Per Ekström

Senior Lecturer, PhD
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  1. 2021
  2. 2020
  3. Cellular mechanisms of hereditary photoreceptor degeneration – Focus on cGMP

    Michael Power, Soumyaparna Das, K. Schütze, Valeria Marigo, Per Ekström & François Paquet-Durand, 2020 Jan, In: Progress in Retinal and Eye Research. 74, 100772.

    Research output: Contribution to journalReview article

  4. 2019
  5. Drug delivery to retinal photoreceptors

    Erico Himawan, Per Ekström, Matej Buzgo, Pieter Gaillard, Einar Stefánsson, Valeria Marigo, Thorsteinn Loftsson & François Paquet-Durand, 2019, In: Drug Discovery Today. 24, 8, p. 1637-1643

    Research output: Contribution to journalReview article

  6. Modulation of Calcium Overload and Calpain Activity

    François Paquet-Durand, Per Ekström & Valeria Marigo, 2019, In: RSC Drug Discovery Series. 2019-January, 66, p. 48-60 13 p.

    Research output: Contribution to journalArticle

  7. Modulation of cGMP-signalling to Prevent Retinal Degeneration

    Valeria Marigo, Per Ekström, Frank Schwede, Andreas Rentsch & François Paquet-Durand, 2019, In: RSC Drug Discovery Series. 2019-January, 66, p. 88-98 11 p.

    Research output: Contribution to journalArticle

  8. 2018
  9. Electrospun nerve guide conduits have the potential to bridge peripheral nerve injuries in vivo.

    Hanna Frost, Tomas Andersson, Sebastian Johansson, Ulrica Englund Johansson, Per Ekström, Lars Dahlin & Fredrik Johansson, 2018 Nov 14, In: Scientific Reports. 8, Article number: 16716, 16716.

    Research output: Contribution to journalArticle

  10. Combination of cGMP analogue and drug delivery system provides functional protection in hereditary retinal degeneration

    Eleonora Vighi, Dragana Trifunovic, Patricia Veiga-Crespo, Andreas Rentsch, Dorit Hoffmann, Ayse Sahaboglu, Torsten Strasser, Manoj Kulkarni, Evelina Bertolotti, Angelique Van Den Heuvel, Tobias Peters, Arie Reijerkerk, Thomas Euler, Marius Ueffing, Frank Schwede, Hans Gottfried Genieser, Pieter Gaillard, Valeria Marigo, Per Ekström & François Paquet-Durand, 2018 Mar 27, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 13, p. E2997-E3006

    Research output: Contribution to journalArticle

  11. 2016
  12. G-CSF prevents caspase 3 activation in Schwann cells after sciatic nerve transection, but does not improve nerve regeneration

    Hanna K Frost, Akira Kodama, Per Ekström & Lars B Dahlin, 2016 Aug 4, In: Neuroscience. 334, p. 55-63 9 p.

    Research output: Contribution to journalArticle

  13. Efficacy of PARP inhibition in Pde6a mutant mouse models for retinitis pigmentosa depends on the quality and composition of individual human mutations

    K Jiao, A Sahaboglu, E Zrenner, M Ueffing, P A R Ekström & F Paquet-Durand, 2016, In: Cell death discovery. 2, 16040 .

    Research output: Contribution to journalArticle

  14. 2014
  15. DNA methylation and differential gene regulation in photoreceptor cell death.

    Pietro Farinelli, A Perera, B Arango-Gonzalez, D Trifunovic, M Wagner, T Carell, M Biel, E Zrenner, S Michalakis, Francois Paquet-Durand & Per Ekström, 2014, In: Cell Death & Disease. 5, e1558.

    Research output: Contribution to journalArticle

  16. How Long Does a Photoreceptor Cell Take to Die? Implications for the Causative Cell Death Mechanisms

    F. Paquet-Durand, A. Sahaboglu, J. Dietter, O. Paquet-Durand, B. Hitzmann, M. Ueffing & Per Ekström, 2014, In: Advances in Experimental Medicine and Biology. 801, p. 575-581

    Research output: Contribution to journalArticle

  17. Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration.

    Blanca Arango-Gonzalez, Dragana Trifunović, Ayse Sahaboglu, Katharina Kranz, Stylianos Michalakis, Pietro Farinelli, Susanne Koch, Fred Koch, Sandra Cottet, Ulrike Janssen-Bienhold, Karin Dedek, Martin Biel, Eberhart Zrenner, Thomas Euler, Per Ekström, Marius Ueffing & Francois Paquet-Durand, 2014, In: PLoS ONE. 9, 11, e112142.

