Lotta Gustafsson

Medical doctor and scientist, M.D, Ph.D, M.Sc, affiliated with the university, Specialist M.D in dermatology and venereology, Medical Doctor M.D, Doctor of Philosophy, Master in Science M.Sc
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  1. HAMLET (human alpha-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death.

    Sonja Aits, Lotta Gustafsson, Oskar Hallgren, Patrick Brest, Mattias Gustafsson, Maria Trulsson, Anki Mossberg, Hans-Uwe Simon, Baharia Mograbi & Catharina Svanborg, 2009, In: International Journal of Cancer. 124, 5, p. 1008-1019

    Research output: Contribution to journalArticle

  2. Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET.

    Patrick Brest, Mattias Gustafsson, Anki Mossberg, Lotta Gustafsson, Caroline Düringer, Ali Hamiche & Catharina Svanborg, 2007, In: Cancer Research. 67, 23, p. 11327-11334

    Research output: Contribution to journalArticle

  3. HAMLET interacts with histones and chromatin in tumor cell nuclei.

    Caroline Düringer, Ali Hamiche, Lotta Gustafsson, Hiroshi Kimura & Catharina Svanborg, 2003, In: Journal of Biological Chemistry. 278, 43, p. 42131-42135

    Research output: Contribution to journalArticle

  4. HAMLET; a novel tool to identify apoptotic pathways in tumor cells.

    Caroline Düringer, Oskar Hallgren, Lotta Gustafsson, Jenny Pettersson, Anki Mossberg, Taras Manolov & Catharina Svanborg, 2005, Application of apoptosis to cancer treatment.. Mels, S. (ed.). Springer, p. 223-245

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  5. Ceramide as a TLR4 agonist; a putative signalling intermediate between sphingolipid receptors for microbial ligands and TLR4.

    Hans Fischer, Patrik Ellström, Kristina Ekström-Holka, Lotta Gustafsson, Mattias Gustafsson & Catharina Svanborg, 2007, In: Cellular Microbiology. 9, 5, p. 1239-1251

    Research output: Contribution to journalArticle

  6. Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival.

    Walter Fischer, Lotta Gustafsson, Anki Mossberg, Janne Gronli, Sverre Mork, Rolf Bjerkvig & Catharina Svanborg, 2004, In: Cancer Research. 64, 6, p. 2105-2112 8 p.

    Research output: Contribution to journalArticle

  7. Uptake and intracellular transportation of a bacterial surface protein in lymphoid cells.

    Inga-Maria Frick, Karol Axcrona, Ylva Härdig, Hans Tapper, Lotta Gustafsson, Roland Kellner, Tomas Leanderson & Lars Björck, 2002, In: Molecular Microbiology. 44, 4, p. 917-934

    Research output: Contribution to journalArticle

  8. HAMLET kills tumor cells by apoptosis: Structure, cellular mechanisms, and therapy

    Lotta Gustafsson, Oskar Hallgren, Anki Mossberg, Jenny Pettersson, W Fischer, Annika Aronsson & Catharina Svanborg, 2005, In: Journal of Nutrition. 135, 5, p. 1299-1303

    Research output: Contribution to journalArticle

  9. Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid

    Lotta Gustafsson, Irene Leijonhufvud, Annika Aronsson, Anki Mossberg & Catharina Svanborg, 2004, In: New England Journal of Medicine. 350, 26, p. 2663-2672

    Research output: Contribution to journalArticle

  10. HAMLET - In vivo effects and mechanisms of tumor-cell death

    Lotta Gustafsson, 2005, Department of Laboratory Medicine, Lund University. 95 p.

    Research output: ThesisDoctoral Thesis (compilation)

  11. Bröstmjölk mot cancerceller

    Lotta Gustafsson, 2007, Illustrerad Vetenskap.

    Research output: Contribution to specialist publication or newspaperNewspaper article

  12. Protective effects of breast milk

    Lotta Gustafsson, 2001 Oct.

    Research output: Contribution to conferenceAbstract

  13. HAMLET induced tumor cell apoptosis - molecular, cellular and therapeutic aspects

    Lotta Gustafsson, 2002 May 31.

    Research output: Contribution to conferenceAbstract

  14. Utan sömn ingen fart

    Lotta Gustafsson, 2008, TEMPO - Om fart och det föränderliga. Cronqvist, M. & Sandberg, H. (eds.). Makadam förlag

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  15. HAMLET - a protein lipid complex from human milk that kills tumor cells

    Lotta Gustafsson, 2002 Oct 6.

    Research output: Contribution to conferenceAbstract

  16. Unfolded Protein Overload, Proteasome Activation and Death in HAMLET-Treated Tumor Cells

    Lotta Gustafsson, Oskar Hallgren, Barbara Spolaore, Carol Robinsson & Catharina Svanborg, 2006, In: IDrugs. 9, 3, p. B29

    Research output: Contribution to journalPublished meeting abstract

  17. Enhancement of anti-tumor effects of checkpoint inhibitors by selenium in melanoma.

    Lotta Gustafsson, 2010 Mar 7.

