Olle Melander

Professor, consultant
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  1. 2019
  2. Association of cardiovascular events and lipoprotein particle size: Development of a risk score based on functional data analysis

    Rowland, C. M., Shiffman, D., Caulfield, M., Garcia, V., Olle Melander & Hastie, T., 2019 Mar 7, In : PLoS ONE. 14, 3, e0213172.

    Research output: Contribution to journalArticle

  3. The co-predictive value of a cardiovascular score for CV outcomes in diabetic patients with no atrial fibrillation

    Patti, G., Sticchi, A., Pasceri, V., Fabrizio Ricci, Renda, G., Viktor Hamrefors, Olle Melander, Sutton, R., Gunnar Engström, De Caterina, R. & Artur Fedorowski, 2019 Feb 21, In : Diabetes/Metabolism Research and Reviews. p. 1-9

    Research output: Contribution to journalArticle

  4. The early identification of disease progression in patients with suspected infection presenting to the emergency department: A multi-centre derivation and validation study

    Saeed, K., Wilson, D. C., Bloos, F., Schuetz, P., Van Der Does, Y., Melander, O., Hausfater, P., Legramante, J. M., Claessens, Y. E., Amin, D., Rosenqvist, M., White, G., Mueller, B., Limper, M., Callejo, C. C., Brandi, A., MacChi, M. A., Cortes, N., Kutz, A., Patka, P. & 9 othersYañez, M. C., Bernardini, S., Beau, N., Dryden, M., Van Gorp, E. C. M., Minieri, M., Chan, L., Rood, P. P. M. & Del Castillo, J. G., 2019 Feb 8, In : Critical Care. 23, 1, 40.

    Research output: Contribution to journalArticle

  5. A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria

    Ahluwalia, T. S., Schulz, C. A., Waage, J., Skaaby, T., Sandholm, N., van Zuydam, N., Charmet, R., Bork-Jensen, J., Almgren, P., Thuesen, B. H., Bedin, M., Brandslund, I., Christensen, C. K., Linneberg, A., Ahlqvist, E., Groop, P. H., Hadjadj, S., Tregouet, D. A., Jørgensen, M. E., Grarup, N. & 9 othersPedersen, O., Simons, M., Leif Groop, Marju Orho-Melander, McCarthy, M. I., Olle Melander, Rossing, P., Kilpeläinen, T. O. & Hansen, T., 2019 Feb, In : Diabetologia. 62, 2, p. 292-305

    Research output: Contribution to journalArticle

  6. A genetic risk score for hypertension is associated with risk of thoracic aortic aneurysm

    Tagetti, A., Bonafini, S., T. Ohlsson, G. Engström, Almgren, P., Minuz, P., G. Smith, O. Melander & C. Fava, 2019 Jan 18, In : Journal of Human Hypertension.

    Research output: Contribution to journalArticle

  7. Effect of acute hypohydration on glycemic regulation in healthy adults: A randomized crossover trial

    Carroll, H. A., Templeman, I., Chen, Y. C., Edinburgh, R. M., Burch, E. K., Jewitt, J. T., Povey, G., Robinson, T. D., Dooley, W. L., Jones, R., Tsintzas, K., Gallo, W., Olle Melander, Thompson, D., James, L. J., Johnson, L. & Betts, J. A., 2019, In : Journal of Applied Physiology. 126, 2, p. 422-430 9 p.

    Research output: Contribution to journalArticle

  8. Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development

    Li, Y., Hans Brunnström, Jonas Manjer, Olle Melander, Amos, C. I. & et al., 2019, In : Oncotarget. 10, 19, p. 1760-1774 15 p.

    Research output: Contribution to journalArticle

  9. Modulation of lung cancer cell plasticity and heterogeneity with the restoration of cisplatin sensitivity by neurotensin antibody

    Wu, Z., Fournel, L., Stadler, N., Liu, J., Boullier, A., Hoyeau, N., Fléjou, J. F., Duchatelle, V., Djebrani-Oussedik, N., Agopiantz, M., Ségal-Bendirdjian, E., Gompel, A., Alifano, M., Olle Melander, Trédaniel, J. & Forgez, P., 2019, In : Cancer Letters. 444, p. 147-161 15 p.

