. W., Feng, G., Weaver, R., Opi, D. H., Kristina E.M. Persson, Richards, J. S., Siba, P. M., Fowkes, F. J. I., Takashima, E., Tsuboi, T., Mueller, I. & Beeson, J. G., 2019 Feb 5, In : Nature Communications. 10, 1, 610.

Research output: Contribution to journalArticle

Sundling, C., Rönnberg, C., Yman, V., Asghar, M., Jahnmatz, P., Lakshmikanth, T., Chen, Y., Mikes, J., Forsell, M. N., Sondén, K., Achour, A., Brodin, P., Kristina E.M. Persson & Färnert, A., 2019, In : JCI Insight. 4, 9, e126492.

Research output: Contribution to journalArticle

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