Peter Zygmunt

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  1. Article
  2. Oxidation of methionine residues activates the high-threshold heat-sensitive ion channel TRPV2

    Fricke, T. C., Echtermeyer, F., Zielke, J., de la Roche, J., Filipovic, M. R., Claverol, S., Herzog, C., Tominaga, M., Pumroy, R. A., Moiseenkova-Bell, V. Y., Peter M. Zygmunt, Leffler, A. & Eberhardt, M. J., 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 48, p. 24359-24365 7 p.

    Research output: Contribution to journalArticle

  3. The antipyretic effect of paracetamol occurs independent of transient receptor potential ankyrin 1–mediated hypothermia and is associated with prostaglandin inhibition in the brain

    Mirrasekhian, E., Johan L.A. Nilsson, Shionoya, K., Anders Blomgren, Peter M. Zygmunt, Engblom, D., Högestätt, E. D. & Blomqvist, A., 2018, In : FASEB Journal. 32, 10, p. 5751-5759 9 p.

    Research output: Contribution to journalArticle

  4. TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p

    Berrout, J., Kyriakopoulou, E., Moparthi, L., Hogea, A. S., Berrout, L., Ivan, C-E., Lorger, M., Boyle, J. F., Peers, C., Muench, S., Gomez, J. E., Hu, X., Hurst, C., Hall, T., Umamaheswaran, S., Wesley, L., Gagea, M., Shires, M., Manfield, I., Knowles, M. A. & 10 others, Davies, S., Suhling, K., Gonzalez, Y. T., Carragher, N., Macleod, K. G., Abbott, N. J., Calin, G. A., Gamper, N., Peter M. Zygmunt & Timsah, Z., 2017 Dec 1, In : Nature Communications. 8, 1, 983.

    Research output: Contribution to journalArticle

  5. The N-terminal Ankyrin Repeat domain is not required for electrophile and heat activation of the purified mosquito TRPA1 receptor

    Survery, S., Moparthi, L., Per Kjellbom, Högestätt, E. D., Peter M. Zygmunt & Urban Johanson, 2016 Dec 23, In : Journal of Biological Chemistry. 291, 52, p. 26899-26912 14 p.

    Research output: Contribution to journalArticle

  6. Photosensitization in porphyrias and photodynamic therapy involves TRPA1 and TRPV1

    Babes, A., Sauer, S. K., Moparthi, L., Kichko, T. I., Neacsu, C., Namer, B., Filipovic, M., Peter M. Zygmunt, Reeh, P. W. & Fischer, M. J. M., 2016 May 11, In : Journal of Neuroscience. 36, 19, p. 5264-5278 15 p.

    Research output: Contribution to journalArticle

  7. Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity

    Moparthi, L., Kichko, T. I., Eberhardt, M., Högestätt, E. D., Per Kjellbom, Urban Johanson, Reeh, P. W., Leffler, A., Filipovic, M. R. & Peter M Zygmunt, 2016, In : Scientific Reports. 6, 28763.

    Research output: Contribution to journalArticle

  8. Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain.

    Moparthi, L., Survery, S., Kreir, M., Simonsen, C., Per Kjellbom, Högestätt, E., Urban Johanson & Peter Zygmunt, 2014, In : Proceedings of the National Academy of Sciences. 111, 47, p. 16901-16906

    Research output: Contribution to journalArticle

  9. TRPV4-mediated calcium influx and ciliary activity in human native airway epithelial cells.

    Lisa Alenmyr, Lena Uller, Greiff, L., Högestätt, E. & Peter Zygmunt, 2014, In : Basic & Clinical Pharmacology & Toxicology. 114, 2, p. 210-216

    Research output: Contribution to journalArticle

  10. H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway.

    Eberhardt, M., Dux, M., Namer, B., Miljkovic, J., Cordasic, N., Will, C., Kichko, T. I., de la Roche, J., Fischer, M., Suárez, S. A., Bikiel, D., Dorsch, K., Leffler, A., Babes, A., Lampert, A., Lennerz, J. K., Jacobi, J., Martí, M. A., Doctorovich, F., Högestätt, E. & 5 others, Peter Zygmunt, Ivanovic-Burmazovic, I., Messlinger, K., Reeh, P. & Filipovic, M. R., 2014, In : Nature Communications. 5, Jul 15, 4381.

