Lotta Gustafsson
Medical doctor and scientist, M.D, Ph.D, M.Sc, affiliated with the university, Specialist M.D in dermatology and venereology, Medical Doctor M.D, Doctor of Philosophy, Master in Science M.Sc-
alpha-Lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells).
Malin Svensson, Jonas Fast, Anki Mossberg, Caroline Düringer, Lotta Gustafsson, Oskar Hallgren, Charles L. Brooks, Lawrence Berliner, Sara Linse & Catharina Svanborg, 2003, In: Protein Science. 12, 12, p. 2794-2804Research output: Contribution to journal › Article
-
Apoptosis and tumor cell death in response to HAMLET (human alpha-lactalbumin made lethal to tumor cells).
Oskar Hallgren, Sonja Aits, Patrick Brest, Lotta Gustafsson, Anki Mossberg, Björn Wullt & Catharina Svanborg, 2008, In: Advances in Experimental Medicine and Biology. 606, p. 217-240Research output: Contribution to journal › Review article
-
Bladder cancers respond to intravesical instillation of HAMLET (human alpha-lactalbumin made lethal to tumor cells).
Anki Mossberg, Björn Wullt, Lotta Gustafsson, Wiking Månsson, Eva Ljunggren & Catharina Svanborg, 2007, In: International Journal of Cancer. 121, 6, p. 1352-1359Research output: Contribution to journal › Article
-
Bröstmjölk mot cancerceller
Lotta Gustafsson, 2007, Illustrerad Vetenskap.Research output: Contribution to specialist publication or newspaper › Newspaper article
-
Can misfolded proteins be beneficial? The HAMLET case.
Jenny Pettersson, Sonja Aits, Lotta Gustafsson, Anki Mossberg, Petter Storm, Maria Trulsson, Filip Persson, K Hun Mok & Catharina Svanborg, 2009, In: Annals of Medicine. 41, p. 162-176Research output: Contribution to journal › Review article
-
Ceramide as a TLR4 agonist; a putative signalling intermediate between sphingolipid receptors for microbial ligands and TLR4.
Hans Fischer, Patrik Ellström, Kristina Ekström-Holka, Lotta Gustafsson, Mattias Gustafsson & Catharina Svanborg, 2007, In: Cellular Microbiology. 9, 5, p. 1239-1251Research output: Contribution to journal › Article
-
Comparison of bacteria and fungus-binding mesh, foam and gauze as fillers in negative pressure wound therapy - pressure transduction, wound edge contraction, microvascular blood flow and fluid retention.
Malin Malmsjö, Richard Ingemansson, Sandra Lindstedt Ingemansson & Lotta Gustafsson, 2013, In: International Wound Journal. 10, 5, p. 597-605Research output: Contribution to journal › Article
-
Effect of vacuum-assisted closure on blood flow in the peristernal thoracic wall after internal mammary artery harvesting.
Rainer Petzina, Lotta Gustafsson, Arash Mokhtari, Richard Ingemansson & Malin Malmsjö, 2006, In: European Journal of Cardio-Thoracic Surgery. 30, 1, p. 85-89Research output: Contribution to journal › Article
-
Endothelin receptor-mediated vasodilatation: Effects of organ culture.
David Nilsson, Angelica Wackenfors, Lotta Gustafsson, Martin Ugander, Per Paulsson, Richard Ingemansson, Lars Edvinsson & Malin Malmsjö, 2008, In: European Journal of Pharmacology. 579, 1-3, p. 233-240Research output: Contribution to journal › Article
-
Enhancement of anti-tumor effects of checkpoint inhibitors by selenium in melanoma.
Lotta Gustafsson, 2010 Mar 7.Research output: Contribution to conference › Abstract
-
Evaluation of the Microvascular Blood Flow, Oxygenation, and Survival of Tarsoconjunctival Flaps Following the Modified Hughes Procedure.
Khashayar Memarzadeh, Lotta Gustafsson, Jonas Blohmé & Malin Malmsjö, 2016 Nov, In: Ophthalmic Plastic and Reconstructive Surgery. 32, 6, p. 468–472Research output: Contribution to journal › Article
-
HAMLET; a novel tool to identify apoptotic pathways in tumor cells.
