Roland Andersson

Professor, consultant

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology
  • Medical and Health Sciences

Keywords

  • Pancreatic cancer , targeted therapy, diagnosis

Research

Pancreatic ductal adenocarcinoma (PDAC) is the fourth cause of cancer-related death, prognosticated to become the second cause if no breakthroughs occur. There is a need for improvement in early diagnosis, as well as improved and tumor-directed therapy. Risk groups exist like hereditary forms, and the association with diabetes mellitus type 2. 80 % of PDAC patients have a new onset diabetes mellitus type 2, or are in a prediabetic state.

Patients are usually asymptomatic or have vague symptoms. The novel biomarkers for PDAC, combined with carbohydrate antigen 19-9 renders an AUC of 0.95. To our knowledge, this is the best diagnostic test described in PDAC. The test has been patented (PCT). We have several sets of validation, first in Sweden/ Scandinavia (about 250 patients), internationally (European; at least 600 patients), and under discussion a Chinese validation. We will evaluate if the diagnostic panel is expressed in serum in asymptomatic patients later developing PDAC, but with new onset diabetes mellitus.

We have developed a novel, ELISA-based, pancreatic cancer diagnostic serum test. Results so far are most promising and may render a breakthrough in diagnosis and thereby outcome of PDAC. Improved biomarker knowledge in cancer tissue will also provide novel biomarkers both for prognosis – treatment prediction/outcome, as well as goals for targeted and tumor-specific treatment.

Highlighted research outputs

D. Ansari, Bauden, M., Bergström, S., Rylance, R., G. Marko-Varga & R. Andersson, 2017 Apr, In : British Journal of Surgery. 104, 5, p. 600-607

Research output: Contribution to journalArticle

Bauden, M., Pamart, D., Daniel Ansari, Herzog, M., Eccleston, M., Micallef, J., Bodil Andersson & Roland Andersson, 2015, In : Clinical Epigenetics. 7, 106.

Research output: Contribution to journalArticle

Daniel Ansari, Roland Andersson, Bauden, M., Bodil Andersson, Connolly, J. B., Charlotte Welinder, Sasor, A. & Marko-Varga, G., 2015, In : Journal of Cancer Research and Clinical Oncology. 141, 2, p. 369-380

Research output: Contribution to journalArticle

Daniel Ansari, Gustafsson, A. & Roland Andersson, 2015, In : World Journal of Gastroenterology. 21, 11, p. 3157-3165

Research output: Contribution to journalDebate/Note/Editorial

Daniel Ansari, Urey, C., Said Hilmersson, K., Bauden, M., Fredrik Ek, Roger Olsson & Roland Andersson, 2014, In : Anticancer research. 34, 10, p. 5269-5276

Research output: Contribution to journalArticle

Daniel Ansari, Urey, C., Gundewar, C., Bauden, M. & Roland Andersson, 2013, In : Scandinavian Journal of Gastroenterology. 48, 10, p. 1183-1187

Research output: Contribution to journalArticle

Gundewar, C., Sasor, A., Said Hilmersson, K., Roland Andersson & Daniel Ansari, 2015, In : Scandinavian Journal of Gastroenterology. 50, 9, p. 1170-1174

Research output: Contribution to journalArticle

Ghatnekar, O., Roland Andersson, Greiff Svensson, M., Ulf Persson, Ringdahl, U., Zeilon, P. & Carl Borrebaeck, 2013, In : International Journal of Cancer. 133, 10, p. 2392-2397

Research output: Contribution to journalArticle

Daniel Ansari, Bobby Tingstedt & Roland Andersson, 2013, In : Acta Oncologica. 52, 6, p. 1146-1151

Research output: Contribution to journalArticle

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