    Research output: Contribution to journalArticle

  10. Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

    International Consortium for Blood Pressure, Giri, A., Almgren, P., Olle Melander, Hung, A. M. & Edwards, T. L., 2019, In : Nature Genetics. 51, 1, p. 51-62 12 p.

    Research output: Contribution to journalArticle

  11. 2018
  12. Genome-wide analysis yields new loci associating with aortic valve stenosis

    Helgadottir, A., Thorleifsson, G., Gretarsdottir, S., Stefansson, O. A., Tragante, V., Thorolfsdottir, R. B., Jonsdottir, I., Bjornsson, T., Steinthorsdottir, V., Verweij, N., Nielsen, J. B., Zhou, W., Folkersen, L., Martinsson, A., Heydarpour, M., Prakash, S., Oskarsson, G., Gudbjartsson, T., Geirsson, A., Olafsson, I. & 26 othersSigurdsson, E. L., Almgren, P., Olle Melander, Franco-Cereceda, A., Hamsten, A., Fritsche, L., Lin, M., Yang, B., Hornsby, W., Guo, D., Brummett, C. M., Abecasis, G., Mathis, M., Milewicz, D., Body, S. C., Eriksson, P., Willer, C. J., Hveem, K., Newton-Cheh, C., J. Gustav Smith, Danielsen, R., Thorgeirsson, G., Thorsteinsdottir, U., Gudbjartsson, D. F., Holm, H. & Stefansson, K., 2018 Dec 1, In : Nature Communications. 9, 1, 987.

    Research output: Contribution to journalArticle

  13. Prognostic significance of noncardiac syncope in the general population: A systematic review and meta-analysis

    Fabrizio Ricci, Sutton, R., Palermi, S., Tana, C., Renda, G., Gallina, S., Olle Melander, De Caterina, R. & Artur Fedorowski, 2018 Dec, In : Journal of Cardiovascular Electrophysiology. 29, 12, p. 1641-1647

    Research output: Contribution to journalArticle

  14. Cardiovascular biomarkers predict fragility fractures in older adults

    Madeleine Johansson, Fabrizio Ricci, Di Martino, G., Cecilia Rogmark, Sutton, R., Viktor Hamrefors, Olle Melander & Artur Fedorowski, 2018 Oct 15, In : Heart. 6 p.

    Research output: Contribution to journalArticle

  15. Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality

    C. Fernandez, Rysä, J., Almgren, P., J. Nilsson, G. Engström, M. Orho-Melander, Ruskoaho, H. & O. Melander, 2018 Oct 1, In : Journal of Internal Medicine. 284, 4, p. 377-387 11 p.

    Research output: Contribution to journalArticle

  16. Multi-ethnic genome-wide association study for atrial fibrillation

    Roselli, C., Chaffin, M. D., Weng, L. C., Aeschbacher, S., Ahlberg, G., Albert, C. M., Almgren, P., Alonso, A., Anderson, C. D., Aragam, K. G., Arking, D. E., Barnard, J., Bartz, T. M., Benjamin, E. J., Bihlmeyer, N. A., Bis, J. C., Bloom, H. L., Boerwinkle, E., Bottinger, E. B., Brody, J. A. & 33 othersCalkins, H., Campbell, A., Cappola, T. P., Carlquist, J., Chasman, D. I., Chen, L. Y., Chen, Y. D. I., Choi, E. K., Choi, S. H., Christophersen, I. E., Chung, M. K., Cole, J. W., Conen, D., Cook, J., Crijns, H. J., Cutler, M. J., Damrauer, S. M., Daniels, B. R., Darbar, D., Delgado, G., Denny, J. C., Dichgans, M., Dörr, M., Dudink, E. A., Dudley, S. C., Gustafsson, S., Lindgren, C. M., Olle Melander, Peter Nilsson, Marju Orho-Melander, Lubitz, S. A., Lunetta, K. L. & Ellinor, P. T., 2018 Sep, In : Nature Genetics. 50, 9, p. 1225-1233

