Tomas Leanderson

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  1. 2019
  2. Pharmacologic exhaustion of suppressor cells with tasquinimod enhances bacterial clearance during tuberculosis

    Gupta, S., Krug, S., Pokkali, S., Tomas Leanderson, Isaacs, J. T., Srikrishna, G. & Bishai, W. R., 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 3, p. 386-389 4 p.

    Research output: Contribution to journalLetter

  3. 2018
  4. Induction of S100A9 homodimer formation in vivo

    Eva Källberg, Tahvili, S., Fredrik Ivars & Tomas Leanderson, 2018 Jun, In : Biochemical and Biophysical Research Communications. p. 564-568 5 p.

    Research output: Contribution to journalArticle

  5. Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation

    Vogl, T., Stratis, A., Wixler, V., Völler, T., Thurainayagam, S., Jorch, S. K., Zenker, S., Dreiling, A., Chakraborty, D., Fröhling, M., Paruzel, P., Wehmeyer, C., Hermann, S., Papantonopoulou, O., Geyer, C., Loser, K., Schäfers, M., Ludwig, S., Stoll, M., Leanderson, T. & 4 others, Schultze, J. L., König, S., Pap, T. & Roth, J., 2018 May 1, In : Journal of Clinical Investigation. 128, 5, p. 1852-1866 15 p.

    Research output: Contribution to journalArticle

  6. Paquinimod prevents development of diabetes in the non-obese diabetic (NOD) mouse

    Tahvili, S., Törngren, M., Dan Holmberg, Tomas Leanderson & Fredrik Ivars, 2018 May 1, In : PLoS ONE. 13, 5, e0196598.

    Research output: Contribution to journalArticle

  7. 2017
  8. 2016
  9. IgA Structure Variations Associate with Immune Stimulations and IgA Mesangial Deposition.

    Oruc, Z., Oblet, C., Boumediene, A., Druilhe, A., Pascal, V., Le Rumeur, E., Cuvillier, A., El Hamel, C., Lecardeur, S., Tomas Leanderson, Morelle, W., Demengeot, J., Aldigier, J-C. & Cogné, M., 2016 Sep, In : Journal of the American Society of Nephrology : JASN. 27, 9, p. 2748-2761

    Research output: Contribution to journalArticle

  10. CD14 is a co-receptor for TLR4 in the S100A9-induced pro-inflammatory response in monocytes

    He, Z., Riva, M., Björk, P., Karl Swärd, Mörgelin, M., Tomas Leanderson & Fredrik Ivars, 2016, In : PLoS ONE. 11, 5, e0156377.

    Research output: Contribution to journalArticle

  11. Paquinimod reduces skin fibrosis in tight skin 1 mice, an experimental model of systemic sclerosis

    Stenström, M., Nyhlén, H. C., Törngren, M., Liberg, D., Sparre, B., Tuvesson, H., Eriksson, H. & Tomas Leanderson, 2016, In : Journal of Dermatological Science. 83, 1, p. 52-59 8 p.

    Research output: Contribution to journalArticle

  12. 2015
  13. Vesicular Location and Transport of S100A8 and S100A9 Proteins in Monocytoid Cells.

    Chakraborty, P., Bjork, P., Eva Källberg, Olsson, A., Riva, M., Mörgelin, M., Liberg, D., Fredrik Ivars & Tomas Leanderson, 2015 Dec, In : PLoS ONE. 10, 12, e0145217.

    Research output: Contribution to journalArticle

  14. Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion.

    Pruenster, M., Kurz, A. R. M., Chung, K-J., Cao-Ehlker, X., Bieber, S., Nussbaum, C. F., Bierschenk, S., Eggersmann, T. K., Rohwedder, I., Heinig, K., Immler, R., Moser, M., Koedel, U., Gran, S., McEver, R. P., Vestweber, D., Verschoor, A., Leanderson, T., Chavakis, T., Roth, J. & 2 others, Vogl, T. & Sperandio, M., 2015, In : Nature Communications. 6, 6915.

