Lars Björck

Senior Professor
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  1. 2020
  2. 2019
  3. A quantitative Streptococcus pyogenes-human protein-protein interaction map reveals localization of opsonizing antibodies

    Lotta Happonen, Simon Hauri, Gabriel Svensson Birkedal, Christofer Karlsson, Therese de Neergaard, Hamed Khakzad, Pontus Nordenfelt, Mats Wikström, Magdalena Wisniewska, Lars Björck, Lars Malmström & Johan Malmström, 2019 Jun 21, In : Nature Communications. 10, 1, p. 2727

    Research output: Contribution to journalArticle

  4. The molecular basis of human igg-mediated enhancement of C4b-binding protein recruitment to group a streptococcus

    David Ermert, Maisem Laabei, Antonin Weckel, Matthias Mörgelin, Martin Lundqvist, Lars Björck, Sanjay Ram, Sara Linse & Anna M. Blom, 2019 Jun 4, In : Frontiers in Immunology. 10, JUN, 1230.

    Research output: Contribution to journalArticle

  5. 2018
  6. Safety, immunogenicity, pharmacokinetics, and efficacy of degradation of anti-HLA antibodies by IdeS (imlifidase) in chronic kidney disease patients

    Tomas Lorant, Mats Bengtsson, Torsten Eich, Britt Marie Eriksson, Lena Winstedt, Sofia Järnum, Yvonne Stenberg, Anna Karin Robertson, Kristina Mosén, Lars Björck, Lars Bäckman, Erik Larsson, Kathryn Wood, Gunnar Tufveson & Christian Kjellman, 2018 Nov, In : American Journal of Transplantation. 18, 11, p. 2752-2762

    Research output: Contribution to journalArticle

  7. Streptococcus pyogenes Infection and the Human Proteome with a Special Focus on the Immunoglobulin G-cleaving Enzyme IdeS

    Christofer A.Q. Karlsson, Sofia Järnum, Lena Winstedt, Christian Kjellman, Lars Björck, Adam Linder & Johan A. Malmström, 2018 Jun 1, In : Molecular and Cellular Proteomics. 17, 6, p. 1097-1111

    Research output: Contribution to journalArticle

  8. Human igg increases virulence of streptococcus pyogenes through complement evasion

    David Ermert, Antonin Weckel, Michal Magda, Matthias Mörgelin, Jutamas Shaughnessy, Peter A. Rice, Lars Björck, Sanjay Ram & Anna M. Blom, 2018 May 15, In : Journal of Immunology. 200, 10, p. 3495-3505 11 p.

    Research output: Contribution to journalArticle

  9. Protein SIC secreted from Streptococcus pyogenes forms complexes with extracellular histones that boost cytokine production

    Johannes Westman, Bhavya Chakrakodi, Johanna Snäll, Matthias Mörgelin, Martin Bruun Madsen, Ole Hyldegaard, Ariane Neumann, Inga Maria Frick, Anna Norrby-Teglund, Lars Björck & Heiko Herwald, 2018 Feb 22, In : Frontiers in Immunology. 9, FEB, p. 1-14 236.

    Research output: Contribution to journalArticle

  10. 2017
  11. In vivo enzymatic modulation of IgG antibodies prevents immune complex-dependent skin injury

    Sidonia Mihai, Heike Albert, Ralf J. Ludwig, Hiroaki Iwata, Lars Björck, Mattias Collin & Falk Nimmerjahn, 2017 Aug, In : Experimental Dermatology. 26, 8

    Research output: Contribution to journalArticle

  12. Toward clinical use of the IgG specific enzymes IdeS and EndoS against antibody-mediated diseases

    Mattias Collin & Lars Björck, 2017, Methods in Molecular Biology. Humana Press, Vol. 1535. p. 339-351 13 p. (Methods in Molecular Biology; vol. 1535).

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  13. 2016
  14. Structure and Interactions of a Dimeric Variant of sHIP, a Novel Virulence Determinant of Streptococcus pyogenes.

    Carl Diehl, Magdalena Wisniewska, Inga-Maria Frick, Werner Streicher, Lars Björck, Johan Malmström & Mats Wikström, 2016, In : Frontiers in Microbiology. 7, 95.

    Research output: Contribution to journalArticle

  15. 2015
  16. Active but inoperable thrombin is accumulated in a plasma protein layer surrounding Streptococcus pyogenes.

    Clément Naudin, Sinead Hurley, Erik Malmström, T Plug, Oonagh Shannon, J C M Meijers, Matthias Mörgelin, Lars Björck & Heiko Herwald, 2015, In : Thrombosis and Haemostasis. 114, 4, p. 717-726

    Research output: Contribution to journalArticle

  17. Complete Removal of Extracellular IgG Antibodies in a Randomized Dose-Escalation Phase I Study with the Bacterial Enzyme IdeS - A Novel Therapeutic Opportunity.

