Sara Ek

Professor

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Keywords

  • B cell lymphomas, SOX11, antibody-based therapy

Research

Cancer Target Group– transcriptional analysis, functional genomics and molecular screening in lymphoid proliferative disorders
Haematological malignancies are heterogeneous in terms of response to treatment and survival within groups of patients. Thus, transcriptional profiling is one tool that can be used to successfully subgroup these malignancies into clinically relevant entities that among others can be related to differences in survival. We use a strategy where transcriptional profiling is used to pin-point important genes and corresponding proteins for further functional analysis, association to clinical parameters and development of antibodies with the aim to improve diagnostics and therapeutic success for patients afflicted by B cell lymphomas. In this process, we have performed several research efforts related to the overexpression of SOX11 in mantle cell lymphoma (MCL) and other malignancies.

Highlighted research outputs

Sara Ek, Andreasson, U., Hober, S., Kampf, C., Ponten, F., Uhlen, M., Merz, H. & Carl Borrebaeck, 2006, In : Molecular & Cellular Proteomics. 5, 6, p. 1072-1081

Research output: Contribution to journalArticle

Conrotto, P., Andreasson, U., Venera Kuci, Carl Borrebaeck & Sara Ek, 2011, In : Molecular Oncology. 5, p. 527-537

Research output: Contribution to journalArticle

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