    Research output: Contribution to journalArticle

  15. Myeloid-related protein 14 promote inflammation and injury in meningitis.

    Wache, C., Klein, M., Ostergaard, C., Angele, B., Häcker, H., Pfister, H-W., Pruenster, M., Sperandio, M., Tomas Leanderson, Roth, J., Vogl, T. & Koedel, U., 2015, In : Journal of Infectious Diseases. 212, 2, p. 247-257

    Research output: Contribution to journalArticle

  16. Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.

    Schelbergen, R. F., Geven, E. J., van den Bosch, M. H. J., Eriksson, H., Tomas Leanderson, Vogl, T., Roth, J., van de Loo, F. A. J., Koenders, M. I., van der Kraan, P. M., van den Berg, W. B., Blom, A. B. & van Lent, P. L. E. M., 2015, In : Annals of the Rheumatic Diseases. 74, 12, p. 2254-2258

    Research output: Contribution to journalArticle

  17. Tasquinimod Modulates Suppressive Myeloid Cells and Enhances Cancer Immunotherapies in Murine Models

    Shen, L., Sundstedt, A., Ciesielski, M., Miles, K. M., Celander, M., Adelaiye, R., Orillion, A., Ciamporcero, E., Ramakrishnan, S., Ellis, L., Fenstermaker, R., Abrams, S. I., Eriksson, H., Tomas Leanderson, Olsson, A. & Pili, R., 2015, In : Cancer immunology research. 3, 2, p. 136-148

    Research output: Contribution to journalArticle

  18. Tasquinimod triggers an early change in the polarization of tumor associated macrophages in the tumor microenvironment.

    Olsson, A., Nakhlé, J., Sundstedt, A., Plas, P., Bauchet, A-L., Pierron, V., Bruetschy, L., Deronic, A., Törngren, M., Liberg, D., Schmidlin, F. & Tomas Leanderson, 2015, In : Journal for ImmunoTherapy of Cancer. 3, 53.

    Research output: Contribution to journalArticle

  19. 2014
  20. Anti-cancer potency of tasquinimod is enhanced via albumin-binding facilitating increased uptake in the tumor microenvironment.

    Isaacs, J. T., Dalrymple, S. L., Rosen, D. M., Hammers, H., Olsson, A. & Tomas Leanderson, 2014, In : Oncotarget. 5, 18, p. 8093-8106

    Research output: Contribution to journalArticle

  21. High density of S100A9 positive inflammatory cells in prostate cancer stroma is associated with poor outcome.

    Tidehag, V., Hammarsten, P., Egevad, L., Granfors, T., Stattin, P., Tomas Leanderson, Wikström, P., Josefsson, A., Hägglöf, C. & Bergh, A., 2014, In : European Journal of Cancer. 50, 10, p. 1829-1835

    Research output: Contribution to journalArticle

  22. 2013
  23. Common Interactions between S100A4 and S100A9 Defined by a Novel Chemical Probe.

    Per Björkman, Eva Källberg, Wellmar, U., Riva, M., Olsson, A., He, Z., Törngren, M., Liberg, D., Fredrik Ivars & Tomas Leanderson, 2013, In : PLoS ONE. 8, 5, e63012.

    Research output: Contribution to journalArticle

  24. Mice Lacking NCF1 Exhibit Reduced Growth of Implanted Melanoma and Carcinoma Tumors.

    Kelkka, T., Pizzolla, A., Laurila, J. P., Friman, T., Gustafsson, R., Eva Källberg, Olsson, O., Tomas Leanderson, Rubin, K., Salmi, M., Jalkanen, S. & Holmdahl, R., 2013, In : PLoS ONE. 8, 12, e84148.

