Thoas Fioretos

Professor, consultant
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  1. 2021
  2. Single-cell sequencing in translational cancer research and challenges to meet clinical diagnostic needs

    Ulrich Pfisterer, Julia Bräunig, Per Brattås, Markus Heidenblad, Göran Karlsson & Thoas Fioretos, 2021 Jul 1, In: Genes, Chromosomes and Cancer. 60, 7, p. 504-524 21 p.

    Research output: Contribution to journalReview article

  3. Clinical and genomic characterization of patients diagnosed with the provisional entity Acute myeloid leukemia with BCR-ABL1, a Swedish population-based study

    Christina Orsmark-Pietras, Niklas Landberg, Fryderyk Lorenz, Bertil Uggla, Martin Höglund, Sören Lehmann, Åsa Derolf, Stefan Deneberg, Petar Antunovic, Jörg Cammenga, Lars Möllgård, Lovisa Wennström, Henrik Lilljebjörn, Marianne Rissler, Thoas Fioretos & Vladimir Lj Lazarevic, 2021 Jun 1, In: Genes, Chromosomes and Cancer. 60, 6, p. 426-433 8 p.

    Research output: Contribution to journalArticle

  4. Trailblazing precision medicine in Europe: A joint view by Genomic Medicine Sweden and the Centers for Personalized Medicine, ZPM, in Germany

    GMS working groups and ZPM working groups GMS working groups and ZPM working groups, 2021, (Accepted/In press) In: Seminars in Cancer Biology.

    Research output: Contribution to journalArticle

  5. 2020
  6. 13q12.2 deletions in acute lymphoblastic leukemia lead to upregulation of FLT3 through enhancer hijacking

    Minjun Yang, Setareh Safavi, Eleanor L Woodward, Nicolas Duployez, Linda Olsson-arvidsson, Jonas Ungerbäck, Mikael Sigvardsson, Marketa Zaliova, Jan Zuna, Thoas Fioretos, Bertil Johansson, Karolin H Nord & Kajsa Paulsson, 2020 Aug 20, In: Blood. 136, 8, p. 946-956 11 p.

    Research output: Contribution to journalArticle

  7. A high-content cytokine screen identifies myostatin propeptide as a positive regulator of primitive chronic myeloid leukemia cells

    Sofia von Palffy, Niklas Landberg, Carl Sandén, Dimitra Zacharaki, Mansi Shah, Naoto Nakamichi, Nils Hansen, Maria Askmyr, Henrik Lilljebjörn, Marianne Rissler, Christine Karlsson, Stefan Scheding, Johan Richter, Connie J. Eaves, Ravi Bhatia, Marcus Järås & Thoas Fioretos, 2020, In: Haematologica. 105, 8, p. 2095-2104 10 p.

    Research output: Contribution to journalArticle

  8. 2019
  9. PAX5 is part of a functional transcription factor network targeted in lymphoid leukemia

    Kazuki Okuyama, Tobias Strid, Jacob Kuruvilla, Rajesh Somasundaram, Susana Cristobal, Emma Smith, Mahadesh Prasad, Thoas Fioretos, Henrik Lilljebjörn, Shamit Soneji, Stefan Lang, Jonas Ungerbäck & Mikael Sigvardsson, 2019 Aug 1, In: PLoS Genetics. 15, 8, e1008280.

    Research output: Contribution to journalArticle

  10. Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia

    Minjun Yang, Mattias Vesterlund, Ioannis Siavelis, Larissa H. Moura-Castro, Anders Castor, Thoas Fioretos, Rozbeh Jafari, Henrik Lilljebjörn, Duncan T. Odom, Linda Olsson, Naveen Ravi, Eleanor L. Woodward, Louise Harewood, Janne Lehtiö & Kajsa Paulsson, 2019 Apr 3, In: Nature Communications. 10, 1, 1519.

