Marcus Järås

Senior Lecturer
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  1. 2019
  2. FLT3 N676K drives acute myeloid leukemia in a xenograft model of KMT2A-MLLT3 leukemogenesis

    Axel Hyrenius-Wittsten, Mattias Pilheden, Falqués-Costa, A., Eriksson, M., Sturesson, H., Schneider, P., Wander, P., Garcia-Ruiz, C., Liu, J., Helena Ågerstam, Anne Hultquist, Henrik Lilljebjörn, Stam, R. W., Marcus Järås & Anna K. Hagström-Andersson, 2019, In : Leukemia.

    Research output: Contribution to journalLetter

  3. 2018
  4. De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia

    Hyrenius-Wittsten, A., Pilheden, M., Sturesson, H., Hansson, J., Walsh, M. P., Song, G., Kazi, J. U., Liu, J., Ramakrishan, R., Garcia-Ruiz, C., Nance, S., Gupta, P., Zhang, J., Rönnstrand, L., Hultquist, A., Downing, J. R., Lindkvist-Petersson, K., Paulsson, K., Järås, M., Gruber, T. A. & 2 othersMa, J. & Anna K. Hagström-Andersson, 2018 Dec 1, In : Nature Communications. 9, 1, 1770.

    Research output: Contribution to journalArticle

  5. 2017
  6. In-depth genetic analysis of sclerosing epithelioid fibrosarcoma reveals recurrent genomic alterations and potential treatment targets

    Elsa Arbajian, Puls, F., Antonescu, C. R., Amary, F. M., Sciot, R., Debiec-Rychter, M., Sumathi, V., Marcus Järås, Magnusson, L., Nilsson, J., Jakob Hofvander & Fredrik Mertens, 2017 Dec, In : Clinical Cancer Research. 23, 23, p. 7426-7434

    Research output: Contribution to journalArticle

  7. Agonistic targeting of TLR1/TLR2 induces p38 MAPK-dependent apoptosis and NFκB-dependent differentiation of AML cells

    Eriksson, M., Pablo Peña-Martínez, Ramprasad Ramakrishnan, Chapellier, M., Högberg, C., Glowacki, G., Christina Orsmark-Pietras, Velasco-Hernández, T., Lazarević, V. L., Gunnar Juliusson, Cammenga, J., Mulloy, J. C., Johan Richter, Thoas Fioretos, Ebert, B. L. & Marcus Järås, 2017 Oct 24, In : Blood Advances. 1, 23, p. 2046-2057 12 p.

    Research output: Contribution to journalArticle

  8. Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells

    Vu, L. P., Prieto, C., Amin, E. M., Chhangawala, S., Krivtsov, A., Calvo-Vidal, M. N., Chou, T., Chow, A., Minuesa, G., Park, S. M., Barlowe, T. S., Taggart, J., Tivnan, P., Deering, R. P., Chu, L. P., Kwon, J. A., Meydan, C., Perales-Paton, J., Arshi, A., Gönen, M. & 23 othersFamulare, C., Patel, M., Paietta, E., Tallman, M. S., Lu, Y., Glass, J., Garret-Bakelman, F. E., Melnick, A., Levine, R. L., Al-Shahrour, F., Marcus Järås, Hacohen, N., Hwang, A., Garippa, R., Lengner, C. J., Armstrong, S. A., Cerchietti, L., Cowley, G. S., Root, D. E., Doench, J., Leslie, C., Ebert, B. L. & Kharas, M. G., 2017 Jun 1, In : Nature Genetics. 49, 6, p. 866-875 10 p.

