Niels-Bjarne Woods

Senior Lecturer

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology


Our principle goal is to understand the molecular processes of hematopoietic stem cell (HSC) emergence and development. Towards this we have developed a pluripotent stem cell differentiation system that generates hematopoietic cells through distinct developmental stages. We have identified several subpopulations of cells in this developmental process, including cells undergoing endothelial-to-hematopoietic transition (EHT). This transition is a critical step for the generation of HSCs, and we are first to be able to sort and functionally differentiate the cells in human setting. This provides a platform for the identification and evaluation of novel factors required in the developmental processes for de novo blood generation. We have identified a number of critical factors influencing various stages of the developmental commitment towards the blood lineage and have used these factors to increased both function and numbers of the most primitive hematopoietic cells (including hematopoietic cells with lymphoid and myeloid differentiation potential). The ultimate goal of our research is to be able to provide an alternative and unlimited source of HSCs using pluripotent stem cells for use in patients with blood disorders and malignancies.

Highlighted research outputs

Saxena, S., Roger E Rönn, Guibentif, C., Moraghebi, R. & Niels-Bjarne Woods, 2016, In : Stem Cell Reports. 6, 5, p. 692-703

Research output: Contribution to journalArticle

Kyttälä, A., Moraghebi, R., Valensisi, C., Kettunen, J., Andrus, C., Pasumarthy, K. K., Nakanishi, M., Nishimura, K., Ohtaka, M., Weltner, J., Van Handel, B., Parkkonen, O., Sinisalo, J., Jalanko, A., Hawkins, R. D., Niels-Bjarne Woods, Otonkoski, T. & Trokovic, R., 2016, In : Stem Cell Reports. 6, 2, p. 200-212

Research output: Contribution to journalArticle

Roger Rönn, Guibentif, C., Moraghebi, R., Chaves Guerrero, P., Saxena, S., Garcia, B. & Niels-Bjarne Woods, 2015, In : Stem Cell Reports. 4, 2, p. 269-281

Research output: Contribution to journalArticle

Martin Wahlestedt, Ameur, A., Moraghebi, R., Norddahl, G., Sten, G., Niels-Bjarne Woods & David Bryder, 2014, In : Stem Cells. 32, 5, p. 1173-1182

Research output: Contribution to journalArticle

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