Leif Groop

Senior Professor
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  1. 2020
  2. Adult-onset type 1 diabetic patients with less severe clinical manifestation have less risk DR-DQ genotypes than childhood-onset patients

    Ren, W., Yang, D., Jiang, Z., Xian, Y., Huang, Q., Luo, S., Zheng, X., Yan, J., Xu, W., Yao, B., Wang, C. Y., Bei, J. X., Leif Groop, Noble, J. A. & Weng, J., 2020 May 28, In : Diabetes/Metabolism Research and Reviews.

    Research output: Contribution to journalArticle

  3. A structural variation reference for medical and population genetics

    Genome Aggregation Database Production Team, Genome Aggregation Database Consortium, Collins, R., Leif Groop, Haiman, C., Olle Melander, Peter M Nilsson & Talkowski, M. E., 2020 May 27, In : Nature. 581, p. 444-451 8 p.

    Research output: Contribution to journalArticle

  4. Evaluating drug targets through human loss-of-function genetic variation

    Genome Aggregation Database Production Team, Genome Aggregation Database Consortium, Vallabh Minikel, E., Leif Groop, Haiman, C., Olle Melander, Peter M Nilsson & MacArthur, D. G., 2020 May 27, In : Nature. 581, p. 459-464 6 p.

    Research output: Contribution to journalArticle

  5. The mutational constraint spectrum quantified from variation in 141,456 humans

    Genome Aggregation Database Consortium, Karczewski, K. J., Leif Groop, Haiman, C., Olle Melander, Peter M Nilsson & MacArthur, D. G., 2020 May 27, In : Nature. 581, p. 434-443 10 p.

    Research output: Contribution to journalArticle

  6. Transcript expression-aware annotation improves rare variant interpretation

    Genome Aggregation Database Production Team, Genome Aggregation Database Consortium, Cummings, B. B., Leif Groop, Haiman, C., Olle Melander, Peter M Nilsson & MacArthur, D. G., 2020 May 27, In : Nature. 581, p. 452-458 7 p.

    Research output: Contribution to journalArticle

  7. Consumption of red meat, genetic susceptibility, and risk of LADA and type 2 diabetes

    Löfvenborg, J. E., Emma Ahlqvist, Alfredsson, L., Andersson, T., Leif Groop, Tuomi, T., Wolk, A. & Carlsson, S., 2020 May 22, In : European Journal of Nutrition.

    Research output: Contribution to journalArticle

  8. High Prevalence of Gestational Diabetes Mellitus in Rural Tanzania-Diagnosis Mainly Based on Fasting Blood Glucose from Oral Glucose Tolerance Test

    Grunnet, L. G., Line Hjort, Minja, D. T., Msemo, O. A., Møller, S. L., Rashmi B Prasad, Leif Groop, Lusingu, J., Nielsen, B. B., Schmiegelow, C., Bygbjerg, I. C. & Christensen, D. L., 2020 Apr 29, In : International Journal of Environmental Research and Public Health. 17, 9, 3109.

    Research output: Contribution to journalArticle

  9. Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease

    Luukkonen, P. K., Tukiainen, T., Juuti, A., Sammalkorpi, H., Nidhina Haridas, P. A., Niemelä, O., Arola, J., Marju Orho-Melander, Hakkarainen, A., Kovanen, P. T., Dwivedi, O., Leif Groop, Hodson, L., Gastaldelli, A., Hyötyläinen, T., Orešič, M. & Yki-Järvinen, H., 2020 Mar 12, In : JCI Insight. 5, 5, e132158.

    Research output: Contribution to journalArticle

  10. Genotypes of HLA, TCF7L2, and FTO as potential modifiers of the association between sweetened beverage consumption and risk of LADA and type 2 diabetes

    Löfvenborg, J. E., Emma Ahlqvist, Alfredsson, L., Andersson, T., Mozhgan Dorkhan, Leif Groop, Tuomi, T., Wolk, A. & Carlsson, S., 2020 Feb, In : European Journal of Nutrition. 59, 1, p. 127-135 9 p.

