Niklas Marklund

Professor, consultant, Consultant Neurosurgeon, Neurosurgery
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  1. 2019
  2. Dynamic protein changes in the perihaemorrhagic zone of Surgically Treated Intracerebral Haemorrhage Patients

    Tobieson, L., Ghafouri, B., Zsigmond, P., Rossitti, S., Hillman, J. & Niklas Marklund, 2019 Feb 28, In : Scientific Reports. 9, 1, 3181.

    Research output: Contribution to journalArticle

  3. Proinflammatory and amyloidogenic S100A9 induced by traumatic brain injury in mouse model

    Wang, C., Iashchishyn, I. A., Kara, J., Foderà, V., Vetri, V., Sancataldo, G., Niklas Marklund & Morozova-Roche, L. A., 2019 Feb 10, In : Neuroscience Letters. 699, p. 199-205 7 p.

    Research output: Contribution to journalArticle

  4. The Fluid Percussion Injury Rodent Model in Preclinical Research on Traumatic Brain Injury

    Clausen, F., Hillered, L. & Niklas Marklund, 2019 Jan 1, Animal Models of Neurotrauma. Risling, M. & Davidsson, J. (eds.). Humana Press, p. 3-18 16 p. (Neuromethods; vol. 149).

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  5. Best zero level for external ICP transducer

    Peter Reinstrup, Mårten Unnerbäck, Niklas Marklund, Schalen, W., Arrocha, J. C., Bloomfield, E. L., Sadegh, V. & Hesselgard, K., 2019, In : Acta Neurochirurgica. 161, 4, p. 635-642

    Research output: Contribution to journalArticle

  6. Differences in neurosurgical treatment of intracerebral haemorrhage: a nation-wide observational study of 578 consecutive patients

    Fahlström, A., Tobieson, L., Henrietta Nittby Redebrandt, Zeberg, H., Bartek, J., Bartley, A., Erkki, M., Hessington, A., Ebba Troberg, Mirza, S., Tsitsopoulos, P. P. & Niklas Marklund, 2019, In : Acta Neurochirurgica. 161, 5, p. 955-965

    Research output: Contribution to journalArticle

  7. Focal traumatic brain injury induces neuroplastic molecular responses in lumbar spinal cord

    Kononenko, O., Hiroyuki Watanabe, Stålhandske, L., Zarelius, A., Clausen, F., Yakovleva, T., Bakalkin, G. & Niklas Marklund, 2019, In : Restorative Neurology and Neuroscience. 37, 2, p. 87-96 10 p.

    Research output: Contribution to journalArticle

  8. Management of concussion in soccer

    Hubertus, V., Niklas Marklund & Vajkoczy, P., 2019, In : Acta Neurochirurgica. 161, 3, p. 425-433

    Research output: Contribution to journalReview article

  9. Persistent Metabolic Disturbance in the Perihemorrhagic Zone Despite a Normalized Cerebral Blood Flow Following Surgery for Intracerebral Hemorrhage

    Tobieson, L., Rossitti, S., Zsigmond, P., Hillman, J. & Niklas Marklund, 2019, In : Neurosurgery. 84, 6, p. 1269-1279

    Research output: Contribution to journalArticle

  10. Primum non nocere: a call for balance when reporting on CTE

    Stewart, W., Niklas Marklund, Smith, D. H. & et al., 2019, In : The Lancet Neurology. 18, 3, p. 231-233 3 p.

    Research output: Contribution to journalArticle

  11. 2018
  12. Proteomic differences between focal and diffuse traumatic brain injury in human brain tissue

    Abu Hamdeh, S., Shevchenko, G., Mi, J., Musunuri, S., Bergquist, J. & Niklas Marklund, 2018 Dec 1, In : Scientific Reports. 8, 1, p. 1-15 6807.

    Research output: Contribution to journalArticle

  13. Neutralization of Interleukin-1β following Diffuse Traumatic Brain Injury in the Mouse Attenuates the Loss of Mature Oligodendrocytes

    Flygt, J., Karsten Ruscher, Norberg, A., Mir, A., Gram, H., Clausen, F. & Niklas Marklund, 2018 Dec, In : Journal of Neurotrauma. 35, 23, p. 2837-2849

    Research output: Contribution to journalArticle

  14. Differential effects of left and right neuropathy on opioid gene expression in lumbar spinal cord

    Kononenko, O., Mityakina, I., Galatenko, V., Hiroyuki Watanabe, Bazov, I., Gerashchenko, A., Sarkisyan, D., Iatsyshyna, A., Yakovleva, T., Tonevitsky, A., Niklas Marklund, Ossipov, M. H. & Bakalkin, G., 2018 Sep 15, In : Brain Research. 1695, p. 78-83 6 p.