    Research output: Contribution to journalArticle

  9. 2016
  10. IL1RAP antibodies block IL-1-induced expansion of candidate CML stem cells and mediate cell killing in xenograft models

    Helena Ågerstam, Hansen, N., Sofia von Palffy, Carl Sandén, Reckzeh, K., Christine Karlsson, Henrik Lilljebjörn, Niklas Landberg, Askmyr, M., Högberg, C., Rissler, M., Porkka, K., Wadenvik, H., Mustjoki, S., Johan Richter, Marcus Järås & Thoas Fioretos, 2016 Dec 8, In : Blood. 128, 23, p. 2683-2693

    Research output: Contribution to journalArticle

  11. Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML

    Puram, R. V., Kowalczyk, M. S., de Boer, C. G., Schneider, R. K., Miller, P. G., McConkey, M., Tothova, Z., Tejero, H., Heckl, D., Marcus Järås, Chen, M. C., Li, H., Tamayo, A., Cowley, G. S., Rozenblatt-Rosen, O., Al-Shahrour, F., Regev, A. & Ebert, B. L., 2016, In : Cell. 165, 2, p. 303-16 14 p.

    Research output: Contribution to journalArticle

  12. 2015
  13. Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

    Krönke, J., Fink, E. C., Hollenbach, P. W., MacBeth, K. J., Hurst, S. N., Udeshi, N. D., Chamberlain, P. P., Mani, D. R., Man, H. W., Gandhi, A. K., Svinkina, T., Schneider, R. K., McConkey, M., Järås, M., Griffiths, E., Wetzler, M., Bullinger, L., Cathers, B. E., Carr, S. A., Chopra, R. & 1 othersEbert, B. L., 2015 Jul 9, In : Nature. 523, 7559, p. 183-188

    Research output: Contribution to journalArticle

  14. Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia.

    Helena Ågerstam, Christine Karlsson, Hansen, N., Carl Sandén, Askmyr, M., Sofia von Palffy, Högberg, C., Rissler, M., Wunderlich, M., Gunnar Juliusson, Johan Richter, Sjöström, K., Bhatia, R., Mulloy, J. C., Marcus Järås & Thoas Fioretos, 2015, In : Proceedings of the National Academy of Sciences. 112, 34, p. 10786-10791

    Research output: Contribution to journalArticle

  15. IL1RAP expression as a measure of leukemic stem cell burden at diagnosis of chronic myeloid leukemia predicts therapy outcome.

    Niklas Landberg, Hansen, N., Askmyr, M., Helena Ågerstam, Lassen, C., Rissler, M., Hansen, H. H., Mustjoki, S., Marcus Järås, Johan Richter & Thoas Fioretos, 2015, In : Leukemia. 30, 1, p. 255-258

    Research output: Contribution to journalArticle

  16. 2014
  17. Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS

    Schneider, R. K., Ademà, V., Heckl, D., Marcus Järås, Mallo, M., Lord, A. M., Chu, L. P., McConkey, M. E., Kramann, R., Mullally, A., Bejar, R., Solé, F. & Ebert, B. L., 2014 Oct 13, In : Cancer Cell. 26, 4, p. 509-520 12 p.

    Research output: Contribution to journalArticle

  18. Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia

    Marcus Järås, Miller, P. G., Chu, L. P., Puram, R. V., Fink, E. C., Schneider, R. K., Al-Shahrour, F., Pablo Peña, Breyfogle, L. J., Hartwell, K. A., McConkey, M. E., Cowley, G. S., Root, D. E., Kharas, M. G., Mullally, A. & Ebert, B. L., 2014, In : Journal of Experimental Medicine. 211, 4, p. 605-612

    Research output: Contribution to journalArticle

  19. 2013
  20. Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

    Hartwell, K. A., Miller, P. G., Mukherjee, S., Kahn, A. R., Stewart, A. L., Logan, D. J., Negri, J. M., Duvet, M., Järås, M., Puram, R. V., Dancik, V., Al-Shahrour, F., Kindler, T., Tothova, Z., Chattopadhyay, S., Hasaka, T., Narayan, R., Dai, M., Huang, C., Shterental, S. & 17 othersChu, L. P., Haydu, J. E., Shieh, J. H., Steensma, D. P., Munoz, B., Bittker, J. A., Shamji, A. F., Clemons, P. A., Tolliday, N. J., Carpenter, A. E., Gilliland, D. G., Stern, A. M., Moore, M. A. S., Scadden, D. T., Schreiber, S. L., Ebert, B. L. & Golub, T. R., 2013 Dec, In : Nature Chemical Biology. 9, 12, p. 840-848 9 p.

