Oxana Klementieva

Associate Senior Lecturer, PhD

Research areas and keywords

UKÄ subject classification

  • Medical and Health Sciences

Keywords

  • Medical and Health Sciences, Neurodegenerative diseases, Protein aggregation, Microspectroscopy

Research

Research Summary/Interest

 Abnormal aggregation of proteins in brain during the course of Alzheimer’s disease and Parkinson’s disease

 

 Ageing of the world’s population has amplified neurodegenerative disorders, of which Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common. Worldwide, nearly 44 million people have Alzheimer’s or a related dementia, and an estimated seven to ten million people have Parkinson’s disease. Both disorders are characterized by the presence of β-sheet enriched aggregates formed by of amyloid proteins, the subsequent damage and loss of neurons, as well as substantial synaptic degradation. AD displays aggregates of insoluble amyloid beta-protein. PD displays aggregates of insoluble α-synucleinHowever, the molecular mechanism (or mechanisms) leading to the abnormal accumulation of Aβ and α‑syn remains unknown and as a result, the pathologies of these diseases are poorly understood, and at present there is no effective cure for neurodegenerative memory impairment.

Using infrared microspectroscopy,  we are developing ultra-sensitive protocols to study amyloid protein aggregation in brain tissue. We pioneered novel and ground-breaking evidence of presymptomatic β-sheet enriched aggregates which appear before plaque and memory decline. Now MMS research team wants to understand why malignant protein aggregation begins in the brain and how these aggregated proteins spread in the brain.

To investigate the mutual effects of α-synuclein, amyloid-β and tau aggregation, we co-use traditional cellular biology approaches and synchrotron-based microspectroscopy techniques.

Recent research outputs

Oxana Klementieva, Sandt, C., Isak Martinsson, Kansiz, M., Gunnar Keppler Gouras & Borondics, F., 2020 Feb 7, In : Advanced Science. 9 p., 1903004.

Research output: Contribution to journalArticle

Benseny-Cases, N., Álvarez-Marimon, E., Aso, E., Carmona, M., Oxana Klementieva, Appelhans, D., Ferrer, I. & Cladera, J., 2020, In : Scientific Reports. 10, 1, 5888.

Research output: Contribution to journalArticle

Oxana Klementieva, 2019 Sep 9, Dendrimers, Dendrons and Dendritic Polymers. Ziemba, B., Franiak-Pietryga, I. & Shcharbin, D. (eds.). London, United Kingdom: InTech Open Access Publisher, Vol. Dendrimers, Dendrons and Dendritic Polymers. p. 1-16 16 p.

Research output: Chapter in Book/Report/Conference proceedingBook chapter

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