Merab Kokaia

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  1. 2020
  2. Gene Therapy Vector Encoding Neuropeptide Y and Its Receptor Y2 for Future Treatment of Epilepsy: Preclinical Data in Rats

    Julia Alicja Szczygieł, Kira Iben Danielsen, Esbjörn Melin, Søren Hofman Rosenkranz, Stanislava Pankratova, Annika Ericsson, Karin Agerman, Merab Kokaia & David Paul Drucker Woldbye, 2020, In : Frontiers in Molecular Neuroscience. 13, 232.

    Research output: Contribution to journalArticle

  3. 2019
  4. Disease Modification by Combinatorial Single Vector Gene Therapy: A Preclinical Translational Study in Epilepsy

    Esbjörn Melin, Avtandil Nanobashvili, Una Avdic, Casper R. Gøtzsche, My Andersson, David P.D. Woldbye & Merab Kokaia, 2019 Dec 13, In : Molecular Therapy - Methods and Clinical Development. 15, p. 179-193 15 p.

    Research output: Contribution to journalArticle

  5. Advancing research toward faster diagnosis, better treatment, and end of stigma in epilepsy

    Asla Pitkänen, David C. Henshall, J. Helen Cross, Renzo Guerrini, Sergiusz Jozwiak, Merab Kokaia, Michele Simonato, Sanjay Sisodiya & Janet Mifsud, 2019, In : Epilepsia.

    Research output: Contribution to journalArticle

  6. Leaky Optoelectrical Fiber for Optogenetic Stimulation and Electrochemical Detection of Dopamine Exocytosis from Human Dopaminergic Neurons

    Shashank Vasudevan, Janko Kajtez, Ada Ioana Bunea, Ana Gonzalez-Ramos, Tania Ramos-Moreno, Arto Heiskanen, Merab Kokaia, Niels B. Larsen, Alberto Martínez-Serrano, Stephan S. Keller & Jenny Emnéus, 2019, In : Advanced Science. 6, 24, 1902011.

    Research output: Contribution to journalArticle

  7. Long-term effects of myoinositol on behavioural seizures and biochemical changes evoked by kainic acid induced epileptogenesis

    Lia Tsverava, Manana Kandashvili, Giorgi Margvelani, Tamar Lortkipanidze, Georgi Gamkrelidze, Eka Lepsveridze, Merab Kokaia & Revaz Solomonia, 2019, In : BioMed Research International. 2019, 4518160.

    Research output: Contribution to journalArticle

  8. Long-Term, Targeted Delivery of GDNF from Encapsulated Cells Is Neuroprotective and Reduces Seizures in the Pilocarpine Model of Epilepsy

    Giovanna Paolone, Chiara Falcicchia, Francesca Lovisari, Merab Kokaia, William J. Bell, Tracie Fradet, Mario Barbieri, Lars U. Wahlberg, Dwaine F. Emerich & Michele Simonato, 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 11, p. 2144-2156 13 p.

    Research output: Contribution to journalArticle

  9. Unilateral ex vivo gene therapy by GDNF in epileptic rats

    Avtandil Nanobashvili, Esbjörn Melin, Dwaine Emerich, Jens Tornøe, Michele Simonato, Lars Wahlberg & Merab Kokaia, 2019, In : Gene Therapy. 26, 3-4, p. 65-74

    Research output: Contribution to journalArticle

  10. 2018
  11. Prolonged life of human acute hippocampal slices from temporal lobe epilepsy surgery

    J. Wickham, N. G. Brödjegård, R. Vighagen, L. H. Pinborg, J. Bengzon, D. P.D. Woldbye, M. Kokaia & M. Andersson, 2018 Dec 1, In : Scientific Reports. 8, 1, 4158.

    Research output: Contribution to journalArticle

  12. 2017
  13. Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus

    Natalia Avaliani, Ulrich Pfisterer, Andreas Heuer, Malin Parmar, Merab Kokaia & My Andersson, 2017 Nov 26, In : Stem Cells International. 2017, 9 p., 5718608.

    Research output: Contribution to journalArticle

  14. Altered chloride homeostasis decreases the action potential threshold and increases hyperexcitability in hippocampal neurons

    Andreas T. Sørensen, Marco Ledri, Miriam Melis, Litsa Nikitidou Ledri, My Andersson & Merab Kokaia, 2017 Nov 1, In : eNeuro. 4, 6, e0172-17.2017.

    Research output: Contribution to journalArticle

  15. Epilepsy and optogenetics: Can seizures be controlled by light?

    Jan Tönnesen & Merab Kokaia, 2017 Jul 15, In : Clinical Science. 131, 14, p. 1605-1616 12 p.

