Sofie Mohlin

Associate Researcher, PhD, Engineer, MScFormer name: Sofie Johnsson

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology
  • Pediatrics
  • Cell and Molecular Biology
  • Developmental Biology
  • Cell Biology

Keywords

Research

My research aims to understand how, when, where and why childhood tumor form neuroblastoma (NB) and adult tumor forms paraganglioma and phenochromocytoma (PPGLs) develop during normal embryogenesis. NB and PPGLs originate from cells of the sympathetic nervous system (SNS) and locate along the sympathetic and parasympathetic ganglia, most commonly within the abdominal region. The SNS in turn derives from the neural crest, an ephemeral structure that arises during nervous system formation during embryogenesis of all vertebrates.

 

I use chick embryos as my main model system, an excellent equivalent to human embryogenesis at corresponding stages of neural crest development. My projects are divided into creating novel embryonic tumor models and investigating the role of disease-associated genes and proteins during normal development to understand their potential role in tumor initation and progression.

 

Childhood tumors are difficult to detect and the majority of patients with high-risk tumors die from their disease or experience severe late effects from heavy treatment. Understanding the origin and transforming events of these tumors can lead to earlier detection of tumors and treatment at earlier stages of tumor progression, increasing the chances of successful treatment and less side effects.

Recent research outputs

Sofie Mohlin, Kunttas, E., Persson, C. U., Abdel-Haq, R., Castillo, A., Murko, C., Bronner, M. E. & Kerosuo, L., 2019 Jan 18, In : Developmental Biology.

Research output: Contribution to journalArticle

Kerosuo, L., Neppala, P., Hsin, J., Sofie Mohlin, Vieceli, F. M., Török, Z., Laine, A., Westermarck, J. & Bronner, M. E., 2018 Jul 31, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 31, p. E7351-E7360

Research output: Contribution to journalArticle

Hamidian, A., Marica Vaapil, Kristoffer von Stedingk, Fujita, T., Persson, C. U., Pontus Eriksson, Srinivas Veerla, De Preter, K., Speleman, F., Fujii, H., Sven Påhlman & Sofie Mohlin, 2018 May 5, In : Biochemical and Biophysical Research Communications. 499, 2, p. 291-298 8 p.

Research output: Contribution to journalArticle

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