Malin Fex

Researcher, Associate Professor
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  1. 2019
  2. Loss of MafA and MafB expression promotes islet inflammation.

    Tania Singh, Colberg, J. K., Luis Sarmiento, Chaves, P., Hansen, L., Bsharat, S., Luis R. Cataldo, Monika Dudenhöffer-Pfeifer, Malin Fex, David Bryder, Dan Holmberg, Ewa Sitnicka, Corrado Cilio, Rashmi B. Prasad & Isabella Artner, 2019 Jun 24, In : Scientific Reports. 9, 1, 9074.

    Research output: Contribution to journalArticle

  3. Serotonergic Regulation of Insulin Secretion

    Luis Rodrigo Cataldo Bascuñan, Claire Lyons, Bennet, H., Isabella Artner & Malin Fex, 2019 Jan, In : Acta Physiologica. 225, 1, e13101.

    Research output: Contribution to journalReview article

  4. Platelet Serotonin Levels Are Associated with Plasma Soluble Leptin Receptor Concentrations in Normoglycemic Women

    Rodrigo Cataldo Buscunan, Suazo, J., Olmos, P., Bravo, C., Galgani, J. E., Malin Fex, Martínez, J. A. & Santos, J. L., 2019, In : Journal of Diabetes Research. 2019, 11 p., 2714049.

    Research output: Contribution to journalArticle

  5. 2018
  6. Glutamine-elicited secretion of glucagon-like peptide 1 is governed by an activated glutamate dehydrogenase

    Andersson, L. E., Shcherbina, L., Al-Majdoub, M., Neelanjan Vishnu, Arroyo, C. B., Carrara, J. A., Claes B. Wollheim, Malin Fex, Hindrik Mulder, Nils Wierup & Peter Spégel, 2018 Mar 1, In : Diabetes. 67, 3, p. 372-384 13 p.

    Research output: Contribution to journalArticle

  7. Early deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats

    Medina, A., Parween, S., Ullsten, S., Neelanjan Vishnu, Siu, Y. T., Quach, M., Bennet, H., Balhuizen, A., Åkesson, L., Nils Wierup, Carlsson, P. O., Ahlgren, U., Åke Lernmark & Malin Fex, 2018, In : Diabetologia. 61, 4, p. 896-905

    Research output: Contribution to journalArticle

  8. The pathogenetic role of β-cell mitochondria in type 2 diabetes

    Malin Fex, Nicholas, L. M., Neelanjan Vishnu, Medina, A., Sharoyko, V. V., David G. Nicholls, Peter Spégel & Hindrik Mulder, 2018, In : Journal of Endocrinology. 236, 3, p. R145-R149

    Research output: Contribution to journalReview article

  9. 2017
  10. Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells

    Nicholas, L. M., Valtat, B., Benavente, A. M., Andersson, L., Abels, M., Mollet, I., Jain, D., Lena Eliasson, Nils Wierup, Malin Fex & Hindrik Mulder, 2017 Jul, In : Molecular Metabolism. 6, 7, p. 651-663 13 p.

    Research output: Contribution to journalArticle

  11. Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes

    Axelsson, A., Mahdi, T., Nenonen, H. A., Singh, T., Hänzelmann, S., Wendt, A., Bagge, A., Reinbothe, T. M., Millstein, J., Yang, X., Zhang, B., Gusmao, E. G., Shu, L., Szabat, M., Tang, Y., Wang, J., Salö, S., Eliasson, L., Artner, I., Fex, M. & 9 others, J D Johnson, C B Wollheim, Derry, J. M. J., Mecham, B., P Spégel, H Mulder, Costa, I. G., E Zhang & Rosengren, A. H., 2017 Jun 6, In : Nature Communications. 8, p. 15652

    Research output: Contribution to journalArticle

  12. Characterization of resident lymphocytes in human pancreatic islets

    Radenkovic, M., Uvebrant, K., Skog, O., Luis Sarmiento-Pérez, Avartsson, J., Storm, P., Vickman, P., Bertilsson, P. A., M. Fex, Korgsgren, O. & C. M. Cilio, 2017 Mar 1, In : Clinical and Experimental Immunology. 187, 3, p. 418-427 10 p.

