Oxana Klementieva

Associate Senior Lecturer, PhD

Research areas and keywords

UKÄ subject classification

  • Medical and Health Sciences

Keywords

  • Medical and Health Sciences, Neurodegenerative diseases, Protein aggregation, Microspectroscopy

Research

Research Summary/Interest

 Abnormal aggregation of proteins in brain during the course of Alzheimer’s disease and Parkinson’s disease

 

 Ageing of the world’s population has amplified neurodegenerative disorders, of which Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the first and second most common disorders, respectively. Worldwide, nearly 44 million people have Alzheimer’s or a related dementia, and an estimated seven to ten million people have Parkinson’s disease. Both disorders are characterized by the presence of β-sheet enriched aggregates formed by of amyloid proteins, the subsequent damage and loss of neurons, as well as substantial synaptic degradation. AD displays aggregates of insoluble amyloid beta-protein. PD displays aggregates of insoluble α-synuclein.However, the molecular mechanism (or mechanisms) leading to the abnormal accumulation of Aβ and α‑syn remains unknown and as a result, the pathologies of these diseases are poorly understood, and there is at present no effective cure for neurodegenerative memory impairment.

Using infrared microspectroscopy, I developed ultra-sensitive protocol to study amyloid protein aggregation in brain tissue and pioneered novel and ground-breaking evidence of presymptomatic β-sheet enriched aggregates. Now me and my research team want to understand why malignant protein aggregation begins in the brain and how these aggregated proteins spread in the brain.

We investigate the effects of mutual effects of α-synuclein, amyloid-β and tau on their biochemistry, cellular localization and interaction by integrating in vitro and in vivo approaches using synchrotron-based microspectrocopy techniques.

Recent research outputs

Aso, E., Isak Martinsson, Appelhans, D., Effenberg, C., Benseny-Cases, N., Gunnar Gouras, Ferrer, I. & Oxana Klementieva, 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. p. 198-209

Research output: Contribution to journalArticle

O. Klementieva, Mathurin, J., A. Engdahl, Freitas, R., Willen, K., P. Uvdal, Miller, L. M. & G. Gouras, 2018 Oct 29, 2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018. IEEE Computer Society, Vol. 2018-September. 8510376

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceeding

View All (15)