    Research output: Contribution to journalArticle

  11. Monoacylglycerols Activate TRPV1 - A Link between Phospholipase C and TRPV1.

    Peter Zygmunt, Ermund, A., Pouya Movahed Rad, Andersson, D. A., Simonsen, C., Jönsson, B. A., Anders Blomgren, Birnir, B., Bevan, S., Eschalier, A., Mallet, C., Gomis, A. & Högestätt, E., 2013, In : PLoS ONE. 8, 12, e81618.

    Research output: Contribution to journalArticle

  12. Fatty Acid Amide Hydrolase-Dependent Generation of Antinociceptive Drug Metabolites Acting on TRPV1 in the Brain

    Barriere, D. A., Mallet, C., Anders Blomgren, Simonsen, C., Daulhac, L., Libert, F., Chapuy, E., Etienne, M., Högestätt, E., Peter Zygmunt & Eschalier, A., 2013, In : PLoS ONE. 8, 8, e70690.

    Research output: Contribution to journalArticle

  13. TRPA1 Contributes to the Acute Inflammatory Response and Mediates Carrageenan-Induced Paw Edema in the Mouse

    Moilanen, L. J., Laavola, M., Kukkonen, M., Korhonen, R., Leppanen, T., Högestätt, E., Peter Zygmunt, Nieminen, R. M. & Moilanen, E., 2012, In : Scientific Reports. 2, 380.

    Research output: Contribution to journalArticle

  14. Effect of Mucosal TRPV1 Inhibition in Allergic Rhinitis.

    Lisa Alenmyr, Greiff, L., Morgan Andersson, Sterner, O., Peter Zygmunt & Högestätt, E., 2012, In : Basic & Clinical Pharmacology & Toxicology. 110, p. 264-268

    Research output: Contribution to journalArticle

  15. Channels: A TR(i)P in the air.

    Peter Zygmunt, 2011, In : Nature Chemical Biology. 7, 10, p. 661-663

    Research output: Contribution to journalArticle

  16. TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Delta(9)-tetrahydrocannabiorcol

    Andersson, D. A., Gentry, C., Lisa Alenmyr, Killander, D., Lewis, S. E., Andersson, A. S., Bucher, B., Galzi, J-L., Olov Sterner, Bevan, S., Högestätt, E. & Peter Zygmunt, 2011, In : Nature Communications. 2, 551.

    Research output: Contribution to journalArticle

  17. TRPV1 and TRPA1 stimulation induces MUC5B secretion in the human nasal airway in vivo.

    Lisa Alenmyr, Herrmann, A., Högestätt, E., Greiff, L. & Peter Zygmunt, 2011, In : Clinical Physiology and Functional Imaging. 31, 6, p. 435-444

    Research output: Contribution to journalArticle

  18. In vitro TRPV1 activity of piperine derived amides

    Andres Correa, E., Högestätt, E., Olov Sterner, Echeverri, F. & Peter Zygmunt, 2010, In : Bioorganic & Medicinal Chemistry. 18, 9, p. 3299-3306

    Research output: Contribution to journalArticle

  19. TRPV1 in Brain Is Involved in Acetaminophen-Induced Antinociception

    Mallet, C., Barriere, D. A., Ermund, A., Jönsson, B. A., Eschalier, A., Peter Zygmunt & Högestätt, E., 2010, In : PLoS ONE. 5, 9

    Research output: Contribution to journalArticle

  20. Transient receptor potential vanilloid 1, vanilloid 2 and melastatin 8 immunoreactive nerve fibers in human skin from individuals with and without Norrbottnian congenital insensitivity to pain.

    Axelsson, H. E., Minde, J. K., Sonesson, A., Toolanen, G., Högestätt, E. & Peter Zygmunt, 2009, In : Neuroscience. 162, p. 1322-1332

    Research output: Contribution to journalArticle

  21. TRPV1-mediated itch in seasonal allergic rhinitis.

    Lisa Alenmyr, Högestätt, E., Peter Zygmunt & Greiff, L., 2009, In : Allergy. 64, p. 807-810

    Research output: Contribution to journalArticle

  22. Distribution and Function of the Hydrogen Sulfide-Sensitive TRPA1 Ion Channel in Rat Urinary Bladder

    Streng, T., Sturesson, H., Petter Hedlund, Andersson, D. A., Jordt, S-E., Bevan, S., Karl-Erik Andersson, Högestätt, E. & Peter Zygmunt, 2008, In : European Urology. 53, 2, p. 391-399

    Research output: Contribution to journalArticle

  23. Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists.