    Research output: Contribution to journalArticle

  11. Life-long impairment of glucose homeostasis upon prenatal exposure to psychostimulants

    Korchynska, S., Krassnitzer, M., Malenczyk, K., Prasad, R. B., Tretiakov, E. O., Rehman, S., Cinquina, V., Gernedl, V., Farlik, M., Petersen, J., Hannes, S., Schachenhofer, J., Reisinger, S. N., Zambon, A., Asplund, O., Artner, I., Keimpema, E., Lubec, G., Mulder, J., Bock, C. & 6 others, Pollak, D. D., Romanov, R. A., Pifl, C., Leif Groop, Hökfelt, T. G. & Harkany, T., 2020 Jan 2, In : EMBO Journal. 39, 1, e100882.

    Research output: Contribution to journalArticle

  12. Absence of Islet Autoantibodies and Modestly Raised Glucose Values at Diabetes Diagnosis Should Lead to Testing for MODY: Lessons From a 5-Year Pediatric Swedish National Cohort Study

    Annelie Carlsson, Shepherd, M., Ellard, S., Weedon, M., Åke Lernmark, Forsander, G., Colclough, K., Qefsere Brahimi, Valtonen-Andre, C., Sten A Ivarsson, Helena Elding Larsson, Samuelsson, U., Örtqvist, E., Leif Groop, Ludvigsson, J., Marcus, C. & Hattersley, A. T., 2020, In : Diabetes Care. 43, 1, p. 82-89

    Research output: Contribution to journalArticle

  13. Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC

    Mishra, R., Åkerlund, M., Cousminer, D. L., Ahlqvist, E., Bradfield, J. P., Chesi, A., Hodge, K. M., Guy, V. C., Brillon, D. J., Pratley, R. E., Rickels, M. R., Vella, A., Ovalle, F., Harris, R. I., Melander, O., Varvel, S., Hakonarson, H., Froguel, P., Lonsdale, J. T., Mauricio, D. & 11 others, Schloot, N. C., Khunti, K., Greenbaum, C. J., Yderstræde, K. B., Tuomi, T., Voight, B. F., Schwartz, S., Boehm, B. O., Leif Groop, Leslie, R. D. & Grant, S. F. A., 2020, In : Diabetes Care. 43, 2, p. 418-425 8 p.

    Research output: Contribution to journalArticle

  14. Ghrelin suppresses insulin secretion in human islets and type 2 diabetes patients have diminished islet ghrelin cell number and lower plasma ghrelin levels

    A Lindqvist, Shcherbina, L., R B Prasad, M G Miskelly, Abels, M., Martínez-Lopéz, J. A., Fred, R. G., Nergård, B. J., J Hedenbro, L Groop, Hjerling-Leffler, J. & N Wierup, 2020, In : Molecular and Cellular Endocrinology. 511, 110835.

    Research output: Contribution to journalArticle

  15. Liver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes

    Jain, R., Özgümüş, T., Jensen, T. M., du Plessis, E., Keindl, M., Møller, C. L., Falhammar, H., Nyström, T., Catrina, S. B., Jörneskog, G., Jessen, L. E., Forsblom, C., Haukka, J. K., Groop, P. H., Rossing, P., Groop, L., Eliasson, M., Eliasson, B., Brismar, K., Al-Majdoub, M. & 6 others, Peter M. Nilsson, Taskinen, M. R., Ferrannini, E., Peter Spégel, Berg, T. J. & Valeriya Lyssenko, 2020, In : Scientific Reports. 10, 1, 11561.

    Research output: Contribution to journalArticle

  16. Metabolic and Genetic Determinants of Glucose Shape After Oral Challenge in Obese Youths: A Longitudinal Study

    Galderisi, A., Tricò, D., Dalla Man, C., Santoro, N., Pierpont, B., Leif Groop, Cobelli, C. & Caprio, S., 2020, In : The Journal of clinical endocrinology and metabolism. 105, 2, dgz207.

