Malin Parmar

Professor, New York Stem Cell Foundation - Robertson Investigator, , ,
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  1. 2019
  2. Designing stem-cell-based dopamine cell replacement trials for Parkinson’s disease

    TRANSEURO consortium, Barker, R. A., Farrell, K., Guzman, N. V., He, X., Lazic, S. E., Moore, S., Morris, R., Tyers, P., Wijeyekoon, R., Daft, D., Hewitt, S., Dayal, V., Foltynie, T., Kefalopoulou, Z., Mahlknecht, P., Lao-Kaim, N. P., Piccini, P., Bjartmarz, H., Björklund, A. & 13 othersOlle Lindvall, Jenny Nelander-Wahlestedt, Malin Parmar, Gesine Paul, Hakan Widner, Church, A., Dunnett, S., Peall, K., Rosser, A., Gurruchaga, J. M., Palfi, S., Piroth, T. & Winkler, C., 2019 Jul, In : Nature Medicine. 25, p. 1045–1053 9 p.

    Research output: Contribution to journalArticle

  3. Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development

    Tiklová, K., Björklund, Å. K., Lahti, L., Alessandro Fiorenzano, Sara Nolbrant, Gillberg, L., Volakakis, N., Yokota, C., Hilscher, M. M., Hauling, T., Holmström, F., Joodmardi, E., Nilsson, M., Malin Parmar & Perlmann, T., 2019 Feb 4, In : Nature Communications. 10, 1, 581.

    Research output: Contribution to journalArticle

  4. Advances in stem cell research and therapeutic development

    De Luca, M., Aiuti, A., Cossu, G., Malin Parmar, Pellegrini, G. & Robey, P. G., 2019, In : Nature Cell Biology. 21, 7, p. 801-811 11 p.

    Research output: Contribution to journalReview article

  5. Cell-based therapy for Parkinson's disease: A journey through decades toward the light side of the Force

    Malin Parmar, Torper, O. & Drouin-Ouellet, J., 2019, In : European Journal of Neuroscience. 49, 4, p. 463-471

    Research output: Contribution to journalArticle

  6. Stem cell culture conditions and stability: a joint workshop of the PluriMes Consortium and Pluripotent Stem Cell Platform

    Stacey, G. N., Andrews, P. W., Barbaric, I., Boiers, C., Chandra, A., Cossu, G., Csontos, L., Frith, T. J., Halliwell, J. A., Hewitt, Z., McCall, M., Moore, H. D., Malin Parmar, Panico, M. B., Pisupati, V., Shichkin, V. P., Stacey, A. R., Tedesco, F. S., Thompson, O. & Wagey, R., 2019, In : Regenerative Medicine. 14, 3, p. 243-255

    Research output: Contribution to journalArticle

  7. 2018
  8. Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation

    Karolina Pircs, Petri, R., Madsen, S., Per Ludvik Brattås, Vuono, R., Daniella R. Ottosson, St-Amour, I., Hersbach, B. A., Matusiak-Brückner, M., Lundh, S. H., Åsa Petersén, Déglon, N., Hébert, S. S., Malin Parmar, Barker, R. A. & Johan Jakobsson, 2018 Aug, In : Cell Reports. 24, 6, p. 1397-1406 10 p.

    Research output: Contribution to journalArticle

  9. Developing defined substrates for stem cell culture and differentiation

    Hagbard, L., Cameron, K., August, P., Penton, C., Malin Parmar, Hay, D. C. & Kallur, T., 2018 Jul 5, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 373, 1750, 20170230.

    Research output: Contribution to journalReview article

  10. New approaches for brain repair-from rescue to reprogramming

    Barker, R. A., Götz, M. & Malin Parmar, 2018 May, In : Nature. 557, 7705, p. 329-334

    Research output: Contribution to journalReview article

  11. Simple Generation of a High Yield Culture of Induced Neurons from Human Adult Skin Fibroblasts

    Shelby Shrigley, Karolina Pircs, Barker, R. A., Malin Parmar & Drouin-ouellet, J., 2018 Feb 5, In : Journal of Visualized Experiments. 132, e56904.