    Research output: Contribution to conferenceAbstract

  18. HAMLET triggers apoptosis but tumor cell death is independent of caspases, Bcl-2 and p53.

    Oskar Hallgren, Lotta Gustafsson, Heikki Irjala, G Selivanova, S Orrenius & Catharina Svanborg, 2006, In: Apoptosis. 11, 2, p. 221-233

    Research output: Contribution to journalArticle

  19. HAMLET, protein folding, and tumor cell death

    K. Hun Mok, Jenny Pettersson, Sten Orrenius, Catharina Svanborg & Lotta Gustafsson, 2007, In: Biochemical and Biophysical Research Communications. 354, 1, p. 1-7

    Research output: Contribution to journalReview article

  20. Sternal stability at different negative pressures during vacuum-assisted closure therapy

    Arash Mokhtari, Rainer Petzina, Lotta Gustafsson, Johan Sjögren, Malin Malmsjö & Richard Ingemansson, 2006, In: Annals of Thoracic Surgery. 82, 3, p. 1063-1067

    Research output: Contribution to journalArticle

  21. Bladder cancers respond to intravesical instillation of HAMLET (human alpha-lactalbumin made lethal to tumor cells).

    Anki Mossberg, Björn Wullt, Lotta Gustafsson, Wiking Månsson, Eva Ljunggren & Catharina Svanborg, 2007, In: International Journal of Cancer. 121, 6, p. 1352-1359

    Research output: Contribution to journalArticle

  22. Endothelin receptor-mediated vasodilatation: Effects of organ culture.

    David Nilsson, Angelica Wackenfors, Lotta Gustafsson, Martin Ugander, Per Paulsson, Richard Ingemansson, Lars Edvinsson & Malin Malmsjö, 2008, In: European Journal of Pharmacology. 579, 1-3, p. 233-240

    Research output: Contribution to journalArticle

  23. Increased ET(A) and ET(B) receptor contraction in the left internal mammary artery from patients with hypertension.

    David Nilsson, Angelica Wackenfors, Lotta Gustafsson, Lars Edvinsson, Per Paulsson, Richard Ingemansson & Malin Malmsjö, 2008, In: Journal of Human Hypertension. 22, 3, p. 226-229

    Research output: Contribution to journalArticle

  24. PKC and MAPK signalling pathways regulate vascular endothelin receptor expression

    David Nilsson, Angelica Wackenfors, Lotta Gustafsson, Martin Ugander, Richard Ingemansson, Lars Edvinsson & Malin Malmsjö, 2008, In: European Journal of Pharmacology. 580, 1-2, p. 190-200

    Research output: Contribution to journalArticle

  25. Can misfolded proteins be beneficial? The HAMLET case.

    Jenny Pettersson, Sonja Aits, Lotta Gustafsson, Anki Mossberg, Petter Storm, Maria Trulsson, Filip Persson, K Hun Mok & Catharina Svanborg, 2009, In: Annals of Medicine. 41, p. 162-176

    Research output: Contribution to journalReview article

  26. Photodynamic therapy and diagnostic measurements of basal cell carcinomas using esterified and non-esterified delta-aminolevulinic acid

    Marcelo Soto Thompson, Lotta Gustafsson, Sara Pålsson, Niels Bendsöe, Maria Stenberg, Claes af Klinteberg, Stefan Andersson-Engels & Katarina Svanberg, 2001, In: Journal of Porphyrins and Phthalocyanines. 5, 2, p. 147

    Research output: Contribution to journalArticle

  27. HAMLET kills tumor cells by an apoptosis-like mechanism--cellular, molecular, and therapeutic aspects.

    Catharina Svanborg, Helena Ågerstam, Annika Aronson, Rolf Bjerkvig, Caroline Düringer, Walter Fischer, Lotta Gustafsson, Oskar Hallgren, Irene Leijonhuvud, Sara Linse, Anki Mossberg, Hanna Nilsson, Jenny Pettersson & Malin Svensson, 2003, In: Advances in Cancer Research. 88, p. 1-29

    Research output: Contribution to journalReview article

  28. HAMLET, a tumoricidal molecular complex from human milk

    C Svanborg, S Aits, P Brest, L Gustafsson, K Mok, C Moreillhon, A Mossberg, J Pettersson, P Storm & M Trulsson, 2009 Jul 24, In: BMC Proceedings. 3, Suppl 5, p. S11

    Research output: Contribution to journalPublished meeting abstract

  29. alpha-Lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells).

    Malin Svensson, Jonas Fast, Anki Mossberg, Caroline Düringer, Lotta Gustafsson, Oskar Hallgren, Charles L. Brooks, Lawrence Berliner, Sara Linse & Catharina Svanborg, 2003, In: Protein Science. 12, 12, p. 2794-2804

    Research output: Contribution to journalArticle