    Research output: Contribution to journalArticle

  15. Exoskeleton gait training after spinal cord injury: An exploratory study on secondary health conditions

    Baunsgaard, C. B., Nissen, U. V., Brust, A. K., Frotzler, A., Ribeill, C., Kalke, Y-B., León, N., Gómez, B., Samuelsson, K., Antepohl, W., Holmström, U., Niklas Marklund, Glott, T., Opheim, A., Benito Penalva, J., Murillo, N., Nachtegaal, J., Faber, W. & Biering-Sørensen, F., 2018 Sep 5, In : Journal of Rehabilitation Medicine.

    Research output: Contribution to journalArticle

  16. Favorable clinical outcome following surgical evacuation of deep-seated and lobar supratentorial intracerebral hemorrhage: a retrospective single-center analysis of 123 cases

    Hessington, A., Tsitsopoulos, P. P., Fahlström, A. & Niklas Marklund, 2018 Sep 1, In : Acta Neurochirurgica. 160, 9, p. 1737-1747 11 p.

    Research output: Contribution to journalArticle

  17. Intracranial pressure elevations in diffuse axonal injury: association with nonhemorrhagic MR lesions in central mesencephalic structures

    Abu Hamdeh, S., Niklas Marklund, Lewén, A., Howells, T., Raininko, R., Wikström, J. & Enblad, P., 2018 Sep 1, In : Journal of Neurosurgery. p. 1-8

    Research output: Contribution to journalArticle

  18. Management of symptomatic sacral perineural cysts with microsurgery and a vascularized fasciocutaneous flap

    Tsitsopoulos, P. P., Niklas Marklund, Salci, K., Holtz, A. & Mani, M., 2018 Sep, In : Journal of spine surgery (Hong Kong). 4, 3, p. 602-609

    Research output: Contribution to journalArticle

  19. Rapid amyloid-β oligomer and protofibril accumulation in traumatic brain injury

    Abu Hamdeh, S., Waara, E. R., Möller, C., Söderberg, L., Basun, H., Alafuzoff, I., Hillered, L., Lannfelt, L., Ingelsson, M. & Niklas Marklund, 2018 Jul, In : Brain Pathology. 28, 4, p. 451-462

    Research output: Contribution to journalArticle

  20. Neurofilament light and tau as blood biomarkers for sports-related concussion

    Shahim, P., Tegner, Y., Niklas Marklund, Blennow, K. & Zetterberg, H., 2018 May 15, In : Neurology. 90, 20, p. e1780-e1788

    Research output: Contribution to journalArticle

  21. Editorial: Monitoring pathophysiology in the injured brain

    Thelin, E. P., Helmy, A., Nelson, D. W. & Niklas Marklund, 2018 Mar 26, In : Frontiers in Neurology. 9, MAR, 193.

    Research output: Contribution to journalArticle

  22. Gait training after spinal cord injury: safety, feasibility and gait function following 8 weeks of training with the exoskeletons from Ekso Bionics

    Bach Baunsgaard, C., Vig Nissen, U., Katrin Brust, A., Frotzler, A., Ribeill, C., Kalke, Y-B., León, N., Gómez, B., Samuelsson, K., Antepohl, W., Holmström, U., Niklas Marklund, Glott, T., Opheim, A., Benito, J., Murillo, N., Nachtegaal, J., Faber, W. & Biering-Sørensen, F., 2018 Feb, In : Spinal Cord. 56, 2, p. 106-116

    Research output: Contribution to journalArticle

  23. Brain tissue Aβ42 levels are linked to shunt response in idiopathic normal pressure hydrocephalus

    Abu Hamdeh, S., Virhammar, J., Sehlin, D., Alafuzoff, I., Cesarini, K. G. & Niklas Marklund, 2018, In : Journal of Neurosurgery. 130, 1, p. 121-129 9 p.

    Research output: Contribution to journalArticle

  24. Neurosurgical untethering with or without syrinx drainage results in high patient satisfaction and favorable clinical outcome in post-traumatic myelopathy patients

    Holmström, U., Tsitsopoulos, P. P., Flygt, H., Holtz, A. & Niklas Marklund, 2018, In : Spinal Cord. 56, 9, p. 873-882

    Research output: Contribution to journalArticle

  25. 2017
  26. Current opportunities for clinical monitoring of axonal pathology in traumatic brain injury

    Tsitsopoulos, P. P., Hamdeh, S. A. & Niklas Marklund, 2017 Nov 20, In : Frontiers in Neurology. 8, 599.