Caroline Düringer, Oskar Hallgren, Lotta Gustafsson, Jenny Pettersson, Anki Mossberg, Taras Manolov & Catharina Svanborg, 2005, Application of apoptosis to cancer treatment.. Mels, S. (ed.). Springer, p. 223-245Research output: Chapter in Book/Report/Conference proceeding › Book chapter
-
HAMLET - a protein lipid complex from human milk that kills tumor cells
Lotta Gustafsson, 2002 Oct 6.Research output: Contribution to conference › Abstract
HAMLET, a tumoricidal molecular complex from human milk
C Svanborg, S Aits, P Brest, L Gustafsson, K Mok, C Moreillhon, A Mossberg, J Pettersson, P Storm & M Trulsson, 2009 Jul 24, In: BMC Proceedings. 3, Suppl 5, p. S11Research output: Contribution to journal › Published meeting abstract
-
HAMLET (human alpha-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death.
Sonja Aits, Lotta Gustafsson, Oskar Hallgren, Patrick Brest, Mattias Gustafsson, Maria Trulsson, Anki Mossberg, Hans-Uwe Simon, Baharia Mograbi & Catharina Svanborg, 2009, In: International Journal of Cancer. 124, 5, p. 1008-1019Research output: Contribution to journal › Article
-
HAMLET induced tumor cell apoptosis - molecular, cellular and therapeutic aspects
Lotta Gustafsson, 2002 May 31.Research output: Contribution to conference › Abstract
HAMLET interacts with histones and chromatin in tumor cell nuclei.
Caroline Düringer, Ali Hamiche, Lotta Gustafsson, Hiroshi Kimura & Catharina Svanborg, 2003, In: Journal of Biological Chemistry. 278, 43, p. 42131-42135Research output: Contribution to journal › Article
-
HAMLET - In vivo effects and mechanisms of tumor-cell death
Lotta Gustafsson, 2005, Department of Laboratory Medicine, Lund University. 95 p.Research output: Thesis › Doctoral Thesis (compilation)
-
HAMLET kills tumor cells by an apoptosis-like mechanism--cellular, molecular, and therapeutic aspects.
Catharina Svanborg, Helena Ågerstam, Annika Aronson, Rolf Bjerkvig, Caroline Düringer, Walter Fischer, Lotta Gustafsson, Oskar Hallgren, Irene Leijonhuvud, Sara Linse, Anki Mossberg, Hanna Nilsson, Jenny Pettersson & Malin Svensson, 2003, In: Advances in Cancer Research. 88, p. 1-29Research output: Contribution to journal › Review article
-
HAMLET kills tumor cells by apoptosis: Structure, cellular mechanisms, and therapy
Lotta Gustafsson, Oskar Hallgren, Anki Mossberg, Jenny Pettersson, W Fischer, Annika Aronsson & Catharina Svanborg, 2005, In: Journal of Nutrition. 135, 5, p. 1299-1303Research output: Contribution to journal › Article
-
HAMLET, protein folding, and tumor cell death
K. Hun Mok, Jenny Pettersson, Sten Orrenius, Catharina Svanborg & Lotta Gustafsson, 2007, In: Biochemical and Biophysical Research Communications. 354, 1, p. 1-7Research output: Contribution to journal › Review article
-
HAMLET triggers apoptosis but tumor cell death is independent of caspases, Bcl-2 and p53.
Oskar Hallgren, Lotta Gustafsson, Heikki Irjala, G Selivanova, S Orrenius & Catharina Svanborg, 2006, In: Apoptosis. 11, 2, p. 221-233Research output: Contribution to journal › Article
-
Hemodynamic effects of vacuum-assisted closure therapy in cardiac surgery: assessment using magnetic resonance imaging.
Rainer Petzina, Martin Ugander, Lotta Gustafsson, Henrik Engblom, Johan Sjögren, Roland Hetzer, Richard Ingemansson, Håkan Arheden & Malin Malmsjö, 2007, In: Journal of Thoracic and Cardiovascular Surgery. 133, 5, p. 1154-1162Research output: Contribution to journal › Article
Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET.