    Research output: Contribution to journalArticle

  18. Knockout of PARG110 confers resistance to cGMP-induced toxicity in mammalian photoreceptors.

    A Sahaboglu, N Tanimoto, S Bolz, M G Garrido, M Ueffing, M W Seeliger, H Löwenheim, Per Ekström & Francois Paquet-Durand, 2014, In: Cell Death & Disease. 5, May 22, e1234.

    Research output: Contribution to journalArticle

  19. Novel In Situ Activity Assays for the Quantitative Molecular Analysis of Neurodegenerative Processes in the Retina

    Per Ekström, M. Ueffing, E. Zrenner & F. Paquet-Durand, 2014, In: Current Medicinal Chemistry. 21, 30, p. 3478-3493

    Research output: Contribution to journalArticle

  20. 2013
  21. Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins

    Dusan Zencak, Karine Schouwey, Danian Chen, Per Ekström, Ellen Tanger, Rod Bremner, Maarten van Lohuizen & Yvan Arsenijevic, 2013, In: Proceedings of the National Academy of Sciences. 110, 7, p. E593-E601

    Research output: Contribution to journalArticle

  22. Retinitis Pigmentosa: Over-expression of anti-ageing protein Klotho in degenerating photoreceptors.

    Pietro Farinelli, Blanca Arango-Gonzalez, Jakob Völkl, Ioana Alesutan, Florian Lang, Eberhart Zrenner, Francois Paquet-Durand & Per Ekström, 2013, In: Journal of Neurochemistry.

    Research output: Contribution to journalArticle

  23. Retinitis pigmentosa: rapid neurodegeneration is governed by slow cell death mechanisms

    A. Sahaboglu, O. Paquet-Durand, J. Dietter, K. Dengler, S. Bernhard-Kurz, Per Ekström, B. Hitzmann, M. Ueffing & F. Paquet-Durand, 2013, In: Cell Death & Disease. 4, e488.

    Research output: Contribution to journalArticle

  24. 2011
  25. Calpain and PARP Activation during Photoreceptor Cell Death in P23H and S334ter Rhodopsin Mutant Rats

    Jasvir Kaur, Stine Mencl, Ayse Sahaboglu, Pietro Farinelli, Theo van Veen, Eberhart Zrenner, Per Ekström, Francois Paquet-Durand & Blanca Arango-Gonzalez, 2011, In: PLoS ONE. 6, 7

    Research output: Contribution to journalArticle

  26. 2010
  27. Antioxidants rescue photoreceptors in rd1 mice: Relationship with thiol metabolism

    Maria Miranda, Emma Arnal, Satpal Ahuja, Raquel Alvarez-Nolting, Rosa Lopez-Pedrajas, Per Ekström, Francisco Bosch-Morell, Theo van Veen & Francisco J. Romero, 2010, In: Free Radical Biology & Medicine. 48, 2, p. 216-222

    Research output: Contribution to journalArticle

  28. Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse

    J. Sancho-Pelluz, Marcel Alavi, A. Sahaboglu, S. Kustermann, Pietro Farinelli, S. Azadi, Theo van Veen, F. J. Romero, F. Paquet-Durand & Per Ekström, 2010, In: Cell Death & Disease. 1

    Research output: Contribution to journalArticle

  29. Human neural progenitor cells promote photoreceptor survival in retinal explants.

    Ulrica Englund Johansson, Camilla Mohlin, Ingela Liljekvist Soltic, Per Ekström & Kjell Johansson, 2010, In: Experimental Eye Research. 90, p. 292-299

    Research output: Contribution to journalArticle

  30. PARP1 Gene Knock-Out Increases Resistance to Retinal Degeneration without Affecting Retinal Function

    Ayse Sahaboglu, Naoyuki Tanimoto, Jasvir Kaur, Javier Sancho-Pelluz, Gesine Huber, Edda Fahl, Blanca Arango-Gonzalez, Eberhart Zrenner, Per Ekström, Hubert Loewenheim, Mathias Seeliger & Francois Paquet-Durand, 2010, In: PLoS ONE. 5, 11

    Research output: Contribution to journalArticle

  31. Photoreceptor rescue and toxicity induced by different calpain inhibitors

    Francois Paquet-Durand, Daniela Sanges, Julianne McCall, Jose Silva, Theo van Veen, Valerio Marigo & Per Ekström, 2010, In: Journal of Neurochemistry. 115, 4, p. 930-940

