Research areas and keywords
UKÄ subject classification
- Cancer and Oncology
- B cell lymphomas, SOX11, antibody-based therapy
Cancer Target Group– transcriptional analysis, functional genomics and molecular screening in lymphoid proliferative disorders
Haematological malignancies are heterogeneous in terms of response to treatment and survival within groups of patients. Thus, transcriptional profiling is one tool that can be used to successfully subgroup these malignancies into clinically relevant entities that among others can be related to differences in survival. We use a strategy where transcriptional profiling is used to pin-point important genes and corresponding proteins for further functional analysis, association to clinical parameters and development of antibodies with the aim to improve diagnostics and therapeutic success for patients afflicted by B cell lymphomas. In this process, we have performed several research efforts related to the overexpression of SOX11 in mantle cell lymphoma (MCL) and other malignancies.
Highlighted research outputs
Research output: Contribution to journal › Article