    Research output: Contribution to journalArticle

  13. An Increased Diagnostic Sensitivity of Truncated GAD65 Autoantibodies in Type 1 Diabetes May Be Related to HLA-DQ8

    Axel Wester, Skärstrand, H., Alexander Lind, Ramelius, A., Annelie Carlsson, Cedervall, E., Jönsson, B., Sten A Ivarsson, Helena Larsson, Larsson, K., Bengt Lindberg, Neiderud, J., Malin Fex, Törn, C. & Åke Lernmark, 2017 Mar, In : Diabetes. 66, 3, p. 735-740 6 p.

    Research output: Contribution to journalArticle

  14. Antibody Affinity Against 2009 A/H1N1 Influenza and Pandemrix Vaccine Nucleoproteins Differs Between Childhood Narcolepsy Patients and Controls

    Alexander Lind, Freyhult, E., Ramelius, A., Olsson, T., Arnheim-Dahlström, L., Lamb, F., Khademi, M., Ambati, A., Maeurer, M., Lima Bomfim, I., Fink, K., Malin Fex, Törn, C., Helena Elding Larsson & Åke Lernmark, 2017, In : Viral Immunology. 30, 8, p. 590-600

    Research output: Contribution to journalArticle

  15. 2016
  16. Glycogen metabolism in the glucose-sensing and supply-driven β-cell

    Andersson, L. E., Nicholas, L. M., Karin Filipsson, Jiangming Sun, Benavente, A. M., Al-Majdoub, M., Malin Fex, Hindrik Mulder & Peter Spégel, 2016 Dec 1, In : FEBS Letters. 590, 23, p. 4242-4251 10 p.

    Research output: Contribution to journalLetter

  17. Influence of a HTR2B stop codon on glucagon homeostasis and glucose excursion in non-diabetic men

    Tikkanen, R., Saukkonen, T., M. Fex, Bennet, H., Rautiainen, M. R., Paunio, T., Koskinen, M., Panarsky, R., Bevilacqua, L., Sjöberg, R. L., Tiihonen, J. & Virkkunen, M., 2016 Oct 1, In : Experimental and Clinical Endocrinology & Diabetes. 124, 9, p. 529-534 6 p.

    Research output: Contribution to journalArticle

  18. The effects of a HTR2B stop codon and testosterone on energy metabolism and beta cell function among antisocial Finnish males

    Tikkanen, R., Saukkonen, T., Malin Fex, Bennet, H., Rautiainen, M. R., Paunio, T., Koskinen, M., Panarsky, R., Bevilacqua, L., Sjöberg, R. L., Tiihonen, J. & Virkkunen, M., 2016 Oct 1, In : Journal of Psychiatric Research. 81, p. 79-86 8 p.

    Research output: Contribution to journalArticle

  19. CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion

    Abels, M., Riva, M., Bennet, H., Ahlqvist, E., Dyachok, O., Nagaraj, V., Shcherbina, L., Fred, R. G., Poon, W., Sörhede-Winzell, M., Fadista, J., Lindqvist, A., Kask, L., Sathanoori, R., Dekker-Nitert, M., Kuhar, M. J., Ahrén, B., Wollheim, C. B., Hansson, O., Tengholm, A. & 5 others, Malin Fex, Erik Renström, Leif Groop, Valeriya Lyssenko & Nils Wierup, 2016 Jun 23, In : Diabetologia. 59, 9, p. 1928–1937 10 p.

    Research output: Contribution to journalArticle

  20. Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes

    Tuomi, T., Nagorny, C. L. F., Singh, P., Bennet, H., Yu, Q., Alenkvist, I., Isomaa, B., Östman, B., Söderström, J., Pesonen, A. K., Martikainen, S., Räikkönen, K., Forsén, T., Hakaste, L., Almgren, P., Storm, P., Asplund, O., Shcherbina, L., Fex, M., Fadista, J. & 4 others, Tengholm, A., Nils Wierup, Leif Groop & Hindrik Mulder, 2016 Jun 14, In : Cell Metabolism. 23, 6, p. 1067-1077 11 p.