    Research output: Contribution to journalArticle

  21. InVivo RNAi Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling

    Miller, P. G., Al-Shahrour, F., Hartwell, K. A., Chu, L. P., Järås, M., Puram, R. V., Puissant, A., Callahan, K. P., Ashton, J., McConkey, M. E., Poveromo, L. P., Cowley, G. S., Kharas, M. G., Labelle, M., Shterental, S., Fujisaki, J., Silberstein, L., Alexe, G., Al-Hajj, M. A., Shelton, C. A. & 8 othersArmstrong, S. A., Root, D. E., Scadden, D. T., Hynes, R. O., Mukherjee, S., Stegmaier, K., Jordan, C. T. & Ebert, B. L., 2013 Jul 8, In : Cancer Cell. 24, 1, p. 45-58 14 p.

    Research output: Contribution to journalArticle

  22. Selective killing of candidate AML stem cells by antibody targeting of IL1RAP.

    Askmyr, M., Helena Ågerstam, Hansen, N., Gordon, S., Alexandros Arvanitakis, Rissler, M., Gunnar Juliusson, Johan Richter, Marcus Järås & Thoas Fioretos, 2013, In : Blood. 121, 18, p. 3709-3713

    Research output: Contribution to journalArticle

  23. SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function.

    Hansen, N., Helena Ågerstam, Martin Wahlestedt, Niklas Landberg, Askmyr, M., Mats Ehinger, Rissler, M., Henrik Lilljebjörn, Johnels, P., Ishiko, J., Melo, J. V., Whalen, A., David Bryder, Marcus Järås & Thoas Fioretos, 2013, In : Leukemia. 27, p. 130-135

    Research output: Contribution to journalArticle

  24. 2011
  25. Power Cut: Inhibiting Mitochondrial Translation to Target Leukemia

    Marcus Järås & Ebert, B. L., 2011 Nov 15, In : Cancer Cell. 20, 5, p. 555-556 2 p.

    Research output: Contribution to journalArticle

  26. 2010
  27. Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein.

    Marcus Järås, Johnels, P., Hansen, N., Helena Ågerstam, Tsapogas, P., Rissler, M., Lassen, C., Olofsson, T., Bjerrum, O. W., Johan Richter & Thoas Fioretos, 2010, In : Proceedings of the National Academy of Sciences. 107, 37, p. 16280-16285

    Research output: Contribution to journalArticle

  28. Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice

    Helena Ågerstam, Marcus Järås, Anna Andersson, Johnels, P., Hansen, N., Lassen, C., Rissler, M., David Gisselsson Nord, Olofsson, T., Johan Richter, Xiaolong Fan, Mats Ehinger & Thoas Fioretos, 2010, In : Blood. 116, 12, p. 2103-2111

    Research output: Contribution to journalArticle

  29. 2009
  30. 2007
  31. 2006
  32. Development of Adenoviral Vectors for Studying Hematopoietic Stem Cell Function

    Marcus Järås, 2006, Divison of Molecular Medicine and Gene Therapy. 104 p.

    Research output: ThesisDoctoral Thesis (compilation)

  33. Human short-term repopulating cells have enhanced telomerase reverse transcriptase expression.

    Marcus Järås, Edqvist, A., Johan Rebetz, Leif Salford, Widegren, B. & Xiaolong Fan, 2006, In : Blood. 108, 3, p. 1084-1091

    Research output: Contribution to journalArticle

  34. Increased expression of cyclin A1 protein is associated with all-trans retinoic acid-induced apoptosis.

    Ekberg, J., Brunhoff, C., Marcus Järås, Xiaolong Fan, Landberg, G. & Persson, J. L., 2006, In : International Journal of Biochemistry & Cell Biology. 38, 8, p. 1330-1339

    Research output: Contribution to journalArticle

  35. 2004