Tomas Leanderson

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  1. 2019
  2. Pharmacologic exhaustion of suppressor cells with tasquinimod enhances bacterial clearance during tuberculosis

    Shashank Gupta, Stefanie Krug, Supriya Pokkali, Tomas Leanderson, John T. Isaacs, Geetha Srikrishna & William R. Bishai, 2019, In: American Journal of Respiratory and Critical Care Medicine. 199, 3, p. 386-389 4 p.

    Research output: Contribution to journalLetter

  3. 2018
  4. Induction of S100A9 homodimer formation in vivo

    Eva Källberg, Sahar Tahvili, Fredrik Ivars & Tomas Leanderson, 2018 Jun, In: Biochemical and Biophysical Research Communications. p. 564-568 5 p.

    Research output: Contribution to journalArticle

  5. Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation

    Thomas Vogl, Athanasios Stratis, Viktor Wixler, Tom Völler, Sumita Thurainayagam, Selina K. Jorch, Stefanie Zenker, Alena Dreiling, Deblina Chakraborty, Mareike Fröhling, Peter Paruzel, Corinna Wehmeyer, Sven Hermann, Olympia Papantonopoulou, Christiane Geyer, Karin Loser, Michael Schäfers, Stephan Ludwig, Monika Stoll, Tomas Leanderson & 4 others, Joachim L. Schultze, Simone König, Thomas Pap & Johannes Roth, 2018 May 1, In: Journal of Clinical Investigation. 128, 5, p. 1852-1866 15 p.

    Research output: Contribution to journalArticle

  6. Paquinimod prevents development of diabetes in the non-obese diabetic (NOD) mouse

    Sahar Tahvili, Marie Törngren, Dan Holmberg, Tomas Leanderson & Fredrik Ivars, 2018 May 1, In: PLoS ONE. 13, 5, e0196598.

    Research output: Contribution to journalArticle

  7. 2017
  8. 2016
  9. IgA Structure Variations Associate with Immune Stimulations and IgA Mesangial Deposition.

    Zeliha Oruc, Christelle Oblet, Ahmed Boumediene, Anne Druilhe, Virginie Pascal, Elisabeth Le Rumeur, Armelle Cuvillier, Chahrazed El Hamel, Sandrine Lecardeur, Tomas Leanderson, Willy Morelle, Jocelyne Demengeot, Jean-Claude Aldigier & Michel Cogné, 2016 Sep, In: Journal of the American Society of Nephrology : JASN. 27, 9, p. 2748-2761

    Research output: Contribution to journalArticle

  10. CD14 is a co-receptor for TLR4 in the S100A9-induced pro-inflammatory response in monocytes

    Zhifei He, Matteo Riva, Per Björk, Karl Swärd, Matthias Mörgelin, Tomas Leanderson & Fredrik Ivars, 2016, In: PLoS ONE. 11, 5, e0156377.

    Research output: Contribution to journalArticle

  11. Paquinimod reduces skin fibrosis in tight skin 1 mice, an experimental model of systemic sclerosis

    Martin Stenström, Helén Carlsson Nyhlén, Marie Törngren, David Liberg, Birgitta Sparre, Helén Tuvesson, Helena Eriksson & Tomas Leanderson, 2016, In: Journal of Dermatological Science. 83, 1, p. 52-59 8 p.

    Research output: Contribution to journalArticle

  12. Platelet-derived S100A8/A9 and cardiovascular disease in systemic lupus erythematosus.

    Christian Lood, Helena Tydén, Birgitta Gullstrand, Andreas Jönsen, Eva Källberg, Matthias Mörgelin, Robin Kahn, Iva Gunnarsson, Tomas Leanderson, Fredrik Ivars, Elisabet Svenungsson & Anders Bengtsson, 2016, In: Arthritis & Rheumatology.

    Research output: Contribution to journalArticle

  13. 2015
  14. Vesicular Location and Transport of S100A8 and S100A9 Proteins in Monocytoid Cells.

    Paramita Chakraborty, Per Bjork, Eva Källberg, Anders Olsson, Matteo Riva, Matthias Mörgelin, David Liberg, Fredrik Ivars & Tomas Leanderson, 2015 Dec, In: PLoS ONE. 10, 12, e0145217.

    Research output: Contribution to journalArticle

  15. Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion.

