Tomas Björklund

Senior Lecturer, Docent, PhD in Medical Science
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  1. 2019
  2. Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson's disease

    Carl Rosenblad, Li, Q., Pioli, E. Y., Dovero, S., Antunes, A. S. L. M., Agúndez, L., Bardelli, M., Linden, R. M., Henckaerts, E., Anders Björklund, Bezard, E. & Tomas Björklund, 2019, In : Brain : a journal of neurology. p. 2402-2416

    Research output: Contribution to journalArticle

  3. 2018
  4. A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency

    Tordo, J., O'Leary, C., Antunes, A. S. L. M., Palomar, N., Aldrin-Kirk, P., Basche, M., Bennett, A., D'Souza, Z., Gleitz, H., Godwin, A., Holley, R. J., Parker, H., Liao, A. Y., Rouse, P., Youshani, A. S., Dridi, L., Martins, C., Levade, T., Stacey, K. B., Davis, D. M. & 11 othersDyer, A., Clément, N., Tomas Björklund, Ali, R. R., Agbandje-McKenna, M., Rahim, A. A., Pshezhetsky, A., Waddington, S. N., Linden, R. M., Bigger, B. W. & Henckaerts, E., 2018 Jul 1, In : Brain. 141, 7, p. 2014-2031 18 p.

    Research output: Contribution to journalArticle

  5. Molecular barcoding of viral vectors enables mapping and optimization of mRNA trans-splicing

    Marcus Davidsson, Díaz-Fernández, P., Torroba, M., Schwich, O. D., Aldrin-Kirk, P., Luis Quintino, Andreas Heuer, Wang, G., Cecilia Lundberg & Tomas Björklund, 2018 May 1, In : RNA. 24, 5, p. 673-687 15 p.

    Research output: Contribution to journalArticle

  6. Chemogenetic modulation of cholinergic interneurons reveals their regulating role on the direct and indirect output pathways from the striatum

    Aldrin-Kirk, P., Andreas Heuer, Rylander Ottosson, D., Marcus Davidsson, Mattsson, B. & Tomas Björklund, 2018 Jan, In : Neurobiology of Disease. 109, p. 148-162

    Research output: Contribution to journalArticle

  7. Repairing the brain: Gene therapy

    Tomas Björklund, 2018, In : Journal of Parkinson's Disease. 8, s1, p. S123-S130

    Research output: Contribution to journalReview article

  8. 2016
  9. A novel process of viral vector barcoding and library preparation enables high-diversity library generation and recombination-free paired-end sequencing

    Marcus Davidsson, Diaz-Fernandez, P., Schwich, O. D., Torroba, M., Wang, G. & Tomas Björklund, 2016 Nov 22, In : Scientific Reports. 6, 37563.

    Research output: Contribution to journalArticle

  10. Identification of multiple QTLs linked to neuropathology in the engrailed-1 heterozygous mouse model of Parkinson's disease

    Kurowska, Z., Jewett, M., Brattås, P. L., Itzia Jimenez, Kenéz, X., Tomas Björklund, Nordström, U., Brundin, P. & Maria Swanberg, 2016 Aug 23, In : Scientific Reports. 6, 31701.

    Research output: Contribution to journalArticle

  11. DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor

    Aldrin-Kirk, P., Andreas Heuer, Wang, G., Mattsson, B., Lundblad, M., Malin Parmar & Tomas Björklund, 2016 Jun 1, In : Neuron. 90, 5, p. 955-968 14 p.

    Research output: Contribution to journalArticle

  12. Expression of Multiple Functional RNAs or Proteins from One Viral Vector.

    Tomas Björklund, 2016, In : Methods in Molecular Biology. 1382, p. 41-56

    Research output: Contribution to journalArticle

  13. 2014
  14. Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.

    Holmqvist, S., Chutna, O., Bousset, L., Aldrin-Kirk, P., Wen Li, Tomas Björklund, Wang, Z-Y., Laurent Roybon, Melki, R. & Jia-Yi Li, 2014, In : Acta Neuropathologica. 128, 6, p. 805-820

    Research output: Contribution to journalArticle

  15. 2013
  16. A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP.

    Christian Hansen, Tomas Björklund, Petit, G., Lundblad, M., Murmu, R., Brundin, P. & Jia-Yi Li, 2013, In : Neurobiology of Disease. 56C, April,30, p. 145-155

    Research output: Contribution to journalArticle

  17. Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease.

    Cederfjäll, E., Nilsson, N., Gurdal Sahin, Chu, Y., Nikitidou, E., Tomas Björklund, Kordower, J. H. & Deniz Kirik, 2013, In : Scientific Reports. 3, 2157.

    Research output: Contribution to journalArticle

  18. 2012
  19. Dysregulated dopamine storage increases the vulnerability to alpha-synuclein in nigral neurons

    Ulusoy, A., Tomas Björklund, Buck, K. & Deniz Kirik, 2012, In : Neurobiology of Disease. 47, 3, p. 367-377

    Research output: Contribution to journalArticle

  20. 2011
  21. Gene therapy for Parkinson's disease shows promise.