    Research output: Contribution to journalArticle

  32. 2009
  33. Physiopathology of retinal degeneration in rd1 mouse model of retinitis pigmentosa: TGF-Β1, proteinases and oxidative stress mechanisms

    Sat pal Ahuja, Poonam Ahuja-Jensen, Romeo A. Caffé, Magnus Abrahamson, Per Ekström & Theo Van Veen, 2009 Feb, Retinal Degeneration: Causes, Diagnosis and Treatment. Catlin, R. B. (ed.). Nova Science Publishers, Inc., p. 1-41 41 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  34. Serum-free retinal explant culture system and comparative rescue effects of LEDGF, GST, CNTF, BDNF, NGF, bFGF and antioxidants in the rd1 mouse model of retinitis pigmentosa

    Sat pal Ahuja, Poonam Ahuja-Jensen, Romeo Caffé, Maria Thereza Perez, Per Ekström & Theo Van Veen, 2009 Feb, Retinal Degeneration: Causes, Diagnosis and Treatment. Nova Science Publishers, Inc., p. 263-299 37 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  35. PKG activity causes photoreceptor cell death in two retinitis pigmentosa models

    Francois Paquet-Durand, Stefanie M. Hauck, Theo van Veen, Marius Ueffing & Per Ekström, 2009, In: Journal of Neurochemistry. 108, 3, p. 796-810

    Research output: Contribution to journalArticle

  36. Study of Gene-Targeted Mouse Models of Splicing Factor Gene Prpf31 Implicated in Human Autosomal Dominant Retinitis Pigmentosa (RP)

    Kinga Bujakowska, Cecilia Maubaret, Christina F. Chakarova, Naoyuki Tanimoto, Susanne C. Beck, Edda Fahl, Marian M. Humphries, Paul F. Kenna, Evgeny Makarov, Olga Makarova, Francois Paquet-Durand, Per Ekström, Theo van Veen, Thierry Leveillard, Peter Humphries, Mathias W. Seeliger & Shomi S. Bhattacharya, 2009, In: Investigative Ophthalmology & Visual Science. 50, 12, p. 5927-5933

    Research output: Contribution to journalArticle

  37. 2008
  38. Identification of paracrine neuroprotective candidate proteins by a functional assay-driven proteomics approach

    Stefanie M. Hauck, Christian J. Gloeckner, Margaret E. Harley, Stephanie Schoeffmann, Karsten Boldt, Per Ekström & Marius Ueffing, 2008, In: Molecular & Cellular Proteomics. 7, 7, p. 1349-1361

    Research output: Contribution to journalArticle

  39. Photoreceptor Cell Death Mechanisms in Inherited Retinal Degeneration

    J. Sancho-Pelluz, B. Arango-Gonzalez, S. Kustermann, F. J. Romero, Theo van Veen, E. Zrenner, Per Ekström & F. Paquet-Durand, 2008, In: Molecular Neurobiology. 38, 3, p. 253-269

    Research output: Contribution to journalReview article

  40. rd1 Mouse retina shows an imbalance in the activity of cysteine protease cathepsins and their endogenous inhibitor cystatin C.

    Sat pal Ahuja, Poonam Ahuja Jensen, Leif Johnson, Romeo Caffé, Magnus Abrahamson, Per Ekström & Theo van Veen, 2008, In: Investigative Ophthalmology & Visual Science. 49, 3, p. 1089-1096

    Research output: Contribution to journalArticle

  41. 2007
  42. Calpain activity in retinal degeneration.

    Francois Paquet-Durand, Leif Johnson & Per Ekström, 2007, In: Journal of Neuroscience Research. 85, 4, p. 693-702

    Research output: Contribution to journalReview article

  43. CNTF plus BDNF treatment and neuroprotective pathways in the rd1 mouse retina

    Seifollah Azadi, Leif Johnson, Francois Paquet-Durand, Maria Thereza Perez, Yiqin Zhang, Per Ekström & Theo van Veen, 2007, In: Brain Research. 1129, 1, p. 116-129

    Research output: Contribution to journalArticle

  44. Excessive activation of poly(ADP-ribose) polymerase contributes to inherited photoreceptor degeneration in the retinal degeneration 1 mouse.