    Research output: Contribution to journalArticle

  17. A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes

    van Zuydam, N. R., Emma Ahlqvist, Ladenvall, C., Almgren, P., Christina-Alexandra Schulz, Marju Orho-Melander, Olle Melander, Valeriya Lyssenko, Tuomi, T., Leif C Groop, McCarthy, M. I., Finnish Diabetic Nephropathy Study (FinnDiane), Hong Kong Diabetes Registry Theme-based Research Scheme Project Group, GENIE (Genetics of Nepropathy an International Effort) Consortium, Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group, SUMMIT Consortium & Jasmina Kravic, 2018 Jul, In : Diabetes. 67, 7, p. 1414-1427

    Research output: Contribution to journalArticle

  18. Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

    Gusarova, V., O'Dushlaine, C., Teslovich, T. M., Benotti, P. N., Mirshahi, T., Gottesman, O., Van Hout, C. V., Murray, M. F., Mahajan, A., Nielsen, J. B., Fritsche, L., Wulff, A. B., Gudbjartsson, D. F., Sjögren, M., Emdin, C. A., Scott, R. A., Lee, W-J., Small, A., Kwee, L. C., Dwivedi, O. P. & 61 othersRashmi B Prasad, Bruse, S., Lopez, A. E., Penn, J., Marcketta, A., Leader, J. B., Still, C. D., Kirchner, H. L., Mirshahi, U. L., Wardeh, A. H., Hartle, C. M., Habegger, L., Fetterolf, S. N., Tusie-Luna, T., Morris, A. P., Holm, H., Steinthorsdottir, V., Sulem, P., Thorsteinsdottir, U., Rotter, J. I., Chuang, L-M., Damrauer, S., Birtwell, D., Brummett, C. M., Khera, A. V., Natarajan, P., Marju Orho-Melander, Flannick, J., Lotta, L. A., Willer, C. J., Holmen, O. L., Ritchie, M. D., Ledbetter, D. H., Murphy, A. J., Borecki, I. B., Reid, J. G., Overton, J. D., Ola Hansson, Leif Groop, Shah, S., Kraus, W. E., Rader, D. J., Ida Chen, Y-D., Hveem, K., Wareham, N. J., Kathiresan, S., Olle Melander, Stefansson, K., Nordestgaard, B. G., Tybjaerg-Hansen, A., Abecasis, G. R., Altshuler, D., Florez, J. C., Boehnke, M., McCarthy, M., Yancopoulos, G. D., Carey, D. J., Shuldiner, A. R., Baras, A., Dewey, F. E. & Gromada, J., 2018 Jun 13, In : Nature Communications. 9, p. 1-11 2252.

    Research output: Contribution to journalArticle

  19. A genome-wide association study of IgM antibody against phosphorylcholine: Shared genetics and phenotypic relationship to chronic lymphocytic leukemia

    Chen, X., Gustafsson, S., Whitington, T., Borné, Y., Lorentzen, E., Sun, J., Almgren, P., Su, J., Karlsson, R., Song, J., Lu, Y., Zhan, Y., Hägg, S., Svensson, P., Smedby, K. E., Slager, S. L., Ingelsson, E., Lindgren, C. M., Morris, A. P., Melander, O. & 9 othersKarlsson, T., de Faire, U., Caidahl, K., Gunnar Engström, Lind, L., Karlsson, M. C. I., Pedersen, N. L., Frostegård, J. & Magnusson, P. K. E., 2018 May 15, In : Human Molecular Genetics. 27, 10, p. 1809-1818 10 p.

    Research output: Contribution to journalArticle

  20. Proneurotensin Predicts Cardiovascular Disease in an Elderly Population

    Ayesha Fawad, Bergmann, A., Struck, J., Peter M. Nilsson, Marju Orho-Melander & Olle Melander, 2018 May 1, In : Journal of Clinical Endocrinology and Metabolism. 103, 5, p. 1940-1947 8 p.