    Research output: Contribution to journalArticle

  17. The effect of LRRK2 loss-of-function variants in humans

    Whiffin, N., Leif Groop, Olle Melander, Peter M. Nilsson, MacArthur, D. G., Genome Aggregation Database Production Team, Genome Aggregation Database Consortium & 23andMe Research Team, 2020, In : Nature Medicine. p. 869–877

    Research output: Contribution to journalArticle

  18. 2019
  19. Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

    Dwivedi, O. P., Lehtovirta, M., Hastoy, B., Chandra, V., Krentz, N. A. J., Kleiner, S., Jain, D., Richard, A-M., Abaitua, F., Beer, N. L., Grotz, A., Prasad, R. B., Hansson, O., Ahlqvist, E., Krus, U., Artner, I., Suoranta, A., Gomez, D., Baras, A., Champon, B. & 27 others, Payne, A. J., Moralli, D., Thomsen, S. K., Kramer, P., Spiliotis, I., Ramracheya, R., Chabosseau, P., Theodoulou, A., Cheung, R., Van De Bunt, M., Flannick, J., Trombetta, M., Bonora, E., Wolheim, C. B., Sarelin, L., Bonadonna, R. C., Rorsman, P., Davies, B., Brosnan, J., Mccarthy, M. I., Otonkoski, T., Jens O. Lagerstedt, Rutter, G. A., Gromada, J., Gloyn, A. L., Tuomi, T. & Leif Groop, 2019 Nov 1, In : Nature Genetics. p. 1-22

    Research output: Contribution to journalArticle

  20. Clusters provide a better holistic view of type 2 diabetes than simple clinical features

    Emma Ahlqvist, Tuomi, T. & Leif Groop, 2019 Sep 1, In : The Lancet Diabetes and Endocrinology. 7, 9, p. 668-669 2 p.

    Research output: Contribution to journalLetter

  21. Heterogeneity of diabetes - An Indian perspective

    Rashmi B Prasad, Emma Ahlqvist & Leif Groop, 2019 Sep, In : Diabetes & metabolic syndrome. 13, 5, p. 3065-3067 3 p.

    Research output: Contribution to journalArticle

  22. What do healthcare professionals need to turn risk models for type 2 diabetes into usable computerized clinical decision support systems? Lessons learned from the MOSAIC project

    Fico, G., Hernanzez, L., Cancela, J., Dagliati, A., Sacchi, L., Martinez-Millana, A., Posada, J., Manero, L., Verdú, J., Facchinetti, A., Ottaviano, M., Zarkogianni, K., Nikita, K., Groop, L., Gabriel-Sanchez, R., Chiovato, L., Traver, V., Merino-Torres, J. F., Cobelli, C., Bellazzi, R. & 1 others, Arredondo, M. T., 2019 Aug 16, In : BMC Medical Informatics and Decision Making. 19, 163.

    Research output: Contribution to journalArticle

  23. Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes

    Miguel-Escalada, I., Bonàs-Guarch, S., Cebola, I., Ponsa-Cobas, J., Mendieta-Esteban, J., Atla, G., Javierre, B. M., Rolando, D. M. Y., Farabella, I., Morgan, C. C., García-Hurtado, J., Beucher, A., Morán, I., Pasquali, L., Ramos-Rodríguez, M., Appel, E. V. R., Linneberg, A., Gjesing, A. P., Witte, D. R., Pedersen, O. & 16 others, Grarup, N., Ravassard, P., Torrents, D., Mercader, J. M., Piemonti, L., Berney, T., de Koning, E. J. P., Kerr-Conte, J., Pattou, F., Fedko, I. O., Leif Groop, Prokopenko, I., Hansen, T., Marti-Renom, M. A., Fraser, P. & Ferrer, J., 2019 Jun 28, In : Nature Genetics. 51, 7, p. 1137-1148

    Research output: Contribution to journalArticle

  24. FOETAL for NCD-FOetal Exposure and Epidemiological Transitions: the role of Anaemia in early Life for Non-Communicable Diseases in later life: a prospective preconception study in rural Tanzania

    Line Hjort, Lykke Møller, S., Minja, D., Msemo, O., Nielsen, B. B., Lund Christensen, D., Theander, T., Nielsen, K., Larsen, L. G., Grunnet, L. G., Leif Groop, Rashmi Prasad, Lusingu, J., Schmiegelow, C. & Bygbjerg, I. C., 2019 May 22, In : BMJ Open. 9, 5, e024861.

