Philipp Kaldis

Professor
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  1. 2021
  2. Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential

    Li Na Zhao, Mikael Björklund, Matias J Caldez, Jie Zheng & Philipp Kaldis, 2021 Mar 4, In: Oncogene.

    Research output: Contribution to journalReview article

  3. Protective functions of ZO-2/Tjp2 expressed in hepatocytes and cholangiocytes against liver injury and cholestasis

    Jianliang Xu, P Jaya Kausalya, Noémi Van Hul, Matias J Caldez, Shiyi Xu, Alicia Ghia Min Ong, Wan Lu Woo, Safiah Mohamed Ali, Philipp Kaldis & Walter Hunziker, 2021 Jan 16, In: Gastroenterology.

    Research output: Contribution to journalArticle

  4. 2020
  5. Remodelling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division

    Jin Rong Ow, Matias J Cadez, Gözde Zafer, Juat Chin Foo, Hong Yu Li, Soumita Ghosh, Heike Wollmann, Amaury Cazenave-Gassiot, Chee Bing Ong, Markus R Wenk, Weiping Han, Hyungwon Choi & Philipp Kaldis, 2020 Dec 21, In: eLife. 9, e63835.

    Research output: Contribution to journalArticle

  6. PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis

    Slim Mzoughi, Jia Yi Fong, David Papadopoli, Cheryl M. Koh, Laura Hulea, Paolo Pigini, Federico Di Tullio, Giuseppe Andreacchio, Michal Marek Hoppe, Heike Wollmann, Diana Low, Matias J. Caldez, Yanfen Peng, Denis Torre, Julia N. Zhao, Oro Uchenunu, Gabriele Varano, Corina Mihaela Motofeanu, Manikandan Lakshmanan, Shun Xie Teo & 19 others, Cheng Mun Wun, Giovanni Perini, Soo Yong Tan, Chee Bing Ong, Muthafar Al-Haddawi, Ravisankar Rajarethinam, Susan Swee Shan Hue, Soon Thye Lim, Choon Kiat Ong, Dachuan Huang, Siok Bian Ng, Emily Bernstein, Dan Hasson, Keng Boon Wee, Philipp Kaldis, Anand Jeyasekharan, David Dominguez-sola, Ivan Topisirovic & Ernesto Guccione, 2020 Dec 1, In: Nature Communications. 11, 1, 3520.

    Research output: Contribution to journalArticle

  7. Loss of hepatocyte cell division leads to liver inflammation and fibrosis

    Matthew R Dewhurst, Jin Rong Ow, Gözde Zafer, Noémi K M van Hul, Heike Wollmann, Xavier Bisteau, David Brough, Hyungwon Choi & Philipp Kaldis, 2020 Nov 4, In: PLoS Genetics. 16, 11, p. e1009084

    Research output: Contribution to journalArticle

  8. Less-well known functions of cyclin/CDK complexes

    Nathan Palmer & Philipp Kaldis, 2020 Nov, In: Seminars in Cell & Developmental Biology. 107, p. 54-62 9 p.

    Research output: Contribution to journalReview article

  9. Cyclin-dependent kinase 1 is essential for muscle regeneration and overload muscle fiber hypertrophy

    Yutaka Kobayashi, Tomoyuki Tanaka, Mieradilli Mulati, Hiroki Ochi, Shingo Sato, Philipp Kaldis, Toshitaka Yoshii, Atsushi Okawa & Hiroyuki Inose, 2020 Oct 14, In: Frontiers in cell and developmental biology. 8, 564581.

    Research output: Contribution to journalArticle

  10. MetaboKit: a comprehensive data extraction tool for untargeted metabolomics

    Pradeep Narayanaswamy, Guoshou Teo, Jin Rong Ow, Adam Lau, Philipp Kaldis, Stephen Tate & Hyungwon Choi, 2020 Oct 1, In: Molecular omics. 16, 5, p. 436-447 12 p.

