Mikael Sigvardsson

Professor, Directly Appointed
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  1. 2020
  2. 13q12.2 deletions in acute lymphoblastic leukemia lead to upregulation of FLT3 through enhancer hijacking

    Minjun Yang, Safavi, S., Eleanor L Woodward, Duployez, N., Olsson-arvidsson, L., Jonas Ungerbäck, Mikael Sigvardsson, Zaliova, M., Zuna, J., Thoas Fioretos, Bertil Johansson, Karolin H Nord & Kajsa Paulsson, 2020 May 8, In : Blood.

    Research output: Contribution to journalArticle

  3. Progression of progenitor B-cell leukemia is associated with alterations of the bone marrow micro-environment

    Åhsberg, J., Xiao, P., Okuyama, K., Somasundaram, R., Tobias Strid, Qian, H. & Mikael Sigvardsson, 2020 Mar, In : Haematologica. 105, 3, p. E102-E106 5 p.

    Research output: Contribution to journalLetter

  4. Ezh2 Represses Transcription of Innate Lymphoid Genes in B Lymphocyte Progenitors and Maintains the B-2 Cell Fate

    Jacobsen, J. A., Bartom, E. T., Mikael Sigvardsson & Kee, B. L., 2020, In : Journal of immunology (Baltimore, Md. : 1950). 204, 7, p. 1760-1769 10 p.

    Research output: Contribution to journalArticle

  5. 2019
  6. PAX5 is part of a functional transcription factor network targeted in lymphoid leukemia

    Okuyama, K., Tobias Strid, Kuruvilla, J., Somasundaram, R., Cristobal, S., Emma Smith, Prasad, M., Thoas Fioretos, Henrik Lilljebjörn, Shamit Soneji, Stefan Lang, Jonas Ungerbäck & Mikael Sigvardsson, 2019 Aug 1, In : PLoS Genetics. 15, 8, e1008280.

    Research output: Contribution to journalArticle

  7. Cutting Edge: Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1

    de Pooter, R. F., Dias, S., Chowdhury, M., Bartom, E. T., Okoreeh, M. K., Mikael Sigvardsson & Kee, B. L., 2019, In : Journal of immunology (Baltimore, Md. : 1950). 202, 10, p. 2837-2842 6 p.

    Research output: Contribution to journalArticle

  8. 2018
  9. Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis

    Christina T Jensen, Åhsberg, J., Mikael N E Sommarin, Tobias Strid, Somasundaram, R., Okuyama, K., Jonas Ungerbäck, Kupari, J., Airaksinen, M. S., Stefan Lang, David Bryder, Shamit Soneji, Göran Karlsson & Mikael Sigvardsson, 2018 Jul 2, In : Journal of Experimental Medicine. 215, 7, p. 1947-1963

    Research output: Contribution to journalArticle

  10. Molecular regulation of differentiation in early B-lymphocyte development

    Mikael Sigvardsson, 2018 Jul 1, In : International Journal of Molecular Sciences. 19, 7, 1928.

    Research output: Contribution to journalReview article

  11. Pioneering, chromatin remodeling, and epigenetic constraint in early T-cell gene regulation by SPI1 (PU.1)

    Jonas Ungerbäck, Hosokawa, H., Wang, X., Tobias Strid, Williams, B. A., Mikael Sigvardsson & Rothenberg, E. V., 2018, In : Genome Research. 28, 10, p. 1508-1519 12 p.

    Research output: Contribution to journalArticle

  12. Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells

    Guzzi, N., Cieśla, M., Ngoc, P. C. T., Lang, S., Arora, S., Dimitriou, M., Pimková, K., Sommarin, M. N. E., Munita, R., Lubas, M., Lim, Y., Okuyama, K., Soneji, S., Karlsson, G., Hansson, J., Jönsson, G., Lund, A. H., Sigvardsson, M., Hellström-Lindberg, E., Hsieh, A. C. & 1 others, Cristian Bellodi, 2018, In : Cell. 173, 5, p. 1204-1216.e26

    Research output: Contribution to journalArticle

  13. 2017
  14. Don't judge a cell by its cover: heterogeneity within early lymphoid progenitors

    Göran Karlsson, Mikael Sigvardsson & Charlotta Böiers, 2017 Dec 15, In : EMBO Journal. 36, 24, p. 3552-3554 3 p.