    Monika Pruenster, Angela R M Kurz, Kyoung-Jin Chung, Xiao Cao-Ehlker, Stephanie Bieber, Claudia F Nussbaum, Susanne Bierschenk, Tanja K Eggersmann, Ina Rohwedder, Kristina Heinig, Roland Immler, Markus Moser, Uwe Koedel, Sandra Gran, Rodger P McEver, Dietmar Vestweber, Admar Verschoor, Tomas Leanderson, Triantafyllos Chavakis, Johannes Roth & 2 others, Thomas Vogl & Markus Sperandio, 2015, In: Nature Communications. 6, 6915.

    Research output: Contribution to journalArticle

  16. Myeloid-related protein 14 promote inflammation and injury in meningitis.

    Christina Wache, Matthias Klein, Christian Ostergaard, Barbara Angele, Hans Häcker, Hans-Walter Pfister, Monika Pruenster, Markus Sperandio, Tomas Leanderson, Johannes Roth, Thomas Vogl & Uwe Koedel, 2015, In: Journal of Infectious Diseases. 212, 2, p. 247-257

    Research output: Contribution to journalArticle

  17. Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.

    R F Schelbergen, E J Geven, M H J van den Bosch, H Eriksson, Tomas Leanderson, T Vogl, J Roth, F A J van de Loo, M I Koenders, P M van der Kraan, W B van den Berg, A B Blom & P L E M van Lent, 2015, In: Annals of the Rheumatic Diseases. 74, 12, p. 2254-2258

    Research output: Contribution to journalArticle

  18. Tasquinimod Modulates Suppressive Myeloid Cells and Enhances Cancer Immunotherapies in Murine Models

    Li Shen, Anette Sundstedt, Michael Ciesielski, Kiersten Marie Miles, Mona Celander, Remi Adelaiye, Ashley Orillion, Eric Ciamporcero, Swathi Ramakrishnan, Leigh Ellis, Robert Fenstermaker, Scott I. Abrams, Helena Eriksson, Tomas Leanderson, Anders Olsson & Roberto Pili, 2015, In: Cancer immunology research. 3, 2, p. 136-148

    Research output: Contribution to journalArticle

  19. Tasquinimod triggers an early change in the polarization of tumor associated macrophages in the tumor microenvironment.

    Anders Olsson, Jessica Nakhlé, Anette Sundstedt, Pascale Plas, Anne-Laure Bauchet, Valérie Pierron, Luce Bruetschy, Adnan Deronic, Marie Törngren, David Liberg, Fabien Schmidlin & Tomas Leanderson, 2015, In: Journal for ImmunoTherapy of Cancer. 3, 53.

    Research output: Contribution to journalArticle

  20. 2014
  21. Anti-cancer potency of tasquinimod is enhanced via albumin-binding facilitating increased uptake in the tumor microenvironment.

    John T Isaacs, Susan L Dalrymple, D Marc Rosen, Hans Hammers, Anders Olsson & Tomas Leanderson, 2014, In: Oncotarget. 5, 18, p. 8093-8106

    Research output: Contribution to journalArticle

  22. High density of S100A9 positive inflammatory cells in prostate cancer stroma is associated with poor outcome.

    Viktor Tidehag, Peter Hammarsten, Lars Egevad, Torvald Granfors, Pär Stattin, Tomas Leanderson, Pernilla Wikström, Andreas Josefsson, Christina Hägglöf & Anders Bergh, 2014, In: European Journal of Cancer. 50, 10, p. 1829-1835

    Research output: Contribution to journalArticle

  23. 2013
  24. Common Interactions between S100A4 and S100A9 Defined by a Novel Chemical Probe.

    Per Björkman, Eva Källberg, Ulf Wellmar, Matteo Riva, Anders Olsson, Zhifei He, Marie Törngren, David Liberg, Fredrik Ivars & Tomas Leanderson, 2013, In: PLoS ONE. 8, 5, e63012.

    Research output: Contribution to journalArticle

  25. Mice Lacking NCF1 Exhibit Reduced Growth of Implanted Melanoma and Carcinoma Tumors.

    Tiina Kelkka, Angela Pizzolla, Juha Petteri Laurila, Tomas Friman, Renata Gustafsson, Eva Källberg, Olof Olsson, Tomas Leanderson, Kristofer Rubin, Marko Salmi, Sirpa Jalkanen & Rikard Holmdahl, 2013, In: PLoS ONE. 8, 12, e84148.