    Research output: Contribution to journalArticle

  11. The Greatwall kinase safeguards the genome integrity by affecting the kinome activity in mitosis

    Xavier Bisteau, Joann Lee, Vinayaka Srinivas, Joanna H.S. Lee, Joanna Niska-Blakie, Gifford Tan, Shannon Y.X. Yap, Kevin W. Hom, Cheng Kit Wong, Jeongjun Chae, Loo Chien Wang, Jinho Kim, Giulia Rancati, Radoslaw M. Sobota, Chris S.H. Tan & Philipp Kaldis, 2020 Sep 25, In: Oncogene.

    Research output: Contribution to journalArticle

  12. Cascading proton transfers are a hallmark of the catalytic mechanism of SAM-dependent methyltransferases

    Li Na Zhao & Philipp Kaldis, 2020 Jul, In: FEBS Letters. 594, 13, p. 2128-2139 12 p.

    Research output: Contribution to journalArticle

  13. Cell cycle regulation in NAFLD: when imbalanced metabolism limits cell division: when imbalanced metabolism limits cell division

    Matias J Caldez, Mikael Bjorklund & Philipp Kaldis, 2020 Jul, In: Hepatology international. 14, 4, p. 463-474 12 p.

    Research output: Contribution to journalReview article

  14. Infertility-Causing Haploinsufficiency Reveals TRIM28/KAP1 Requirement in Spermatogonia

    Joel H L Tan, Heike Wollmann, Ans M M van Pelt, Philipp Kaldis & Daniel M Messerschmidt, 2020 Apr 1, In: Stem Cell Reports.

    Research output: Contribution to journalArticle

  15. Role of cyclin-dependent kinase 2 in the progression of mouse juvenile cystic kidney disease

    Jennifer Qin Jing Zhang, Jane Burgess, Daria Stepanova, Sayanthooran Saravanabavan, Annette T Y Wong, Philipp Kaldis & Gopala K Rangan, 2020 Jan 8, In: Laboratory Investigation.

    Research output: Contribution to journalArticle

  16. A novel function for CDK2 activity at meiotic crossover sites

    Nathan Palmer, S Zakiah A Talib, Priti Singh, Christine M F Goh, Kui Liu, John C Schimenti & Philipp Kaldis, 2020, In: PLoS Biology. 18, 10, e3000903.

    Research output: Contribution to journalArticle

  17. 2019
  18. Discovery of a chemical probe for PRDM9

    Abdellah Allali-Hassani, Magdalena M Szewczyk, Danton Ivanochko, Shawna L Organ, Jabez Bok, Jessica Sook Yuin Ho, Florence P H Gay, Fengling Li, Levi Blazer, Mohammad S Eram, Levon Halabelian, David Dilworth, Genna M Luciani, Evelyne Lima-Fernandes, Qin Wu, Peter Loppnau, Nathan Palmer, S Zakiah A Talib, Peter J Brown, Matthieu Schapira & 10 others, Philipp Kaldis, Ronan C O'Hagan, Ernesto Guccione, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, John M Sanders, Solomon D Kattar, D Jonathan Bennett, Benjamin Nicholson & Masoud Vedadi, 2019 Dec 17, In: Nature Communications. 10, 1, p. 1-11 5759.

    Research output: Contribution to journalArticle

  19. Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype

    Joanna Niska-Blakie, Lakshmi Gopinathan, Kia Ngee Low, Yang Lay Kien, Christine M.F. Goh, Matias J. Caldez, Elisabeth Pfeiffenberger, Oliver S. Jones, Chee Bing Ong, Igor V. Kurochkin, Vincenzo Coppola, Lino Tessarollo, Hyungwon Choi, Yoganathan Kanagasundaram, Frank Eisenhaber, Sebastian Maurer-Stroh & Philipp Kaldis, 2019 Nov, In: Cellular and Molecular Life Sciences.