    Research output: Contribution to journalArticle

  25. Tasquinimod Is an Allosteric Modulator of HDAC4 Survival Signaling within the Compromised Cancer Microenvironment

    Isaacs, J. T., Antony, L., Dalrymple, S. L., Brennen, W. N., Gerber, S., Hammers, H., Wissing, M., Kachhap, S., Luo, J., Xing, L., Bjork, P., Olsson, A., Bjork, A. & Tomas Leanderson, 2013, In : Cancer Research. 74, 4, p. 1386-1399

    Research output: Contribution to journalArticle

  26. The radical-binding lipocalin A1M binds to a Complex I subunit and protects mitochondrial structure and function.

    Magnus Gram, Wester Rosenlöf, L., Kotarsky, H., Olofsson, T., Tomas Leanderson, Mörgelin, M., Vineta Fellman & Bo Åkerström, 2013, In : Antioxidants & Redox Signaling. 18, 16, p. 2017-2028

    Research output: Contribution to journalArticle

  27. 2012
  28. CD11b(+)Ly6C(++)Ly6G(-) cells show distinct function in mice with chronic inflammation or tumor burden

    Eva Källberg, Stenström, M., Liberg, D., Fredrik Ivars & Tomas Leanderson, 2012, In : BMC Immunology. 13, 69.

    Research output: Contribution to journalArticle

  29. Induction of NFκB responses by the S100A9 protein is TLR4-dependent.

    Riva, M., Eva Källberg, Björk, P., Hancz, D., Vogl, T., Roth, J., Fredrik Ivars & Tomas Leanderson, 2012, In : Immunology. 137, 2, p. 172-182

    Research output: Contribution to journalArticle

  30. Inhibition of metastasis in a castration resistant prostate cancer model by the quinoline-3-carboxamide tasquinimod (ABR-215050)

    Jennbacken, K., Welen, K., Olsson, A., Axelsson, B., Torngren, M., Damber, J-E. & Tomas Leanderson, 2012, In : The Prostate. 72, 8, p. 913-924

    Research output: Contribution to journalArticle

  31. S100A9 and tumor growth.

    Tomas Leanderson & Fredrik Ivars, 2012, In : OncoImmunology. 1, 8, p. 1404-1405

    Research output: Contribution to journalArticle

  32. S100A9 Interaction with TLR4 Promotes Tumor Growth.

    Eva Källberg, Vogl, T., Liberg, D., Olsson, A., Per Björkman, Wikström, P., Bergh, A., Roth, J., Fredrik Ivars & Tomas Leanderson, 2012, In : PLoS ONE. 7, 3, e34207.

    Research output: Contribution to journalArticle

  33. 2011
  34. Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia

    Coulon, S., Dussiot, M., Grapton, D., Maciel, T. T., Wang, P. H. M., Callens, C., Tiwari, M. K., Agarwal, S., Fricot, A., Vandekerckhove, J., Tamouza, H., Zermati, Y., Ribeil, J-A., Djedaini, K., Oruc, Z., Pascal, V., Courtois, G., Arnulf, B., Alyanakian, M-A., Mayeux, P. & 6 others, Tomas Leanderson, Benhamou, M., Cogne, M., Monteiro, R. C., Hermine, O. & Moura, I. C., 2011, In : Nature Medicine. 17, 11, p. 1456-U163

    Research output: Contribution to journalArticle

  35. 2010
  36. Indoleamine 2,3-dioxygenase (IDO) activity influence tumor growth in the TRAMP prostate cancer model.

    Eva Källberg, Wikström, P., Bergh, A., Fredrik Ivars & Tomas Leanderson, 2010, In : The Prostate. 70, 13, p. 1461-1470

    Research output: Contribution to journalArticle

  37. Selective depletion of splenic CD4 dendritic cells in mice treated with immunomodulatory quinoline-3-carboxamide ABR-215757.

    Stenström, M., Anderson, P., Eroukhmanoff, L., Tomas Leanderson & Fredrik Ivars, 2010, In : International Immunopharmacology. May 4, p. 837-842

    Research output: Contribution to journalArticle

  38. 2009
  39. Antioxidant metabolism induced by quinic acid. increased urinary excretion of tryptophan and nicotinamide.