    Research output: Contribution to journalArticle

  11. Genetic profiling of a chondroblastoma-like osteosarcoma/malignant phosphaturic mesenchymal tumor of bone reveals a homozygous deletion of CDKN2A, intragenic deletion of DMD, and a targetable FN1-FGFR1 gene fusion

    Karim H Saba, Louise Cornmark, Marianne Rissler, Thoas Fioretos, Kristina Åström, Felix Haglund, Andrew E Rosenberg, Otte Brosjö & Karolin H Nord, 2019, In: Genes, Chromosomes and Cancer. 58, 10, p. 731-736

    Research output: Contribution to journalArticle

  12. 2018
  13. A field guide for cancer diagnostics using cell-free DNA: From principles to practice and clinical applications

    Anna Lena Volckmar, Holger Sültmann, Anja Riediger, Thoas Fioretos, Peter Schirmacher, Volker Endris, Albrecht Stenzinger & Steffen Dietz, 2018 Mar 1, In: Genes Chromosomes and Cancer. 57, 3, p. 123-139 17 p.

    Research output: Contribution to journalReview article

  14. Mutation, methylation, and gene expression profiles in dup(1q)-positive pediatric B-cell precursor acute lymphoblastic leukemia

    Rebeqa Gunnarsson, Sebastian Dilorenzo, Kristina B. Lundin-Ström, Linda Olsson, Andrea Biloglav, Henrik Lilljebjörn, Marianne Rissler, Per Wahlberg, Anders Lundmark, Anders Castor, Mikael Behrendtz, Thoas Fioretos, Kajsa Paulsson, Anders Isaksson & Bertil Johansson, 2018, In: Leukemia. 32, 10, p. 2117-2125

    Research output: Contribution to journalArticle

  15. Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases

    Jian Feng Li, Yu Ting Dai, Henrik Lilljebjörn, Shu Hong Shen, Bo Wen Cui, Ling Bai, Yuan Fang Liu, Mao Xiang Qian, Yasuo Kubota, Hitoshi Kiyoi, Itaru Matsumura, Yasushi Miyazaki, Linda Olsson, Ah Moy Tan, Hany Ariffin, Jing Chen, Junko Takita, Takahiko Yasuda, Hiroyuki Mano, Bertil Johansson & 8 others, Jun J. Yang, Allen Eng Juh Yeoh, Fumihiko Hayakawa, Zhu Chen, Ching Hon Pui, Thoas Fioretos, Sai Juan Chen & Jin Yan Huang, 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 50, p. E11711-E11720

    Research output: Contribution to journalArticle

  16. 2017
  17. Agonistic targeting of TLR1/TLR2 induces p38 MAPK-dependent apoptosis and NFκB-dependent differentiation of AML cells

    Mia Eriksson, Pablo Peña-Martínez, Ramprasad Ramakrishnan, Marion Chapellier, Carl Högberg, Gabriella Glowacki, Christina Orsmark-Pietras, Talía Velasco-Hernández, Vladimir Lj Lazarević, Gunnar Juliusson, Jörg Cammenga, James C Mulloy, Johan Richter, Thoas Fioretos, Benjamin L Ebert & Marcus Järås, 2017 Oct 24, In: Blood Advances. 1, 23, p. 2046-2057 12 p.

    Research output: Contribution to journalArticle

  18. Transgenic expression of human cytokines in immunodeficient mice does not facilitate myeloid expansion of BCR-ABL1 transduced human cord blood cells

    Maria Askmyr, Sofia Von Palffy, Nils Hansen, Niklas Landberg, Carl Högberg, Marianne Rissler, Helena Ågerstam & Thoas Fioretos, 2017 Oct 1, In: PLoS ONE. 12, 10, e0186035.

    Research output: Contribution to journalArticle

  19. Loss of the tumor suppressor gene AIP mediates the browning of human brown fat tumors

    Linda Magnusson, Nils Hansen, Karim H Saba, Jenny Nilsson, Thoas Fioretos, Pehr Rissler & Karolin Hansén Nord, 2017 Oct, In: Journal of Pathology. 243, 2, p. 160-164

    Research output: Contribution to journalArticle

  20. New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia

    Henrik Lilljebjörn & Thoas Fioretos, 2017 Sep 21, In: Blood. 130, 12, p. 1395-1401

