Paul Bourgine

Bone as an Organ system

Bone is a complex Organ offering structural and mechanical support of our body, but also consisting in our principal hematopoietic center. The formation of Bone involves distinct stages, including cartilage, vasculature, bone and bone marrow establishment. Our lab aims at compiling human-specific knowledge on these processes, toward the development of innovative Regenerative Therapies. Precisely, three main research axes are being explored:

(i) Deciphering the cellular/molecularmechanisms involved in Bone formation

(ii) In vitro developmentof 3D Bone models

(iii) Design of 3D biological grafts for skeletal tissue regeneration