    Research output: Contribution to journalReview article

  16. Common data elements and data management: Remedy to cure underpowered preclinical studies

    Niina Lapinlampi, Esbjörn Melin, Eleonora Aronica, Jens P. Bankstahl, Albert Becker, Cristophe Bernard, Jan A. Gorter, Olli Gröhn, Anu Lipsanen, Katarzyna Lukasiuk, Wolfgang Löscher, Jussi Paananen, Teresa Ravizza, Paolo Roncon, Michele Simonato, Annamaria Vezzani, Merab Kokaia & Asla Pitkänen, 2017 Jan 1, In : Epilepsy Research. 129, p. 87-90 4 p.

    Research output: Contribution to journalArticle

  17. Toward an Optogenetic Therapy for Epilepsy

    Jan Tönnesen, Marco Ledri & Merab Kokaia, 2017, Optogenetics: From Neuronal Function to Mapping and Disease Biology. Appasani, K. (ed.). Cambridge: Cambridge University Press, p. 292-307

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  18. 2016
  19. DREADDs suppress seizure-like activity in a mouse model of pharmacoresistant epileptic brain tissue

    N. Avaliani, M. Andersson, A. H. Runegaard, D. Woldbye & M. Kokaia, 2016 Oct 1, In : Gene Therapy. 23, 10, p. 760-766 7 p.

    Research output: Contribution to journalArticle

  20. Advances in the development of biomarkers for epilepsy

    Asla Pitkänen, Wolfgang Löscher, Annamaria Vezzani, Albert J. Becker, Michele Simonato, Katarzyna Lukasiuk, Olli Gröhn, Jens P. Bankstahl, Alon Friedman, Eleonora Aronica, Jan A. Gorter, Teresa Ravizza, Sanjay M. Sisodiya, Merab Kokaia & Heinz Beck, 2016 Jul 1, In : Lancet Neurology. 15, 8, p. 843-856 14 p.

    Research output: Contribution to journalReview article

  21. Optogenetic control of human neurons in organotypic brain cultures

    My Andersson, Natalia Avaliani, Andreas Svensson, Jenny Wickham, Lars H. Pinborg, Bo Jespersen, Søren H. Christiansen, Johan Bengzon, David P D Woldbye & Merab Kokaia, 2016 Apr 21, In : Scientific Reports. 6, 24818.

    Research output: Contribution to journalArticle

  22. Short-term grafting of human neural stem cells: Electrophysiological properties and motor behavioral amelioration in experimental Parkinson’s disease

    Alberto Martínez-Serrano, Marta P. Pereira, Natalia Avaliani, Anna Nelke, Merab Kokaia & Tania Ramos-Moreno, 2016, In : Cell Transplantation. 25, 12, p. 2083-2097 15 p.

    Research output: Contribution to journalArticle

  23. Translational approach for gene therapy in epilepsy: Model system and unilateral overexpression of neuropeptide Y and Y2 receptors.

    Litsa Nikitidou, Esbjörn Melin, Søren H Christiansen, Casper R Gøtzsche, Alessandra Cifra, David P D Woldbye & Merab Kokaia, 2016, In : Neurobiology of Disease. 86, nov 19, p. 52-61

    Research output: Contribution to journalArticle

  24. 2015
  25. Differential Effect of Neuropeptides on Excitatory Synaptic Transmission in Human Epileptic Hippocampus.

    Marco Ledri, Andreas T Sørensen, Marita Grönning Madsen, Søren H Christiansen, Litsa Nikitidou Ledri, Alessandra Cifra, Johan Bengzon, Eva Lindberg, Lars H Pinborg, Bo Jespersen, Casper R Gøtzsche, David P D Woldbye, My Andersson & Merab Kokaia, 2015, In : Journal of Neuroscience. 35, 26, p. 9622-9631

    Research output: Contribution to journalArticle

  26. 2014
  27. A compact multifunctional microfluidic platform for exploring cellular dynamics in real-time using electrochemical detection

    K. Zor, A. Heiskanen, C. Caviglia, M. Vergani, E. Landini, F. Shah, M. Carminati, A. Martinez-Serrano, Tania Ramos Moreno, Merab Kokaia, D. Benayahu, Zs. Keresztes, D. Papkovsky, U. Wollenberger, W. E. Svendsen, M. Dimaki, G. Ferrari, R. Raiteri, M. Sampietro, M. Dufva & 1 others, J. Emneus, 2014, In : RSC Advances. 4, 109, p. 63761-63771

    Research output: Contribution to journalArticle

  28. Encapsulated galanin-producing cells attenuate focal epileptic seizures in the hippocampus.

    Litsa Nikitidou, Malene Torp, Lone Fjord-Larsen, Philip Kusk, Lars U Wahlberg & Merab Kokaia, 2014, In : Epilepsia. 55, 1, p. 167-174

