Mattias Belting

Professor, consultant

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Keywords

  • Tumour biology, Oncology

Research

Our research is focused on elucidating the molecular events involved in the formation and progression of malignant tumors, and on the development of novel strategies for targeted therapy of cancer. We use advanced experimental models in conjunction with clinical intervention studies to investigate the role of stress-related phenomena of the tumor microenvironment, such as hypoxia and coagulation activation, as biomarkers and treatment targets of cancer. Clinical studies will determine the effect of coagulation inhibition on the survival of cancer patients, and aim at the identification of predictive biomarkers of thrombotic events.
Stress-induced signaling select for tumor cells that successfully adapt to the hostile tumor microenvironment, further resulting in resistance to conventional cancer therapies. Importantly, such mechanisms also represent potential Achilles’ heels of the cancer cell machinery. We have provided novel insights into the role of cancer cell exosomes in hypoxia-driven tumor development (Svensson, K, et al., PNAS, 2011; Kucharzewska, P, et al. PNAS, 2013). We have discovered an important role of heparan sulfate proteoglycan (HSPG) and endocytosis in exosome transfer (Christanson, H, et al. PNAS, 2013; Svensson, K, et al. JBC, 2013). Based on previous findings we will explore the hypothesis that exosomes and microvesicles promote tumor aggressiveness and constitute novel therapeutic targets and non-invasive biomarkers of cancer.

Professional work

Professor of Oncology, Senior Consultant of Oncology

 

Highlighted research outputs

Bourseau-Guilmain, E., Menard, J., Lindqvist, E., Indira Chandran, V., CHRISTIANSON, HELENA., Myriam Cerezo Magana, Lidfeldt, J., György Marko-Varga, Charlotte Welinder & Mattias Belting, 2016 Apr 20, In : Nature Communications. 7, p. 1-13 13 p., 11371.

Research output: Contribution to journalArticle

Olle Melander, Marju Orho-Melander, Jonas Manjer, Svensson, T., Almgren, P., Peter Nilsson, Gunnar Engström, Bo Hedblad, Signe Borgquist, Hartmann, O., Struck, J., Bergmann, A. & Mattias Belting, 2015, In : Journal of Clinical Oncology. 33, 24, p. 2632-U81

Research output: Contribution to journalArticle

Christianson, H., Svensson, K., van Kuppevelt, T. H., Li, J-P. & Mattias Belting, 2013, In : Proceedings of the National Academy of Sciences. 110, 43, p. 17380-17385

Research output: Contribution to journalArticle

Kucharzewska, P., Christianson, H., Welch, J., Svensson, K., Fredlund, E., Markus Ringnér, Mörgelin, M., Bourseau-Guilmain, E., Johan Bengzon & Mattias Belting, 2013, In : Proceedings of the National Academy of Sciences. 110, 18, p. 7312-7317

Research output: Contribution to journalArticle

Svensson, K., Kucharzewska, P., Christianson, H., Sköld, S., Löfstedt, T., Maria C Johansson, Mörgelin, M., Johan Bengzon, Ruf, W. & Mattias Belting, 2011, In : Proceedings of the National Academy of Sciences. 108, 32, p. 13147-13152

Research output: Contribution to journalArticle

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