    Research output: Contribution to journalArticle

  15. EZH2 regulates the developmental timing of effectors of the pre-Antigen receptor checkpoints

    Jacobsen, J. A., Woodard, J., Mandal, M., Clark, M. R., Bartom, E. T., Mikael Sigvardsson & Kee, B. L., 2017 Jun 15, In : Journal of Immunology. 198, 12, p. 4682-4691 10 p.

    Research output: Contribution to journalArticle

  16. Cellular plasticity in B-cell leukemia

    Somasundaram, R., Tobias Strid & Mikael Sigvardsson, 2017, In : Cell Cycle. 16, 6, p. 495-496 2 p.

    Research output: Contribution to journalDebate/Note/Editorial

  17. 2016
  18. Clonal conversion of B lymphoid leukemia reveals cross-lineage transfer of malignant states

    Somasundaram, R., Åhsberg, J., Okuyama, K., Ungerbäck, J., Henrik Lilljebjörn, Thoas Fioretos, Tobias Strid & Mikael Sigvardsson, 2016 Nov 15, In : Genes and Development. 30, 22, p. 2486-2499 14 p.

    Research output: Contribution to journalArticle

  19. Exploring the multifaceted nature of the common lymphoid progenitor compartment.

    Christina Jensen, Strid, T. & Mikael Sigvardsson, 2016, In : Current Opinion in Immunology. 39, p. 121-126

    Research output: Contribution to journalReview article

  20. 2015
  21. A novel Lin-CD34+CD38-integrin α2- bipotential megakaryocyte-erythrocyte progenitor population in human bone marrow.

    Wong, W. M., Dolinska, M., Mikael Sigvardsson, Marja Ekblom & Qian, H., 2015, In : Leukemia. 30, p. 1399-1402

    Research output: Contribution to journalArticle

  22. Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency.

    Prasad, M. A. J., Ungerbäck, J., Åhsberg, J., Somasundaram, R., Strid, T., Larsson, M., Månsson, R., De Paepe, A., Henrik Lilljebjörn, Thoas Fioretos, Hagman, J. & Mikael Sigvardsson, 2015, In : Blood. 125, 26, p. 4052-4059

    Research output: Contribution to journalArticle

  23. 2013
  24. An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state.

    Martin Wahlestedt, Norddahl, G., Sten, G., Amol Ugale, Micha Frisk, M-A., Mattsson, R., Tomas Deierborg, Mikael Sigvardsson & David Bryder, 2013, In : Blood. 121, 21, p. 4257-4264

    Research output: Contribution to journalArticle

  25. Expression of Integrin A2 Receptor in Human Cord Blood Cd34+Cd38-Cd90+ Stem Cells Engrafting Long-Term in Nod/Scid-Il2rγ(C) Null Mice.

    Wong, W. M., Mikael Sigvardsson, Åstrand-Grundström, I., Hogge, D., Jonas Larsson, Qian, H. & Marja Ekblom, 2013, In : Stem Cells. 31, 2, p. 360-371

    Research output: Contribution to journalArticle

  26. 2012
  27. 2011
  28. A dose-dependent role for EBF1 in repressing non-B-cell-specific genes

    Lukin, K., Fields, S., Guerrettaz, L., Straign, D., Rodriguez, V., Zandi, S., Månsson, R., Cambier, J. C., Mikael Sigvardsson & Hagman, J., 2011, In : European Journal of Immunology. 41, 6, p. 1787-1793

    Research output: Contribution to journalArticle

  29. B-lymphocyte commitment: Identifying the point of no return.

    Welinder, E., Ahsberg, J. & Mikael Sigvardsson, 2011, In : Seminars in Immunology. 23, p. 335-340

    Research output: Contribution to journalArticle

  30. 2010
  31. Epigenetic chromatin states uniquely define the developmental plasticity of murine hematopoietic stem cells.

    Weishaupt, H., Mikael Sigvardsson & Attema, J., 2010, In : Blood. 115, p. 247-256

    Research output: Contribution to journalArticle

  32. Genomics based analysis of interactions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication

    Zetterblad, J., Qian, H., Zandi, S., Månsson, R., Lagergren, A., Hansson, F., David Bryder, Paulsson, N. & Mikael Sigvardsson, 2010, In : BMC Genomics. 11, 108.