    Research output: Contribution to journalArticle

  12. Towards stem cell based therapies for parkinson’s disease

    Malin Parmar, 2018 Jan 1, In : Development (Cambridge). 145, 1, dev156117.

    Research output: Contribution to journalArticle

  13. Repairing the brain: Cell replacement using stem cell-based technologies

    Henchcliffe, C. & Malin Parmar, 2018, In : Journal of Parkinson's Disease. 8, s1, p. S131-S137

    Research output: Contribution to journalReview article

  14. 2017
  15. Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus

    Avaliani, N., Pfisterer, U., Andreas Heuer, Malin Parmar, Merab Kokaia & My Andersson, 2017 Nov 26, In : Stem Cells International. 2017, 9 p., 5718608.

    Research output: Contribution to journalArticle

  16. Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson's Disease: Dawn of a New Era

    Barker, R. A., Malin Parmar, Studer, L. & Takahashi, J., 2017 Nov 2, In : Cell Stem Cell. 21, 5, p. 569-573 5 p.

    Research output: Contribution to journalDebate/Note/Editorial

  17. Direct neuronal reprogramming for disease modeling studies using patient-derived neurons: What have we learned?

    Drouin-Ouellet, J., Karolina Pircs, Barker, R. A., Johan Jakobsson & Malin Parmar, 2017 Sep 28, In : Frontiers in Neuroscience. 11, SEP, 530.

    Research output: Contribution to journalReview article

  18. Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model

    Kikuchi, T., Morizane, A., Doi, D., Magotani, H., Onoe, H., Hayashi, T., Mizuma, H., Takara, S., Takahashi, R., Inoue, H., Morita, S., Yamamoto, M., Okita, K., Nakagawa, M., Malin Parmar & Takahashi, J., 2017 Aug 30, In : Nature. 548, 7669, p. 592-596 5 p.

    Research output: Contribution to journalLetter

  19. Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli

    Tornero, D., Tsupykov, O., Granmo, M., Rodriguez-Fontenla, C., Grønning-Hansen, M., Jonas Thelin, Smozhanik, E., Laterza, C., Wattananit, S., Ge, R., Tatarishvili, J., Shane Grealish, Brüstle, O., Skibo, G., Malin Parmar, Jens Schouenborg, Olle Lindvall & Zaal Kokaia, 2017 Mar 1, In : Brain. 140, 3, p. 692-706 15 p.

    Research output: Contribution to journalArticle

  20. Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson's Disease

    Agnete Kirkeby, Sara Nolbrant, Tiklova, K., Andreas Heuer, Kee, N., Tiago Cardoso, Daniella Rylander Ottosson, Lelos, M. J., Rifes, P., Dunnett, S. B., Shane Grealish, Perlmann, T. & Malin Parmar, 2017 Jan 5, In : Cell Stem Cell. 20, 1, p. 135-148 14 p.

    Research output: Contribution to journalArticle

  21. Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages

    Kee, N., Volakakis, N., Agnete Kirkeby, Dahl, L., Storvall, H., Sara Nolbrant, Lahti, L., Björklund, Å. K., Gillberg, L., Joodmardi, E., Sandberg, R., Malin Parmar & Perlmann, T., 2017 Jan 5, In : Cell Stem Cell. 20, 1, p. 29-40 12 p.

    Research output: Contribution to journalArticle

  22. TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells

    Per Ludvik Brattås, Marie E. Jönsson, Fasching, L., Jenny Nelander Wahlestedt, Shahsavani, M., Falk, R., Falk, A. H., Jern, P., Malin Parmar & Johan Jakobsson, 2017 Jan 3, In : Cell Reports. 18, 1, p. 1-11 11 p.