    Research output: Contribution to journalReview article

  27. Interleukin-33 Promotes Recruitment of Microglia/Macrophages in Response to Traumatic Brain Injury

    Wicher, G., Wallenquist, U., Lei, Y., Enoksson, M., Li, X., Fuchs, B., Abu Hamdeh, S., Niklas Marklund, Hillered, L., Nilsson, G. & Forsberg-Nilsson, K., 2017 Nov 15, In : Journal of Neurotrauma. 34, 22, p. 3173-3182

    Research output: Contribution to journalArticle

  28. The Swedish study of Irrigation-fluid temperature in the evacuation of Chronic subdural hematoma (SIC!): study protocol for a multicenter randomized controlled trial

    Bartley, A., Jakola, A. S., Bartek, J., Sundblom, J., Förander, P., Niklas Marklund & Tisell, M., 2017 Oct 11, In : Trials. 18, 1, 471.

    Research output: Contribution to journalArticle

  29. Coagulopathy and haemorrhagic progression in traumatic brain injury: advances in mechanisms, diagnosis, and management

    Maegele, M., Schöchl, H., Menovsky, T., Maréchal, H., Niklas Marklund, Buki, A. & Stanworth, S., 2017 Aug 1, In : The Lancet Neurology. 16, 8, p. 630-647 18 p.

    Research output: Contribution to journalReview article

  30. Cerebral amyloid angiopathy: a long-term consequence of traumatic brain injury?

    Niklas Marklund, 2017 Jan, In : Acta Neurochirurgica. 159, 1, p. 21-23 3 p.

    Research output: Contribution to journalArticle

  31. Extended Anatomical Grading in Diffuse Axonal Injury Using MRI: Hemorrhagic Lesions in the Substantia Nigra and Mesencephalic Tegmentum Indicate Poor Long-Term Outcome

    Abu Hamdeh, S., Niklas Marklund, Lannsjö, M., Howells, T., Raininko, R., Wikström, J. & Enblad, P., 2017, In : Journal of Neurotrauma. 34, 2, p. 341-352 12 p.

    Research output: Contribution to journalArticle

  32. Intra- and interregional coregulation of opioid genes: broken symmetry in spinal circuits

    Kononenko, O., Galatenko, V., Andersson, M., Bazov, I., Hiroyuki Watanabe, Zhou, X. W., Iatsyshyna, A., Mityakina, I., Yakovleva, T., Sarkisyan, D., Ponomarev, I., Krishtal, O., Niklas Marklund, Tonevitsky, A., Adkins, D. L. & Bakalkin, G., 2017, In : FASEB Journal. 31, 5, p. 1953-1963

    Research output: Contribution to journalArticle

  33. 2016
  34. Direct imaging of elemental distributions in tissue sections by laser ablation mass spectrometry

    Shariatgorji, M., Nilsson, A., Bonta, M., Gan, J., Niklas Marklund, Clausen, F., Källback, P., Loden, H., Limbeck, A. & Andrén, P. E., 2016 Jul 1, In : Methods. 104, p. 86-92

    Research output: Contribution to journalArticle

  35. Human Traumatic Brain Injury Results in Oligodendrocyte Death and Increases the Number of Oligodendrocyte Progenitor Cells

    Flygt, J., Gumucio, A., Ingelsson, M., Skoglund, K., Holm, J., Alafuzoff, I. & Niklas Marklund, 2016 Jun, In : Journal of Neuropathology and Experimental Neurology. 75, 6, p. 503-15 13 p.

    Research output: Contribution to journalArticle

  36. Targeting coagulation factor XII as a novel therapeutic option in brain trauma

    Hopp, S., Albert-Weissenberger, C., Mencl, S., Bieber, M., Schuhmann, M. K., Stetter, C., Nieswandt, B., Schmidt, P. M., Monoranu, C-M., Alafuzoff, I., Niklas Marklund, Nolte, M. W., Sirén, A-L. & Kleinschnitz, C., 2016 Jun, In : Annals of Neurology. 79, 6, p. 970-82

    Research output: Contribution to journalArticle

  37. Diffuse traumatic axonal injury in mice induces complex behavioural alterations that are normalized by neutralization of interleukin-1β

    Ekmark-Lewén, S., Flygt, J., Fridgeirsdottir, G. A., Kiwanuka, O., Hånell, A., Meyerson, B. J., Mir, A. K., Gram, H., Lewén, A., Clausen, F., Hillered, L. & Niklas Marklund, 2016 Apr, In : European Journal of Neuroscience. 43, 8, p. 1016-33 18 p.

