Oonagh Shannon

Researcher, PhD, Reader in Experimental Infection Medicine, Academy of Medical Scientists, Ireland, PhD, BSc

Research areas and keywords

UKÄ subject classification

  • Medical and Health Sciences
  • Microbiology in the medical area
  • Immunology in the medical area


  • sepsis, Platelets, Streptococcus


Immunomodulatory effects of platelets during inflammation and infection

Platelets are circulating blood cells that priimarily partciptate in blood clotting. The aim of my research is to elucidate the complementary role of platelets in inflammation and bacterial infection. Bacteria that breach the bloodstream can cause invasive infections, such as sepsis and septic shock. A delicately balanced and intercommunicating immune system exists to combat infection, however in sepsis these host defence systems become pathologically augmented and deregulated. Projects within my research group investigate the molecular mechanisms involved in platelet activation in response to bacterial pathogens and inflammatory stimuli, and the subsequent consequences for immune defence systems; leukocytes, endothelial cells and the complement system. The knowledge generated will identify novel targets for diagnosis, prognosis and treatment of severe manifestations of infection and inflammation, such as sepsis.

Recent research outputs

Oonagh Shannon, 2021, In: Research and practice in thrombosis and haemostasis. 5, 1, p. 27-37

Research output: Contribution to journalArticle

Axel Broman, Lotta Happonen, Frida Palm, Oonagh Shannon, Johan Malmström & Thomas Laurell, 2020, MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, p. 148-149 2 p. (MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceeding

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