Oonagh Shannon

Researcher, PhD, Reader in Experimental Infection Medicine, Academy of Medical Scientists, Ireland, PhD, BSc

Research areas and keywords

UKÄ subject classification

  • Medical and Health Sciences
  • Microbiology in the medical area
  • Immunology in the medical area

Keywords

  • sepsis, Platelets, Streptococcus

Research

Immunomodulatory effects of platelets during inflammation and infection

Platelets are circulating blood cells that priimarily partciptate in blood clotting. The aim of my research is to elucidate the complementary role of platelets in inflammation and bacterial infection. Bacteria that breach the bloodstream can cause invasive infections, such as sepsis and septic shock. A delicately balanced and intercommunicating immune system exists to combat infection, however in sepsis these host defence systems become pathologically augmented and deregulated. Projects within my research group investigate the molecular mechanisms involved in platelet activation in response to bacterial pathogens and inflammatory stimuli, and the subsequent consequences for immune defence systems; leukocytes, endothelial cells and the complement system. The knowledge generated will identify novel targets for diagnosis, prognosis and treatment of severe manifestations of infection and inflammation, such as sepsis.

Recent research outputs

Ulrika Lindberg, Svensson, L., Thomas Hellmark, Segelmark, M. & Oonagh Shannon, 2018 Feb 1, In : Thrombosis Research. 162, p. 32-37 6 p.

Research output: Contribution to journalArticle

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