    Research output: Contribution to journalArticle

  26. Tasquinimod Is an Allosteric Modulator of HDAC4 Survival Signaling within the Compromised Cancer Microenvironment

    John T. Isaacs, Lizamma Antony, Susan L. Dalrymple, W. Nathaniel Brennen, Stephanie Gerber, Hans Hammers, Michel Wissing, Sushant Kachhap, Jun Luo, Li Xing, Per Bjork, Anders Olsson, Anders Bjork & Tomas Leanderson, 2013, In: Cancer Research. 74, 4, p. 1386-1399

    Research output: Contribution to journalArticle

  27. The radical-binding lipocalin A1M binds to a Complex I subunit and protects mitochondrial structure and function.

    Magnus Gram, Lena Wester Rosenlöf, Heike Kotarsky, Tor Olofsson, Tomas Leanderson, Matthias Mörgelin, Vineta Fellman & Bo Åkerström, 2013, In: Antioxidants & Redox Signaling. 18, 16, p. 2017-2028

    Research output: Contribution to journalArticle

  28. 2012
  29. CD11b(+)Ly6C(++)Ly6G(-) cells show distinct function in mice with chronic inflammation or tumor burden

    Eva Källberg, Martin Stenström, David Liberg, Fredrik Ivars & Tomas Leanderson, 2012, In: BMC Immunology. 13, 69.

    Research output: Contribution to journalArticle

  30. Induction of NFκB responses by the S100A9 protein is TLR4-dependent.

    Matteo Riva, Eva Källberg, Per Björk, Dora Hancz, Thomas Vogl, Johannes Roth, Fredrik Ivars & Tomas Leanderson, 2012, In: Immunology. 137, 2, p. 172-182

    Research output: Contribution to journalArticle

  31. Inhibition of metastasis in a castration resistant prostate cancer model by the quinoline-3-carboxamide tasquinimod (ABR-215050)

    Karin Jennbacken, Karin Welen, Anders Olsson, Bengt Axelsson, Marie Torngren, Jan-Erik Damber & Tomas Leanderson, 2012, In: The Prostate. 72, 8, p. 913-924

    Research output: Contribution to journalArticle

  32. S100A9 and tumor growth.

    Tomas Leanderson & Fredrik Ivars, 2012, In: OncoImmunology. 1, 8, p. 1404-1405

    Research output: Contribution to journalArticle

  33. S100A9 Interaction with TLR4 Promotes Tumor Growth.

    Eva Källberg, Thomas Vogl, David Liberg, Anders Olsson, Per Björkman, Pernilla Wikström, Anders Bergh, Johannes Roth, Fredrik Ivars & Tomas Leanderson, 2012, In: PLoS ONE. 7, 3, e34207.

    Research output: Contribution to journalArticle

  34. 2011
  35. Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia

    Severine Coulon, Michael Dussiot, Damien Grapton, Thiago Trovati Maciel, Pamella Huey Mei Wang, Celine Callens, Meetu Kaushik Tiwari, Saurabh Agarwal, Aurelie Fricot, Julie Vandekerckhove, Houda Tamouza, Yael Zermati, Jean-Antoine Ribeil, Kamel Djedaini, Zeliha Oruc, Virginie Pascal, Genevieve Courtois, Bertrand Arnulf, Marie-Alexandra Alyanakian, Patrick Mayeux & 6 others, Tomas Leanderson, Marc Benhamou, Michel Cogne, Renato C. Monteiro, Olivier Hermine & Ivan C. Moura, 2011, In: Nature Medicine. 17, 11, p. 1456-U163

    Research output: Contribution to journalArticle

  36. 2010
  37. Indoleamine 2,3-dioxygenase (IDO) activity influence tumor growth in the TRAMP prostate cancer model.

    Eva Källberg, Pernilla Wikström, Anders Bergh, Fredrik Ivars & Tomas Leanderson, 2010, In: The Prostate. 70, 13, p. 1461-1470

    Research output: Contribution to journalArticle

  38. Selective depletion of splenic CD4 dendritic cells in mice treated with immunomodulatory quinoline-3-carboxamide ABR-215757.