    Research output: Contribution to journalArticle

  23. Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming

    Ruetz, T., Pfisterer, U., Di Stefano, B., Ashmore, J., Beniazza, M., Tian, T. V., Kaemena, D. F., Tosti, L., Tan, W., Manning, J. R., Chantzoura, E., Daniella Rylander Ottosson, Collombet, S., Johnsson, A., Cohen, E., Yusa, K., Linnarsson, S., Graf, T., Malin Parmar & Kaji, K., 2017, In : Cell Stem Cell. p. 791–805.e9

    Research output: Contribution to journalArticle

  24. IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells

    Lehnen, D., Barral, S., Tiago Cardoso, Shane Grealish, Andreas Heuer, Smiyakin, A., Agnete Kirkeby, Kollet, J., Cremer, H., Malin Parmar, Bosio, A. & Knöbel, S., 2017, In : Stem Cell Reports. 9, 4, p. 1207-1220

    Research output: Contribution to journalArticle

  25. REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways

    Drouin-Ouellet, J., Lau, S., Per Ludvik Brattås, Daniella Ottosson, Karolina Pircs, Daniela A Grassi, Collins, L. M., Vuono, R., Andersson Sjöland, A., Gunilla Westergren-Thorsson, Graff, C., Lennart Minthon, Håkan Toresson, Barker, R. A., Johan Jakobsson & Malin Parmar, 2017, In : EMBO Molecular Medicine. 9, 8, p. 1117-1131

    Research output: Contribution to journalArticle

  26. Strategies for bringing stem cell-derived dopamine neurons to the clinic: A European approach (STEM-PD)

    A. Kirkeby, M. Parmar & Barker, R. A., 2017, Functional Neural Transplantation IV Translation to Clinical Application, Part A. Dunnett, S. B. & Björklund, A. (eds.). Vol. 230. p. 165-190 (Progress in Brain Research; vol. 230).

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  27. 2016
  28. Small molecules increase direct neural conversion of human fibroblasts

    Pfisterer, U., Fredrik Ek, Lang, S., Shamit Soneji, Roger Olsson & Malin Parmar, 2016 Dec 5, In : Scientific Reports. 6, 38290.

    Research output: Contribution to journalArticle

  29. Plug and Play Brain: Understanding Integration of Transplanted Neurons for Brain Repair

    Shane Grealish & Malin Parmar, 2016 Dec 1, In : Cell Stem Cell. 19, 6, p. 679-680 2 p.

    Research output: Contribution to journalArticle

  30. Brain repair and reprogramming: the route to clinical translation

    S. Grealish, Drouin-Ouellet, J. & M. Parmar, 2016 Sep 1, In : Journal of Internal Medicine. 280, 3, p. 265-275 11 p.

    Research output: Contribution to journalReview article

  31. Comparability: Manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14-15 September 2015

    Williams, D. J., Archer, R., Archibald, P., Bantounas, I., Baptista, R., Barker, R., Barry, J., Bietrix, F., Blair, N., Braybrook, J., Campbell, J., Canham, M., Chandra, A., Foldes, G., Gilmanshin, R., Girard, M., Gorjup, E., Hewitt, Z., Hourd, P., Hyllner, J. & 29 othersJesson, H., Kee, J., Kerby, J., Kotsopoulou, N., Kowalski, S., Leidel, C., Marshall, D., Masi, L., McCall, M., McCann, C., Medcalf, N., Moore, H., Ozawa, H., Pan, D., Malin Parmar, Plant, A. L., Reinwald, Y., Sebastian, S., Stacey, G., Thomas, R. J., Thomas, D., Thurman-Newell, J., Turner, M., Vitillio, L., Wall, I., Wilson, A., Wolfrum, J., Yang, Y. & Zimmerman, H., 2016 Jul 1, In : Regenerative Medicine. 11, 5, p. 483-492 10 p.

    Research output: Contribution to journalArticle

  32. DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor

    Aldrin-Kirk, P., Andreas Heuer, Wang, G., Mattsson, B., Lundblad, M., Malin Parmar & Tomas Björklund, 2016 Jun 1, In : Neuron. 90, 5, p. 955-968 14 p.