Patrick Brest, Mattias Gustafsson, Anki Mossberg, Lotta Gustafsson, Caroline Düringer, Ali Hamiche & Catharina Svanborg, 2007, In: Cancer Research. 67, 23, p. 11327-11334Research output: Contribution to journal › Article
-
Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival.
Walter Fischer, Lotta Gustafsson, Anki Mossberg, Janne Gronli, Sverre Mork, Rolf Bjerkvig & Catharina Svanborg, 2004, In: Cancer Research. 64, 6, p. 2105-2112 8 p.Research output: Contribution to journal › Article
-
Hypoxia-inducible factor and vascular endothelial growth factor in the neuroretina and retinal blood vessels after retinal ischemia
Gisela Håkansson, Bodil Gesslein, Lotta Gustafsson, Ulrica Englund-Johansson & Malin Malmsjö, 2010 Mar, In: Journal of Ocular Biology, Diseases, and Informatics. 3, 1, p. 20-29 10 p.Research output: Contribution to journal › Article
-
Increased ET(A) and ET(B) receptor contraction in the left internal mammary artery from patients with hypertension.
David Nilsson, Angelica Wackenfors, Lotta Gustafsson, Lars Edvinsson, Per Paulsson, Richard Ingemansson & Malin Malmsjö, 2008, In: Journal of Human Hypertension. 22, 3, p. 226-229Research output: Contribution to journal › Article
Kinetics of the superficial perfusion and temperature in connection with photodynamic therapy of basal cell carcinomas using esterified and non-esterified 5-aminolaevulinic acid.
Sara Pålsson, Lotta Gustafsson, Niels Bendsöe, Marcelo Soto Thompson, Stefan Andersson-Engels & Katarina Svanberg, 2003, In: British Journal of Dermatology. 148, 6, p. 1179-1188Research output: Contribution to journal › Article
-
Mitogen-activated protein kinases in the porcine retinal arteries and neuroretina following retinal ischemia-reperfusion.
Bodil Gesslein, Gisela Håkansson, Ronald Carpio, Lotta Gustafsson, Maria Thereza Perez & Malin Malmsjö, 2010, In: Molecular Vision. 16, p. 392-407Research output: Contribution to journal › Article
-
Negative Pressure Wound Therapy-associated Tissue Trauma and Pain: A Controlled In vivo Study Comparing Foam and Gauze Dressing Removal by Immunohistochemistry for Substance P and Calcitonin Gene-related Peptide in the Wound Edge.
Malin Malmsjö, Lotta Gustafsson, Sandra Lindstedt Ingemansson & Richard Ingemansson, 2011, In: Ostomy - Wound Management. 57, 12, p. 30-35Research output: Contribution to journal › Article
-
Photodynamic therapy and diagnostic measurements of basal cell carcinomas using esterified and non-esterified delta-aminolevulinic acid
Marcelo Soto Thompson, Lotta Gustafsson, Sara Pålsson, Niels Bendsöe, Maria Stenberg, Claes af Klinteberg, Stefan Andersson-Engels & Katarina Svanberg, 2001, In: Journal of Porphyrins and Phthalocyanines. 5, 2, p. 147Research output: Contribution to journal › Article
-
PKC and MAPK signalling pathways regulate vascular endothelin receptor expression
David Nilsson, Angelica Wackenfors, Lotta Gustafsson, Martin Ugander, Richard Ingemansson, Lars Edvinsson & Malin Malmsjö, 2008, In: European Journal of Pharmacology. 580, 1-2, p. 190-200Research output: Contribution to journal › Article
-
Pressure transduction to the thoracic cavity during topical negative pressure therapy of a sternotomy wound.