    Research output: Contribution to journalArticle

  20. CDK2 kinase activity is a regulator of male germ cell fate

    Priti Singh, Ravi K Patel, Nathan Palmer, Jennifer K Grenier, Darius Paduch, Philipp Kaldis, Andrew Grimson & John C Schimenti, 2019 Oct 3, In: Development (Cambridge).

    Research output: Contribution to journalArticle

  21. CDK2 regulates the NRF1/Ehmt1 axis during meiotic prophase I

    Nathan Palmer, S Zakiah A Talib, Chandrahas Koumar Ratnacaram, Diana Low, Xavier Bisteau, Joanna Hui Si Lee, Elisabeth Pfeiffenberger, Heike Wollmann, Joel Heng Loong Tan, Sheena Wee, Radoslaw Sobota, Jayantha Gunaratne, Daniel M Messerschmidt, Ernesto Guccione & Philipp Kaldis, 2019 Sep 2, In: Journal of Cell Biology. 218, 9, p. 2896-2918

    Research output: Contribution to journalArticle

  22. The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes

    Victor S Tapia, Michael J D Daniels, Pablo Palazón-Riquelme, Matthew Dewhurst, Nadia M Luheshi, Jack Rivers-Auty, Jack Green, Elena Redondo-Castro, Philipp Kaldis, Gloria Lopez-Castejon & David Brough, 2019 May 24, In: Journal of Biological Chemistry. 294, 21, p. 8325-8335

    Research output: Contribution to journalArticle

  23. Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality

    Radoslaw Szmyd, Joanna Niska-Blakie, M Kasim Diril, Patrícia Renck Nunes, Konstantinos Tzelepis, Aurélie Lacroix, Noémi van Hul, Lih-Wen Deng, Joao Matos, Oliver Dreesen, Xavier Bisteau & Philipp Kaldis, 2019 Feb, In: Oncogene. 38, 7, p. 998-1018

    Research output: Contribution to journalArticle

  24. Diverse roles for CDK-associated activity during spermatogenesis

    Nathan Palmer, S Zakiah A Talib & Philipp Kaldis, 2019, In: FEBS Letters. 593, 20, p. 2925-2949

    Research output: Contribution to journalReview article

  25. 2018
  26. Loss of cyclin-dependent kinase 1 impairs bone formation, but does not affect the bone-anabolic effects of parathyroid hormone

    Akira Takahashi, Mieradili Mulati, Masanori Saito, Hoashi Numata, Yutaka Kobayashi, Hiroki Ochi, Shingo Sato, Philipp Kaldis, Atsushi Okawa & Hiroyuki Inose, 2018 Dec 14, In: Journal of Biological Chemistry. 293, 50, p. 19387-19399

    Research output: Contribution to journalArticle

  27. Metabolic Remodeling during Liver Regeneration

    Matias J Caldez, Noémi Van Hul, Hiromi W L Koh, Xing Qi Teo, Jun Jun Fan, Peck Yean Tan, Matthew R Dewhurst, Peh Gek Too, S Zakiah A Talib, Beatrice E Chiang, Walter Stünkel, Hanry Yu, Philip Lee, Tobias Fuhrer, Hyungwon Choi, Mikael Björklund & Philipp Kaldis, 2018 Nov 19, In: Developmental Cell. 47, 4, p. 425-438

    Research output: Contribution to journalArticle

  28. Dual roles of TRF1 in tethering telomeres to the nuclear envelope and protecting them from fusion during meiosis

    Lina Wang, Zhaowei Tu, Chao Liu, Hongbin Liu, Philipp Kaldis, Zijiang Chen & Wei Li, 2018 Jun, In: Cell Death and Differentiation. 25, 6, p. 1174-1188 15 p.