    Research output: Contribution to journalArticle

  25. Roadmap for a precision-medicine initiative in the Nordic region

    Njølstad, P. R., Andreassen, O. A., Brunak, S., Børglum, A. D., Dillner, J., Esko, T., Franks, P. W., Freimer, N., Groop, L., Heimer, H., Hougaard, D. M., Hovig, E., Hveem, K., Jalanko, A., Kaprio, J., Knudsen, G. P., Melbye, M., Metspalu, A., Mortensen, P. B., Palmgren, J. & 11 others, Palotie, A., Reed, W., Stefánsson, H., Stitziel, N. O., Sullivan, P. F., Thorsteinsdóttir, U., Vaudel, M., Vuorio, E., Werge, T., Stoltenberg, C. & Stefánsson, K., 2019 Apr 15, In : Nature Genetics.

    Research output: Contribution to journalDebate/Note/Editorial

  26. Phenotypic and genotypic differences between Indian and Scandinavian women with gestational diabetes mellitus

    Arora, G. P., Mikael Åkerlund, Brøns, C., Moen, G-H., Wasenius, N. S., Sommer, C., Jenum, A. K., Almgren, P., Thaman, R. G., Marju Orho-Melander, Eriksson, J., Qvigstad, E., Birkeland, K., Kerstin Berntorp, Allan A Vaag, Leif Groop & Rashmi B Prasad, 2019 Mar 27, In : Journal of Internal Medicine.

    Research output: Contribution to journalArticle

  27. The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects

    Middeldorp, C. M., Leif Groop, Rashmi Prasad, McCarthy, M. I., Emma Ahlqvist, EArly Genetics Lifecourse Epidemiology (EAGLE) consortium & Early Growth Genetics (EGG) consortium, 2019 Mar, In : European Journal of Epidemiology. 34, 3, p. 279-300

    Research output: Contribution to journalArticle

  28. A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria

    Ahluwalia, T. S., Schulz, C. A., Waage, J., Skaaby, T., Sandholm, N., van Zuydam, N., Charmet, R., Bork-Jensen, J., Almgren, P., Thuesen, B. H., Bedin, M., Brandslund, I., Christensen, C. K., Linneberg, A., Ahlqvist, E., Groop, P. H., Hadjadj, S., Tregouet, D. A., Jørgensen, M. E., Grarup, N. & 9 others, Pedersen, O., Simons, M., Leif Groop, Marju Orho-Melander, McCarthy, M. I., Olle Melander, Rossing, P., Kilpeläinen, T. O. & Hansen, T., 2019 Feb, In : Diabetologia. 62, 2, p. 292-305

    Research output: Contribution to journalArticle

  29. Preserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in β Cells

    Enming Zhang, Israa Mohammed, Mohammed, S., Cheng Luan, Olof Asplund, Ahmed, M., Ye Yingying, Ben-Hail, D., Soni, A., Vishnu, N., Bompada Pradeep, Yang de Marinis, Leif Groop, Shoshan-Barmatz, V., Erik Renström, Claes Wollheim & S Albert Salehi, 2019 Jan 8, In : Cell Metabolism. 29, 1, p. 64-77.e6

    Research output: Contribution to journalArticle

  30. 1-Hour Post-OGTT Glucose Improves the Early Prediction of Type 2 Diabetes by Clinical and Metabolic Markers

    Peddinti, G., Bergman, M., Tuomi, T. & Leif Groop, 2019, In : The Journal of clinical endocrinology and metabolism. 104, 4, p. 1131-1140 10 p.