Christian Torbrand, Richard Ingemansson, Lotta Gustafsson, Per Paulsson & Malin Malmsjö, 2008, In: International Wound Journal. 5, 4, p. 579-584Research output: Contribution to journal › Article
-
Protective effects of breast milk
Lotta Gustafsson, 2001 Oct.Research output: Contribution to conference › Abstract
-
Real-time confocal imaging of HAMLET (Human Alpha-lactalbumine Made LEthal to Tumour cells) in transfomred and non-transformed cells.
Lotta Gustafsson, Caroline Düringer & Catharina Svanborg, 2001, In: International Journal of Molecular Medicine. 8, Suppl , p. S91 448.Research output: Contribution to journal › Published meeting abstract
Sternal stability at different negative pressures during vacuum-assisted closure therapy
Arash Mokhtari, Rainer Petzina, Lotta Gustafsson, Johan Sjögren, Malin Malmsjö & Richard Ingemansson, 2006, In: Annals of Thoracic Surgery. 82, 3, p. 1063-1067Research output: Contribution to journal › Article
The effects of variable, intermittent, and continuous negative pressure wound therapy, using foam or gauze, on wound contraction, granulation tissue formation, and ingrowth into the wound filler
Malin Malmsjö, Lotta Gustafsson, Sandra Lindstedt, Bodil Gesslein & Richard Ingemansson, 2012, In: Eplasty: Open Access Journal of Plastic and Reconstructive Surgery. 12, e5.Research output: Contribution to journal › Article
-
Topical negative pressure therapy of a sternotomy wound increases sternal fluid content but does not affect internal thoracic artery blood flow: assessment using magnetic resonance imaging.
Rainer Petzina, Martin Ugander, Lotta Gustafsson, Henrik Engblom, Roland Hetzer, Håkan Arheden, Richard Ingemansson & Malin Malmsjö, 2008, In: The Journal of thoracic and cardiovascular surgery. 135, 5, p. 1007-1013Research output: Contribution to journal › Article
Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid
Lotta Gustafsson, Irene Leijonhufvud, Annika Aronsson, Anki Mossberg & Catharina Svanborg, 2004, In: New England Journal of Medicine. 350, 26, p. 2663-2672Research output: Contribution to journal › Article
-
Tumor necrosis factor and its receptors in the neuroretina and retinal vasculature after ischemia-reperfusion injury in the pig retina.
Bodil Gesslein, Gisela Håkansson, Lotta Gustafsson, Per Ekström & Malin Malmsjö, 2010, In: Molecular Vision. 16, p. 2317-2327Research output: Contribution to journal › Article
-
Unfolded Protein Overload, Proteasome Activation and Death in HAMLET-Treated Tumor Cells
Lotta Gustafsson, Oskar Hallgren, Barbara Spolaore, Carol Robinsson & Catharina Svanborg, 2006, In: IDrugs. 9, 3, p. B29Research output: Contribution to journal › Published meeting abstract
-
Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways.
David Nilsson, Lotta Gustafsson, Angelica Wackenfors, Bodil Gesslein, Lars Edvinsson, Per Paulsson, Richard Ingemansson & Malin Malmsjö, 2008, In: BMC Cardiovascular Disorders. 8, 21.Research output: Contribution to journal › Article
-
Uptake and intracellular transportation of a bacterial surface protein in lymphoid cells.
Inga-Maria Frick, Karol Axcrona, Ylva Härdig, Hans Tapper, Lotta Gustafsson, Roland Kellner, Tomas Leanderson & Lars Björck, 2002, In: Molecular Microbiology. 44, 4, p. 917-934Research output: Contribution to journal › Article
Use of bacteria- and fungus-binding mesh in negative pressure wound therapy provides significant granulation tissue without tissue ingrowth.
Malin Malmsjö, Sandra Lindstedt Ingemansson, Richard Ingemansson & Lotta Gustafsson, 2014, In: Eplasty: Open Access Journal of Plastic and Reconstructive Surgery. 14, p. e3Research output: Contribution to journal › Article
-
Utan sömn ingen fart
Lotta Gustafsson, 2008, TEMPO - Om fart och det föränderliga. Cronqvist, M. & Sandberg, H. (eds.). Makadam förlagResearch output: Chapter in Book/Report/Conference proceeding › Book chapter