    Research output: Contribution to journalArticle

  29. Modulation of Protein-Interaction States through the Cell Cycle

    Lingyun Dai, Tianyun Zhao, Xavier Bisteau, Wendi Sun, Nayana Prabhu, Yan Ting Lim, Radoslaw M Sobota, Philipp Kaldis & Pär Nordlund, 2018 May 31, In: Cell. 173, 6, p. 1481-1494

    Research output: Contribution to journalArticle

  30. Genetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death

    Quentin Marlier, Florian Jibassia, Sébastien Verteneuil, Jérôme Linden, Philipp Kaldis, Laurent Meijer, Laurent Nguyen, Renaud Vandenbosch & Brigitte Malgrange, 2018 Mar 16, In: Cell death discovery. 4, 43, p. 1-12

    Research output: Contribution to journalArticle

  31. Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells

    Chris Soon Heng Tan, Ka Diam Go, Xavier Bisteau, Lingyun Dai, Chern Han Yong, Nayana Prabhu, Mert Burak Ozturk, Yan Ting Lim, Lekshmy Sreekumar, Johan Lengqvist, Vinay Tergaonkar, Philipp Kaldis, Radoslaw M Sobota & Pär Nordlund, 2018 Mar 9, In: Science (New York, N.Y.). 359, 6380, p. 1170-1177 8 p.

    Research output: Contribution to journalArticle

  32. 2017
  33. CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays

    Christian Windpassinger, Juliette Piard, Carine Bonnard, Majid Alfadhel, Shuhui Lim, Xavier Bisteau, Stéphane Blouin, Nur'Ain B. Ali, Alvin Yu Jin Ng, Hao Lu, Sumanty Tohari, S. Zakiah A. Talib, Noémi van Hul, Matias J. Caldez, Lionel Van Maldergem, Gökhan Yigit, Hülya Kayserili, Sameh A. Youssef, Vincenzo Coppola, Alain de Bruin & 17 others, Lino Tessarollo, Hyungwon Choi, Verena Rupp, Katharina Roetzer, Paul Roschger, Klaus Klaushofer, Janine Altmüller, Sudipto Roy, Byrappa Venkatesh, Rudolf Ganger, Franz Grill, Farid Ben Chehida, Bernd Wollnik, Umut Altunoglu, Ali Al Kaissi, Bruno Reversade & Philipp Kaldis, 2017 Sep 7, In: American Journal of Human Genetics. 101, 3, p. 391-403 13 p.

    Research output: Contribution to journalArticle

  34. Cell size control – a mechanism for maintaining fitness and function

    Teemu P. Miettinen, Matias J. Caldez, Philipp Kaldis & Mikael Björklund, 2017 Sep, In: BioEssays. 39, 9, 1700058.

    Research output: Contribution to journalReview article

  35. Cyclin-dependent kinasedependent phosphorylation of Sox2 at serine 39 regulates neurogenesis

    Shuhui Lim, Akshay Bhinge, Sara Bragado Alonso, Irene Aksoy, Julieta Aprea, Chit Fang Cheok, Federico Calegari, Lawrence W. Stanton & Philipp Kaldis, 2017 Aug, In: Molecular and Cellular Biology. 37, 16, e00201-17.

    Research output: Contribution to journalArticle

  36. Emi2 Is Essential for Mouse Spermatogenesis

    Lakshmi Gopinathan, Radoslaw Szmyd, Diana Low, M. Kasim Diril, Heng Yu Chang, Vincenzo Coppola, Kui Liu, Lino Tessarollo, Ernesto Guccione, Ans M.M. van Pelt & Philipp Kaldis, 2017 Jul 18, In: Cell Reports. 20, 3, p. 697-708 12 p.

    Research output: Contribution to journalArticle

  37. Loss of cyclin-dependent kinase 2 in the pancreas links primary β-cell dysfunction to progressive depletion of β-cell mass and diabetes

    So Yoon Kim, Ji Hyeon Lee, Matthew J. Merrins, Oksana Gavrilova, Xavier Bisteau, Philipp Kaldis, Leslie S. Satin & Sushil G. Rane, 2017 Mar 3, In: Journal of Biological Chemistry. 292, 9, p. 3841-3853 13 p.