    Pouya Movahed Rad, Jönsson, B. A., Birnir, B., Wingstrand, J., Dyhring Jørgensen, T., Ermund, A., Olov Sterner, Peter Zygmunt & Högestätt, E., 2005, In : Journal of Biological Chemistry. 280, 46, p. 38496-38504

    Research output: Contribution to journalArticle

  24. Pungent products from garlic activate the sensory ion channel TRPA1

    Bautista, D. M., Pouya Movahed Rad, Hinman, A., Sturesson, H., Olov Sterner, Högestätt, E., Julius, D., Jordt, S. E. & Peter Zygmunt, 2005, In : Proceedings of the National Academy of Sciences. 102, 34, p. 12248-12252

    Research output: Contribution to journalArticle

  25. Conversion of acetaminophen to the bioactive N-acyl phenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system.

    Högestätt, E., Jönsson, B. A., Ermund, A., Andersson, D., Björk, H., Alexander, J. P., Cravatt, B. F., Basbaum, A. I. & Peter Zygmunt, 2005, In : Journal of Biological Chemistry. 280, 36, p. 31405-31412

    Research output: Contribution to journalArticle

  26. Vascular effects of anandamide and N-acylvanillylamines in the human forearm and skin microcirculation.

    Pouya Movahed Rad, Evilevitch, V., Andersson, T., Jönsson, B. A., Per Wollmer, Peter Zygmunt & Högestätt, E., 2005, In : British Journal of Pharmacology. 146, 2, p. 171-179

    Research output: Contribution to journalArticle

  27. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

    Jordt, S-E., Bautista, D. M., Chuang, H., McKemy, D. D., Peter Zygmunt, Högestätt, E., Meng, I. D. & Julius, D., 2004, In : Nature. 427, 6971, p. 260-265

    Research output: Contribution to journalArticle

  28. Δ9-Tetrahydrocannabinol and Cannabinol Activate Capsaicin-Sensitive Sensory Nerves via a CB1 and CB2 Cannabinoid Receptor-Independent Mechanism

    Peter M. Zygmunt, Andersson, D. A. & Högestätt, E. D., 2002 Jun 1, In : Journal of Neuroscience. 22, 11, p. 4720-4727 8 p.

    Research output: Contribution to journalArticle

  29. Mechanisms underlying tissue selectivity of anandamide and other vanilloid receptor agonists.

    Andersson, D., Adner, M., Högestätt, E. & Peter Zygmunt, 2002, In : Molecular Pharmacology. 62, 3, p. 705-713

    Research output: Contribution to journalArticle

  30. The anandamide transport inhibitor AM404 activates vanilloid receptors

    Peter M. Zygmunt, Chuang, H. H., Movahed, P., Julius, D. & Högestätt, E. D., 2000 May 12, In : European Journal of Pharmacology. 396, 1, p. 39-42 4 p.

    Research output: Contribution to journalArticle

  31. Involvement of sensory nerves in vasodilator responses to acetylcholine and potassium ions in rat hepatic artery

    Högestätt, E. D., Johansson, R., Andersson, D. A. & Peter M. Zygmunt, 2000 Jan 1, In : British Journal of Pharmacology. 130, 1, p. 27-32 6 p.

    Research output: Contribution to journalArticle

  32. Differential actions of anandamide, potassium ions and endothelium- derived hyperpolarizing factor in guinea-pig basilar artery

    Peter M. Zygmunt, Sørgård, M., Jesper Petersson, Johansson, R. & Högestätt, E. D., 2000 Jan 1, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 361, 5, p. 535-542 8 p.

    Research output: Contribution to journalArticle

  33. Vanilloid receptors on capsaicin-sensitive sensory nerves mediate relaxation to methanandamide in the rat isolated mesenteric arterial bed and small mesenteric arteries

    Ralevic, V., Kendall, D. A., Randall, M. D., P. M. Zygmunt, Movahed, P. & Högestätt, E. D., 2000 Jan 1, In : British Journal of Pharmacology. 130, 7, p. 1483-1488 6 p.

    Research output: Contribution to journalArticle

  34. Interactions between endothelium-derived relaxing factors in the rat hepatic artery: Focus on regulation of EDHF

    Peter M. Zygmunt, Plane, F., Paulsson, M., Garland, C. J. & Högestätt, E. D., 1998 Jan 1, In : British Journal of Pharmacology. 124, 5, p. 992-1000 9 p.