    Research output: Contribution to journalArticle

  29. Global Optogenetic Activation of Inhibitory Interneurons during Epileptiform Activity.

    Marco Ledri, Marita Grönning Madsen, Litsa Nikitidou, Deniz Kirik & Merab Kokaia, 2014, In : Journal of Neuroscience. 34, 9, p. 3364-3377

    Research output: Contribution to journalArticle

  30. How Might Novel Technologies Such as Optogenetics Lead to Better Treatments in Epilepsy?

    Esther Krook-Magnuson, Marco Ledri, Ivan Soltesz & Merab Kokaia, 2014, Issues in Clinical Epileptology: A View From the Bench. Scharfman, H. E. & Buckmaster, P. S. (eds.). Springer, Vol. 813. p. 319-336 (Advances in Experimental Medicine and Biology; vol. 813).

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  31. Optogenetic inhibition of chemically induced hypersynchronized bursting in mice.

    Fredrik Berglind, Marco Ledri, Andreas Toft Sørensen, Litsa Nikitidou, Miriam Melis, Pascal Bielefeld, Deniz Kirik, Karl Deisseroth, My Andersson & Merab Kokaia, 2014, In : Neurobiology of Disease. 65, p. 133-141

    Research output: Contribution to journalArticle

  32. Optogenetics reveal delayed afferent synaptogenesis on grafted human induced pluripotent stem cell-derived neural progenitors.

    Natalia Avaliani, Andreas Toft Sörensen, Marco Ledri, Johan Bengzon, Philipp Koch, Oliver Brüstle, Karl Deisseroth, My Andersson & Merab Kokaia, 2014, In : Stem Cells. 32, 12, p. 3088-3098

    Research output: Contribution to journalArticle

  33. WONOEP appraisal: Optogenetic tools to suppress seizures and explore the mechanisms of epileptogenesis

    Laura Mantoan Ritter, Peyman Golshani, Koji Takahashi, Suzie Dufour, Taufik Valiante & Merab Kokaia, 2014, In : Epilepsia. 55, 11, p. 1693-1702

    Research output: Contribution to journalArticle

  34. 2013
  35. An optogenetic approach in epilepsy.

    Merab Kokaia, My Andersson & Marco Ledri, 2013, In : Neuropharmacology. 69, Jun 12, p. 89-95

    Research output: Contribution to journalReview article

  36. Epilepsy therapy development: Technical and methodologic issues in studies with animal models

    Aristea S. Galanopoulou, Merab Kokaia, Jeffrey A. Loeb, Astrid Nehlig, Asla Pitkanen, Michael A. Rogawski, Kevin J. Staley, Vicky H. Whittemore & F. Edward Dudek, 2013, In : Epilepsia. 54, p. 13-23

    Research output: Contribution to journalArticle

  37. Proposal for a "phase II" multicenter trial model for preclinical new antiepilepsy therapy development

    Terence J. O'Brien, Elinor Ben-Menachem, Edward H. III Bertram, Stephen D. Collins, Merab Kokaia, Holger Lerche, Henrik Klitgaard, Kevin J. Staley, Elisabetta Vaudano, Matthew C. Walker & Michele Simonato, 2013, In : Epilepsia. 54, p. 70-74

    Research output: Contribution to journalArticle

  38. 2012
  39. Altered profile of basket cell afferent synapses in hyper-excitable dentate gyrus revealed by optogenetic and two-pathway stimulations.

    Marco Ledri, Litsa Nikitidou, Ferenc Erdelyi, Gabor Szabo, Deniz Kirik, Karl Deisseroth & Merab Kokaia, 2012, In : European Journal of Neuroscience. 36, 1, p. 1971-1983

    Research output: Contribution to journalArticle

  40. Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures

    Casper R. Gotzsche, Litsa Nikitidou, Andreas Toft Sörensen, Mikkel V. Olesen, Gunnar Sorensen, Soren H. O. Christiansen, Mikael Ängehagen, David P. D. Woldbye & Merab Kokaia, 2012, In : Neurobiology of Disease. 45, 1, p. 288-296

    Research output: Contribution to journalArticle

  41. Human midbrain precursors activate the expected developmental genetic program and differentiate long-term to functional A9 dopamine neurons in vitro. Enhancement by Bcl-X-L

    Emma G. Seiz, Milagros Ramos-Gomez, Elise T. Courtois, Jan Tönnesen, Merab Kokaia, Isabel Liste Noya & Alberto Martinez-Serrano, 2012, In : Experimental Cell Research. 318, 19, p. 2446-2459

    Research output: Contribution to journalArticle

  42. Neuropeptide Y Y1 Receptor Hippocampal Overexpression Via Viral Vectors Is Associated With Modest Anxiolytic-Like and Proconvulsant Effects in Mice

    M. V. Olesen, S. H. Christiansen, C. R. Gotzsche, Litsa Nikitidou, Merab Kokaia & D. P. D. Woldbye, 2012, In : Journal of Neuroscience Research. 90, 2, p. 498-507

    Research output: Contribution to journalArticle

  43. Novel approaches to epilepsy treatment.

    Andreas T Sørensen & Merab Kokaia, 2012, In : Epilepsia.