    Research output: Contribution to journalArticle

  31. Association of IRS1 genetic variants with glucose control and insulin resistance in type 2 diabetic patients from Bosnia and Herzegovina

    Mahmutovic, L., Bego, T., Sterner, M., Gremsperger, G., Emma Ahlqvist, Velija Asimi, Z., Prnjavorac, B., Hamad, N., Causevic, A., Leif Groop & Semiz, S., 2019, In : Drug Metabolism and Personalized Therapy. 34, 1, 20180031.

    Research output: Contribution to journalArticle

  32. Associations of autozygosity with a broad range of human phenotypes

    Clark, D. W., Rashmi B Prasad, Leif Groop, Wilson, J. F. & et al., 2019, In : Nature Communications. 10, 1, 4957.

    Research output: Contribution to journalArticle

  33. DOLORisk: Study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain [version 2; referees: 2 approved]

    Pascal, M. M. V., Themistocleous, A. C., Baron, R., Binder, A., Bouhassira, D., Crombez, G., Finnerup, N. B., Gierthmühlen, J., Granovsky, Y., Groop, L., Hebert, H. L., Jensen, T. S., Johnsen, K., McCarthy, M. I., Meng, W., Palmer, C. N. A., Rice, A. S. C., Serra, J., Solà, R., Yarnitsky, D. & 3 others, Smith, B. H., Attal, N. & Bennett, D. L. H., 2019, In : Wellcome Open Research. 3, 63.

    Research output: Contribution to journalArticle

  34. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

    Flannick, J., Valeriya Lyssenko, Leif Groop, Peter Nilsson, Boehnke, M. & DiscovEHR Collaboration, 2019, In : Nature. 570, 7759, p. 71-76 6 p.

    Research output: Contribution to journalArticle

  35. Fostering improved human islet research: a European perspective

    Marchetti, P., Schulte, A. M., Marselli, L., Schoniger, E., Bugliani, M., Kramer, W., Overbergh, L., Ullrich, S., Gloyn, A. L., Ibberson, M., Rutter, G., Froguel, P., Groop, L., McCarthy, M. I., Dotta, F., Scharfmann, R., Magnan, C., Eizirik, D. L., Mathieu, C., Cnop, M. & 2 others, Thorens, B. & Solimena, M., 2019, In : Diabetologia. 62, 8, p. 1514-1516

    Research output: Contribution to journalLetter

  36. Genome editing of human pancreatic beta cell models: problems, possibilities and outlook

    Balboa, D., Rashmi B Prasad, Leif Groop & Otonkoski, T., 2019, In : Diabetologia. 62, 8, p. 1329-1336

    Research output: Contribution to journalReview article

  37. Interaction Between Overweight and Genotypes of HLA, TCF7L2, and FTO in Relation to the Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes

    Hjort, R., Löfvenborg, J. E., Emma Ahlqvist, Alfredsson, L., Andersson, T., Grill, V., Leif Groop, Sørgjerd, E. P., Tuomi, T., Åsvold, B. O. & Carlsson, S., 2019, In : The Journal of clinical endocrinology and metabolism. 104, 10, p. 4815-4826 12 p.

    Research output: Contribution to journalArticle

  38. Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control

    Pollack, S., Leif Groop, Emma Ahlqvist, Valeriya Lyssenko, Elisabet Agardh, Sobrin, L. & Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group, 2019, In : Diabetes. 68, 2, p. 441-456 16 p.

    Research output: Contribution to journalArticle

  39. Precision medicine in Type 2 Diabetes

    Rashmi B Prasad & Leif Groop, 2019, In : Journal of Internal Medicine. 285, 1, p. 40-48

    Research output: Contribution to journalReview article

  40. Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study

    Zaharia, O. P., Strassburger, K., Strom, A., Bönhof, G. J., Karusheva, Y., Antoniou, S., Bódis, K., Markgraf, D. F., Burkart, V., Müssig, K., Hwang, J. H., Asplund, O., Groop, L., Ahlqvist, E., Seissler, J., Nawroth, P., Kopf, S., Schmid, S. M., Stumvoll, M., Pfeiffer, A. F. H. & 8 others, Kabisch, S., Tselmin, S., Häring, H. U., Ziegler, D., Kuss, O., Szendroedi, J., Roden, M. & German Diabetes Study Group, 2019, In : The Lancet Diabetes and Endocrinology. 7, 9, p. 684-694