    Research output: Contribution to journalArticle

  33. Load and lock: the molecular mechanisms of B-lymphocyte commitment.

    Zandi, S., David Bryder & Mikael Sigvardsson, 2010, In : Immunological Reviews. 238, 1, p. 47-62

    Research output: Contribution to journalArticle

  34. Nuclear Factor of Activated T Cells Regulates Osteopontin Expression in Arterial Smooth Muscle in Response to Diabetes-Induced Hyperglycemia.

    Lisa Berglund, Zetterqvist, A., Öhman, J., Mikael Sigvardsson, González Bosc, L. V., Smith, M-L., S Albert Salehi, Elisabet Agardh, Nordin Fredrikson, G., Agardh, C-D., Jan Nilsson, Wamhoff, B. R., Anna Hultgårdh & Maria Gomez, 2010, In : Arteriosclerosis, Thrombosis and Vascular Biology. 30, p. 218-U154

    Research output: Contribution to journalArticle

  35. Shaping up a lineage-lessons from B lymphopoesis.

    David Bryder & Mikael Sigvardsson, 2010, In : Current Opinion in Immunology. Apr 7, p. 148-153

    Research output: Contribution to journalArticle

  36. Single cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity.

    Månsson, R., Zandi, S., Welinder, E., Tsapogas, P., Sakaguchi, N., David Bryder & Mikael Sigvardsson, 2010, In : Blood. 115, 13, p. 2601-2609

    Research output: Contribution to journalArticle

  37. 2008
  38. B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells

    Månsson, R., Zandi, S., Anderson, K., Martensson, I-L., Jacobsen, S. E. W., David Bryder & Mikael Sigvardsson, 2008, In : Blood. 112, 4, p. 1048-1055

    Research output: Contribution to journalArticle

  39. Deciphering developmental stages of adult myelopoiesis.

    Pronk, C. J., Attema, J., Rossi, D. J., Mikael Sigvardsson & David Bryder, 2008, In : Cell Cycle. 7, 6, p. 706-713

    Research output: Contribution to journalArticle

  40. EBF1 is essential for B-Lineage priming and establishment of a transcription factor network in common lymphoid progenitors

    Zandi, S., Månsson, R., Tsapogas, P., Zetterblad, J., David Bryder & Mikael Sigvardsson, 2008, In : Journal of Immunology. 181, 5, p. 3364-3372

    Research output: Contribution to journalArticle

  41. Exit of pediatric pre-B acute lymphoblastic leukaemia cells from the bone marrow to the peripheral blood is not associated with cell maturation or alterations in gene expression.

    Hansson, F., Toporski, J., Månsson, R., Bertil Johansson, Norén-Nyström, U., Jacobsen, S. E. W., Thomas Wiebe, Larsson, M., Mikael Sigvardsson & Anders Castor, 2008, In : Molecular Cancer. 7, 67.

    Research output: Contribution to journalArticle

  42. Molecular profiling reveals distinct functional attributes of CD1d-restricted natural killer (NK) T cell subsets

    Rolf, J., Berntman, E., Stenström, M., Emma Smith, Månsson, R., Stenstad, H., Yamagata, T., William Agace, Mikael Sigvardsson & Cardell, S., 2008, In : Molecular Immunology. 45, 9, p. 2607-2620

    Research output: Contribution to journalArticle

  43. Permissive roles of hematopoietin and cytokine tyrosine kinase receptors in early T cell development

    Christina Jensen, Charlotta Böiers, Kharazi, S., Lübking, A., Rydén, T., Mikael Sigvardsson, Ewa Sitnicka Quinn & Jacobsen, S. E. W., 2008, In : Blood. 111, 4, p. 2083-2090

    Research output: Contribution to journalArticle

  44. 2007
  45. A critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade.

    Jimenez, M. A., Akerblad, P., Mikael Sigvardsson & Rosen, E. D., 2007, In : Molecular and Cellular Biology. 27, Oct 23, p. 743-757

    Research output: Contribution to journalArticle

  46. Critical role of FLT3 ligand in IL-7 receptor-independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors

    Ewa Sitnicka Quinn, Buza-Vidas, N., Henrik Ahlenius, Corrado Cilio, Gekas, C., Nygren, J., Månsson, R., Cheng, M., Christina Jensen, Svensson Frej, M., Karin Leandersson, William Agace, Mikael Sigvardsson & Jacobsen, S. E. W., 2007, In : Blood. 110, 8, p. 2955-2964

    Research output: Contribution to journalArticle

  47. Ectopic expression of PAX5 promotes self renewal of bi-phenotypic myeloid progenitors co-expressing myeloid and B-cell lineage associated genes.