    Research output: Contribution to journalReview article

  21. Distinct global binding patterns of the Wilms' tumor gene 1 (WT1) -KTS and +KTS isoforms in leukemic cells

    Tove Ullmark, Linnea Järvstråt, Carl Sanden, Giorgia Montano, Helena Jernmark-Nilsson, Henrik Lilljebjörn, Andreas Lennartsson, Thoas Fioretos, Kristina Drott, Karina Vidovic, Björn Nilsson & Urban Gullberg, 2017, In: Haematologica. 102, 2, p. 336-345

    Research output: Contribution to journalArticle

  22. Gain-of-function SAMD9L mutations cause a syndrome of cytopenia, immunodeficiency, MDS and neurological symptoms

    Bianca Tesi, Josef Davidsson, Matthias Voss, Elisa Rahikkala, Tim D Holmes, Samuel C C Chiang, Jonna Komulainen-Ebrahim, Sorina Gorcenco, Alexandra Rundberg Nilsson, Tim Ripperger, Hannaleena Kokkonen, David Bryder, Thoas Fioretos, Jan-Inge Henter, Merja Möttönen, Riitta Niinimäki, Lars Nilsson, Kees-Jan Pronk, Andreas Puschmann, Hong Qian & 5 others, Johanna Uusimaa, Jukka S. Moilanen, Ulf Tedgård, Jörg Cammenga & Yenan T Bryceson, 2017, In: Blood. 129, 16, p. 2266-2279 15 p.

    Research output: Contribution to journalArticle

  23. 2016
  24. IL1RAP antibodies block IL-1-induced expansion of candidate CML stem cells and mediate cell killing in xenograft models

    Helena Ågerstam, Nils Hansen, Sofia von Palffy, Carl Sandén, Kristian Reckzeh, Christine Karlsson, Henrik Lilljebjörn, Niklas Landberg, Maria Askmyr, Carl Högberg, Marianne Rissler, Kimmo Porkka, Hans Wadenvik, Satu Mustjoki, Johan Richter, Marcus Järås & Thoas Fioretos, 2016 Dec 8, In: Blood. 128, 23, p. 2683-2693

    Research output: Contribution to journalArticle

  25. Clonal conversion of B lymphoid leukemia reveals cross-lineage transfer of malignant states

    Rajesh Somasundaram, Josefine Åhsberg, Kazuki Okuyama, Jonas Ungerbäck, Henrik Lilljebjörn, Thoas Fioretos, Tobias Strid & Mikael Sigvardsson, 2016 Nov 15, In: Genes and Development. 30, 22, p. 2486-2499 14 p.

    Research output: Contribution to journalArticle

  26. Leukemic stem cell quantification in newly diagnosed chronic myeloid leukemia patients predicts response to nilotinib therapy

    Noortje Thielen, Johan Richter, Matthias Baldauf, Gisela Barbany, Thoas Fioretos, Francis Giles, Bjørn Tore Gjertsen, Andreas Hochhaus, Gerrit Jan Schuurhuis, Sieghart Sopper, Leif Stenke, Sarah Thunberg, Dominik Wolf, Gert Ossenkoppele, Kimmo Porkka, Jeroen Janssen & Satu Mustjoki, 2016 Aug 15, In: Clinical Cancer Research. 22, 16, p. 4030-4038 9 p.

    Research output: Contribution to journalArticle

  27. 2015
  28. Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia.

    Helena Ågerstam, Christine Karlsson, Nils Hansen, Carl Sandén, Maria Askmyr, Sofia von Palffy, Carl Högberg, Marianne Rissler, Mark Wunderlich, Gunnar Juliusson, Johan Richter, Kjell Sjöström, Ravi Bhatia, James C Mulloy, Marcus Järås & Thoas Fioretos, 2015, In: Proceedings of the National Academy of Sciences. 112, 34, p. 10786-10791

    Research output: Contribution to journalArticle

  29. Chronic myeloid leukemia

    Thoas Fioretos, 2015, Cancer Cytogenetics: Chromosomal and Molecular Genetic Aberrations of Tumor Cells. Heim, S. & Mitelman, F. (eds.). 4 ed. Wiley-Blackwell, p. 153-174 22 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  30. Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency.