    Lena Winstedt, Sofia Järnum, Emma Andersson Nordahl, Andreas Olsson, Anna Runström, Robert Bockermann, Christofer Karlsson, Johan Malmström, Gabriella Samuelsson Palmgren, Ulf Malmqvist, Lars Björck & Christian Kjellman, 2015, In : PLoS ONE. 10, 7, e0132011.

    Research output: Contribution to journalArticle

  18. 2014
  19. Functional and Structural Properties of a Novel Protein and Virulence Factor (sHIP) in Streptococcus pyogenes.

    Magdalena Wisniewska, Lotta Happonen, Fredrik Kahn, Markku Varjosalo, Lars Malmström, George Rosenberger, Christofer Karlsson, Giuseppe Cazzamali, Irina Pozdnyakova, Inga-Maria Frick, Lars Björck, Werner Streicher, Johan Malmström & Mats Wikström, 2014, In : Journal of Biological Chemistry. 289, 26, p. 18175-18188

    Research output: Contribution to journalArticle

  20. Identification of molecular mechanisms used by Finegoldia magna to penetrate and colonise human skin.

    Elizabeth Murphy, Matthias Mörgelin, Dieter P Reinhardt, Anders Olin, Lars Björck & Inga-Maria Frick, 2014, In : Molecular Microbiology. 94, 2, p. 403-417

    Research output: Contribution to journalArticle

  21. 2013
  22. IgG-binding bacterial proteins and pathogenesis.

    Pontus Nordenfelt & Lars Björck, 2013, In : Future Microbiology. 8, 3, p. 299-301

    Research output: Contribution to journalDebate/Note/Editorial

  23. 2012
  24. Antibody orientation at bacterial surfaces is related to invasive infection.

    Pontus Nordenfelt, Sofia Waldemarson, Adam Linder, Matthias Mörgelin, Christofer Karlsson, Johan Malmström & Lars Björck, 2012, In : Journal of Experimental Medicine. 209, 13, p. 2367-2381

    Research output: Contribution to journalArticle

  25. Streptococcal surface proteins activate the contact system and control its antibacterial activity.

    Kristofer Wollein Waldetoft, Lisbeth Svensson, Matthias Mörgelin, Anders Olin, Patric Nitsche, Lars Björck & Inga-Maria Frick, 2012, In : Journal of Biological Chemistry. 287, 30, p. 25010-25018

    Research output: Contribution to journalArticle

  26. Streptococcus pyogenes in human plasma: adaptive mechanisms analyzed by mass spectrometry based proteomics.

    Johan Malmström, Christofer Karlsson, Pontus Nordenfelt, Reto Ossola, Hendrik Weisser, Andreas Quandt, Karin Hansson, Ruedi Aebersold, Lars Malmstrom & Lars Björck, 2012, In : Journal of Biological Chemistry. 287, 2, p. 1415-1425

    Research output: Contribution to journalArticle

  27. 2011
  28. Binding of albumin promotes bacterial survival at the epithelial surface.

    Arne Egesten, Inga-Maria Frick, Matthias Mörgelin, Anders Olin & Lars Björck, 2011, In : Journal of Biological Chemistry. Dec, p. 2469-2476

    Research output: Contribution to journalArticle

  29. The factor H-binding fragment of PspC as a vaccine antigen for the induction of protective humoral immunity against experimental pneumococcal sepsis

    Susanna Ricci, Robert Janulczyk, Alice Gerlini, Velia Braione, Leonarda Colomba, Francesco Iannelli, Damiana Chiavolini, Marco Rinaldo Oggioni, Lars Björck & Gianni Pozzi, 2011, In : Vaccine. 29, 46, p. 8241-8249

    Research output: Contribution to journalArticle

  30. 2010
  31. Erysipelas Caused by Group A Streptococcus Activates the Contact System and Induces the Release of Heparin-Binding Protein.

    Adam Linder, Linda Johansson, Pontus Thulin, Erika Hertzén, Matthias Mörgelin, Bertil Christensson, Lars Björck, Anna Norrby-Teglund & Per Åkesson, 2010, In : Journal of Investigative Dermatology. 130, p. 1365-1372

    Research output: Contribution to journalArticle

  32. Histidine-rich glycoprotein promotes bacterial entrapment in clots and decreases mortality in a mouse model of sepsis.

    Oonagh Shannon, Victoria Rydengård, Artur Schmidtchen, Matthias Mörgelin, Per Alm, Ole E Sørensen & Lars Björck, 2010, In : Blood. 116, p. 2365-2372

    Research output: Contribution to journalArticle

  33. Streptococcal inhibitor of complement-mediated lysis (SIC): an anti-inflammatory virulence determinant

    Per Åkesson, Heiko Herwald, Magnus Rasmussen, Katarina Håkansson, Magnus Abrahamson, Ahmed A. K. Hasan, Alvin H. Schmaier, Werner Mueller-Ester & Lars Björck, 2010, In : Microbiology. 156, p. 3660-3668

    Research output: Contribution to journalArticle

  34. Successful treatment of experimental glomerulonephritis with IdeS and EndoS, IgG-degrading streptococcal enzymes

    Rui Yang, Marielle A. Otten, Thomas Hellmark, Mattias Collin, Lars Björck, Ming-Hui Zhao, Mohamed R. Daha & Mårten Segelmark, 2010, In : Nephrology Dialysis Transplantation. 25, 8, p. 2479-2486

    Research output: Contribution to journalArticle

  35. 2009
  36. SufA - a bacterial enzyme that cleaves fibrinogen and blocks fibrin network formation.