    Anderson, K., Rusterholz, C., Månsson, R., Christina Jensen, Karl Bacos, Zandi, S., Sasaki, Y., Nerlov, C., Mikael Sigvardsson & Jacobsen, S. E. W., 2007, In : Blood. 109, Jan 11, p. 3697-3705

    Research output: Contribution to journalArticle

  48. Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy

    Pronk, C. J. H., Rossi, D. J., Månsson, R., Attema, J., Norddahl, G., Chan, C. K. F., Mikael Sigvardsson, Weissman, I. L. & David Bryder, 2007, In : Cell Stem Cell. 1, 4, p. 428-442

    Research output: Contribution to journalArticle

  49. HOXA10 is a critical regulator for hematopoietic stem cells and erythroid/megakaryocyte development.

    Mattias Magnusson, Brun, A., Miyake, N., Jonas Larsson, Mats Ehinger, Björnsson, J. M., Wutz, A., Mikael Sigvardsson & Stefan Karlsson, 2007, In : Blood. 109, 9, p. 3687-3696

    Research output: Contribution to journalArticle

  50. Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon.

    Holm, P., Mader, M. T., Haubst, N., Wizenmann, A., Mikael Sigvardsson & Gotz, M., 2007, In : Molecular and Cellular Neuroscience. 34, 1, p. 99-119

    Research output: Contribution to journalReview article

  51. Loss of bHLH transcription factor E2A activity in primary effusion lymphoma confers resistance to apoptosis

    Lietz, A., Janz, M., Mikael Sigvardsson, Jundt, F., Doerken, B. & Mathas, S., 2007, In : British Journal of Haematology. 137, 4, p. 342-348

    Research output: Contribution to journalArticle

  52. Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors.

    Månsson, R., Anne Hultquist, Luc, S., Yang, L., Anderson, K., Kharazi, S., Al-Hashmi, S., Liuba, K., Thorén, L., Adolfsson, J., Buza-Vidas, N., Qian, H., Soneji, S., Enver, T., Mikael Sigvardsson & Jacobsen, S. E. W., 2007, In : Immunity. 26, 4, p. 407-419

    Research output: Contribution to journalArticle

  53. The CD53 and CEACAM-1 genes are genetic targets for early B cell factor.

    Månsson, R., Lagergren, A., Hansson, F., Emma Smith & Mikael Sigvardsson, 2007, In : European Journal of Immunology. 37, 5, p. 1365-1376

    Research output: Contribution to journalArticle

  54. The CXCL12, periostin and CCL9 genes are direct targets for early B-cell factor (EBF) in OP-9 stroma cells.

    Lagergren, A., Månsson, R., Zetterblad, J., Emma Smith, Basta, B., David Bryder, Akerblad, P. & Mikael Sigvardsson, 2007, In : Journal of Biological Chemistry. 282, 19, p. 14454-14462

    Research output: Contribution to journalArticle

  55. The molecular signature of MDS stem cells supports a stem-cell origin of 5q - myelodysplastic syndromes

    Nilsson, L., Patrik Edén, Olsson, E., Månsson, R., Åstrand-Grundström, I., Strömbeck, B., Theilgaard-Moench, K., Anderson, K., Hast, R., Hellström, E., Samuelsson, J., Bergh, G., Nerlov, C., Bertil Johansson, Mikael Sigvardsson, Åke Borg & Jacobsen, S. E. W., 2007, In : Blood. 110, 8, p. 3005-3014

    Research output: Contribution to journalArticle

  56. 2006
  57. Immune status and inflammatory response differ locally and systemically in severe acute pancreatitis.

    Shi, C., Zhao, X., Lagergren, A., Mikael Sigvardsson, Wang, X. & Roland Andersson, 2006, In : Scandinavian Journal of Gastroenterology. 41, 4, p. 472-480

    Research output: Contribution to journalArticle

  58. Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma

    Mathas, S., Janz, M., Hummel, F., Hummel, M., Wollert-Wulf, B., Lusatis, S., Anagnostopoulos, I., Lietz, A., Mikael Sigvardsson, Jundt, F., Johrens, K., Bommert, K., Stein, H. & Dorken, B., 2006, In : Nature Immunology. 7, 2, p. 207-215

    Research output: Contribution to journalArticle

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