    Mahadesh A J Prasad, Jonas Ungerbäck, Josefine Åhsberg, Rajesh Somasundaram, Tobias Strid, Malin Larsson, Robert Månsson, Ayla De Paepe, Henrik Lilljebjörn, Thoas Fioretos, James Hagman & Mikael Sigvardsson, 2015, In: Blood. 125, 26, p. 4052-4059

    Research output: Contribution to journalArticle

  31. IL1RAP expression as a measure of leukemic stem cell burden at diagnosis of chronic myeloid leukemia predicts therapy outcome.

    Niklas Landberg, Nils Hansen, Maria Askmyr, Helena Ågerstam, Carin Lassen, Marianne Rissler, H H Hansen, S Mustjoki, Marcus Järås, Johan Richter & Thoas Fioretos, 2015, In: Leukemia. 30, 1, p. 255-258

    Research output: Contribution to journalArticle

  32. Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer.

    Linda Holmquist Mengelbier, Jenny Karlsson, David Lindgren, Anders Valind, Henrik Lilljebjörn, Caroline Jansson, Daniel Bexell, Noémie Braekeveldt, Adam Ameur, Tord Jonson, Hanna Göransson Kultima, Anders Isaksson, Jurate Asmundsson, Rogier Versteeg, Marianne Rissler, Thoas Fioretos, Bengt Sandstedt, Anna Börjesson, Torbjörn Backman, Niklas Pal & 3 others, Ingrid Øra, Markus Mayrhofer & David Gisselsson Nord, 2015, In: Nature Communications. 6, 6125.

    Research output: Contribution to journalArticle

  33. The emerging complexity of gene fusions in cancer.

    Fredrik Mertens, Bertil Johansson, Thoas Fioretos & Felix Mitelman, 2015, In: Nature Reviews. Cancer. 15, 6, p. 371-381

    Research output: Contribution to journalReview article

  34. The genomic landscape of high hyperdiploid childhood acute lymphoblastic leukemia.

    Kajsa Paulsson, Henrik Lilljebjörn, Andrea Biloglav, Linda Olsson, Marianne Rissler, Anders Castor, Gisela Barbany, Linda Fogelstrand, Ann Nordgren, Helene Sjögren, Thoas Fioretos & Bertil Johansson, 2015, In: Nature Genetics. 47, 6, p. 672-676

    Research output: Contribution to journalArticle

  35. The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias.

    Anna Andersson, Jing Ma, Jianmin Wang, Xiang Chen, Amanda Larson Gedman, Jinjun Dang, Joy Nakitandwe, Linda Holmfeldt, Matthew Parker, John Easton, Robert Huether, Richard Kriwacki, Michael Rusch, Gang Wu, Yongjin Li, Heather Mulder, Susana Raimondi, Stanley Pounds, Guolian Kang, Lei Shi & 30 others, Jared Becksfort, Pankaj Gupta, Debbie Payne-Turner, Bhavin Vadodaria, Kristy Boggs, Donald Yergeau, Jayanthi Manne, Guangchun Song, Michael Edmonson, Panduka Nagahawatte, Lei Wei, Cheng Cheng, Deqing Pei, Rosemary Sutton, Nicola C Venn, Albert Chetcuti, Amanda Rush, Daniel Catchpoole, Jesper Heldrup, Thoas Fioretos, Charles Lu, Li Ding, Ching-Hon Pui, Sheila Shurtleff, Charles G Mullighan, Elaine R Mardis, Richard K Wilson, Tanja A Gruber, Jinghui Zhang & James R Downing, 2015, In: Nature Genetics. 47, 4, p. 330-U192

    Research output: Contribution to journalArticle

  36. 2014
  37. Comprehensive genetic characterization of pediatric T-cell acute lymphoblastic leukemia

    Kristina Karrman, Anders Castor, Mikael Behrendtz, Erik Forestier, Linda Olsson, Mats Ehinger, Andrea Biloglav, Thoas Fioretos, Kajsa Paulsson & Bertil Johansson, 2014 Dec 6, In: Blood. 124, 21, p. 1084

    Research output: Contribution to journalPublished meeting abstract

  38. A glioma classification scheme based on coexpression modules of EGFR and PDGFRA

    Yingyu Sun, Wei Zhang, Dongfeng Chen, Yuhong Lv, Junxiong Zheng, Henrik Lilljebjörn, Liang Ran, Zhaoshi Bao, Charlotte Soneson, Hans Olov Sjögren, Leif G. Salford, Jianguang Ji, Pim J. Frenc, Thoas Fioretos, Tao Jiang & Xiaolong Fan, 2014 Mar 4, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 9, p. 3538-3543 6 p.