    Research output: Contribution to journalArticle

  21. Novel subgroups of adult-onset diabetes and their association with outcomes: A data-driven cluster analysis of six variables

    Ahlqvist, E., Storm, P., Käräjämäki, A., Martinell, M., Dorkhan, M., Carlsson, A., Vikman, P., Prasad, R. B., Aly, D. M., Almgren, P., Wessman, Y., Shaat, N., Spégel, P., Mulder, H., Lindholm, E., Melander, O., Hansson, O., Malmqvist, U., Lernmark, Å., Lahti, K. & 4 othersForsén, T., Tuomi, T., Anders H. Rosengren & Leif Groop, 2018 May, In : The Lancet Diabetes and Endocrinology. 6, 5, p. 361-369

    Research output: Contribution to journalArticle

  22. Neurotensin is a lipid-induced gastrointestinal peptide associated with visceral adipose tissue inflammation in obesity

    Barchetta, I., Cimini, F. A., Capoccia, D., Bertoccini, L., Ceccarelli, V., Chiappetta, C., Leonetti, F., Di Cristofano, C., Silecchia, G., Marju Orho-Melander, Olle Melander & Cavallo, M. G., 2018 Apr 23, In : Nutrients. 10, 4, 526.

    Research output: Contribution to journalArticle

  23. Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies

    Wood, A. M., Kaptoge, S., Butterworth, A., Willeit, P., Warnakula, S., Bolton, T., Paige, E., Paul, D. S., Sweeting, M., Burgess, S., Bell, S., Astle, W., Stevens, D., Koulman, A., Selmer, R. M., Verschuren, W. M. M., Sato, S., Njølstad, I., Woodward, M., Salomaa, V. & 31 othersNordestgaard, B. G., Yeap, B. B., Fletcher, A., Olle Melander, Kuller, L. H., Balkau, B., Marmot, M., Koenig, W., Casiglia, E., Cooper, C., Arndt, V., Franco, O. H., Wennberg, P., Gallacher, J., de la Cámara, A. G., Völzke, H., Dahm, C. C., Dale, C. E., Bergmann, M., Crespo, C., van der Schouw, Y. T., Kaaks, R., Simons, L. A., Lagiou, P., Schoufour, J. D., Boer, J. M. A., Key, T. J., Rodriguez, B., Moreno-Iribas, C., Davidson, K. W. & Emerging Risk Factors Collaboration, 2018 Apr 14, In : The Lancet. 391, 10129, p. 1513-1523 11 p.

    Research output: Contribution to journalArticle

  24. Role of blood lipids in the development of ischemic stroke and its subtypes: A mendelian randomization study

    George Hindy, Gunnar Engström, Larsson, S. C., Traylor, M., Markus, H. S., Olle Melander & Marju Orho-Melander, 2018 Apr 1, In : Stroke. 49, 4, p. 820-827 8 p.

    Research output: Contribution to journalArticle

  25. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

    Malik, R., Chauhan, G., Traylor, M., Sargurupremraj, M., Okada, Y., Mishra, A., Almgren, P., Olle Melander, Gunnar Engström, Arne Lindgren, Hossein Delavaran, Andreea Ilinca, Bo Norrving & MEGASTROKE Consortium, 2018 Apr, In : Nature Genetics. 50, 4, p. 524-537