    Research output: Contribution to journalArticle

  33. Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016?

    Barker, R. A., Malin Parmar, Agnete Kirkeby, Anders Björklund, Thompson, L. & Brundin, P., 2016, In : Journal of Parkinson's Disease. 6, 1, p. 57-63 7 p.

    Research output: Contribution to journalArticle

  34. 2015
  35. Cell-based therapies for Parkinson disease-past insights and future potential.

    Barker, R., Drouin-Ouellet, J. & Malin Parmar, 2015, In : Nature Reviews Neurology. 11, 9, p. 492-503

    Research output: Contribution to journalReview article

  36. In Vivo Reprogramming for Brain and Spinal Cord Repair(1,2,3).

    Chen, G., Wernig, M., Berninger, B., Nakafuku, M., Malin Parmar & Zhang, C-L., 2015, In : eNeuro. 2, 5

    Research output: Contribution to journalReview article

  37. In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry.

    Torper, O., Daniella Rylander, Pereira, M. J. M., Lau, S., Tiago Cardoso, Shane Grealish & Malin Parmar, 2015, In : Cell Reports. 12, 3, p. 474-481

    Research output: Contribution to journalArticle

  38. 2014
  39. Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain.

    Pereira, M. J. M., Pfisterer, U., Daniella Rylander, Torper, O., Lau, S., Lundblad, M., Shane Grealish & Malin Parmar, 2014, In : Scientific Reports. 4, 6330.

    Research output: Contribution to journalArticle

  40. Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson's Disease.

    Shane Grealish, Diguet, E., Agnete Kirkeby, Mattsson, B., Andreas Heuer, Bramoulle, Y., Van Camp, N., Perrier, A. L., Hantraye, P., Anders Björklund & Malin Parmar, 2014, In : Cell Stem Cell. 15, 5, p. 653-665

    Research output: Contribution to journalArticle

  41. Isolation of human induced pluripotent stem cell-derived dopaminergic progenitors by cell sorting for successful transplantation.

    Doi, D., Samata, B., Katsukawa, M., Kikuchi, T., Morizane, A., Ono, Y., Sekiguchi, K., Nakagawa, M., Malin Parmar & Takahashi, J., 2014, In : Stem Cell Reports. 2, 3, p. 337-350

    Research output: Contribution to journalArticle

  42. The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons

    Iovino, M., Pfisterer, U., Holton, J. L., Lashley, T., Swingler, R. J., Calo, L., Treacy, R., Revesz, T., Malin Parmar, Goedert, M., Muqit, M. M. K. & Spillantini, M. G., 2014, In : Acta Neuropathologica. 127, 2, p. 283-295

    Research output: Contribution to journalArticle

  43. 2013
  44. Efficient expansion and dopaminergic differentiation of human fetal ventral midbrain neural stem cells by midbrain morphogens

    Ribeiro, D., Goya, R. L., Ravindran, G., Vuono, R., Parish, C. L., Foldi, C., Piroth, T., Yang, S., Malin Parmar, Nikkhah, G., Hjerling-Leffler, J., Olle Lindvall, Barker, R. & Arenas, E., 2013, In : Neurobiology of Disease. 49, p. 118-127

    Research output: Contribution to journalArticle

  45. Generation of induced neurons via direct conversion in vivo.

    Torper, O., Pfisterer, U., Wolf, D., Pereira, M. J. M., Lau, S., Johan Jakobsson, Anders Björklund, Shane Grealish & Malin Parmar, 2013, In : Proceedings of the National Academy of Sciences. 110, 17, p. 7038-7043

    Research output: Contribution to journalArticle

  46. 2012
  47. Characterization and criteria of embryonic stem and induced pluripotent stem cells for a dopamine replacement therapy

    Cooper, O., Malin Parmar & Isacson, O., 2012, In : Progress in Brain Research. 200, p. 265-76 12 p.

    Research output: Contribution to journalArticle

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