    Research output: Contribution to journalArticle

  39. A novel SERPINE1-FOSB fusion gene results in transcriptional up-regulation of FOSB in pseudomyogenic haemangioendothelioma.

    Charles Walther, Johnbosco Tayebwa, Henrik Lilljebjörn, Linda Magnusson, Jenny Nilsson, Fredrik Vult von Steyern, Ingrid Øra, Henryk Domanski, Thoas Fioretos, Karolin Hansén Nord, Christopher Dm Fletcher & Fredrik Mertens, 2014, In: Journal of Pathology. 232, 5, p. 534-540

    Research output: Contribution to journalArticle

  40. Fusions involving protein kinase C and membrane-associated proteins in benign fibrous histiocytoma.

    Anna Płaszczyca, Jenny Nilsson, Linda Magnusson, Otte Brosjö, Olle Larsson, Fredrik Vult von Steyern, Henryk Domanski, Henrik Lilljebjörn, Thoas Fioretos, Johnbosco Tayebwa, Nils Mandahl, Karolin Hansén Nord & Fredrik Mertens, 2014, In: International Journal of Biochemistry & Cell Biology. 53, Apr 8, p. 475-481

    Research output: Contribution to journalArticle

  41. 2013
  42. Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patients

    S. Mustjoki, Johan Richter, G. Barbany, Hans Ehrencrona, Thoas Fioretos, T. Gedde-Dahl, B. T. Gjertsen, R. Hovland, S. Hernesniemi, D. Josefsen, P. Koskenvesa, I. Dybedal, B. Markevarn, Tobias Olofsson, U. Olsson-Stromberg, K. Rapakko, S. Thunberg, L. Stenke, B. Simonsson, K. Porkka & 1 others, H. Hjorth-Hansen, 2013, In: Leukemia. 27, 7, p. 1520-1526

    Research output: Contribution to journalArticle

  43. Selective killing of candidate AML stem cells by antibody targeting of IL1RAP.

    Maria Askmyr, Helena Ågerstam, Nils Hansen, Sandra Gordon, Alexandros Arvanitakis, Marianne Rissler, Gunnar Juliusson, Johan Richter, Marcus Järås & Thoas Fioretos, 2013, In: Blood. 121, 18, p. 3709-3713

    Research output: Contribution to journalArticle

  44. SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function.

    Nils Hansen, Helena Ågerstam, Martin Wahlestedt, Niklas Landberg, Maria Askmyr, Mats Ehinger, Marianne Rissler, Henrik Lilljebjörn, Petra Johnels, J Ishiko, J V Melo, Alexander Whalen, David Bryder, Marcus Järås & Thoas Fioretos, 2013, In: Leukemia. 27, p. 130-135 6 p.

    Research output: Contribution to journalArticle

  45. 2012
  46. Whole-exome sequencing of pediatric acute lymphoblastic leukemia.

    Henrik Lilljebjörn, Marianne Rissler, Carin Lassen, Jesper Heldrup, M Behrendtz, Felix Mitelman, Bertil Johansson & Thoas Fioretos, 2012, In: Leukemia. 26, p. 1602-1607

    Research output: Contribution to journalArticle

  47. 2011
  48. Fusion Gene Microarray Reveals Cancer Type-Specificity Among Fusion Genes

    Marthe Lovf, Gard O. S. Thomassen, Anne Cathrine Bakken, Ricardo Celestino, Thoas Fioretos, Guro E. Lind, Ragnhild A. Lothe & Rolf I. Skotheim, 2011, In: Genes, Chromosomes and Cancer. 50, 5, p. 348-357

    Research output: Contribution to journalArticle

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