    Francois Paquet-Durand, José Silva, Tanuja Talukdar, Leif Johnson, Seifollah Azadi, Theo van Veen, Marius Ueffing, Stefanie M Hauck & Per Ekström, 2007, In: Journal of Neuroscience. 27, 38, p. 10311-10319

    Research output: Contribution to journalArticle

  45. Significant photoreceptor rescue by treatment with a combination of antioxidants in an animal model for retinal degeneration.

    M M Sanz, Leif Johnson, Sat pal Ahuja, Per Ekström, J Romero & Theo van Veen, 2007, In: Neuroscience. 145, 3, p. 1120-1129

    Research output: Contribution to journalArticle

  46. 2006
  47. Calpain is activated in degenerating photoreceptors in the rd1 mouse.

    Francois Paquet-Durand, Seifollah Azadi, Stefanie M Hauck, Marius Ueffing, Theo van Veen & Per Ekström, 2006, In: Journal of Neurochemistry. 96, 3, p. 802-814

    Research output: Contribution to journalArticle

  48. Differential modification of phosducin protein in degenerating rd1 ret is associated with constitutively active CaMKII in rod outer segments.

    Stefanie M Hauck, Per Ekström, Poonam Ahuja Jensen, Sabine Suppman, Francois Paquet-Durand, Theo van Veen & Marius Ueffing, 2006, In: Molecular & Cellular Proteomics. 5, 2, p. 324-336

    Research output: Contribution to journalArticle

  49. rd1 Mouse Retina Shows Imbalance in Cellular Distribution and Levels of TIMP-1/MMP-9, TIMP-2/MMP-2 and Sulfated Glycosaminoglycans.

    Sat pal Ahuja, Poonam Ahuja Jensen, Romeo Caffé, Per Ekström, Magnus Abrahamson & Theo van Veen, 2006, In: Ophthalmic Research. 38, 3, p. 125-136

    Research output: Contribution to journalArticle

  50. Up-regulation and increased phosphorylation of protein kinase C (PKC) delta, mu and theta in the degenerating rd1 mouse retina.

    Seifollah Azadi, Francois Paquet-Durand, Patrik Medstrand, Theo van Veen & Per Ekström, 2006, In: Molecular and Cellular Neuroscience. 31, 4, p. 759-773

    Research output: Contribution to journalArticle

  51. 2005
  52. Decreased glutathione transferase levels in rd1/rd1 mouse retina: Replenishment protects photoreceptors in retinal explants.

    Poonam Ahuja, Romeo Caffé, Sat pal Ahuja, Per Ekström & Theo van Veen, 2005, In: Neuroscience. 131, 4, p. 935-943

    Research output: Contribution to journalArticle

  53. Differential Akt activation in the photoreceptors of normal and rd1 mice.

    Leif Johnson, Theo van Veen & Per Ekström, 2005, In: Cell and Tissue Research. 320, 2, p. 213-222

    Research output: Contribution to journalArticle

  54. 2004
  55. Glutathione S-transferase µ(GST) modifies activities of proteases and levels of cystatin C secreted by mouse retinal explants

    Sat pal Ahuja, Poonam Ahuja Jensen, Romeo Caffé, Per Ekström, Katarina Håkansson, Magnus Abrahamson & Theo van Veen, 2004, In: Investigative Ophthalmology & Visual Science. 45, p. U352-U352

    Research output: Contribution to journalPublished meeting abstract

  56. 2003
  57. Involvement of alpha 7 beta 1 integrin in the conditioning-lesion effect on sensory axon regeneration

    Per Ekström, U Mayer, A Panjwani, D Pountney, J Pizzey & DA Tonge, 2003, In: Molecular and Cellular Neuroscience. 22, 3, p. 383-395

    Research output: Contribution to journalArticle

  58. 2002
  59. 2000
  60. Leukemia inhibitory factor null mice: Unhampered in vitro outgrowth of sensory axons but reduced stimulatory potential by nerve segments

    Per A R Ekström, Nóra Kerekes & Tomas Hökfelt, 2000 Mar 10, In: Neuroscience Letters. 281, 2-3, p. 107-110 4 p.

    Research output: Contribution to journalArticle

  61. 1999
  62. Protein kinase C inhibition has only a transient growth arresting effect on in vitro regenerating mouse sensory neurons

    Peter Wiklund & Per Ekström, 1999 Nov 19, In: Neuroscience Letters. 275, 3, p. 155-158 4 p.

    Research output: Contribution to journalArticle

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