    Research output: Contribution to journalArticle

  35. Studies on the effects of anandamide in rat hepatic artery

    Peter M. Zygmunt, Högestätt, E. D., Waldeck, K., Edwards, G., Kirkup, A. J. & Weston, A. H., 1997 Dec 1, In : British Journal of Pharmacology. 122, 8, p. 1679-1686 8 p.

    Research output: Contribution to journalArticle

  36. Characterization of the potassium channels involved in EDHF-mediated relaxation in cerebral arteries

    Jesper Petersson, Peter M. Zygmunt & Högestätt, E. D., 1997 Apr 17, In : British Journal of Pharmacology. 120, 7, p. 1344-1350 7 p.

    Research output: Contribution to journalArticle

  37. Involvement of voltage-dependent potassium channels in the EDHF-mediated relaxation of rat hepatic artery

    Peter M. Zygmunt, Edwards, G., Weston, A. H., Larsson, B. & Högestätt, E. D., 1997 Jan 1, In : British Journal of Pharmacology. 121, 1, p. 141-149 9 p.

    Research output: Contribution to journalArticle

  38. Minor components with smooth muscle relaxing properties from scented myrrh (Commiphora guidotti)

    Andersson, M., Ola Bergendorff, Shan, R., Peter Zygmunt & Olov Sterner, 1997, In : Planta Medica. 63, 3, p. 251-254

    Research output: Contribution to journalArticle

  39. Effects of cytochrome P450 inhibitors on EDHF-mediated relaxation in the rat hepatic artery

    Peter M. Zygmunt, Edwards, G., Weston, A. H., Davis, S. C. & Högestätt, E. D., 1996 Jan 1, In : British Journal of Pharmacology. 118, 5, p. 1147-1152 6 p.

    Research output: Contribution to journalArticle

  40. Role of potassium channels in endothelium-dependent relaxation resistant to nitroarginine in the rat hepatic artery

    Peter M. Zygmunt & Högestätt, E. D., 1996 Jan 1, In : British Journal of Pharmacology. 117, 7, p. 1600-1606 7 p.

    Research output: Contribution to journalArticle

  41. Effects of cytochrome P450 inhibitors on potassium currents and mechanical activity in rat portal vein

    Edwards, G., Peter M. Zygmunt, Högestätt, E. D. & Weston, A. H., 1996 Jan 1, In : British Journal of Pharmacology. 119, 4, p. 691-701 11 p.

    Research output: Contribution to journalArticle

  42. Substance P-induced relaxation and hyperpolarization in human cerebral arteries

    Jesper Petersson, Peter M Zygmunt, Brandt, L. & Högestätt, E. D., 1995 Jul, In : British Journal of Pharmacology. 115, 6, p. 889-94

    Research output: Contribution to journalArticle

  43. NANC neurotransmission in lamina propria of the rabbit urethra: regulation by different subsets of calcium channels

    Zygmunt, P. K. E., Peter M. Zygmunt, Högestätt, E. D. & Karl‐Erik Andersson, 1995 Jan 1, In : British Journal of Pharmacology. 115, 6, p. 1020-1026 7 p.

    Research output: Contribution to journalArticle

  44. Regional differences in endothelium‐dependent relaxation in the rat: contribution of nitric oxide and nitric oxide‐independent mechanisms

    P. M. ZYGMUNT, RYMAN, T. & HÖGESTÄTT, E. D., 1995 Jan 1, In : Acta Physiologica Scandinavica. 155, 3, p. 257-266 10 p.

    Research output: Contribution to journalArticle

  45. The endothelium mediates a nitric oxide‐independent hyperpolarization and relaxation in the rat hepatic artery

    P. M. ZYGMUNT, WALDECK, K. & HÖGESTÄTT, E. D., 1994 Dec, In : Acta Physiologica Scandinavica. 152, 4, p. 375-384

    Research output: Contribution to journalArticle

  46. Endothelium‐dependent relaxation resistant to N/ω‐nitro‐L‐arginine in the rat hepatic artery and aorta

    P. M. ZYGMUNT, L. GRUNDEMAR & HÖGESTÄTT, E. D., 1994 Jan 1, In : Acta Physiologica Scandinavica. 152, 1, p. 107-114 8 p.

    Research output: Contribution to journalArticle

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