Ruben Smith

affiliated with the university, House officer, Skåne University Hospital (AT-läkare), PhD-student, Unit for Neuronal Survival, Lund University, Registrar in Neurology, Skåne University Hospital, PhD
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  1. 2020
  2. Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease

    Vogel, J. W., Iturria-Medina, Y., Olof T. Strandberg, Ruben Smith, Levitis, E., Evans, A. C., Oskar Hansson, Alzheimer’s Disease Neuroimaging Initiative, Swedish BioFinder Study, Jimmy Lätt, Markus Nilsson, Freddy Ståhlberg, Pia Maly Sundgren, Danielle van Westen, Jonas Jögi, Douglas Hägerström, Olsson, T. G. & Per Wollmer, 2020 May 26, In : Nature Communications. 11, 2612.

    Research output: Contribution to journalArticle

  3. Plasma P-tau181 in Alzheimer’s disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer’s dementia

    Shorena Janelidze, Niklas Mattsson, Sebastian Palmqvist, Ruben Smith, Beach, T. G., Serrano, G. E., Chai, X., Proctor, N. K., Eichenlaub, U., Zetterberg, H., Blennow, K., Reiman, E. M., Erik Stomrud, Dage, J. L. & Oskar Hansson, 2020 Mar 2, In : Nature Medicine. 26, 3, p. 379-386 8 p.

    Research output: Contribution to journalArticle

  4. Assessment of Demographic, Genetic, and Imaging Variables Associated with Brain Resilience and Cognitive Resilience to Pathological Tau in Patients with Alzheimer Disease

    Rik Ossenkoppele, Lyoo, C. H., Jonas Jester-Broms, Sudre, C. H., Cho, H., Ryu, Y. H., Choi, J. Y., Ruben Smith, Olof Strandberg, Sebastian Palmqvist, Kramer, J., Boxer, A. L., Gorno-Tempini, M. L., Miller, B. L., La Joie, R., Rabinovici, G. D. & Oskar Hansson, 2020 Feb 24, In : JAMA Neurology.

    Research output: Contribution to journalArticle

  5. Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease

    Rik Ossenkoppele, Lyoo, C. H., Sudre, C. H., Danielle van Westen, Cho, H., Ryu, Y. H., Choi, J. Y., Ruben Smith, Olof Strandberg, Sebastian Palmqvist, Westman, E., Tsai, R., Kramer, J., Boxer, A. L., Gorno-Tempini, M. L., La Joie, R., Miller, B. L., Rabinovici, G. D. & Oskar Hansson, 2020 Feb, In : Alzheimer's and Dementia. 16, 2, p. 335-344 10 p.

    Research output: Contribution to journalArticle

  6. Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease

    Shorena Janelidze, Erik Stomrud, Ruben Smith, Sebastian Palmqvist, Niklas Mattsson, Airey, D. C., Proctor, N. K., Chai, X., Shcherbinin, S., Sims, J. R., Triana-Baltzer, G., Theunis, C., Slemmon, R., Mercken, M., Kolb, H., Dage, J. L. & Oskar Hansson, 2020, In : Nature Communications. 11, 1, 1683.

    Research output: Contribution to journalArticle

  7. No symphony without bassoon and piccolo: Changes in synaptic active zone proteins in Huntington's disease

    Huang, T. T., Ruben Smith, Karl Bacos, Song, D. Y., Faull, R. M., Waldvogel, H. J. & Jia Yi Li, 2020, In : Acta neuropathologica communications. 8, 1, 77.

    Research output: Contribution to journalArticle

  8. 2019
  9. Regional times to equilibria and their impact on semi-quantification of [18F]AV-1451 uptake

    Heurling, K., Ruben Smith, Olof T. Strandberg, Schain, M., Ohlsson, T., Oskar Hansson & Michael Schöll, 2019 Nov 1, In : Journal of Cerebral Blood Flow and Metabolism. 39, 11, p. 2223-2232 10 p.

    Research output: Contribution to journalArticle

  10. A Deep Learning Approach to MR-less Spatial Normalization for Tau PET Images

    Alvén, J., Heurling, K., Ruben Smith, Olof Strandberg, Michael Schöll, Oskar Hansson & Kahl, F., 2019 Oct 10, Medical Image Computing and Computer Assisted Intervention : MICCAI 2019 - 22nd International Conference, Proceedings. Shen, D., Yap, P-T., Liu, T., Peters, T. M., Khan, A., Staib, L. H., Essert, C. & Zhou, S. (eds.). Springer Nature Switzerland AG, p. 355-363 9 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 11765 LNCS).

    Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceeding

  11. 18 F-Flortaucipir in TDP-43 associated frontotemporal dementia

    R. Smith, A. F. Santillo, M. Landqvist Waldö, O. Strandberg, D. Berron, S. Vestberg, D. van Westen, van Swieten, J., Honer, M. & O. Hansson, 2019 Apr 15, In : Scientific Reports. 9, 1, 6082.

    Research output: Contribution to journalArticle

  12. 2018
  13. Discriminative accuracy of [18F]flortaucipir positron emission tomography for Alzheimer disease vs other neurodegenerative disorders

    Ossenkoppele, R., Rabinovici, G. D., Smith, R., Cho, H., Scholl, M., Strandberg, O., Palmqvist, S., Mattsson, N., Janelidze, S., Santillo, A., Ohlsson, T., Jogi, J., Tsai, R., La Joie, R., Kramer, J., Boxer, A. L., Gorno-Tempini, M. L., Miller, B. L., Choi, J. Y., Ryu, Y. H. & 2 others, Lyoo, C. H. & Oskar Hansson, 2018 Sep 18, In : JAMA - Journal of the American Medical Association. 320, 11, p. 1151-1162 12 p.

    Research output: Contribution to journalArticle

  14. Comparing 18 F-AV-1451 with CSF t-tau and p-tau for diagnosis of Alzheimer disease

    Niklas Mattsson, Ruben Smith, Olof Strandberg, Sebastian Palmqvist, Michael Schöll, Philip S. Insel, Douglas Hägerström, Ohlsson, T., Zetterberg, H., Blennow, K., Jonas Jögi & Oskar Hansson, 2018 Jan 30, In : Neurology. 90, 5, p. e388-e395

    Research output: Contribution to journalArticle

  15. 2017
  16. Distinct 18F-AV-1451 tau PET retention patterns in early- and late-onset Alzheimer's disease

    Michael Schöll, Ossenkoppele, R., Olof Strandberg, Sebastian Palmqvist, Jonas Jögi, Ohlsson, T., Ruben Smith, Oskar Hansson & The Swedish BioFINDER study, 2017 Sep 1, In : Brain. 140, 9, p. 2286-2294 9 p.

    Research output: Contribution to journalArticle

  17. In vivo retention of (18)F-AV-1451 in corticobasal syndrome

    Ruben Smith, Michael Schöll, Håkan Widner, Danielle van Westen, Svenningsson, P., Douglas Hägerström, Ohlsson, T., Jonas Jögi, Nilsson, C. & Oskar Hansson, 2017 Aug 22, In : Neurology. 89, 8, p. 845-853 9 p.

    Research output: Contribution to journalArticle

  18. Increased basal ganglia binding of 18F-AV-1451 in patients with progressive supranuclear palsy

    Ruben Smith, Schain, M., Nilsson, C., Olof Strandberg, Olsson, T., Douglas Hägerström, Jonas Jögi, Borroni, E., Michael Schöll, Honer, M. & Oskar Hansson, 2017 Jan, In : Movement Disorders. 32, 1, p. 108-114

    Research output: Contribution to journalArticle

  19. Tau neuropathology correlates with FDG-PET, but not AV-1451-PET, in progressive supranuclear palsy

    Ruben Smith, Michael Schöll, Honer, M., Nilsson, C. F., Elisabet Englund & Oskar Hansson, 2017 Jan, In : Acta Neuropathologica. 133, 1, p. 149-151

    Research output: Contribution to journalArticle

  20. Modeling strategies for quantification of in vivo 18F-AV1451 binding in patients with tau pathology

    Hahn, A., Schain, M., Erlandsson, M., Sjölin, P., James, G., Olof Strandberg, Douglas Hägerström, Lanzenberger, R., Jonas Jögi, Olsson, T. G., Ruben Smith & Oskar Hansson, 2017, In : Journal of Nuclear Medicine. 58, 4, p. 623-631

    Research output: Contribution to journalArticle

  21. 2016
  22. 18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology in MAPT mutation carriers

    Ruben Smith, Andreas Puschmann, Michael Schöll, Ohlsson, T., Van Swieten, J., Honer, M., Elisabet Englund & Oskar Hansson, 2016 Sep 1, In : Brain. 139, 9, p. 2372-2379 8 p.

    Research output: Contribution to journalArticle

  23. 2015
  24. The role of pallidal serotonergic function in Parkinson's disease dyskinesias: a positron emission tomography study.