    Research output: Contribution to journalArticle

  21. Serotonin (5-HT) and 5-HT2A receptor agonists suppress lipolysis in primary rat adipose cells

    Björn Hansson, Benavente, A. M., Fryklund, C., Malin Fex & Karin G. Stenkula, 2016 May 27, In : Biochemical and Biophysical Research Communications. 474, 2, p. 357-363 7 p.

    Research output: Contribution to journalArticle

  22. Differential effects of three echovirus strains on cell lysis and insulin secretion in beta cell derived lines.

    Luis Sarmiento-Pérez, Medina Benavente, A., Eitan Netanyah, Anagandula, M., Cabrera-Rode, E., Malin Fex, Frisk, G. & Corrado Cilio, 2016, In : Journal of Medical Virology. 88, 6, p. 971-978

    Research output: Contribution to journalArticle

  23. MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes.

    Ganic, E., Tania Singh, Cheng Luan, Fadista, J., Johansson, J., Cyphert, H. A., Bennet, H., Storm, P., Prost, G., Henrik Ahlenius, Erik Renström, Stein, R., Leif Groop, Malin Fex & Isabella Artner, 2016, In : Cell Reports. 14, 8, p. 1991-2002

    Research output: Contribution to journalArticle

  24. Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.

    Bennet, H., Mollet, I., Balhuizen, A., Medina Benavente, A., Nagorny, C., Bagge, A., Fadista, J., Ottosson Laakso, E., Petter Vikman, Dekker Nitert, M., Lena Eliasson, Nils Wierup, Isabella Artner & Malin Fex, 2016, In : Diabetologia. 59, 4, p. 744-754

    Research output: Contribution to journalArticle

  25. 2015
  26. Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes.

    Bennet, H., Balhuizen, A., Medina Benavente, A., Dekker Nitert, M., Ottosson Laakso, E., Essén, S., Peter Spégel, Storm, P., Krus, U., Nils Wierup & Malin Fex, 2015, In : Peptides. 71, p. 113-120

    Research output: Contribution to journalArticle

  27. Doubly reactive INS-IGF2 autoantibodies in children with newly diagnosed autoimmune (type 1) diabetes.

    Norio Kanatsuna, Delli, A., Cecilia K Andersson, Anna-Lena Nilsson, Vaziri Sani, F., Larsson, K., Annelie Carlsson, Cedervall, E., Jönsson, B., Neiderud, J., Helena Larsson, Sten Ivarsson, Törn, C., Malin Fex & Åke Lernmark, 2015, In : Scandinavian Journal of Immunology. 82, 4, p. 361-369

    Research output: Contribution to journalArticle

  28. Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome.

    Gu Urban, G. J., Friedman, M., Ren, P., Törn, C., Malin Fex, Hampe, C. S., Åke Lernmark, Landegren, U. & Kamali-Moghaddam, M., 2015, In : Scientific Reports. 5, 11196.

    Research output: Contribution to journalArticle

  29. Photocoagulation of human retinal pigment epithelium in vitro: unravelling the effects on ARPE-19 by transcriptomics and proteomics.

    Poya T-Khani, de la Torre, C., Canals, F., Bennet, H., Simo, R., Hernandez, C., Malin Fex, Agardh, C-D., Ola Hansson & Elisabet Agardh, 2015, In : Acta Ophthalmologica. 93, 4, p. 348-354

    Research output: Contribution to journalArticle

  30. Serum cytokine pattern in young children with screening detected celiac disease.

    Björck, S., Lindehammer, S., Malin Fex & Daniel Agardh, 2015, In : Clinical and Experimental Immunology. 179, 2, p. 230-235

    Research output: Contribution to journalArticle

  31. 2014
  32. TCF7L2 is a master regulator of insulin production and processing.

