Peter Spégel

Senior Lecturer, Ass Prof
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  1. 2019
  2. Metabolomics Analysis of Nutrient Metabolism in β-Cells

    Peter Spégel & Hindrik Mulder, 2019 Jul 17, In : Journal of Molecular Biology.

    Research output: Contribution to journalReview article

  3. Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production

    Knudsen, J. G., Alexander Hamilton, Ramracheya, R., Tarasov, A. I., Brereton, M., Haythorne, E., Chibalina, M. V., Peter Spégel, Hindrik Mulder, Zhang, Q., Ashcroft, F. M., Adam, J. & Rorsman, P., 2019, In : Cell Metabolism. 29, 2, p. 430-442.e4

    Research output: Contribution to journalArticle

  4. 2018
  5. Population-Level Analysis to Determine Parameters That Drive Variation in the Plasma Metabolite Profiles

    Al-Majdoub, M., Katharina Herzog, Daka, B., Martin Magnusson, Lennart Råstam, Lindblad, U. & Peter Spégel, 2018 Nov 15, In : Metabolites. 8, 4, 78.

    Research output: Contribution to journalArticle

  6. Effect of metformin on plasma metabolite profile in the Copenhagen Insulin and Metformin Therapy (CIMT) trial

    Safai, N., Suvitaival, T., Ali, A., P. Spégel, Al-Majdoub, M., Carstensen, B., Vestergaard, H. & M. Ridderstråle, 2018 Jul, In : Diabetic Medicine. 35, 7, p. 944-953

    Research output: Contribution to journalArticle

  7. Novel subgroups of adult-onset diabetes and their association with outcomes: A data-driven cluster analysis of six variables

    Ahlqvist, E., Storm, P., Käräjämäki, A., Martinell, M., Dorkhan, M., Carlsson, A., Vikman, P., Prasad, R. B., Aly, D. M., Almgren, P., Wessman, Y., Shaat, N., Spégel, P., Mulder, H., Lindholm, E., Melander, O., Hansson, O., Malmqvist, U., Lernmark, Å., Lahti, K. & 4 others, Forsén, T., Tuomi, T., Anders H. Rosengren & Leif Groop, 2018 May, In : The Lancet Diabetes and Endocrinology. 6, 5, p. 361-369

    Research output: Contribution to journalArticle

  8. Glutamine-elicited secretion of glucagon-like peptide 1 is governed by an activated glutamate dehydrogenase

    Andersson, L. E., Shcherbina, L., Al-Majdoub, M., Neelanjan Vishnu, Arroyo, C. B., Carrara, J. A., Claes B. Wollheim, Malin Fex, Hindrik Mulder, Nils Wierup & Peter Spégel, 2018 Mar 1, In : Diabetes. 67, 3, p. 372-384 13 p.

    Research output: Contribution to journalArticle

  9. Probiotic fruit beverages with different polyphenol profiles attenuated early insulin response

    Xu, J., Tommy Jönsson, Plaza, M., Åsa Håkansson, Antonsson, M., Ahrén, I. L., Charlotta Turner, Peter Spégel & Yvonne Granfeldt, 2018 Feb 27, In : Nutrition Journal. 17, 1, 34.

    Research output: Contribution to journalArticle

  10. The pathogenetic role of β-cell mitochondria in type 2 diabetes

    Malin Fex, Nicholas, L. M., Neelanjan Vishnu, Medina, A., Sharoyko, V. V., David G. Nicholls, Peter Spégel & Hindrik Mulder, 2018, In : Journal of Endocrinology. 236, 3, p. R145-R149

    Research output: Contribution to journalReview article

  11. 2017
  12. Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

    Adam, J., Ramracheya, R., Chibalina, M. V., Ternette, N., Hamilton, A., Tarasov, A. I., Zhang, Q., Rebelato, E., Rorsman, N. J. G., Martín-del-Río, R., Lewis, A., Özkan, G., Do, H. W., Spégel, P., Saitoh, K., Kato, K., Igarashi, K., Kessler, B. M., Pugh, C. W., Tamarit-Rodriguez, J. & 8 others, Hindrik Mulder, Clark, A., Frizzell, N., Soga, T., Ashcroft, F. M., Silver, A., Pollard, P. J. & Rorsman, P., 2017 Sep 26, In : Cell Reports. 20, 13, p. 3135-3148 14 p.