    Research output: Contribution to journalArticle

  38. 2015
  39. Consensus statement from the 2014 International Microdialysis Forum

    Hutchinson, P. J., Jalloh, I., Helmy, A., Carpenter, K. L. H., Rostami, E., Bellander, B-M., Boutelle, M. G., Chen, J. W., Claassen, J., Dahyot-Fizelier, C., Enblad, P., Gallagher, C. N., Helbok, R., Hillered, L., Le Roux, P. D., Magnoni, S., Mangat, H. S., Menon, D. K., Nordström, C-H., O'Phelan, K. H. & 28 othersOddo, M., Perez Barcena, J., Robertson, C., Ronne-Engström, E., Sahuquillo, J., Smith, M., Stocchetti, N., Belli, A., Carpenter, T. A., Coles, J. P., Czosnyka, M., Dizdar, N., Goodman, J. C., Gupta, A. K., Nielsen, T. H., Niklas Marklund, Montcriol, A., O'Connell, M. T., Poca, M. A., Sarrafzadeh, A., Shannon, R. J., Skjøth-Rasmussen, J., Smielewski, P., Stover, J. F., Timofeev, I., Vespa, P., Zavala, E. & Ungerstedt, U., 2015 Sep, In : Intensive Care Medicine. 41, 9, p. 1517-28

    Research output: Contribution to journalArticle

  40. A delayed spinocutaneous fistula after anterior cervical discectomy and fusion

    Tsitsopoulos, P. P. & Niklas Marklund, 2015 Apr 1, In : Spine Journal. 15, 4, p. 783-4 2 p.

    Research output: Contribution to journalDebate/Note/Editorial

  41. 2014
  42. The neurological wake-up test does not alter cerebral energy metabolism and oxygenation in patients with severe traumatic brain injury

    Skoglund, K., Hillered, L., Purins, K., Tsitsopoulos, P. P., Flygt, J., Engquist, H., Lewén, A., Enblad, P. & Niklas Marklund, 2014 Jun, In : Neurocritical Care. 20, 3, p. 413-26 14 p.

    Research output: Contribution to journalArticle

  43. Fibula osteo-adipofascial flap for reconstruction of a cervical spine and posterior pharyngeal wall defect

    Rodriguez-Lorenzo, A., Mani, M. R., Thor, A., Gudjonsson, O., Niklas Marklund, Olerud, C. & Ekberg, T., 2014 May, In : Microsurgery. 34, 4, p. 314-8

    Research output: Contribution to journalArticle

  44. Outcome from spontaneous subarachnoid haemorrhage--results from 2007-2011 and comparison with our previous series

    Ronne-Engström, E., Borota, L., Kothimbakam, R., Niklas Marklund, Lewén, A. & Enblad, P., 2014 Mar, In : Upsala Journal of Medical Sciences. 119, 1, p. 38-43

    Research output: Contribution to journalArticle

  45. Monitoring of β-amyloid dynamics after human traumatic brain injury

    Niklas Marklund, Farrokhnia, N., Hånell, A., Vanmechelen, E., Enblad, P., Zetterberg, H., Blennow, K. & Hillered, L., 2014 Jan 1, In : Journal of Neurotrauma. 31, 1, p. 42-55 14 p.

    Research output: Contribution to journalArticle

  46. Altered expression of myelin-associated inhibitors and their receptors after traumatic brain injury in the mouse

    Israelsson, C., Flygt, J., Åstrand, E., Kiwanuka, O., Bengtsson, H. & Niklas Marklund, 2014, In : Restorative Neurology and Neuroscience. 32, 5, p. 717-31

    Research output: Contribution to journalArticle

  47. Structured evaluation of rodent behavioral tests used in drug discovery research

    Hånell, A. & Niklas Marklund, 2014, In : Frontiers in Behavioral Neuroscience. 8, p. 1-13 252.

    Research output: Contribution to journalArticle

  48. 2013
  49. Improved outcome of patients with severe thalamic hemorrhage treated with cerebrospinal fluid drainage and neurocritical care during 1990-1994 and 2005-2009

    Tsitsopoulos, P. P., Enblad, P., Wanhainen, A., Tobieson, L., Hårdemark, H-G. & Niklas Marklund, 2013 Nov, In : Acta Neurochirurgica. 155, 11, p. 2105-13 9 p.

    Research output: Contribution to journalArticle

  50. Myelin loss and oligodendrocyte pathology in white matter tracts following traumatic brain injury in the rat

    Flygt, J., Djupsjö, A., Lenne, F. & N Marklund, 2013 Jul, In : European Journal of Neuroscience. 38, 1, p. 2153-65 13 p.

    Research output: Contribution to journalArticle

  51. Traumatic axonal injury in the mouse is accompanied by a dynamic inflammatory response, astroglial reactivity and complex behavioral changes

    Ekmark-Lewén, S., Flygt, J., Kiwanuka, O., Meyerson, B. J., Lewén, A., Hillered, L. & Niklas Marklund, 2013 Apr 4, In : Journal of Neuroinflammation. 10, p. 1-19 44.

    Research output: Contribution to journalArticle

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