Patrik Medstrand

Professor

Research areas and keywords

UKÄ subject classification

  • Microbiology in the medical area
  • Public Health, Global Health, Social Medicine and Epidemiology

Keywords

  • hiv, hcv, drug resistance, molecular epidemiology, diagnostics

Research

The purpose of my research is to investigate the human immunodeficiency virus (HIV) and hepatitis C virus (HCV) genetic diversity, transmission dynamics and drug resistance. I am combining a strong global health component (with active projects in sub-Saharan Africa)  with laboratory investigations and state-of-art computational approaches.

Most-at-risk-populations (MARPs) are a core group and pool for spread into the general population, and for this reason close surveillance of such populations are critical in order to address the epidemics of these viruses in an effective way. Advances in population genetic methods have integrated epidemiological models to accommodate viral sequence data in computational approaches and represent powerful and well established tools for hypothesis testing, estimating evolutionary rates of viruses both within an infected individual and in a population, associate transmissions clusters with sociodemographic data of the hosts and estimate population sizes.

The use of these powerful techniques has greatly improved our understanding of the complex virus-host-population interactions and represents an invaluable asset in studies of viral genetic variability and evolution, and the link to disease progression and drug resistance development.

Monitoring of these epidemics, through genetic characterization of the virus, drug resistance prevalence and the dynamics of the molecular epidemiology will be instrumental for designing novel diagnostic, prevention and treatment interventions, which will be important in the implementation of improved of public health policies.

Recent research outputs

Nader Alaridah, Hallbäck, E. T., Tångrot, J., Niclas Winqvist, Erik Sturegård, Florén-Johansson, K., Jönsson, B., Erik Tenland, Welinder-Olsson, C., Patrik Medstrand, Kaijser, B. & Gabriela Godaly, 2019 Mar 20, In : Scientific Reports. 9, 1, 4931.

Research output: Contribution to journalArticle

Palm, A. A., Lemey, P., Marianne Jansson, Fredrik Månsson, Anders Kvist, Szojka, Z., Biague, A., da Silva, Z. J., Rowland-Jones, S. L., Hans Norrgren, Joakim Esbjörnsson & Patrik Medstrand, 2019 Jan 8, In : mBio. 10, 1, e01245-18.

Research output: Contribution to journalArticle

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