    Research output: Contribution to journalArticle

  38. MASTL is essential for anaphase entry of proliferating primordial germ cells and establishment of female germ cells in mice

    Sanjiv Risal, Jingjing Zhang, Deepak Adhikari, Xiaoman Liu, Jingchen Shao, Mengwen Hu, Kiran Busayavalasa, Zhaowei Tu, Zijiang Chen, Philipp Kaldis & Kui Liu, 2017 Feb 7, In: Cell Discovery. 3, 16052.

    Research output: Contribution to journalArticle

  39. Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase i independent of Cdk2 activation

    Zhaowei Tu, Mustafa Bilal Bayazit, Hongbin Liu, Jingjing Zhang, Kiran Busayavalasa, Sanjiv Risal, Jingchen Shao, Ande Satyanarayana, Vincenzo Coppola, Lino Tessarollo, Meenakshi Singh, Chunwei Zheng, Chunsheng Han, Zijiang Chen, Philipp Kaldis, Jan Åke Gustafsson & Kui Liu, 2017 Jan 17, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 3, p. 592-597 6 p.

    Research output: Contribution to journalArticle

  40. 2016
  41. Cyclin A2 regulates erythrocyte morphology and numbers

    Senthil Raja Jayapal, Heather Yin Kuan Ang, Chelsia Qiuxia Wang, Xavier Bisteau, Matias J. Caldez, Gan Xiao Xuan, Weimiao Yu, Vinay Tergaonkar, Motomi Osato, Bing Lim & Philipp Kaldis, 2016 Nov 16, In: Cell Cycle. 15, 22, p. 3070-3081 12 p.

    Research output: Contribution to journalArticle

  42. Impairing Cohesin Smc1/3 Head Engagement Compensates for the Lack of Eco1 Function

    Roland G. Huber, Irina Kulemzina, Keven Ang, Alap P. Chavda, Sasikala Suranthran, Jun Thing Teh, Dimitar Kenanov, Gaowen Liu, Giulia Rancati, Radoslaw Szmyd, Philipp Kaldis, Peter J. Bond & Dmitri Ivanov, 2016 Nov 1, In: Structure. 24, 11, p. 1991-1999

    Research output: Contribution to journalArticle

  43. Inhibitory phosphorylation of Cdk1 mediates prolonged prophase I arrest in female germ cells and is essential for female reproductive lifespan

    Deepak Adhikari, Kiran Busayavalasa, Jingjing Zhang, Mengwen Hu, Sanjiv Risal, Mustafa Bilal Bayazit, Meenakshi Singh, M. Kasim Diril, Philipp Kaldis & Kui Liu, 2016 Oct 21, In: Cell Research. 26, 11, p. 1212-1225

    Research output: Contribution to journalArticle

  44. Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint

    M. Kasim Diril, Xavier Bisteau, Mayumi Kitagawa, Matias J. Caldez, Sheena Wee, Jayantha Gunaratne, Sang Hyun Lee & Philipp Kaldis, 2016 Sep 15, In: PLoS Genetics. 12, 9, p. 1-26 e1006310.

    Research output: Contribution to journalArticle

  45. Quo Vadis cell growth and division?

    Philipp Kaldis, 2016 Aug 30, In: Frontiers in cell and developmental biology. 4, AUG, 95.

    Research output: Contribution to journalDebate/Note/Editorial

  46. The Speedy A, Cdk2, p27 triangle

    Matthew R. Dewhurst & Philipp Kaldis, 2016 Feb 16, In: Cell Cycle. 15, 4, p. 489-490

    Research output: Contribution to journalDebate/Note/Editorial

  47. Cdk2 catalytic activity is essential for meiotic cell division in vivo

    Sangeeta Chauhan, M. Kasim Diril, Joanna H.S. Lee, Xavier Bisteau, Vanessa Manoharan, Deepak Adhikari, Chandrahas Koumar Ratnacaram, Baptiste Janela, Juliane Noffke, Florent Ginhoux, Vincenzo Coppola, Kui Liu, Lino Tessarollo & Philipp Kaldis, 2016 Jan 1, In: Biochemical Journal. 473, 18, p. 2783-2798 16 p.