    Pero, R. W., Lund, H. & Tomas Leanderson, 2009, In : Phytotherapy Research. Oct 9, p. 335-346

    Research output: Contribution to journalArticle

  40. From the fetal liver to spleen and gut: the highway to natural antibody

    Rosado, M. M., Aranburu, A., Capolunghi, F., Giorda, E., Cascioli, S., Cenci, F., Petrini, S., Miller, E., Tomas Leanderson, Bottazzo, G. F., Natali, P. G. & Carsetti, R., 2009, In : Mucosal Immunology. 2, 4, p. 351-361

    Research output: Contribution to journalArticle

  41. Identification of human S100A9 as a novel target for treatment of autoimmune disease via binding to quinoline-3-carboxamides.

    Björk, P., Björk, A., Vogl, T., Stenström, M., Liberg, D., Olsson, A., Roth, J., Fredrik Ivars & Tomas Leanderson, 2009, In : PLoS Biology. 7, 4, p. 800-812

    Research output: Contribution to journalArticle

  42. 2008
  43. A subset of dendritic cells express joining chain (J-chain) protein

    Eva Källberg & Tomas Leanderson, 2008, In : Immunology. 129, 4, p. 590-599

    Research output: Contribution to journalArticle

  44. Effect on interferon-inducible gene expression signature by ABR215757, a new drug in development for SLE

    Liberg, D., Eva Källberg, Olsson, A., Anders Bengtsson, Ronnblom, L. & Tomas Leanderson, 2008, In : Arthritis and Rheumatism. 58, 9, p. S567-S568

    Research output: Contribution to journalPublished meeting abstract

  45. IFN-alpha/beta signaling is required for polarization of cytokine responses toward a protective type 1 pattern during experimental cryptococcosis

    Biondo, C., Midiri, A., Gambuzza, M., Gerace, E., Falduto, M., Galbo, R., Bellantoni, A., Beninati, C., Teti, G., Tomas Leanderson & Mancuso, G., 2008, In : Journal of Immunology. 181, 1, p. 566-573

    Research output: Contribution to journalArticle

  46. 2007
  47. Type I IFN signaling is crucial for host resistance against different species of pathogenic bacteria

    Mancuso, G., Midiri, A., Biondo, C., Beninati, C., Zummo, S., Galbo, R., Tomasello, F., Gambuzza, M., Macri, G., Ruggeri, A., Tomas Leanderson & Teti, G., 2007, In : Journal of Immunology. 178, 5, p. 3126-3133

    Research output: Contribution to journalArticle

  48. 2006
  49. CArG box-binding factor-A interacts with multiple motifs in immunoglobulin promoters and has a regulated subcellular distribution.

    Aranburu, A., Liberg, D., Honoré, B. & Tomas Leanderson, 2006, In : European Journal of Immunology. 36, 8, p. 2192-2202

    Research output: Contribution to journalArticle

  50. Identification of ABR-215050 as lead second generation quinoline-3-carboxamide anti-angiogenic agent for the treatment of prostate cancer.

    Isaacs, J. T., Pili, R., Qian, D. Z., Dalrymple, S. L., Garrison, J. B., Kyprianou, N., Bjork, A., Olsson, A. & Tomas Leanderson, 2006, In : The Prostate. 66, 16, p. 1768-1778

    Research output: Contribution to journalArticle

  51. Joining-chain (J-chain) negative mice are B cell memory deficient.

    Eva Källberg & Tomas Leanderson, 2006, In : European Journal of Immunology. 36, 6, p. 1398-1403

    Research output: Contribution to journalArticle

  52. SPI-C and STAT6 can cooperate to stimulate IgE germline transcription.

    Robert Carlsson, Thorell, K., Liberg, D. & Tomas Leanderson, 2006, In : Biochemical and Biophysical Research Communications. 344, 4, p. 1155-1160

    Research output: Contribution to journalArticle

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