    Research output: Contribution to journalArticle

  13. Metabolite profiling of obese individuals before and after a one year weight loss program

    Geidenstam, N., Al-Majdoub, M., M. Ekman, P. Spégel & M. Ridderstråle, 2017 Sep 1, In : International Journal of Obesity. 41, 9, p. 1369-1378 10 p.

    Research output: Contribution to journalArticle

  14. Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes

    Axelsson, A., Mahdi, T., Nenonen, H. A., Singh, T., Hänzelmann, S., Wendt, A., Bagge, A., Reinbothe, T. M., Millstein, J., Yang, X., Zhang, B., Gusmao, E. G., Shu, L., Szabat, M., Tang, Y., Wang, J., Salö, S., Eliasson, L., Artner, I., Fex, M. & 9 others, J D Johnson, C B Wollheim, Derry, J. M. J., Mecham, B., P Spégel, H Mulder, Costa, I. G., E Zhang & Rosengren, A. H., 2017 Jun 6, In : Nature Communications. 8, p. 15652

    Research output: Contribution to journalArticle

  15. NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells

    Santos, L. R. B., Muller, C., de Souza, A. H., Takahashi, H. K., Peter Spégel, Sweet, I. R., Chae, H., Hindrik Mulder & Jonas, J. C., 2017 Jun, In : Molecular Metabolism. 6, 6, p. 535-547 13 p.

    Research output: Contribution to journalArticle

  16. Metabolite profiling of LADA challenges the view of a metabolically distinct subtype

    Al-Majdoub, M., Ali, A., Storm, P., Anders H. Rosengren, Leif Groop & Peter Spégel, 2017 Apr 1, In : Diabetes. 66, 4, p. 806-814 9 p.

    Research output: Contribution to journalArticle

  17. Branched-chain amino acids are associated with odd-chain fatty acids in normoglycaemic individuals

    Al-Majdoub, M., Geidenstam, N., Ali, A., M. Ridderstråle, Storm, P., L. Groop, Louise Bennet & P. Spégel, 2017, In : Diabetes & Metabolism. 43, 5, p. 475-479

    Research output: Contribution to journalLetter

  18. 2016
  19. Glycogen metabolism in the glucose-sensing and supply-driven β-cell

    Andersson, L. E., Nicholas, L. M., Karin Filipsson, Jiangming Sun, Benavente, A. M., Al-Majdoub, M., Malin Fex, Hindrik Mulder & Peter Spégel, 2016 Dec 1, In : FEBS Letters. 590, 23, p. 4242-4251 10 p.

    Research output: Contribution to journalLetter

  20. Discriminative prediction of A-To-I RNA editing events from DNA sequence

    Jiangming Sun, Yang De Marinis, Osmark, P., Singh, P., Bagge, A., Valtat, B., Petter Vikman, Peter Spégel & Hindrik Mulder, 2016 Oct 1, In : PLoS ONE. 11, 10, e0164962.

    Research output: Contribution to journalArticle

  21. 2015
  22. Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes.

    Bennet, H., Balhuizen, A., Medina Benavente, A., Dekker Nitert, M., Ottosson Laakso, E., Essén, S., Peter Spégel, Storm, P., Krus, U., Nils Wierup & Malin Fex, 2015, In : Peptides. 71, p. 113-120

    Research output: Contribution to journalArticle

  23. Characterization of Stimulus-Secretion Coupling in the Human Pancreatic EndoC-βH1 Beta Cell Line.

    Andersson, L., Valtat, B., Bagge, A., Sharoyko, V., David Nicholls, Ravassard, P., Scharfmann, R., Peter Spégel & Hindrik Mulder, 2015, In : PLoS ONE. 10, 3, e0120879.

    Research output: Contribution to journalArticle

  24. Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion

    Stamenkovic, J., Andersson, L., Adriaenssens, A. E., Bagge, A., Sharoyko, V., Gribble, F., Reimann, F., Claes Wollheim, Hindrik Mulder & Peter Spégel, 2015, In : Biochemical Journal. 468, p. 49-63

    Research output: Contribution to journalArticle

  25. Unique and Shared Metabolic Regulation in Clonal β-cells and Primary Islets Derived from Rat Revealed by Metabolomics Analysis.

    Peter Spégel, Andersson, L., Storm, P., Sharoyko, V., Göhring, I., Anders Rosengren & Hindrik Mulder, 2015, In : Endocrinology. 156, 6, p. 1995-2005

    Research output: Contribution to journalArticle

  26. 2014
  27. Genotype-based treatment of type 2 diabetes with an α2A-adrenergic receptor antagonist.