    Anders Björklund & Tomas Björklund, 2011, In : Science Translational Medicine. 3, 79, p. 79ed1

    Research output: Contribution to journalArticle

  22. Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits.

    Hult Lundh, S., Rana Soylu, Tomas Björklund, Belgardt, B. F., Mauer, J., Brüning, J. C., Deniz Kirik & Åsa Petersén, 2011, In : Cell Metabolism. 13, 4, p. 428-439

    Research output: Contribution to journalArticle

  23. 2010
  24. A General Chemical Method to Regulate Protein Stability in the Mammalian Central Nervous System

    Iwamoto, M., Tomas Björklund, Cecilia Lundberg, Deniz Kirik & Wandless, T. J., 2010, In : Chemistry and Biology. 17, 9, p. 981-988

    Research output: Contribution to journalArticle

  25. Differential Transduction Following Basal Ganglia Administration of Distinct Pseudotyped AAV Capsid Serotypes in Nonhuman Primates

    Dodiya, H. B., Tomas Björklund, Stansell, J. III., Mandel, R. J., Deniz Kirik & Kordower, J. H., 2010, In : Molecular Therapy. 18, 3, p. 579-587

    Research output: Contribution to journalArticle

  26. Gene therapy for dopamine replacement.

    Tomas Björklund, Cederfjäll, E. & Deniz Kirik, 2010, In : Progress in Brain Research. 184, p. 221-235

    Research output: Contribution to journalReview article

  27. Gene therapy for Parkinson's disease.

    Tomas Björklund & Kordower, J. H., 2010, In : Movement Disorders. 25 Suppl 1, p. S161-S173

    Research output: Contribution to journalArticle

  28. 2009
  29. Dose Optimization for Long-term rAAV-mediated RNA Interference in the Nigrostriatal Projection Neurons.

    Ulusoy, A., Gurdal Sahin, Tomas Björklund, Aebischer, P. & Deniz Kirik, 2009, In : Molecular Therapy. 17, p. 1574-1584

    Research output: Contribution to journalArticle

  30. Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats

    Tomas Björklund, Hall, H., Breysse, N., Soneson, C., Carlsson, T., Mandel, R. J., Carta, M. & Deniz Kirik, 2009, In : Journal of Neurochemistry. 111, 2, p. 355-367

    Research output: Contribution to journalArticle

  31. Positron Emission Tomography Imaging Demonstrates Correlation between Behavioral Recovery and Correction of Dopamine Neurotransmission after Gene Therapy

    Leriche, L., Tomas Björklund, Breysse, N., Besret, L., Gregoire, M-C., Carlsson, T., Dolle, F., Mandel, R. J., Deglon, N., Hantraye, P. & Deniz Kirik, 2009, In : Journal of Neuroscience. 29, 5, p. 1544-1553

    Research output: Contribution to journalArticle

  32. 2008
  33. Applications of lentiviral vectors for biology and gene therapy of neurological disorders.

    Cecilia Lundberg, Tomas Björklund, Carlsson, T., Johan Jakobsson, Hantraye, P., Déglon, N. & Deniz Kirik, 2008, In : Current Gene Therapy. 8, 6, p. 461-473

    Research output: Contribution to journalArticle

  34. Future Cell- and Gene-Based Therapies for Parkinson's Disease

    Tomas Björklund, Morizane, A., Deniz Kirik & Brundin, P., 2008, Therapeutics of Parkinson's Disease and Other Movement Disorders. Hallett, M. & Poewe, P. (eds.). John Wiley & Sons, p. 145-156

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  35. In vivo gene delivery for development of mammalian models for Parkinson's disease

    Ulusoy, A., Tomas Björklund, Hermening, S. & Deniz Kirik, 2008, In : Experimental Neurology. 209, 1, p. 89-100

    Research output: Contribution to journalReview article

  36. 2007
  37. Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain.

    Eslamboli, A., Romero-Ramos, M., Burger, C., Tomas Björklund, Muzyczka, N., Mandel, R. J., Baker, H., Ridley, R. M. & Deniz Kirik, 2007, In : Brain. 130, 3, p. 799-815

    Research output: Contribution to journalArticle

  38. 2006
  39. Morphometric and psychometric comparisons between non-substance-abusing patients with posttraumatic stress disorder and normal controls

    Emdad, R., Bonekamp, D., Sondergaard, H. P., Tomas Björklund, Agartz, I., Ingvar, M. & Theorell, T., 2006, In : Psychotherapy and Psychosomatics. 75, 2, p. 122-132

    Research output: Contribution to journalLetter

  40. 2005
  41. Imaging in cell-based therapy for neurodegenerative diseases.

    Deniz Kirik, Breysse, N., Tomas Björklund, Besret, L. & Hantraye, P., 2005, In : European Journal of Nuclear Medicine and Molecular Imaging. 32, Suppl 2, p. S417-S434

    Research output: Contribution to journalReview article