    Research output: Contribution to journalArticle

  44. VEGF receptor-2 (flk-1) overexpression in mice counteracts focal epileptic seizures.

    Litsa Nikitidou, Irene Kanter Schlifke, Joke Dhondt, Peter Carmeliet, Diether Lambrechts & Merab Kokaia, 2012, In : PLoS ONE. 7, 7, e40535.

    Research output: Contribution to journalArticle

  45. Y5 neuropeptide Y receptor overexpression in mice neither affects anxiety- and depression-like behaviours nor seizures but confers moderate hyperactivity

    M. V. Olesen, S. H. Christiansen, C. R. Gotzsche, B. Holst, Merab Kokaia & D. P. D. Woldbye, 2012, In : Neuropeptides. 46, 2, p. 71-79

    Research output: Contribution to journalArticle

  46. 2011
  47. Activity-dependent long-term plasticity of afferent synapses on grafted stem/progenitor cell-derived neurons.

    Andreas Toft Sörensen, Nina Rogelius, Cecilia Lundberg & Merab Kokaia, 2011, In : Experimental Neurology. 229, p. 274-281

    Research output: Contribution to journalArticle

  48. Functional integration of grafted neural stem cell-derived dopaminergic neurons monitored by optogenetics in an in vitro Parkinson model.

    Jan Tønnesen, Clare L Parish, Andreas Toft Sörensen, Angelica Andersson, Cecilia Lundberg, Karl Deisseroth, Ernest Arenas, Olle Lindvall & Merab Kokaia, 2011, In : PLoS ONE. 6, 3, e17560.

    Research output: Contribution to journalArticle

  49. Light-activated channels in acute seizures.

    Merab Kokaia, 2011, In : Epilepsia. 52 Suppl 8, p. 16-18

    Research output: Contribution to journalArticle

  50. Seizure-induced neurogenesis in the adult brain.

    Merab Kokaia, 2011, In : European Journal of Neuroscience. 33, 6, p. 1133-1138

    Research output: Contribution to journalArticle

  51. The treatment of neurological diseases under a new light: the importance of optogenetics.

    Merab Kokaia & Andreas Toft Sörensen, 2011, In : Drugs of Today. 47, 1, p. 53-62

    Research output: Contribution to journalReview article

  52. Tuning afferent synapses of hippocampal interneurons by neuropeptide Y.

    Marco Ledri, Andreas Toft Sörensen, Ferenc Erdelyi, Gabor Szabo & Merab Kokaia, 2011, In : Hippocampus. 21, p. 198-211

    Research output: Contribution to journalArticle

  53. 2010
  54. Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures.

    David P D Woldbye, Mikael Ängehagen, Casper R Gøtzsche, Heidi Elbrønd-Bek, Andreas Toft Sörensen, Søren H Christiansen, Mikkel V Olesen, Litsa Nikitidou, Thomas V O Hansen, Irene Kanter Schlifke & Merab Kokaia, 2010, In : Brain. 133, Pt 9, p. 2778-2788

    Research output: Contribution to journalArticle

  55. Functional properties of the human ventral mesencephalic neural stem cell line hVM1.

    Jan Tønnesen, Emma Gonzalez Seiz, Milagros Ramos, Olle Lindvall, Alberto Martinez-Serrano & Merab Kokaia, 2010, In : Experimental Neurology. 223, p. 653-656

    Research output: Contribution to journalArticle

  56. Gene therapy of focal-onset epilepsy by adeno-associated virus vector-mediated overexpression of neuropeptide Y

    Francesco M. Noe, Andreas Toft Sörensen, Merab Kokaia & Annamaria Vezzani, 2010, In : Epilepsia. 51, p. 96-96

    Research output: Contribution to journalArticle

  57. 2009
  58. BDNF downregulates 5-HT2A receptor protein levels in hippocampal cultures

    V. Trajkovska, M. A. Santini, A. B. Marcussen, M. S. Thomsen, H. H. Hansen, J. D. Mikkelsen, L. Arneberg, Merab Kokaia, G. M. Knudsen & S. Aznar, 2009, In : Neurochemistry International. 55, 7, p. 697-702

    Research output: Contribution to journalArticle

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