    Ruben Smith, Wu, K., Hart, T., Loane, C., Brooks, D. J., Anders Björklund, Per Odin, Piccini, P. & Politis, M., 2015, In : Neurobiology of Aging. 36, 4, p. 1736-1742

    Research output: Contribution to journalArticle

  25. 2013
  26. NGF rescues hippocampal cholinergic neuronal markers, restores neurogenesis, and improves the spatial working memory in a mouse model of Huntington's Disease

    Zhang, H., Petit, G., Gaughwin, P., Christian Hansen, Ranganathan, S., Zuo, X., Ruben Smith, Laurent Roybon, Brundin, P., Mobley, W. C. & Jia-Yi Li, 2013 Jan 1, In : Journal of Huntington's disease. 2, 1, p. 69-82

    Research output: Contribution to journalArticle

  27. 2009
  28. Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment

    Maynard, C. J., Bottcher, C., Ortega, Z., Ruben Smith, Florea, B. I., Diaz-Hernandez, M., Brundin, P., Overkleeft, H. S., Jia-Yi Li, Lucas, J. J. & Dantuma, N. P., 2009, In : Proceedings of the National Academy of Sciences. 106, 33, p. 13986-13991

    Research output: Contribution to journalArticle

  29. Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion.

    Ruben Smith, Karl Bacos, Fedele, V., Soulet, D., Jones, H., Obermüller, S., Lindqvist, A., Maria Björkqvist, Klein, P., Patrik Önnerfjord, Brundin, P., Hindrik Mulder & Jia-Yi Li, 2009, In : Human Molecular Genetics. 18, 20, p. 3942-3954

    Research output: Contribution to journalArticle

  30. 2008
  31. Increased metabolism in the R6/2 mouse model of Huntington's disease.

    van der Burg, J. M., Karl Bacos, Wood, N. I., Andreas Lindqvist, Nils Wierup, Woodman, B., Wamsteeker, J., Ruben Smith, Tomas Deierborg, Kuhar, M. J., Bates, G. P., Hindrik Mulder, Charlotte Erlanson-Albertsson, Morton, J., Brundin, P., Åsa Petersén & Maria Björkqvist, 2008, In : Neurobiology of Disease. 29, 1, p. 41-51

    Research output: Contribution to journalArticle

  32. 2007
  33. Communication breakdown - synaptic dysfunction in Huntington's disease.

    Ruben Smith, 2007, Ruben Smith, Inst. för Experimentell Medicinsk Vetenskap, Lunds Universitet.

    Research output: ThesisDoctoral Thesis (compilation)

  34. Loss of SNAP-25 and rabphilin 3a in sensory-motor cortex in Huntington's disease.

    Ruben Smith, Klein, P., Koc-Schmitz, Y., Waldvogel, H. J., Faull, R. L. M., Brundin, P., Plomann, M. & Li, J-Y., 2007, In : Journal of Neurochemistry. 103, 1, p. 115-123

    Research output: Contribution to journalArticle

  35. 2006
  36. Cholinergic neuronal defect without cell loss in Huntington's disease.

    Ruben Smith, Chung, H., Rundquist, S., Maat-Schieman, M. L. C., Colgan, L., Elisabet Englund, Liu, Y-J., Roos, R. A. C., Faull, R. L. M., Brundin, P. & Jia-Yi Li, 2006, In : Human Molecular Genetics. 15, 21, p. 3119-3131

    Research output: Contribution to journalArticle

  37. 2005
  38. Orexin loss in Huntington's disease.

    Åsa Petersén, Gil, J., Maat-Schieman, M. L. C., Maria Björkqvist, Tanila, H., Araújo, I. M., Ruben Smith, Popovic, N., Nils Wierup, Norlén, P., Jia-Yi Li, Roos, R. A., Sundler, F., Hindrik Mulder & Brundin, P., 2005, In : Human Molecular Genetics. 14, 1, p. 39-47

    Research output: Contribution to journalArticle

  39. Synaptic dysfunction in Huntington's disease: a new perspective

    Ruben Smith, Brundin, P. & Jia-Yi Li, 2005, In : Cellular and Molecular Life Sciences. 62, 17, p. 1901-1912

    Research output: Contribution to journalReview article

  40. 2003
  41. Fria radikaler och sjuka proteiner - bovarna bakom Parkinsons sjukdom?[Free radicals and ailing proteins - the culprits behind Parkinson’s disease?]

    Ruben Smith, Lotharius, J. & Brundin, P., 2003, In : Läkartidningen. 100, 15, p. 1324-6, 1329

    Research output: Contribution to journalArticle