    Research output: Contribution to journalArticle

  48. Regulation of the Embryonic Cell Cycle During Mammalian Preimplantation Development

    N. Palmer & P. Kaldis, 2016 Jan 1, Mammalian Preimplantation Development, 2016. De Pamphilis, M. L. (ed.). Academic Press, p. 1-53 (Current Topics in Developmental Biology; vol. 120).

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  49. The indispensable role of cyclin-dependent kinase 1 in skeletal development

    Masanori Saito, Mieradili Mulati, S. Zakiah A. Talib, Philipp Kaldis, Shu Takeda, Atsushi Okawa & Hiroyuki Inose, 2016 Jan 1, In: Scientific Reports. 6, 20622.

    Research output: Contribution to journalArticle

  50. 2015
  51. A haploid genetic screen identifies the G1/S regulatory machinery as a determinant of Wee1 inhibitor sensitivity

    Anne Margriet Heijink, Vincent A. Blomen, Xavier Bisteau, Fabian Degener, Felipe Yu Matsushita, Philipp Kaldis, Floris Foijer & Marcel A.T.M. Van Vugt, 2015 Dec 8, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 49, p. 15160-15165

    Research output: Contribution to journalArticle

  52. TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression

    Victor Ho, Tong Seng Lim, Justin Lee, Jeffrey Steinberg, Radoslaw Szmyd, Muly Tham, Jadegoud Yaligar, Philipp Kaldis, Jean Pierre Abastado & Valerie Chew, 2015 Jul 23, In: Oncotarget. 6, 29, p. 27252-27266

    Research output: Contribution to journalArticle

  53. Hematopoiesis specific loss of Cdk2 and Cdk4 results in increased erythrocyte size and delayed platelet recovery following stress

    Senthil Raja Jayapal, Chelsia Qiuxia Wang, Xavier Bisteau, Matias J. Caldez, Shuhui Lim, Vinay Tergaonkar, Motomi Osato & Philipp Kaldis, 2015 Apr, In: Haematologica. 100, 4, p. 431-438

    Research output: Contribution to journalArticle

  54. Mastl/PP2A regulate Cdk1 in ooycte maturation

    Deepak Adhikari, Kui Liu & Philipp Kaldis, 2015 Jan 1, In: Oncotarget. 6, 22, p. 18734-18735 2 p.

    Research output: Contribution to journalReview (Book/Film/Exhibition/etc.)

  55. MEN1 tumorigenesis in the pituitary and pancreatic islet requires CDK4 but not Cdk2

    M. P. Gillam, D. Nimbalkar, L. Sun, K. Christov, D. Ray, P. Kaldis, X. Liu & H. Kiyokawa, 2015, In: Oncogene. 34, 7, p. 932-938

    Research output: Contribution to journalArticle

  56. 2014
  57. Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II

    Deepak Adhikari, M. Kasim Diril, Kiran Busayavalasa, Sanjiv Risal, Shoma Nakagawa, Rebecca Lindkvist, Yan Shen, Vincenzo Coppola, Lino Tessarollo, Nobuaki R. Kudo, Philipp Kaldis & Kui Liu, 2014 Sep 29, In: Journal of Cell Biology. 206, 7, p. 843-853

    Research output: Contribution to journalArticle

  58. Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis

    Lakshmi Gopinathan, Shawn Lu Wen Tan, V. C. Padmakumar, Vincenzo Coppola, Lino Tessarollo & Philipp Kaldis, 2014 Jul, In: Cancer Research. 74, 14, p. 3870-3879 10 p.

    Research output: Contribution to journalArticle

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