    Zhou, Y., Park, S-Y., Su, J., Bailey, K., Ottosson Laakso, E., Shcherbina, L., Nikolay Oskolkov, Enming Zhang, Thevenin, T., Fadista, J., Bennet, H., Petter Vikman, Nils Wierup, Malin Fex, Rung, J., Claes Wollheim, Nobrega, M., Erik Renström, Leif Groop & Ola Hansson, 2014, In : Human Molecular Genetics. 23, 24, p. 6419-6431

    Research output: Contribution to journalArticle

  33. The Complement Inhibitor CD59 Regulates Insulin Secretion by Modulating Exocytotic Events.

    Krus, U., Ben King, Nagaraj, V., Gandasi, N. R., Jonatan Sjölander, Pawel Buda, Eliana Garcia Vaz, Maria Gomez, Ottosson Laakso, E., Storm, P., Malin Fex, Petter Vikman, Enming Zhang, Barg, S., Anna Blom & Erik Renström, 2014, In : Cell Metabolism. 19, 5, p. 883-890

    Research output: Contribution to journalArticle

  34. 2013
  35. Autoimmunity against INS-IGF2 expressed in human pancreatic islets.

    Norio Kanatsuna, Taneera, J., Vaziri Sani, F., Nils Wierup, Helena Larsson, Delli, A., Skärstrand, H., Balhuizen, A., Bennet, H., Steiner, D. F., Törn, C., Malin Fex & Åke Lernmark, 2013, In : Journal of Biological Chemistry. 288, 40, p. 29013-29023

    Research output: Contribution to journalArticle

  36. Microphthalmia transcription factor regulates pancreatic β-cell function

    Mazur, M., Winkler, M., Ganic, E., Colberg, J. K., Johansson, J., Bennet, H., Malin Fex, Nuber, U. & Isabella Artner, 2013, In : Diabetes. 62, 8, p. 2834-2842

    Research output: Contribution to journalArticle

  37. 2012
  38. HTR1A a Novel Type 1 Diabetes Susceptibility Gene on Chromosome 5p13-q13

    Asad, S., Nikamo, P., Gyllenberg, A., Bennet, H., Hansson, O., Wierup, N., Annelie Carlsson, Forsander, G., Sten Ivarsson, Helena Larsson, Åke Lernmark, Lindblad, B., Ludvigsson, J., Marcus, C., Ronningen, K. S., Nerup, J., Pociot, F., Holger Luthman, Malin Fex & Kockum, I., 2012, In : PLoS ONE. 7, 5

    Research output: Contribution to journalArticle

  39. 2011
  40. Early human pregnancy serum cytokine levels predict autoimmunity in offspring.

    Lindehammer, S., Björck, S., Lynch, K., Brundin, C., Karel Marsal, Daniel Agardh & Malin Fex, 2011, In : Autoimmunity. 44, p. 445-452

    Research output: Contribution to journalArticle

  41. 2010
  42. Apelin is a novel islet peptide.

    Ringström, C., Dekker Nitert, M., Bennet, H., Malin Fex, Valet, P., Rehfeld, J. F., Friis-Hansen, L. & Nils Wierup, 2010, In : Regulatory Peptides. 162, p. 44-51

    Research output: Contribution to journalArticle

  43. Apelin is expressed in human and rodent islets and regulates insulin secretion

    Ringstrom, C., Dekker Nitert, M., Bennet, H., Malin Fex, Valet, P., Rehfeld, J. F., Friis-Hansen, L. & Nils Wierup, 2010, In : Regulatory Peptides. 164, 1, p. 27-27

    Research output: Contribution to journalPublished meeting abstract

  44. C-peptide in dried blood spots.

    Johansson, J., Charlotte Becker, Persson, N., Malin Fex & Törn, C., 2010, In : Scandinavian Journal of Clinical and Laboratory Investigation. 70, p. 404-409