    Research output: Contribution to journalArticle

  41. Serum kidney injury molecule 1 and β2-microglobulin perform as well as larger biomarker panels for prediction of rapid decline in renal function in type 2 diabetes

    Colombo, M., Looker, H. C., Farran, B., Hess, S., Leif Groop, Palmer, C. N. A., Brosnan, M. J., Dalton, R. N., Wong, M., Turner, C., Emma Ahlqvist, Dunger, D., Agakov, F., Durrington, P., Livingstone, S., Betteridge, J., McKeigue, P. M., Colhoun, H. M. & SUMMIT Investigators, 2019, In : Diabetologia. 62, 1, p. 156-168

    Research output: Contribution to journalArticle

  42. The associations of daylight and melatonin receptor 1B gene rs10830963 variant with glycemic traits: the prospective PPP-Botnia study

    Haljas, K., Hakaste, L., Lahti, J., Isomaa, B., Leif Groop, Tuomi, T. & Räikkönen, K., 2019, In : Annals of Medicine. 51, 1, p. 58-67

    Research output: Contribution to journalArticle

  43. 2018
  44. N1-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism

    Ström, K., Morales-Alamo, D., Ottosson, F., Edlund, A., Hjort, L., Jörgensen, S. W., Almgren, P., Zhou, Y., Martin-Rincon, M., Ekman, C., Pérez-López, A., Ekström, O., Perez-Suarez, I., Mattiasson, M., De Pablos-Velasco, P., Oskolkov, N., Ahlqvist, E., Wierup, N., Eliasson, L., Vaag, A. & 6 others, Leif Groop, Karin G. Stenkula, Céline Fernandez, Calbet, J. A. L., Holmberg, H. C. & Ola Hansson, 2018 Dec 1, In : Scientific Reports. 8, 1, 3016.

    Research output: Contribution to journalArticle

  45. Predictors of responses to clinic-based childhood obesity care

    Hagman, E., Hecht, L., Marko, L., Azmanov, H., Leif Groop, Santoro, N., Caprio, S. & Weiss, R., 2018 Dec, In : Pediatric Diabetes. 19, 8, p. 1351-1356

    Research output: Contribution to journalArticle

  46. First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes

    Cousminer, D. L., Emma Ahlqvist, Mikael Åkerlund, Olle Melander, Voight, B. F., Tuomi, T., Leif Groop, Leslie, R. D., Grant, S. F. A. & Bone Mineral Density in Childhood Study, 2018 Nov, In : Diabetes Care. 41, 11, p. 2396-2403

    Research output: Contribution to journalArticle

  47. Turning vice into virtue: Using Batch-Effects to Detect Errors in Large Genomic Datasets

    Mafessoni, F., Rashmi B Prasad, Leif Groop, Ola Hansson & Prüfer, K., 2018 Sep 10, In : Genome Biology and Evolution. 10, 10, p. 2697–2708

    Research output: Contribution to journalArticle

  48. Coffee consumption, genetic susceptibility and risk of latent autoimmune diabetes in adults: A population-based case-control study

    Rasouli, B., E. Ahlqvist, Alfredsson, L., Andersson, T., Carlsson, P. O., L. Groop, Löfvenborg, J. E., Martinell, M., Rosengren, A., Tuomi, T., Wolk, A. & Carlsson, S., 2018 Sep, In : Diabetes and Metabolism. 44, 4, p. 354-360

    Research output: Contribution to journalArticle

  49. Association between genetic risk variants and glucose intolerance during pregnancy in north Indian women

    Arora, G., Almgren, P., Brøns, C., Thaman, R. G., Allan Vaag, Leif Groop & Rashmi Prasad, 2018 Aug 8, In : BMC Medical Genomics. 11, 10 p., 64.

    Research output: Contribution to journalArticle

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