    Research output: Contribution to journalArticle

  26. Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population

    Li, Y., Xiao, X., Han, Y., Gorlova, O., Qian, D., Leighl, N., Johansen, J. S., Barnett, M., Chen, C., Goodman, G., Cox, A., Taylor, F., Woll, P., Wichmann, H. E., Manz, J., Muley, T., Risch, A., Rosenberger, A., Arnold, S. M., Haura, E. B. & 56 othersBolca, C., Holcatova, I., Janout, V., Kontic, M., Lissowska, J., Mukeria, A., Ognjanovic, S., Orlowski, T. M., Scelo, G., Swiatkowska, B., Zaridze, D., Bakke, P., Skaug, V., Zienolddiny, S., Duell, E. J., Butler, L. M., Houlston, R., Artigas, M. S., Grankvist, K., Johansson, M., Shepherd, F. A., Marcus, M. W., Hans Brunnström, Jonas Manjer, Olle Melander, Muller, D. C., Overvad, K., Trichopoulou, A., Tumino, R., Liu, G., Bojesen, S. E., Wu, X., Marchand, L. L., Albanes, D., Bickeböller, H., Aldrich, M. C., Bush, W. S., Tardon, A., Rennert, G., Dawn Teare, M., Field, J. K., Kiemeney, L. A., Lazarus, P., Haugen, A., Lam, S., Schabath, M. B., Andrew, A. S., Bertazzi, P. A., Pesatori, A. C., Christiani, D. C., Caporaso, N., Johansson, M., McKay, J. D., Brennan, P., Hung, R. J. & Amos, C. I., 2018 Mar 8, In : Carcinogenesis. 39, 3, p. 336-346 11 p.

    Research output: Contribution to journalArticle

  27. Proteomic Profiling for Cardiovascular Biomarker Discovery in Orthostatic Hypotension

    Madeleine Johansson, Fabrizio Ricci, Aung, N., Sutton, R., Olle Melander & Artur Fedorowski, 2018 Mar, In : Hypertension. 71, 3, p. 465-472 8 p.

    Research output: Contribution to journalArticle

  28. Interaction of dietary and genetic factors influencing body iron status and risk of type 2 diabetes within the EPIC-InterAct study

    Meidtner, K., Podmore, C., Kröger, J., Van Der Schouw, Y. T., Bendinelli, B., Agnoli, C., Arriola, L., Barricarte, A., Boeing, H., Cross, A. J., Dow, C., Ekblom, K., Fagherazzi, G., Franks, P. W., Gunter, M. J., Huerta, J. M., Jakszyn, P., Jenab, M., Katzke, V. A., Key, T. J. & 22 othersKhaw, K. T., Kühn, T., Kyrø, C., Mancini, F. R., Olle Melander, Peter M. Nilsson, Overvad, K., Palli, D., Panico, S., Ramón Quirós, J., Rodríguez-Barranco, M., Sacerdote, C., Sluijs, I., Stepien, M., Tjonneland, A., Tumino, R., Forouhi, N. G., Sharp, S. J., Langenberg, C., Schulze, M. B., Riboli, E. & Wareham, N. J., 2018 Feb 1, In : Diabetes Care. 41, 2, p. 277-285 9 p.

    Research output: Contribution to journalArticle

  29. Separate and combined associations of obesity and metabolic health with coronary heart disease: A pan-European case-cohort analysis

    Lassale, C., Tzoulaki, I., Moons, K. G. M., Sweeting, M., Boer, J., Johnson, L., Huerta, J. M., Agnoli, C., Freisling, H., Weiderpass, E., Wennberg, P., Van Der A, D. L., Arriola, L., Benetou, V., Boeing, H., Bonnet, F., Colorado-Yohar, S. M., Engström, G., Eriksen, A. K., Ferrari, P. & 29 othersGrioni, S., Johansson, M., Kaaks, R., Katsoulis, M., Katzke, V., Key, T. J., Matullo, G., Olle Melander, Molina-Portillo, E., Moreno-Iribas, C., Norberg, M., Overvad, K., Panico, S., Quiros, J. R., Saieva, C., Skeie, G., Steffen, A., Stepien, M., Tjønneland, A., Trichopoulou, A., Tumino, R., Van Der Schouw, Y. T., Verschuren, W. M. M., Langenberg, C., Di Angelantonio, E., Riboli, E., Wareham, N. J., Danesh, J. & Butterworth, A. S., 2018 Feb 1, In : European Heart Journal. 39, 5, p. 397-406 10 p.

    Research output: Contribution to journalArticle

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