    Research output: Contribution to journalArticle

  45. First trimester cytokine levels in mothers to children diagnosed with islet autoimmunity or type 1 diabetes before eight years of age

    Lindehammer, S., Malin Fex, Karel Marsal & Åke Lernmark, 2010, In : Diabetologia. 53, Suppl. 1, p. 343

    Research output: Contribution to journalPublished meeting abstract

  46. First trimester cytokine levels in mothers to children diagnosed with islet autoimmunity or type 1 diabetes before eight years of age

    Malin Fex, Björck, S., Lynch, K., Brundin, C., Karel Marsal, Daniel Agardh & Lindehammer, S., 2010, In : Diabetologia. 53, Suppl. 1, p. 344

    Research output: Contribution to journalPublished meeting abstract

  47. Pancreatic islets of melatonin receptor knock-out mice

    Nagorny, C., Ulrikke Voss, Bennet, H., Stamenkovic, J., Sathanoori, R., Malin Fex, Nils Wierup & Hindrik Mulder, 2010, In : Diabetologia. 53, Suppl. 1, p. 294

    Research output: Contribution to journalPublished meeting abstract

  48. Stimulation of 5-HT1a receptor decreased insulin secretion in islets of Langerhans from mice and humans

    Bennet, H., Nagorny, C., Nils Wierup, Dekker Nitert, M., Åke Lernmark & Malin Fex, 2010, In : Diabetologia. 53, Suppl. 1, p. 547

    Research output: Contribution to journalPublished meeting abstract

  49. 2009
  50. A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis.

    Malin Fex, Haemmerle, G., Nils Wierup, Dekker Nitert, M., Rehn, M., Ristow, M., Zechner, R., Sundler, F., Cecilia Holm, Eliasson, L. & Hindrik Mulder, 2009, In : Diabetologia. 52, p. 271-280

    Research output: Contribution to journalArticle

  51. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.

    Lyssenko, V., Nagorny, C., Erdos, M. R., Wierup, N., Jonsson, A., Spégel, P., Bugliani, M., Saxena, R., Fex, M., Pulizzi, N., Isomaa, B., Tuomi, T., Nilsson, P., Kuusisto, J., Tuomilehto, J., Boehnke, M., Altshuler, D., Sundler, F., Eriksson, J. G., Jackson, A. U. & 5 others, Laakso, M., Marchetti, P., Watanabe, R. M., Hindrik Mulder & Leif Groop, 2009, In : Nature Genetics. 41, 1, p. 82-88

    Research output: Contribution to journalArticle

  52. 2008
  53. Lipases in the pancreatic beta-cell: implications for insulin secretion.

    Malin Fex & Hindrik Mulder, 2008, In : Biochemical Society Transactions. 36, Pt 5, p. 885-890

    Research output: Contribution to journalArticle

  54. Proteomic studies in animal models of diabetes

    Resjö, S., Karin Berger, Malin Fex & Ola Hansson, 2008, In : Proteomics Clinical Applications. 2, 5, p. 654-669

    Research output: Contribution to journalReview article

  55. 2007
  56. Rat insulin promoter 2-Cre recombinase mice bred onto a pure C57BL/6J background exhibit unaltered glucose tolerance

    Malin Fex, Nils Wierup, Dekker Nitert, M., Ristow, M. & Hindrik Mulder, 2007, In : Journal of Endocrinology. 194, 3, p. 551-555

    Research output: Contribution to journalArticle

  57. 2006
  58. {beta}-Cell Lipases and Insulin Secretion.

    Malin Fex, Lucas, S., Sörhede Winzell, M., Bo Ahrén, Cecilia Holm & Hindrik Mulder, 2006, In : Diabetes. 55, Suppl 2, p. S24-S31

    Research output: Contribution to journalArticle

  59. Lipid metabolism in the pancreatic beta-cell. Implications for insulin secretion.

    Malin Fex, 2006, Experimental Medical Science, Lund University. 98 p.

    Research output: ThesisDoctoral Thesis (compilation)

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