Oxana Klementieva

Senior Lecturer, PhD

Research areas and keywords

UKÄ subject classification

  • Medical and Health Sciences

Keywords

  • Medical and Health Sciences, Neurodegenerative diseases, Protein aggregation, Microspectroscopy

Research

Research Summary/Interest

 Abnormal aggregation of proteins in brain during the course of Alzheimer’s disease and Parkinson’s disease

 

 Ageing of the world’s population has amplified neurodegenerative disorders, of which Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common. Worldwide, nearly 44 million people have Alzheimer’s or a related dementia, and an estimated seven to ten million people have Parkinson’s disease. Both disorders are characterized by the presence of β-sheet enriched aggregates formed by of amyloid proteins, the subsequent damage and loss of neurons, as well as substantial synaptic degradation. AD displays aggregates of insoluble amyloid beta-protein. PD displays aggregates of insoluble α-synucleinHowever, the molecular mechanism (or mechanisms) leading to the abnormal accumulation of Aβ and α‑syn remains unknown and as a result, the pathologies of these diseases are poorly understood, and at present there is no effective cure for neurodegenerative memory impairment.

Using infrared microspectroscopy,  we are developing ultra-sensitive protocols to study amyloid protein aggregation in brain tissue. We pioneered novel and ground-breaking evidence of presymptomatic β-sheet enriched aggregates which appear before plaque and memory decline. Now MMS research team wants to understand why malignant protein aggregation begins in the brain and how these aggregated proteins spread in the brain.

To investigate the mutual effects of α-synuclein, amyloid-β and tau aggregation, we co-use traditional cellular biology approaches and synchrotron-based microspectroscopy techniques.

Recent research outputs

Mustafa Kanziz, Alice Spadea, Jayakrupakar Nallala, Cassio Lima, Howbeer Muhamadali, Joanna Denbigh, Jayne Lawrence, Gorkem Bakir, Peter Gardner, Nick Stone, Roy Goodacre, Kathleen Gough & Oxana Klementieva, 2021 Mar 5, In: Advanced Chemical Microscopy for Life Science and Translational Medicine. 11656, 1165617.

Research output: Contribution to journalReview article

Oxana Klementieva, Christophe Sandt, Isak Martinsson, Mustafa Kansiz, Gunnar Keppler Gouras & Ferenc Borondics, 2020 Feb 7, In: Advanced Science. 9 p., 1903004.

Research output: Contribution to journalArticle

View All (21)