Satpal Ahuja

affiliated with the university, MVSc, PhD (Biochemistry), FNAVS (India)

Research areas and keywords

UKÄ subject classification

  • Ophthalmology

Research

Retinitis pigmentosa (RP) and other inherited retinal degenerative diseases are responsible for blindness in the humans. RP, a representative blinding disease, is characterized by slow death of photoreceptors and / or associated retinal cells. Death of such cells leads to retinal degeneration and progressive blindness. Therefore, an understanding of the pathophysiological processes involved in retinal development and degeneration, at biochemical / molecular level, is needed to identify diagnostic markers and to develop rational therapies to minimize the impact of RP. We use retinal degeneration 1 (rd1) mouse, an experimental animal model for RP, for this purpose. Since the year 2000, I have been associated with the studies investigating the role of proteinases / proteinase inhibitors; oxidative stress / antioxidants; and glycans / glycan associated proteins in the retinal pathophysiology using rd1 mice as compared to the control wild type (wt) mice.

Current interest:

Glycans conjugated to rd1 retinal proteins are modified during retinal development and degeneration and possibly regulate the electrophysiological function of the retina. So identification of the glycans and glycan associated glycoproteins and understanding of their role in retinal pathophysiology is of interest, to identify diagnostic marker(s) and to develop rational therapies for retinal degenerative diseases. Relevance of such studies becomes important for ophthalmic and other inherited diseases as the recent gene therapy approach using the CRISPR-Cas emphasizes replacement of proteins without consideration for the role of glycan(s) associated with glycoproteins. 

Recent research outputs

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