    Christofer Karlsson, Matthias Mörgelin, Mattias Collin, Rolf Lood, Marie-Louise Andersson, Artur Schmidtchen, Lars Björck & Inga-Maria Frick, 2009, In : Microbiology. 155, Pt 1, p. 238-248

    Research output: Contribution to journalArticle

  37. Synthesis and biological evaluation of reversible inhibitors of IdeS, a bacterial cysteine protease and virulence determinant

    Kristina Berggren, Björn Johansson, Tomas Fex, Jan Kihlberg, Lars Björck & Kristina Luthman, 2009, In : Bioorganic & Medicinal Chemistry. 17, 9, p. 3463-3470

    Research output: Contribution to journalArticle

  38. Treatment of invasive streptococcal infection with a peptide derived from human high molecular weight kininogen.

    Sonja Oehmcke, Oonagh Shannon, Maren von Kockritz-Blickwede, Matthias Mörgelin, Adam Linder, Anders Olin, Lars Björck & Heiko Herwald, 2009, In : Blood. 114, 2, p. 444-451

    Research output: Contribution to journalArticle

  39. 2008
  40. Antibodies against a surface protein of Streptococcus pyogenes promote a pathological inflammatory response.

    Fredrik Kahn, Matthias Mörgelin, Oonagh Shannon, Anna Norrby-Teglund, Heiko Herwald, Anders Olin & Lars Björck, 2008, In : PLoS Pathogens. 4, 9, e1000149.

    Research output: Contribution to journalArticle

  41. Identification of a novel protein promoting the colonization and survival of Finegoldia magna, a bacterial commensal and opportunistic pathogen.

    Inga-Maria Frick, Christofer Karlsson, Matthias Mörgelin, Anders I Olin, Radmila Janjusevic, Clara Hammarström, Elisabet Holst, Maarten de Château & Lars Björck, 2008, In : Molecular Microbiology. 70, p. 695-708

    Research output: Contribution to journalArticle

  42. IdeS: A Bacterial Proteolytic Enzyme with Therapeutic Potential.

    Björn Johansson, Oonagh Shannon & Lars Björck, 2008, In : PLoS ONE. 3, 2, e1692.

    Research output: Contribution to journalArticle

  43. Proteolysis of purified IgGs by human and bacterial enzymes in vitro and the detection of specific proteolytic fragments of endogenous IgG in rheumatoid synovial fluid

    Mary H Ryan, Diane Petrone, Jennifer F Nemeth, Evan Barnathan, Lars Björck & Robert E Jordan, 2008, In : Molecular Immunology. 45, 7, p. 1837-1846

    Research output: Contribution to journalArticle

  44. Targeted quantitative analysis of Streptococcus pyogenes virulence factors by multiple reaction monitoring

    Vinzenz Lange, Johan A. Malmstroem, John Didion, Nichole L. King, Björn Johansson, Juliane Schaefer, Jonathan Rameseder, Chee-Hong Wong, Eric W. Deutsch, Mi-Youn Brusniak, Peter Buehlmann, Lars Björck, Bruno Domon & Ruedi Aebersold, 2008, In : Molecular & Cellular Proteomics. 7, 8, p. 1489-1500

    Research output: Contribution to journalArticle

  45. 2007
  46. Blocking of experimental arthritis by cleavage of IgG antibodies in vivo

    Kutty Selva Nandakumar, Björn Johansson, Lars Björck & Rikard Holmdahl, 2007, In : Arthritis and Rheumatism. 56, 10, p. 3253-3260

    Research output: Contribution to journalArticle

  47. Deoxyribonucleoside kinases activate nucleoside antibiotics in severe pathogenic bacteria.

    Michael Sandrini, Oonagh Shannon, Anders Ranegaard Clausen, Lars Björck & Jure Piskur, 2007, In : Antimicrobial Agents and Chemotherapy. 51, 8, p. 2726-2732

    Research output: Contribution to journalArticle

  48. Severe streptococcal infection is associated with M protein-induced platelet activation and thrombus formation.

    Oonagh Shannon, Erika Hertzén, Anna Norrby-Teglund, Matthias Mörgelin, Ulf Sjöbring & Lars Björck, 2007, In : Molecular Microbiology. 65, 5, p. 1147-1157

    Research output: Contribution to journalArticle

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