    Martin Stenström, Per Anderson, Lena Eroukhmanoff, Tomas Leanderson & Fredrik Ivars, 2010, In: International Immunopharmacology. May 4, p. 837-842

    Research output: Contribution to journalArticle

  39. 2009
  40. Antioxidant metabolism induced by quinic acid. increased urinary excretion of tryptophan and nicotinamide.

    Ronald W Pero, Harald Lund & Tomas Leanderson, 2009, In: Phytotherapy Research. Oct 9, p. 335-346

    Research output: Contribution to journalArticle

  41. From the fetal liver to spleen and gut: the highway to natural antibody

    M. M. Rosado, A. Aranburu, F. Capolunghi, E. Giorda, S. Cascioli, F. Cenci, S. Petrini, Eva Miller, Tomas Leanderson, G. F. Bottazzo, P. G. Natali & R. Carsetti, 2009, In: Mucosal Immunology. 2, 4, p. 351-361

    Research output: Contribution to journalArticle

  42. Identification of human S100A9 as a novel target for treatment of autoimmune disease via binding to quinoline-3-carboxamides.

    Per Björk, Anders Björk, Thomas Vogl, Martin Stenström, David Liberg, Anders Olsson, Johannes Roth, Fredrik Ivars & Tomas Leanderson, 2009, In: PLoS Biology. 7, 4, p. 800-812

    Research output: Contribution to journalArticle

  43. 2008
  44. A subset of dendritic cells express joining chain (J-chain) protein

    Eva Källberg & Tomas Leanderson, 2008, In: Immunology. 129, 4, p. 590-599

    Research output: Contribution to journalArticle

  45. Effect on interferon-inducible gene expression signature by ABR215757, a new drug in development for SLE

    David Liberg, Eva Källberg, Anders Olsson, Anders Bengtsson, Lars Ronnblom & Tomas Leanderson, 2008, In: Arthritis and Rheumatism. 58, 9, p. S567-S568

    Research output: Contribution to journalPublished meeting abstract

  46. IFN-alpha/beta signaling is required for polarization of cytokine responses toward a protective type 1 pattern during experimental cryptococcosis

    Carmelo Biondo, Angelina Midiri, Maria Gambuzza, Elisabetta Gerace, Maria Falduto, Roberta Galbo, Antonella Bellantoni, Concetta Beninati, Giuseppe Teti, Tomas Leanderson & Giuseppe Mancuso, 2008, In: Journal of Immunology. 181, 1, p. 566-573

    Research output: Contribution to journalArticle

  47. 2007
  48. Type I IFN signaling is crucial for host resistance against different species of pathogenic bacteria

    Giuseppe Mancuso, Angelina Midiri, Carmelo Biondo, Concetta Beninati, Sebastiana Zummo, Roberta Galbo, Francesco Tomasello, Maria Gambuzza, Giancarlo Macri, Alessia Ruggeri, Tomas Leanderson & Giuseppe Teti, 2007, In: Journal of Immunology. 178, 5, p. 3126-3133

    Research output: Contribution to journalArticle

  49. 2006
  50. CArG box-binding factor-A interacts with multiple motifs in immunoglobulin promoters and has a regulated subcellular distribution.

    Alaitz Aranburu, David Liberg, Bent Honoré & Tomas Leanderson, 2006, In: European Journal of Immunology. 36, 8, p. 2192-2202

    Research output: Contribution to journalArticle

  51. Identification of ABR-215050 as lead second generation quinoline-3-carboxamide anti-angiogenic agent for the treatment of prostate cancer.

    J T Isaacs, R Pili, D Z Qian, S L Dalrymple, J B Garrison, N Kyprianou, A Bjork, A Olsson & Tomas Leanderson, 2006, In: The Prostate. 66, 16, p. 1768-1778

    Research output: Contribution to journalArticle

  52. Joining-chain (J-chain) negative mice are B cell memory deficient.

    Eva Källberg & Tomas Leanderson, 2006, In: European Journal of Immunology. 36, 6, p. 1398-1403

    Research output: Contribution to journalArticle

  53. SPI-C and STAT6 can cooperate to stimulate IgE germline transcription.

    Robert Carlsson, Kaisa Thorell, David Liberg & Tomas Leanderson, 2006, In: Biochemical and Biophysical Research Communications. 344, 4, p. 1155-1160

    Research output: Contribution to journalArticle

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