Sofie Singbrant

ResearcherFormer name: Sofie Singbrant Söderberg

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Keywords

  • Myelodysplastic syndrome (MDS), Anemia, Hematoietic stem cells (HSC)

Research

Anemia, the lack of red blood cells, results in too little oxygen being transported to the cells. Anemia is associated with rising age, systemic infections and inflammations. Furthermore, the majority of cancer patients get anemic either from disease or treatment, which results in reduced survival and quality of life of the patients. Current treatments for anemia include blood transfusions and injections of the hormone Erythropoietin (EPO). However, repeated blood transfusions result in iron over-load with severe side effects, and many forms of anemia do not respond EPO. Furthermore, clinical trials have reported reduced survival during EPO-treatment of cancer patients, resulting in revised guidelines for its use during cancer therapy. It is therefore important to find new ways to enhance red blood cell production. The overall aim of our research is to derive conceptually novel means to treat anemia with the goal to improve quality of life and survival of patients.

The blood system is constantly renewed and every day about 1 trillion new blood cells are formed, the majority of which are red blood cells. This ultimately depends on a small number of hematopoietic stem cells that are able to both self-renew to maintain the stem cell pool, and to mature into all types of mature blood cells. Part of our research is focused on understanding how anemia affects the ability of hematopoietic stem cells to provide balanced production of all blood lineages.

Recent research outputs

Gundry, M. C., Dever, D. P., David Yudovich, Bauer, D. E., Haas, S., Wilkinson, A. C. & Sofie Singbrant, 2017, In : Experimental Hematology.

Research output: Contribution to journalArticle

Sandra Capellera-Garcia, Pulecio, J., Dhulipala, K., Siva, K., Rayon-Estrada, V., Sofie Singbrant, Mikael N E Sommarin, Walkley, C. R., Shamit Soneji, Göran Karlsson, Raya, Á., Sankaran, V. G. & Johan Flygare, 2016 Jun 14, In : Cell Reports. 15, 11, p. 2550-2562 13 p.

Research output: Contribution to journalArticle

Sofie Singbrant, van Galen, P., Lucas, D., Challen, G., Rossi, D. J. & Daley, G. Q., 2015, In : Experimental Hematology. 43, 9, p. 756-759

Research output: Contribution to journalArticle

View All (17)