    Tang, Y., Axelsson, A., Peter Spégel, Andersson, L., Hindrik Mulder, Leif Groop, Erik Renström & Anders Rosengren, 2014, In : Science Translational Medicine. 6, 257, p. 257ra139

    Research output: Contribution to journalArticle

  28. Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes.

    Sharoyko, V., Abels, M., Jiangming Sun, Nicholas, L., Mollet, I., Stamenkovic, J., Göhring, I., Malmgren, S., Storm, P., Fadista, J., Peter Spégel, Metodiev, M. D., Larsson, N-G., Lena Eliasson, Nils Wierup & Hindrik Mulder, 2014, In : Human Molecular Genetics. 23, 21, p. 5733-5749

    Research output: Contribution to journalArticle

  29. Metabolite profile deviations in an oral glucose tolerance test-A comparison between lean and obese individuals.

    Geidenstam, N., Peter Spégel, Hindrik Mulder, Karin Filipsson, Martin Ridderstråle & Danielsson, A., 2014, In : Obesity. 22, 11, p. 2388-2395

    Research output: Contribution to journalArticle

  30. 2013
  31. Coordinate changes in histone modifications, mRNA levels and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity.

    Malmgren, S., Peter Spégel, Danielsson, A., Nagorny, C., Andersson, L., Dekker Nitert, M., Martin Ridderstråle, Hindrik Mulder & Charlotte Ling, 2013, In : Journal of Biological Chemistry. 288, 17, p. 11973-11987

    Research output: Contribution to journalArticle

  32. Time-resolved metabolomics analysis of beta-cells implicates the pentose phosphate pathway in the control of insulin release

    Peter Spégel, Sharoyko, V., Göhring, I., Danielsson, A., Malmgren, S., Nagorny, C., Andersson, L., Köck, T., Sharp, G. W. G., Straub, S. G., Claes Wollheim & Hindrik Mulder, 2013, In : Biochemical Journal. 450, p. 595-605

    Research output: Contribution to journalArticle

  33. 2012
  34. Development of a gas chromatography/mass spectrometry based metabolomics protocol by means of statistical experimental design

    Danielsson, A., Moritz, T., Hindrik Mulder & Peter Spégel, 2012, In : Metabolomics. 8, 1, p. 50-63

    Research output: Contribution to journalArticle

  35. NFATc3 Regulates Trypsinogen Activation, Neutrophil Recruitment, and Tissue Damage in Acute Pancreatitis in Mice.

    Awla, D., Zetterqvist, A., Abdulla, A., Camello, C., Lisa Berglund, Peter Spégel, Pozo, M. J., Camello, P. J., Sara Regnér, Maria Gomez & Henrik Thorlacius, 2012, In : Gastroenterology. 143, 5, p. 1352

    Research output: Contribution to journalArticle

  36. 2011
  37. Continuous full filling capillary electrochromatography-electrospraying chromatographic nanoparticles

    Malmstrom, D., Axen, J., Bergquist, J., Viberg, P. & Peter Spégel, 2011, In : Electrophoresis. 32, 2, p. 261-267

    Research output: Contribution to journalArticle

  38. 2010
  39. A distinct metabolic profile at birth identifies children developing type 1 diabetes before 20 years of age

    Daria La Torre, Åke Lernmark, Peter Spégel, Elding Larsson, H., Sten Ivarsson & Oresic, M., 2010, In : Diabetologia. 53, p. 261

    Research output: Contribution to journalPublished meeting abstract

  40. A lipotoxicity model in the INS-1 832/13 beta cell line and the epigenetic alterations induced by it

    Malmgren, S., Sharoyko, V., David Nicholls, Nagorny, C., Peter Spégel, Dekker Nitert, M., Hindrik Mulder & Charlotte Ling, 2010, In : Diabetologia. 53, Suppl. 1, p. 348

    Research output: Contribution to journalPublished meeting abstract

  41. Development and optimization of a metabolomic method for analysis of adherent cell cultures

    Danielsson, A., Moritz, T., Hindrik Mulder & Peter Spégel, 2010, In : Analytical Biochemistry. 404, 1, p. 30-39

    Research output: Contribution to journalArticle

  42. Metabolomic analysis of a human oral glucose tolerance test reveals fatty acids as reliable indicators of regulated metabolism

    Peter Spégel, Danielsson, A., Karl Bacos, Nagorny, C., Moritz, T., Hindrik Mulder & Karin Filipsson, 2010, In : Metabolomics. 6, 1, p. 56-66

    Research output: Contribution to journalArticle

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